US20100286378A1 - Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor - Google Patents
Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor Download PDFInfo
- Publication number
- US20100286378A1 US20100286378A1 US12/675,620 US67562008A US2010286378A1 US 20100286378 A1 US20100286378 A1 US 20100286378A1 US 67562008 A US67562008 A US 67562008A US 2010286378 A1 US2010286378 A1 US 2010286378A1
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- Prior art keywords
- strand
- mimetic
- mirna
- airna
- nucleotides
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/31—Chemical structure of the backbone
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- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/675,620 US20100286378A1 (en) | 2007-08-27 | 2008-08-27 | Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96825707P | 2007-08-27 | 2007-08-27 | |
US2975308P | 2008-02-19 | 2008-02-19 | |
US3895408P | 2008-03-24 | 2008-03-24 | |
PCT/US2008/074531 WO2009029690A1 (en) | 2007-08-27 | 2008-08-27 | Composition of asymmetric rna duplex as microrna mimetic or inhibitor |
US12/675,620 US20100286378A1 (en) | 2007-08-27 | 2008-08-27 | Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US61029753 Continuation | 2008-02-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100286378A1 true US20100286378A1 (en) | 2010-11-11 |
Family
ID=40387778
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/675,620 Abandoned US20100286378A1 (en) | 2007-08-27 | 2008-08-27 | Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor |
US12/199,797 Active 2029-02-25 US9328345B2 (en) | 2007-08-27 | 2008-08-27 | Compositions of asymmetric interfering RNA and uses thereof |
US15/081,559 Active 2028-10-18 US10266821B2 (en) | 2007-08-27 | 2016-03-25 | Compositions of asymmetric interfering RNA and uses thereof |
US16/280,830 Active US10927376B2 (en) | 2007-08-27 | 2019-02-20 | Compositions of asymmetric interfering RNA and uses thereof |
US16/298,545 Active US11015195B2 (en) | 2007-08-27 | 2019-03-11 | Compositions of asymmetric interfering RNA and uses thereof |
US17/237,856 Pending US20210301292A1 (en) | 2007-08-27 | 2021-04-22 | Compositions of Asymmetric Interfering RNA and Uses Thereof |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/199,797 Active 2029-02-25 US9328345B2 (en) | 2007-08-27 | 2008-08-27 | Compositions of asymmetric interfering RNA and uses thereof |
US15/081,559 Active 2028-10-18 US10266821B2 (en) | 2007-08-27 | 2016-03-25 | Compositions of asymmetric interfering RNA and uses thereof |
US16/280,830 Active US10927376B2 (en) | 2007-08-27 | 2019-02-20 | Compositions of asymmetric interfering RNA and uses thereof |
US16/298,545 Active US11015195B2 (en) | 2007-08-27 | 2019-03-11 | Compositions of asymmetric interfering RNA and uses thereof |
US17/237,856 Pending US20210301292A1 (en) | 2007-08-27 | 2021-04-22 | Compositions of Asymmetric Interfering RNA and Uses Thereof |
Country Status (9)
Country | Link |
---|---|
US (6) | US20100286378A1 (ja) |
EP (4) | EP2201022A4 (ja) |
JP (7) | JP2010537639A (ja) |
CN (3) | CN101842381A (ja) |
CA (2) | CA2735166C (ja) |
DK (1) | DK2193140T3 (ja) |
ES (2) | ES2873350T3 (ja) |
HK (2) | HK1148534A1 (ja) |
WO (2) | WO2009029688A2 (ja) |
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WO2013138280A1 (en) * | 2012-03-12 | 2013-09-19 | Eaker Shannon | IMPROVED ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs |
WO2014063155A1 (en) | 2012-10-21 | 2014-04-24 | University Of Rochester | Thy1 (cd90) as a novel therapy to control adipose tissue accumulation |
WO2014123935A1 (en) * | 2013-02-05 | 2014-08-14 | 1Globe Health Institute Llc | Biodegradable and clinically-compatible nanop articles as drug delivery carriers |
US9523099B2 (en) | 2006-12-08 | 2016-12-20 | Iowa State University Research Foundation, Inc. | Plant genes involved in nitrate uptake and metabolism |
US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
WO2019004420A1 (ja) * | 2017-06-30 | 2019-01-03 | 国立大学法人東京医科歯科大学 | ヘテロ二本鎖型antimiR |
US10266821B2 (en) | 2007-08-27 | 2019-04-23 | 1Globe Health Institute Llc | Compositions of asymmetric interfering RNA and uses thereof |
US10570395B2 (en) | 2014-11-14 | 2020-02-25 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
US10729785B2 (en) * | 2014-05-19 | 2020-08-04 | BioNTech SE | Particles comprising protamine and RNA in combination with endosome destabilizing agents |
US10920227B2 (en) | 2014-11-14 | 2021-02-16 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11193129B2 (en) | 2016-05-18 | 2021-12-07 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
US11603542B2 (en) | 2017-05-05 | 2023-03-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11752181B2 (en) | 2017-05-05 | 2023-09-12 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
US11931375B2 (en) | 2017-10-16 | 2024-03-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
US11951121B2 (en) | 2016-05-18 | 2024-04-09 | Voyager Therapeutics, Inc. | Compositions and methods for treating Huntington's disease |
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MX2016005778A (es) | 2013-11-04 | 2016-12-20 | Monsanto Technology Llc | Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos. |
RU2744194C2 (ru) | 2013-12-02 | 2021-03-03 | Фио Фармасьютикалс Корп | Иммунотерапия рака |
UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
CN106068324B (zh) * | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
AR099092A1 (es) | 2014-01-15 | 2016-06-29 | Monsanto Technology Llc | Métodos y composiciones para el control de malezas utilizando polinucleótidos epsps |
JP2017506228A (ja) | 2014-02-05 | 2017-03-02 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドYeda Research And Development Co.Ltd. | セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロrnaおよび該マイクロrnaを含む組成物 |
TW201620525A (zh) * | 2014-03-14 | 2016-06-16 | 波士頓生醫公司 | 使k-ras靜默之非對稱干擾rna組成物及其使用方法 |
EP3125676A4 (en) | 2014-04-01 | 2018-02-14 | Monsanto Technology LLC | Compositions and methods for controlling insect pests |
WO2015168108A2 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic targeting mdm2 or mycn |
KR101681669B1 (ko) * | 2014-05-27 | 2016-12-02 | 주식회사 제노포커스 | 유전자 침묵에 의한 목적 단백질의 과발현 방법 |
CA2953347A1 (en) | 2014-06-23 | 2015-12-30 | Monsanto Technology Llc | Compositions and methods for regulating gene expression via rna interference |
US11807857B2 (en) | 2014-06-25 | 2023-11-07 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
CN114009454A (zh) | 2014-07-29 | 2022-02-08 | 孟山都技术公司 | 用于控制昆虫害虫的组合物和方法 |
KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
JP6637652B2 (ja) * | 2014-11-21 | 2020-01-29 | 株式会社バイオシンクタンク | 抗腫瘍剤の選択方法およびその抗腫瘍剤が含有するsiRNA |
US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
MX2017008587A (es) * | 2014-12-27 | 2017-10-20 | Bonac Corp | Mirna natural para controlar la expresion de gen y uso del mismo. |
CN108064288B (zh) | 2015-01-22 | 2021-11-26 | 孟山都技术公司 | 用于控制叶甲属的组合物和方法 |
CN104673796A (zh) * | 2015-02-09 | 2015-06-03 | 暨南大学 | 靶向hsv-1病毒ul18基因的小干扰rna及应用 |
WO2016149370A1 (en) * | 2015-03-16 | 2016-09-22 | MiRagen Therapeutics, Inc. | Mirna mimetics and their use in treating sensory conditions |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
EP3302053B1 (en) | 2015-06-02 | 2021-03-17 | Monsanto Technology LLC | Compositions and methods for delivery of a polynucleotide into a plant |
US10655136B2 (en) | 2015-06-03 | 2020-05-19 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
WO2016196935A1 (en) | 2015-06-03 | 2016-12-08 | Boston Biomedical, Inc. | Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer |
KR20190118688A (ko) | 2015-06-05 | 2019-10-18 | 미라젠 세러퓨틱스 인코포레이티드 | 피부 t 세포 림프종(ctcl) 치료용 mir-155 억제제 |
CN108135923B (zh) | 2015-07-06 | 2021-03-02 | 菲奥医药公司 | 靶向超氧化物歧化酶1(sod1)的核酸分子 |
US10808247B2 (en) | 2015-07-06 | 2020-10-20 | Phio Pharmaceuticals Corp. | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
GB201516685D0 (en) * | 2015-09-21 | 2015-11-04 | Varghese Oommen P And Oommen Oommen P | Nucleic acid molecules with enhanced activity |
EP3365446A4 (en) | 2015-10-19 | 2019-06-26 | Phio Pharmaceuticals Corp. | SELF ADMINISTRATION-REDUCED SIZE NUCLEIC ACID COMPOUNDS TARGETING LONGS NON-CODING LONGS |
WO2017085550A1 (en) | 2015-11-16 | 2017-05-26 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
WO2017100127A1 (en) | 2015-12-06 | 2017-06-15 | Boston Biomedical, Inc. | ASYMMETRIC INTERFERING RNAs, AND COMPOSITIONS, USE, OR PREPARATION THEREOF |
BR112018008344A2 (pt) | 2015-12-13 | 2018-10-30 | Nitto Denko Corp | molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição |
JP2019503394A (ja) | 2016-01-31 | 2019-02-07 | ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts | 分岐オリゴヌクレオチド |
JP7003044B2 (ja) | 2016-02-02 | 2022-01-20 | オリックス ファーマシューティカルズ,インコーポレーテッド | Angpt2およびpdgfbを標的化するrna複合体を用いる血管新生関連疾患の処置 |
CA3022874A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | Treatment of atopic dermatitis and asthma using rna complexes that target il4ra, trpa1, or f2rl1 |
EP3414329A1 (en) * | 2016-02-12 | 2018-12-19 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Rna/dna hybrid nanoparticles modified with single stranded rna toeholds and uses thereof |
MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル, インコーポレイテッド | がんを処置するための方法 |
KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
CN107630015B (zh) | 2016-07-19 | 2021-03-09 | 上海市东方医院 | 一种稳定的dna-rna双链结构 |
US11753638B2 (en) | 2016-08-12 | 2023-09-12 | University Of Massachusetts | Conjugated oligonucleotides |
US10874688B2 (en) * | 2016-10-31 | 2020-12-29 | Gifu University | Double-stranded nucleic acid molecule and use thereof |
WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
JP7106563B2 (ja) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | ナフトフラン誘導体、その調製、および使用方法 |
CA3052038C (en) * | 2017-01-31 | 2023-08-01 | Curigin Co., Ltd. | Nucleic acid simultaneously inhibiting expression of mtor gene and stat3 gene |
US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
WO2018160887A1 (en) * | 2017-03-01 | 2018-09-07 | Boston Biomedical, Inc. | Pdl1-specific and beta-catenin-specific asymmetric interfering rna compositions, uses or preparation thereof |
US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
EP3642341A4 (en) * | 2017-06-23 | 2021-06-16 | University Of Massachusetts | TWO-DAY SELF-RELEASING SIRNA AND RELATED PROCEDURES |
EP3696270A4 (en) | 2017-10-11 | 2021-07-07 | Nitto Denko Corporation | REGULATION OF THE EXPRESSION OF NUCLEIC ACID MOLECULES |
WO2019103581A1 (ko) * | 2017-11-27 | 2019-05-31 | (주)프로스테믹스 | 이중 가닥의 올리고뉴클레오티드 및 그 제조 방법 |
WO2019113393A1 (en) | 2017-12-06 | 2019-06-13 | Avidity Biosciences Llc | Compositions and methods of treating muscle atrophy and myotonic dystrophy |
KR102316727B1 (ko) * | 2018-08-03 | 2021-10-26 | 주식회사 레모넥스 | 아토피성 질환 예방 또는 치료용 약학적 조성물 |
BR112021002440A2 (pt) | 2018-08-10 | 2021-05-04 | University Of Massachusetts | oligonucleotídeos modificados visando snps |
WO2020149702A1 (ko) * | 2019-01-18 | 2020-07-23 | 올릭스 주식회사 | Nrl(neural retina leucine zipper)의 발현을 억제하는 비대칭 sirna |
CN113795581A (zh) * | 2019-05-03 | 2021-12-14 | 迪克纳制药公司 | 具有缩短的有义链的双链核酸抑制剂分子 |
AU2021237465A1 (en) | 2020-03-19 | 2022-10-13 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
JP2024508780A (ja) | 2021-02-18 | 2024-02-28 | ワングローブ ホールディングス リミテッド | オリゴヌクレオチドおよび炭水化物をコンジュゲートするための組成物 |
WO2022240824A1 (en) | 2021-05-13 | 2022-11-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for treating sickle cell diseases |
WO2022256354A1 (en) | 2021-05-29 | 2022-12-08 | 1Globe Health Institute Llc | Short duplex dna as a novel gene silencing technology and use thereof |
AU2022285661A1 (en) | 2021-05-29 | 2023-12-21 | 1Globe Health Institute Llc | Asymmetric short duplex dna as a novel gene silencing technology and use thereof |
BR112023026862A2 (pt) | 2021-06-23 | 2024-03-05 | Beth Israel Deaconess Medical Ct Inc | Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos |
CA3227144A1 (en) * | 2021-07-22 | 2023-01-26 | Microbio (Shanghai) Co., Ltd. | Modified small interfering rna molecules with reduced off-target effects |
US11912779B2 (en) | 2021-09-16 | 2024-02-27 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
TW202333750A (zh) * | 2021-11-08 | 2023-09-01 | 美商黛瑟納製藥公司 | RNAi寡核苷酸共軛體 |
WO2023207615A1 (zh) * | 2022-04-26 | 2023-11-02 | 南京明德新药研发有限公司 | 一类含由天然核苷酸组成突出端的双链RNAi化合物 |
WO2024040531A1 (en) | 2022-08-25 | 2024-02-29 | 1Globe Health Institute, Nanjing | Novel compositions for conjugating oligonucleotides and carbohydrates |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040229266A1 (en) * | 2000-12-01 | 2004-11-18 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | RNA interference mediating small RNA molecules |
US20050203047A1 (en) * | 2004-03-10 | 2005-09-15 | Ulrich Thomann | Delivery vectors for short interfering RNA, micro-RNA and antisense RNA |
US20050255487A1 (en) * | 2002-11-14 | 2005-11-17 | Dharmacon, Inc. | Methods and compositions for selecting siRNA of improved functionality |
US20050266552A1 (en) * | 2003-12-05 | 2005-12-01 | Doench John G | Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi |
US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
US20060211642A1 (en) * | 2001-05-18 | 2006-09-21 | Sirna Therapeutics, Inc. | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
US20090208564A1 (en) * | 2007-08-27 | 2009-08-20 | Chiang Jia Li | Compositions of asymmetric interfering RNA and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070042983A1 (en) * | 2001-05-18 | 2007-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US20040248299A1 (en) * | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
WO2005079533A2 (en) * | 2004-02-17 | 2005-09-01 | University Of Massachusetts | Methods and compositions for mediating gene silencing |
EP1742958B1 (en) * | 2004-03-15 | 2017-05-17 | City of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도 |
TW201620525A (zh) | 2014-03-14 | 2016-06-16 | 波士頓生醫公司 | 使k-ras靜默之非對稱干擾rna組成物及其使用方法 |
-
2008
- 2008-08-27 CN CN200880113323A patent/CN101842381A/zh active Pending
- 2008-08-27 EP EP08798830A patent/EP2201022A4/en not_active Withdrawn
- 2008-08-27 CA CA2735166A patent/CA2735166C/en active Active
- 2008-08-27 JP JP2010523120A patent/JP2010537639A/ja active Pending
- 2008-08-27 WO PCT/US2008/074528 patent/WO2009029688A2/en active Application Filing
- 2008-08-27 EP EP16187862.4A patent/EP3121281B1/en active Active
- 2008-08-27 US US12/675,620 patent/US20100286378A1/en not_active Abandoned
- 2008-08-27 DK DK08828867.5T patent/DK2193140T3/en active
- 2008-08-27 CN CN201510250692.XA patent/CN105018492B/zh active Active
- 2008-08-27 WO PCT/US2008/074531 patent/WO2009029690A1/en active Application Filing
- 2008-08-27 ES ES16187862T patent/ES2873350T3/es active Active
- 2008-08-27 CA CA2735167A patent/CA2735167A1/en not_active Abandoned
- 2008-08-27 ES ES08828867.5T patent/ES2617877T3/es active Active
- 2008-08-27 EP EP21158616.9A patent/EP3889261A1/en active Pending
- 2008-08-27 US US12/199,797 patent/US9328345B2/en active Active
- 2008-08-27 CN CN200880113236.9A patent/CN101835789B/zh active Active
- 2008-08-27 JP JP2010523121A patent/JP2010537640A/ja active Pending
- 2008-08-27 EP EP08828867.5A patent/EP2193140B1/en active Active
-
2011
- 2011-03-14 HK HK11102556.9A patent/HK1148534A1/xx unknown
-
2014
- 2014-02-24 JP JP2014032700A patent/JP5986596B2/ja active Active
-
2015
- 2015-04-20 JP JP2015085681A patent/JP2015130885A/ja active Pending
-
2016
- 2016-03-25 US US15/081,559 patent/US10266821B2/en active Active
- 2016-05-03 HK HK16105036.7A patent/HK1217349A1/zh unknown
- 2016-06-07 JP JP2016113256A patent/JP6236498B2/ja active Active
- 2016-06-21 JP JP2016122512A patent/JP6453275B2/ja active Active
-
2017
- 2017-05-01 JP JP2017091309A patent/JP2017127333A/ja active Pending
-
2019
- 2019-02-20 US US16/280,830 patent/US10927376B2/en active Active
- 2019-03-11 US US16/298,545 patent/US11015195B2/en active Active
-
2021
- 2021-04-22 US US17/237,856 patent/US20210301292A1/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040229266A1 (en) * | 2000-12-01 | 2004-11-18 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | RNA interference mediating small RNA molecules |
US20060211642A1 (en) * | 2001-05-18 | 2006-09-21 | Sirna Therapeutics, Inc. | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
US20050255487A1 (en) * | 2002-11-14 | 2005-11-17 | Dharmacon, Inc. | Methods and compositions for selecting siRNA of improved functionality |
US20050266552A1 (en) * | 2003-12-05 | 2005-12-01 | Doench John G | Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi |
US20050203047A1 (en) * | 2004-03-10 | 2005-09-15 | Ulrich Thomann | Delivery vectors for short interfering RNA, micro-RNA and antisense RNA |
US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
US20090208564A1 (en) * | 2007-08-27 | 2009-08-20 | Chiang Jia Li | Compositions of asymmetric interfering RNA and uses thereof |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10364437B2 (en) | 2006-12-08 | 2019-07-30 | Iowa State University Research Foundation, Inc. | Plant genes involved in nitrate uptake and metabolism |
US9523099B2 (en) | 2006-12-08 | 2016-12-20 | Iowa State University Research Foundation, Inc. | Plant genes involved in nitrate uptake and metabolism |
US10266821B2 (en) | 2007-08-27 | 2019-04-23 | 1Globe Health Institute Llc | Compositions of asymmetric interfering RNA and uses thereof |
US11753641B2 (en) | 2010-04-23 | 2023-09-12 | Cold Spring Harbor Laboratory | Structurally designed shRNAs |
US8273871B2 (en) | 2010-04-23 | 2012-09-25 | Cold Spring Harbir Laboratory | Structurally designed shRNAs |
US10329562B2 (en) | 2010-04-23 | 2019-06-25 | Cold Spring Harbor Laboratory | Structurally designed shRNAs |
US8993532B2 (en) | 2010-04-23 | 2015-03-31 | Cold Spring Harbor Laboratory | Structurally designed shRNAs |
US9624494B2 (en) | 2010-04-23 | 2017-04-18 | Cold Spring Harbor Laboratory | Structurally designed shRNAs |
US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
WO2013138280A1 (en) * | 2012-03-12 | 2013-09-19 | Eaker Shannon | IMPROVED ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs |
WO2014063155A1 (en) | 2012-10-21 | 2014-04-24 | University Of Rochester | Thy1 (cd90) as a novel therapy to control adipose tissue accumulation |
US11001840B2 (en) | 2013-02-05 | 2021-05-11 | 1Globe Health Institute Llc | Biodegradable and clinically-compatible nanoparticles as drug delivery carriers |
WO2014123935A1 (en) * | 2013-02-05 | 2014-08-14 | 1Globe Health Institute Llc | Biodegradable and clinically-compatible nanop articles as drug delivery carriers |
US10729785B2 (en) * | 2014-05-19 | 2020-08-04 | BioNTech SE | Particles comprising protamine and RNA in combination with endosome destabilizing agents |
US10570395B2 (en) | 2014-11-14 | 2020-02-25 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
US10920227B2 (en) | 2014-11-14 | 2021-02-16 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11198873B2 (en) | 2014-11-14 | 2021-12-14 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
US11542506B2 (en) | 2014-11-14 | 2023-01-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11193129B2 (en) | 2016-05-18 | 2021-12-07 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
US11951121B2 (en) | 2016-05-18 | 2024-04-09 | Voyager Therapeutics, Inc. | Compositions and methods for treating Huntington's disease |
US11603542B2 (en) | 2017-05-05 | 2023-03-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
US11752181B2 (en) | 2017-05-05 | 2023-09-12 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
WO2019004420A1 (ja) * | 2017-06-30 | 2019-01-03 | 国立大学法人東京医科歯科大学 | ヘテロ二本鎖型antimiR |
US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
US11931375B2 (en) | 2017-10-16 | 2024-03-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
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