US9254318B2 - High titer recombinant influenza viruses for vaccines - Google Patents

High titer recombinant influenza viruses for vaccines Download PDF

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Publication number
US9254318B2
US9254318B2 US11/729,557 US72955707A US9254318B2 US 9254318 B2 US9254318 B2 US 9254318B2 US 72955707 A US72955707 A US 72955707A US 9254318 B2 US9254318 B2 US 9254318B2
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influenza virus
vector
virus
operably linked
seq
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US20070231348A1 (en
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Yoshihiro Kawaoka
Taisuke Horimoto
Shin Murakami
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT reassignment NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Assignors: UNIVERSITY OF WISCONSIN-MADISON
Assigned to WISCONSIN ALUMNI RESEARCH FOUNDATION reassignment WISCONSIN ALUMNI RESEARCH FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KAWAOKA, YOSHIHIRO
Assigned to WISCONSIN ALUMNI RESEARCH FOUNDATION reassignment WISCONSIN ALUMNI RESEARCH FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HORIMOTO, TAISUKE
Assigned to WISCONSIN ALUMNI RESEARCH FOUNDATION reassignment WISCONSIN ALUMNI RESEARCH FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MURAKAMI, SHIN
Priority to US15/000,851 priority patent/US9926535B2/en
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N2760/16011—Orthomyxoviridae
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase

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US11/729,557 2006-03-31 2007-03-29 High titer recombinant influenza viruses for vaccines Active US9254318B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US11/729,557 US9254318B2 (en) 2006-03-31 2007-03-29 High titer recombinant influenza viruses for vaccines
US15/000,851 US9926535B2 (en) 2006-03-31 2016-01-19 High titer recombinant influenza viruses for vaccines
US15/905,454 US20190048324A1 (en) 2006-03-31 2018-02-26 High titer recombinant influenza viruses for vaccines

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Application Number Priority Date Filing Date Title
US78776606P 2006-03-31 2006-03-31
US11/729,557 US9254318B2 (en) 2006-03-31 2007-03-29 High titer recombinant influenza viruses for vaccines

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US20070231348A1 US20070231348A1 (en) 2007-10-04
US9254318B2 true US9254318B2 (en) 2016-02-09

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US15/000,851 Active US9926535B2 (en) 2006-03-31 2016-01-19 High titer recombinant influenza viruses for vaccines
US15/905,454 Abandoned US20190048324A1 (en) 2006-03-31 2018-02-26 High titer recombinant influenza viruses for vaccines

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US15/905,454 Abandoned US20190048324A1 (en) 2006-03-31 2018-02-26 High titer recombinant influenza viruses for vaccines

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US (3) US9254318B2 (fr)
EP (1) EP2010557B1 (fr)
JP (3) JP2009532352A (fr)
CN (1) CN101472941B (fr)
AU (1) AU2007245192B2 (fr)
CA (1) CA2647985C (fr)
WO (1) WO2007126810A2 (fr)

Cited By (13)

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US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US9926535B2 (en) 2006-03-31 2018-03-27 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses for vaccines
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10119124B2 (en) 2007-06-18 2018-11-06 Wisconsin Alumni Research Foundation (Warf) Influenza M2 protein mutant viruses as live influenza attenuated vaccines
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
US10808229B2 (en) 2009-10-26 2020-10-20 Wisconsin Alumni Research Foundation (“WARF”) High titer recombinant influenza viruses with enhanced replication in vero cells
US11197925B2 (en) 2016-02-19 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line

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WO2001079273A2 (fr) * 2000-04-14 2001-10-25 Wisconsin Alumni Research Foundation Virus contenant une proteine mutante de canal ionique
EP1364006A2 (fr) 2001-02-23 2003-11-26 Wisconsin Alumni Research Foundation Methode d'identification de cellulles mutantes avec acid sialic modifie
BRPI0307679A2 (pt) * 2002-02-13 2016-11-08 Wisconsin Alumni Res Found vetor viral de influenza, vírus recombinate de influenza, molécula isolada de ácido nucleico e métodos para expressar um segmento heterólogo de ácido nucleico em uma célula e para preparar vírus semelhante a influenza incompetente na replicação.
WO2004094466A2 (fr) * 2003-04-23 2004-11-04 Wisconsin Alumni Research Foundation Virus codant une proteine membranaire mutante
WO2004112831A2 (fr) * 2003-05-28 2004-12-29 Wisconsin Alumni Research Foundation Virus influenza de recombinaison a titre eleve pour vaccins et therapie genique
US9072701B2 (en) * 2006-04-21 2015-07-07 St. Jude Children's Research Hospital Avian influenza viruses, vaccines, compositions, formulations, and methods
US8597661B2 (en) * 2007-05-04 2013-12-03 Wisconsin Alumni Research Foundation Neuraminidase-deficient live influenza vaccines
US9005632B2 (en) * 2009-11-20 2015-04-14 Takeda Vaccines, Inc. Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains
CN101914498B (zh) * 2010-02-08 2013-07-03 中国农业科学院上海兽医研究所 稳定表达高致病力禽流感病毒ha蛋白的mdck细胞系及其用途
US9173933B2 (en) * 2010-10-15 2015-11-03 Bavarian Nordic A/S Recombinant modified vaccinia virus Ankara influenza vaccine
EP2747778B1 (fr) 2011-08-26 2017-12-06 Wisconsin Alumni Research Foundation Virus de la grippe ayant un segment génique pb2 mutant en tant que vaccins vivants atténués
AU2014203051C1 (en) * 2012-03-02 2016-09-01 Seqirus UK Limited Influenza Virus Reassortment
EP2820126B1 (fr) * 2012-03-02 2017-05-17 Seqirus UK Limited Réassortiment du virus de la grippe
US9803251B2 (en) * 2012-05-03 2017-10-31 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of detecting influenza virus
CA2886769C (fr) * 2012-10-05 2022-01-04 Denka Seiken Co., Ltd. Methode de mesure de l'hemagglutinine provenant du virus de la grippe
CN105120893B (zh) * 2012-12-03 2018-11-13 诺华股份有限公司 流感病毒重配
US10232031B2 (en) 2013-03-13 2019-03-19 Seqirus UK Limited Influenza virus reassortment
CN103865923B (zh) * 2014-01-28 2017-04-26 中国人民解放军第三0二医院 流感病毒为载体的HAdV嵌合疫苗的制备及其应用
CN105985446B (zh) * 2014-10-17 2019-05-14 中国农业大学 可优化病毒复制的培养基
CN104372023B (zh) * 2014-11-10 2017-02-08 中国农业大学 一种拯救流感病毒的方法
EP3341018A1 (fr) 2015-08-28 2018-07-04 Wisconsin Alumni Research Foundation Génération de virus de la grippe infectieux à partir de pseudo-particules virales (vlp)
PT3436593T (pt) * 2016-03-28 2023-01-31 Ultragenyx Pharmaceutical Inc Métodos de inativação pelo calor de adenovírus
EP3471767A4 (fr) 2016-06-15 2020-01-15 Icahn School of Medicine at Mount Sinai Hémagglutinines du virus de la grippe et utilisations de celles-ci
EP3606555A4 (fr) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai Anticorps anti-neuraminidase du virus influenza de type b et leurs utilisations
US11197926B2 (en) * 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US20220249652A1 (en) * 2019-06-26 2022-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus neuraminidase and uses thereof

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US20070231348A1 (en) 2007-10-04
US20190048324A1 (en) 2019-02-14
CN101472941B (zh) 2017-08-08
WO2007126810A3 (fr) 2008-03-13
JP2014131516A (ja) 2014-07-17
AU2007245192A1 (en) 2007-11-08
AU2007245192B2 (en) 2012-04-12
JP6352974B2 (ja) 2018-07-04
CA2647985A1 (fr) 2007-11-08
US20160208223A1 (en) 2016-07-21
JP2009532352A (ja) 2009-09-10
CN101472941A (zh) 2009-07-01
CA2647985C (fr) 2014-12-30
JP2016169225A (ja) 2016-09-23
US9926535B2 (en) 2018-03-27

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