UY25686A1 - Procedimiento para preparar sales de trovafloxacina de adición de ácidos - Google Patents
Procedimiento para preparar sales de trovafloxacina de adición de ácidosInfo
- Publication number
- UY25686A1 UY25686A1 UY25686A UY25686A UY25686A1 UY 25686 A1 UY25686 A1 UY 25686A1 UY 25686 A UY25686 A UY 25686A UY 25686 A UY25686 A UY 25686A UY 25686 A1 UY25686 A1 UY 25686A1
- Authority
- UY
- Uruguay
- Prior art keywords
- acid
- procedure
- trovafloxacin
- general formula
- acid addition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 4
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical class C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 chloro, bromo, iodo groups Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 229960000497 trovafloxacin Drugs 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- MTHFROHDIWGWFD-UHFFFAOYSA-N n-butyl-n-methylbutan-1-amine Chemical compound CCCCN(C)CCCC MTHFROHDIWGWFD-UHFFFAOYSA-N 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9894498P | 1998-09-03 | 1998-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25686A1 true UY25686A1 (es) | 2000-03-31 |
Family
ID=22271674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25686A UY25686A1 (es) | 1998-09-03 | 1999-08-31 | Procedimiento para preparar sales de trovafloxacina de adición de ácidos |
Country Status (40)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104892507B (zh) * | 2015-05-26 | 2018-08-28 | 徐州天意动物药业股份有限公司 | 水溶性甲磺酸沙拉沙星及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| CZ286896B6 (en) * | 1994-01-18 | 2000-07-12 | Pfizer | Process for preparing pharmaceutically acceptable salts of naphthyridone carboxylic acid and intermediates for this preparation |
| DE69503066T2 (de) * | 1995-06-06 | 1998-10-15 | Pfizer Inc., New York, N.Y. | KRISTALLFORM VON WASSERFREIEN 7-((1a,5a,6a)-6-AMINO-3-AZABICYCLO (3.1.0.) HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDIN-CARBONSÄURE METHANESULFONSÄURE SALZ |
| JPH0912547A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | ニューキノロン系化合物中間体の製造方法 |
| JPH0912546A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | アザビシクロ環化合物および製造方法 |
| TR199800339T1 (xx) * | 1995-08-29 | 1998-06-22 | Pfizer Inc. | Trovafloksasinin melez iyonik bi�imleri. |
| PA8464701A1 (es) * | 1998-01-16 | 2000-09-29 | Pfizer Prod Inc | Procedimiento e intermedios para preparar naftiridonas |
| US6184380B1 (en) * | 1999-01-25 | 2001-02-06 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
-
1999
- 1999-08-17 HN HN1999000141A patent/HN1999000141A/es unknown
- 1999-08-25 GT GT199900142A patent/GT199900142A/es unknown
- 1999-08-25 SK SK1165-99A patent/SK116599A3/sk unknown
- 1999-08-26 IL IL13161499A patent/IL131614A0/xx unknown
- 1999-08-26 US US09/383,320 patent/US6359137B1/en not_active Expired - Fee Related
- 1999-08-27 AU AU44826/99A patent/AU761035B2/en not_active Ceased
- 1999-08-30 TW TW088114861A patent/TW520369B/zh active
- 1999-08-30 IS IS5168A patent/IS5168A/is unknown
- 1999-08-31 OA OA9900199A patent/OA11152A/en unknown
- 1999-08-31 PA PA19998481001A patent/PA8481001A1/es unknown
- 1999-08-31 UY UY25686A patent/UY25686A1/es not_active Application Discontinuation
- 1999-09-01 SG SG1999004240A patent/SG74748A1/en unknown
- 1999-09-01 CA CA002281244A patent/CA2281244C/en not_active Expired - Fee Related
- 1999-09-01 PE PE1999000878A patent/PE20001026A1/es not_active Application Discontinuation
- 1999-09-01 MA MA25749A patent/MA24966A1/fr unknown
- 1999-09-01 TN TNTNSN99164A patent/TNSN99164A1/fr unknown
- 1999-09-01 ZA ZA9905630A patent/ZA995630B/xx unknown
- 1999-09-01 IN IN1171DE1999 patent/IN191583B/en unknown
- 1999-09-01 MY MYPI99003775A patent/MY130800A/en unknown
- 1999-09-01 EP EP99306947A patent/EP0989119A1/en not_active Withdrawn
- 1999-09-01 BG BG103703A patent/BG103703A/bg unknown
- 1999-09-01 EA EA199900708A patent/EA002340B1/ru not_active IP Right Cessation
- 1999-09-01 JP JP24737399A patent/JP3354526B2/ja not_active Expired - Fee Related
- 1999-09-02 AP APAP/P/1999/001667A patent/AP1118A/en active
- 1999-09-02 ID IDP990831D patent/ID23718A/id unknown
- 1999-09-02 SV SV1999000144A patent/SV1999000144A/es not_active Application Discontinuation
- 1999-09-02 KR KR1019990037060A patent/KR20000022858A/ko not_active Abandoned
- 1999-09-02 HU HU9902967A patent/HUP9902967A3/hu unknown
- 1999-09-02 AR ARP990104424A patent/AR021475A1/es unknown
- 1999-09-02 NO NO994261A patent/NO994261L/no unknown
- 1999-09-02 EE EEP199900457A patent/EE04118B1/xx not_active IP Right Cessation
- 1999-09-02 CN CN99118470A patent/CN1248580A/zh active Pending
- 1999-09-02 YU YU43199A patent/YU43199A/sh unknown
- 1999-09-02 NZ NZ337605A patent/NZ337605A/xx unknown
- 1999-09-02 TR TR1999/02138A patent/TR199902138A2/xx unknown
- 1999-09-03 HR HR990274A patent/HRP990274A2/hr not_active Application Discontinuation
- 1999-09-03 GE GEAP19994978A patent/GEP20022785B/en unknown
- 1999-09-03 PL PL99335246A patent/PL335246A1/xx not_active Application Discontinuation
- 1999-09-03 CO CO99055924A patent/CO5251466A1/es not_active Application Discontinuation
- 1999-09-03 BR BR9904082-4A patent/BR9904082A/pt not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20110728 |