EA199900708A2 - Способ получения кислотных солей тровафлоксацина - Google Patents
Способ получения кислотных солей тровафлоксацинаInfo
- Publication number
- EA199900708A2 EA199900708A2 EA199900708A EA199900708A EA199900708A2 EA 199900708 A2 EA199900708 A2 EA 199900708A2 EA 199900708 A EA199900708 A EA 199900708A EA 199900708 A EA199900708 A EA 199900708A EA 199900708 A2 EA199900708 A2 EA 199900708A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acid
- acid salts
- trovafloxacin
- salts
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Кислотные соли тровафлоксацина получают посредством гидролиза иминных промежуточных соединений с использованием минеральной кислоты, включая, но не ограничиваясь ими, метансульфоновую кислоту, этансульфоновую кислоту, бензолсульфоновую кислоту, азотную кислоту, серную кислоту, фосфорную кислоту, соляную кислоту, бромоводородную кислоту, винную кислоту, лимонную кислоту, уксусную кислоту и малеиновую кислоту. Кислотные соли тровафлоксацина пригодны в качестве антибиотических агентов.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9894498P | 1998-09-03 | 1998-09-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA199900708A2 true EA199900708A2 (ru) | 2000-04-24 |
| EA199900708A3 EA199900708A3 (ru) | 2000-08-28 |
| EA002340B1 EA002340B1 (ru) | 2002-04-25 |
Family
ID=22271674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199900708A EA002340B1 (ru) | 1998-09-03 | 1999-09-01 | Способ получения кислотных солей тровафлоксацина |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6359137B1 (ru) |
| EP (1) | EP0989119A1 (ru) |
| JP (1) | JP3354526B2 (ru) |
| KR (1) | KR20000022858A (ru) |
| CN (1) | CN1248580A (ru) |
| AP (1) | AP1118A (ru) |
| AR (1) | AR021475A1 (ru) |
| AU (1) | AU761035B2 (ru) |
| BG (1) | BG103703A (ru) |
| BR (1) | BR9904082A (ru) |
| CA (1) | CA2281244C (ru) |
| CO (1) | CO5251466A1 (ru) |
| EA (1) | EA002340B1 (ru) |
| EE (1) | EE04118B1 (ru) |
| GE (1) | GEP20022785B (ru) |
| GT (1) | GT199900142A (ru) |
| HN (1) | HN1999000141A (ru) |
| HR (1) | HRP990274A2 (ru) |
| HU (1) | HUP9902967A3 (ru) |
| ID (1) | ID23718A (ru) |
| IL (1) | IL131614A0 (ru) |
| IN (1) | IN191583B (ru) |
| IS (1) | IS5168A (ru) |
| MA (1) | MA24966A1 (ru) |
| MY (1) | MY130800A (ru) |
| NO (1) | NO994261L (ru) |
| NZ (1) | NZ337605A (ru) |
| OA (1) | OA11152A (ru) |
| PA (1) | PA8481001A1 (ru) |
| PE (1) | PE20001026A1 (ru) |
| PL (1) | PL335246A1 (ru) |
| SG (1) | SG74748A1 (ru) |
| SK (1) | SK116599A3 (ru) |
| SV (1) | SV1999000144A (ru) |
| TN (1) | TNSN99164A1 (ru) |
| TR (1) | TR199902138A2 (ru) |
| TW (1) | TW520369B (ru) |
| UY (1) | UY25686A1 (ru) |
| YU (1) | YU43199A (ru) |
| ZA (1) | ZA995630B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104892507B (zh) * | 2015-05-26 | 2018-08-28 | 徐州天意动物药业股份有限公司 | 水溶性甲磺酸沙拉沙星及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| RU2147303C1 (ru) * | 1994-01-18 | 2000-04-10 | Пфайзер Инк. | Промежуточные продукты и способ получения солей нафтиридонкарбоновой кислоты |
| DK0789697T3 (da) * | 1995-06-06 | 1998-10-19 | Pfizer | Krystalform af vandfrit 7-([1alfa, 5alfa, 6alfa,]-6-amino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluor-1-(2,4-difluorphenyl)-1,4-d |
| JPH0912546A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | アザビシクロ環化合物および製造方法 |
| JPH0912547A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | ニューキノロン系化合物中間体の製造方法 |
| PL325170A1 (en) * | 1995-08-29 | 1998-07-06 | Pfizer | Bipolar forms of throwaflocacin |
| PA8464701A1 (es) * | 1998-01-16 | 2000-09-29 | Pfizer Prod Inc | Procedimiento e intermedios para preparar naftiridonas |
| US6184380B1 (en) * | 1999-01-25 | 2001-02-06 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
-
1999
- 1999-08-17 HN HN1999000141A patent/HN1999000141A/es unknown
- 1999-08-25 SK SK1165-99A patent/SK116599A3/sk unknown
- 1999-08-25 GT GT199900142A patent/GT199900142A/es unknown
- 1999-08-26 IL IL13161499A patent/IL131614A0/xx unknown
- 1999-08-26 US US09/383,320 patent/US6359137B1/en not_active Expired - Fee Related
- 1999-08-27 AU AU44826/99A patent/AU761035B2/en not_active Ceased
- 1999-08-30 TW TW088114861A patent/TW520369B/zh active
- 1999-08-30 IS IS5168A patent/IS5168A/is unknown
- 1999-08-31 UY UY25686A patent/UY25686A1/es not_active Application Discontinuation
- 1999-08-31 PA PA19998481001A patent/PA8481001A1/es unknown
- 1999-08-31 OA OA9900199A patent/OA11152A/en unknown
- 1999-09-01 CA CA002281244A patent/CA2281244C/en not_active Expired - Fee Related
- 1999-09-01 TN TNTNSN99164A patent/TNSN99164A1/fr unknown
- 1999-09-01 IN IN1171DE1999 patent/IN191583B/en unknown
- 1999-09-01 BG BG103703A patent/BG103703A/bg unknown
- 1999-09-01 SG SG1999004240A patent/SG74748A1/en unknown
- 1999-09-01 EP EP99306947A patent/EP0989119A1/en not_active Withdrawn
- 1999-09-01 MY MYPI99003775A patent/MY130800A/en unknown
- 1999-09-01 JP JP24737399A patent/JP3354526B2/ja not_active Expired - Fee Related
- 1999-09-01 PE PE1999000878A patent/PE20001026A1/es not_active Application Discontinuation
- 1999-09-01 EA EA199900708A patent/EA002340B1/ru not_active IP Right Cessation
- 1999-09-01 ZA ZA9905630A patent/ZA995630B/xx unknown
- 1999-09-01 MA MA25749A patent/MA24966A1/fr unknown
- 1999-09-02 TR TR1999/02138A patent/TR199902138A2/xx unknown
- 1999-09-02 NO NO994261A patent/NO994261L/no unknown
- 1999-09-02 NZ NZ337605A patent/NZ337605A/xx unknown
- 1999-09-02 HU HU9902967A patent/HUP9902967A3/hu unknown
- 1999-09-02 EE EEP199900457A patent/EE04118B1/xx not_active IP Right Cessation
- 1999-09-02 ID IDP990831D patent/ID23718A/id unknown
- 1999-09-02 YU YU43199A patent/YU43199A/sh unknown
- 1999-09-02 AR ARP990104424A patent/AR021475A1/es unknown
- 1999-09-02 CN CN99118470A patent/CN1248580A/zh active Pending
- 1999-09-02 AP APAP/P/1999/001667A patent/AP1118A/en active
- 1999-09-02 SV SV1999000144A patent/SV1999000144A/es not_active Application Discontinuation
- 1999-09-02 KR KR1019990037060A patent/KR20000022858A/ko active IP Right Grant
- 1999-09-03 CO CO99055924A patent/CO5251466A1/es not_active Application Discontinuation
- 1999-09-03 BR BR9904082-4A patent/BR9904082A/pt not_active Application Discontinuation
- 1999-09-03 GE GEAP19994978A patent/GEP20022785B/en unknown
- 1999-09-03 PL PL99335246A patent/PL335246A1/xx not_active Application Discontinuation
- 1999-09-03 HR HR990274A patent/HRP990274A2/hr not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |