ATE226208T1 - 4-oxo-4,7-dihydro-thieno(2,3-b)pyridin-5- carboxamide als antivirale mittel - Google Patents

4-oxo-4,7-dihydro-thieno(2,3-b)pyridin-5- carboxamide als antivirale mittel

Info

Publication number
ATE226208T1
ATE226208T1 AT00913786T AT00913786T ATE226208T1 AT E226208 T1 ATE226208 T1 AT E226208T1 AT 00913786 T AT00913786 T AT 00913786T AT 00913786 T AT00913786 T AT 00913786T AT E226208 T1 ATE226208 T1 AT E226208T1
Authority
AT
Austria
Prior art keywords
thieno
carboxamide
dihydro
oxo
pyridine
Prior art date
Application number
AT00913786T
Other languages
English (en)
Inventor
Mark E Schnute
Michele M Cudahy
Allen Scott
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE226208T1 publication Critical patent/ATE226208T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AT00913786T 1999-03-09 2000-03-07 4-oxo-4,7-dihydro-thieno(2,3-b)pyridin-5- carboxamide als antivirale mittel ATE226208T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09
PCT/US2000/005937 WO2000053610A2 (en) 1999-03-09 2000-03-07 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS

Publications (1)

Publication Number Publication Date
ATE226208T1 true ATE226208T1 (de) 2002-11-15

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00913786T ATE226208T1 (de) 1999-03-09 2000-03-07 4-oxo-4,7-dihydro-thieno(2,3-b)pyridin-5- carboxamide als antivirale mittel

Country Status (25)

Country Link
US (2) US6239142B1 (de)
EP (1) EP1159279B1 (de)
JP (1) JP2002539130A (de)
KR (1) KR20010102543A (de)
CN (1) CN1347417A (de)
AT (1) ATE226208T1 (de)
AU (1) AU759875B2 (de)
BR (1) BR0008804A (de)
CA (1) CA2366609A1 (de)
CZ (1) CZ20013028A3 (de)
DE (1) DE60000611T2 (de)
DK (1) DK1159279T3 (de)
EA (1) EA003607B1 (de)
ES (1) ES2184705T3 (de)
HK (1) HK1045518A1 (de)
HU (1) HUP0200324A3 (de)
IL (1) IL145005A0 (de)
NO (1) NO20014363L (de)
NZ (1) NZ513758A (de)
PL (1) PL350651A1 (de)
PT (1) PT1159279E (de)
SK (1) SK12582001A3 (de)
TW (1) TWI222451B (de)
WO (1) WO2000053610A2 (de)
ZA (1) ZA200107255B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
BR0211214A (pt) 2001-08-30 2004-07-13 Upjohn Co 4-tioxo-4,7-dihidro-tieno [2,3-b]piridina-5-carboxamidas como agentes antivirais
WO2003020728A1 (en) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
CN1620439A (zh) * 2001-12-20 2005-05-25 Osi药物公司 胰脂肪酶抑制剂化合物、其合成方法和应用
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AU2003222077A1 (en) * 2002-04-22 2003-11-03 Pharmacia And Upjohn Company A trifluoroacetic acid process to prepare (2,3-b)pyridine intermediates
EA007953B1 (ru) 2002-08-09 2007-02-27 Янссен Фармацевтика Н.В. Способы получения 4-[[4-[[4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила
WO2004019940A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040102473A1 (en) * 2002-08-30 2004-05-27 Wathen Michael W. Method of preventing or treating atherosclerosis or restenosis
AU2003262946A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019932A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004022567A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Heteroaryl-ethanolamine derivatives as antiviral agents
AU2003304151A1 (en) * 2002-09-04 2005-01-21 Pharmacia And Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022568A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Aryl-ethanolamine derivatives as antiviral agents
US6831081B2 (en) * 2002-09-04 2004-12-14 Pharmacia & Upjohn 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
EP1756082A1 (de) * 2004-04-13 2007-02-28 Astex Therapeutics Limited Pharmazeutische 5-morpholinylmethylthiophenylverbindungen als modulatoren der p38-map-kinase
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
AU2010218152B2 (en) * 2009-02-27 2015-04-09 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of Dengue virus infections
EA201891854A1 (ru) 2016-02-16 2019-01-31 Вандербилт Юниверсити Положительные аллостерические модуляторы мускаринового ацетилхолинового рецептора m
WO2018063552A1 (en) * 2016-09-30 2018-04-05 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
AR120045A1 (es) 2019-09-26 2022-01-26 Novartis Ag Compuestos antivirales de pirazolopiridinona
CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物

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Also Published As

Publication number Publication date
CN1347417A (zh) 2002-05-01
SK12582001A3 (sk) 2002-02-05
NZ513758A (en) 2001-09-28
CZ20013028A3 (cs) 2002-03-13
EP1159279A2 (de) 2001-12-05
AU3516200A (en) 2000-09-28
HK1045518A1 (zh) 2002-11-29
EP1159279B1 (de) 2002-10-16
NO20014363D0 (no) 2001-09-07
IL145005A0 (en) 2002-06-30
DK1159279T3 (da) 2003-02-17
CA2366609A1 (en) 2000-09-14
EA003607B1 (ru) 2003-06-26
PL350651A1 (en) 2003-01-27
BR0008804A (pt) 2002-04-16
WO2000053610A2 (en) 2000-09-14
HUP0200324A3 (en) 2003-07-28
HUP0200324A2 (en) 2002-06-29
JP2002539130A (ja) 2002-11-19
KR20010102543A (ko) 2001-11-15
EA200100955A1 (ru) 2002-02-28
NO20014363L (no) 2001-11-08
DE60000611T2 (de) 2003-06-26
US6239142B1 (en) 2001-05-29
AU759875B2 (en) 2003-05-01
DE60000611D1 (en) 2002-11-21
PT1159279E (pt) 2003-02-28
WO2000053610A3 (en) 2001-01-25
US20020006937A1 (en) 2002-01-17
TWI222451B (en) 2004-10-21
ZA200107255B (en) 2002-12-02
US6495683B2 (en) 2002-12-17
ES2184705T3 (es) 2003-04-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee