UY25686A1 - Procedimiento para preparar sales de trovafloxacina de adición de ácidos - Google Patents
Procedimiento para preparar sales de trovafloxacina de adición de ácidosInfo
- Publication number
- UY25686A1 UY25686A1 UY25686A UY25686A UY25686A1 UY 25686 A1 UY25686 A1 UY 25686A1 UY 25686 A UY25686 A UY 25686A UY 25686 A UY25686 A UY 25686A UY 25686 A1 UY25686 A1 UY 25686A1
- Authority
- UY
- Uruguay
- Prior art keywords
- acid
- procedure
- trovafloxacin
- general formula
- acid addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Procedimiento para preparar sales de trovafloxacina de adición de ácidos, de fórmula general (IV) representada en la figura1, donde ZH es un ácido mineral; el procedimiento comprende la etapa de poner en contacto un compuesto de fórmula general (I) representado en la figura 2, donde R es un grupo alquilo y el anillo de bencilideno está sustituido opcionalmente con uno o más grupos fluoro, cloro, bromo, yodo, alquilo o alcoxi, con una composición que comprende el ácido mineral ZH (por ejemplo ácido metanosulfónico, ácido etanosulfónico, ácido bencenosulfónico, ácido nítrico, ácido fosfórico, ácido clorhídrico, ácido bromhídrico, ácido tartárico, ácido cítrico, ácido acético y ácido maleico) y agua; este procedimiento se puede realizar en presencia de un disolvente orgánico inerte. En especial se incluye un procedimiento por hidrólisis de un intermedio imino seleccionado por ejemplo de trietilamina, N,N-diisopropiletilamina, metildibutilamina, entre otros, usando condiciones suaves. Un compuesto de fórmula general (I) preferido es el: (1alpha, 5alpha, 6alpha)-7-(6-bencilidenilamino-3-azabiciclo[3.1.0]hex-3-il)-1-(2,4-difluorofenil)-6-fluoro-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilato de etilo. Las slaes de trovafloxacina de adición de ácidos son útiles como agentes antibióticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9894498P | 1998-09-03 | 1998-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25686A1 true UY25686A1 (es) | 2000-03-31 |
Family
ID=22271674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25686A UY25686A1 (es) | 1998-09-03 | 1999-08-31 | Procedimiento para preparar sales de trovafloxacina de adición de ácidos |
Country Status (40)
Country | Link |
---|---|
US (1) | US6359137B1 (es) |
EP (1) | EP0989119A1 (es) |
JP (1) | JP3354526B2 (es) |
KR (1) | KR20000022858A (es) |
CN (1) | CN1248580A (es) |
AP (1) | AP1118A (es) |
AR (1) | AR021475A1 (es) |
AU (1) | AU761035B2 (es) |
BG (1) | BG103703A (es) |
BR (1) | BR9904082A (es) |
CA (1) | CA2281244C (es) |
CO (1) | CO5251466A1 (es) |
EA (1) | EA002340B1 (es) |
EE (1) | EE04118B1 (es) |
GE (1) | GEP20022785B (es) |
GT (1) | GT199900142A (es) |
HN (1) | HN1999000141A (es) |
HR (1) | HRP990274A2 (es) |
HU (1) | HUP9902967A3 (es) |
ID (1) | ID23718A (es) |
IL (1) | IL131614A0 (es) |
IN (1) | IN191583B (es) |
IS (1) | IS5168A (es) |
MA (1) | MA24966A1 (es) |
MY (1) | MY130800A (es) |
NO (1) | NO994261L (es) |
NZ (1) | NZ337605A (es) |
OA (1) | OA11152A (es) |
PA (1) | PA8481001A1 (es) |
PE (1) | PE20001026A1 (es) |
PL (1) | PL335246A1 (es) |
SG (1) | SG74748A1 (es) |
SK (1) | SK116599A3 (es) |
SV (1) | SV1999000144A (es) |
TN (1) | TNSN99164A1 (es) |
TR (1) | TR199902138A2 (es) |
TW (1) | TW520369B (es) |
UY (1) | UY25686A1 (es) |
YU (1) | YU43199A (es) |
ZA (1) | ZA995630B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104892507B (zh) * | 2015-05-26 | 2018-08-28 | 徐州天意动物药业股份有限公司 | 水溶性甲磺酸沙拉沙星及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
EP0740667A1 (en) * | 1994-01-18 | 1996-11-06 | Pfizer Inc. | Process and intermediates for preparing naphthyridonecarboxylic acid salts |
CA2223404C (en) * | 1995-06-06 | 2001-01-16 | Thomas A. Morris | Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt |
JPH0912546A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | アザビシクロ環化合物および製造方法 |
JPH0912547A (ja) * | 1995-06-23 | 1997-01-14 | Chisso Corp | ニューキノロン系化合物中間体の製造方法 |
PL325170A1 (en) * | 1995-08-29 | 1998-07-06 | Pfizer | Bipolar forms of throwaflocacin |
US6184380B1 (en) * | 1999-01-25 | 2001-02-06 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
PA8464701A1 (es) * | 1998-01-16 | 2000-09-29 | Pfizer Prod Inc | Procedimiento e intermedios para preparar naftiridonas |
-
1999
- 1999-08-17 HN HN1999000141A patent/HN1999000141A/es unknown
- 1999-08-25 SK SK1165-99A patent/SK116599A3/sk unknown
- 1999-08-25 GT GT199900142A patent/GT199900142A/es unknown
- 1999-08-26 US US09/383,320 patent/US6359137B1/en not_active Expired - Fee Related
- 1999-08-26 IL IL13161499A patent/IL131614A0/xx unknown
- 1999-08-27 AU AU44826/99A patent/AU761035B2/en not_active Ceased
- 1999-08-30 TW TW088114861A patent/TW520369B/zh active
- 1999-08-30 IS IS5168A patent/IS5168A/is unknown
- 1999-08-31 OA OA9900199A patent/OA11152A/en unknown
- 1999-08-31 PA PA19998481001A patent/PA8481001A1/es unknown
- 1999-08-31 UY UY25686A patent/UY25686A1/es not_active Application Discontinuation
- 1999-09-01 BG BG103703A patent/BG103703A/bg unknown
- 1999-09-01 ZA ZA9905630A patent/ZA995630B/xx unknown
- 1999-09-01 SG SG1999004240A patent/SG74748A1/en unknown
- 1999-09-01 EP EP99306947A patent/EP0989119A1/en not_active Withdrawn
- 1999-09-01 TN TNTNSN99164A patent/TNSN99164A1/fr unknown
- 1999-09-01 EA EA199900708A patent/EA002340B1/ru not_active IP Right Cessation
- 1999-09-01 MY MYPI99003775A patent/MY130800A/en unknown
- 1999-09-01 PE PE1999000878A patent/PE20001026A1/es not_active Application Discontinuation
- 1999-09-01 JP JP24737399A patent/JP3354526B2/ja not_active Expired - Fee Related
- 1999-09-01 IN IN1171DE1999 patent/IN191583B/en unknown
- 1999-09-01 CA CA002281244A patent/CA2281244C/en not_active Expired - Fee Related
- 1999-09-01 MA MA25749A patent/MA24966A1/fr unknown
- 1999-09-02 EE EEP199900457A patent/EE04118B1/xx not_active IP Right Cessation
- 1999-09-02 NZ NZ337605A patent/NZ337605A/xx unknown
- 1999-09-02 SV SV1999000144A patent/SV1999000144A/es not_active Application Discontinuation
- 1999-09-02 HU HU9902967A patent/HUP9902967A3/hu unknown
- 1999-09-02 KR KR1019990037060A patent/KR20000022858A/ko active IP Right Grant
- 1999-09-02 NO NO994261A patent/NO994261L/no unknown
- 1999-09-02 YU YU43199A patent/YU43199A/sh unknown
- 1999-09-02 AR ARP990104424A patent/AR021475A1/es unknown
- 1999-09-02 CN CN99118470A patent/CN1248580A/zh active Pending
- 1999-09-02 ID IDP990831D patent/ID23718A/id unknown
- 1999-09-02 TR TR1999/02138A patent/TR199902138A2/xx unknown
- 1999-09-02 AP APAP/P/1999/001667A patent/AP1118A/en active
- 1999-09-03 BR BR9904082-4A patent/BR9904082A/pt not_active Application Discontinuation
- 1999-09-03 PL PL99335246A patent/PL335246A1/xx not_active Application Discontinuation
- 1999-09-03 HR HR990274A patent/HRP990274A2/hr not_active Application Discontinuation
- 1999-09-03 CO CO99055924A patent/CO5251466A1/es not_active Application Discontinuation
- 1999-09-03 GE GEAP19994978A patent/GEP20022785B/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20110728 |