US20070104721A1 - Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 - Google Patents

Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 Download PDF

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Publication number
US20070104721A1
US20070104721A1 US11/592,066 US59206606A US2007104721A1 US 20070104721 A1 US20070104721 A1 US 20070104721A1 US 59206606 A US59206606 A US 59206606A US 2007104721 A1 US2007104721 A1 US 2007104721A1
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Prior art keywords
herceptin
hki
rapamycin
mammal
unit
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Abandoned
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US11/592,066
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Laurence Moore
Charles Zacharchuk
Sridhar Rabindran
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Wyeth LLC
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Wyeth LLC
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37845244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20070104721(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
Priority to US11/592,066 priority Critical patent/US20070104721A1/en
Assigned to WYETH reassignment WYETH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RABINDRAN, SRIDHAR K., MOORE, LAURENCE, ZACHARCHUK, CHARLES
Publication of US20070104721A1 publication Critical patent/US20070104721A1/en
Priority to US12/539,914 priority patent/US20090297519A1/en
Priority to US13/454,768 priority patent/US20120308560A1/en
Priority to US13/874,147 priority patent/US10729672B2/en
Priority to US17/548,340 priority patent/US20220354820A1/en
Priority to US17/871,397 priority patent/US20230201155A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Definitions

  • FIG. 3 is a 3-dimensional contour plot with the plane at 0% representing additive interaction, and peaks and valleys representing areas of synergy or antagonism between the herceptin and HKI-272 in MDA-MB-361 [HER-2 + (non-amplified); adenocarcinoma; ATCC HTB 27] cells.
  • an HKI-272 refers to a compound having the following core, or a derivative or pharmaceutically acceptable salt thereof. Suitable derivatives may include, e.g., an ester, ether, or carbamate.
  • the core structure, HKI-272 has the chemical name (E)-N- ⁇ 4-[3-chloro-4-(2-pyridinylmethoxy) anilino]-3-cyano-7-ethoxy-6-quinolinyl ⁇ -4-(dimethylam ino)-2-butenamide.
  • a pharmaceutical pack contains a course of treatment of a neoplasm for one individual mammal, wherein the pack contains units of an mTOR inhibitor in unit dosage form and units of herceptin in unit dosage form, optionally further in combination with units of an HKI-272 in unit dosage form.
  • a pharmaceutical pack contains a course of treatment of a neoplasm for one individual mammal, wherein the pack contains units of an mTOR inhibitor in unit dosage form and units of HKI-272 in unit dosage form, optionally further in combination with units of herceptin in unit dosage form.
  • herceptin single doses and multiple doses are contemplated.
  • a single loading dose of herceptin is administered as a 90-minute intravenous infusion in a range of about 4-5 mg/kg on day 1, followed by about 2 mg/kg per week starting on day 8.
  • 3 weeks is 1 cycle. From 1, to 2 to 3, weeks may be provided between cycles.
  • Herceptin may also be given at a dose of 6 mg/kg once every 3-4 weeks.
  • herceptin may also be given after completion of chemotherapy as maintenance therapy.
  • a compound of the invention is in the form of a unit dose.
  • Suitable unit dose forms include tablets, capsules and powders in sachets or vials.
  • Such unit dose forms may contain from 0.1 to 300 mg of a compound of the invention and preferably from 2 to 100 mg.
  • Still further preferred unit dosage forms contain 5 to 50 mg of a compound of the present invention.
  • the compounds of the present invention can be administered at a dose range of about 0.01 to 100 mg/kg or preferably at a dose range of 0.1 to 10 mg/kg.
  • the compounds are administered orally from 1 to 6 times a day, more usually from I to 4 times a day.
  • the compounds may be administered through another suitable route, e.g., intravenous.
  • Fludarabine (9-H-Purin-6-amine,2-fluoro-9-(5-O-phosphono-(beta)-D-a-rabinofuranosyl) is commercially available as a liquid injectable containing 50 mg/vial (FLUDARA).
  • 6-Mercaptopurine (1,7-dihydro-6H-purine-6-thione) is commercially available in 50 mg oral tablets (PURINETHOL).
  • the invention includes a product or pharmaceutical pack containing a course of an anti-neoplastic treatment for one individual mammal comprising one or more container(s) having one, one to four, or more unit(s) of an mTOR inhibitor (e.g., temsirolimus) in unit dosage form and, optionally, one, one to four, or more unit(s) of herceptin, and optionally, another active agent.
  • an mTOR inhibitor e.g., temsirolimus
  • Temsirolimus is administered IV weekly over a 30-minute period using an in-line filter and an automatic dispensing pump.
  • antihistamine diphenhydramine, 25 to 50 mg IV or the equivalent
  • temsirolimus infusion is administered.
  • the Pritchard and Shipman method was modified to allow determination of the combination effects at different levels of statistical significance (p-values 0.05, 0.01, 0.001). A p-value of 0.05 is considered significant.
  • the method of estimating statistical variability within each experiment was also modified. Variability was determined across all compound combinations, whereas in the original version, variability was estimated separately for each compound combination. It is believed that better estimates of the variability are obtained with the modified approach. In general, single points of synergy or antagonism are not considered representative of either synergistic or antagonistic activity. Thus, single point peaks or valleys are disregarded in the analysis.

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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US11/592,066 2005-11-04 2006-11-02 Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 Abandoned US20070104721A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US11/592,066 US20070104721A1 (en) 2005-11-04 2006-11-02 Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
US12/539,914 US20090297519A1 (en) 2005-11-04 2009-08-12 ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272
US13/454,768 US20120308560A1 (en) 2005-11-04 2012-04-24 Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272
US13/874,147 US10729672B2 (en) 2005-11-04 2013-04-30 Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272
US17/548,340 US20220354820A1 (en) 2005-11-04 2021-12-10 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272
US17/871,397 US20230201155A1 (en) 2005-11-04 2022-07-22 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73356205P 2005-11-04 2005-11-04
US83750906P 2006-08-14 2006-08-14
US11/592,066 US20070104721A1 (en) 2005-11-04 2006-11-02 Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272

Related Child Applications (1)

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US12/539,914 Division US20090297519A1 (en) 2005-11-04 2009-08-12 ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272

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US20070104721A1 true US20070104721A1 (en) 2007-05-10

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Family Applications (6)

Application Number Title Priority Date Filing Date
US11/592,066 Abandoned US20070104721A1 (en) 2005-11-04 2006-11-02 Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
US12/539,914 Abandoned US20090297519A1 (en) 2005-11-04 2009-08-12 ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272
US13/454,768 Abandoned US20120308560A1 (en) 2005-11-04 2012-04-24 Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272
US13/874,147 Active 2027-02-14 US10729672B2 (en) 2005-11-04 2013-04-30 Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272
US17/548,340 Pending US20220354820A1 (en) 2005-11-04 2021-12-10 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272
US17/871,397 Pending US20230201155A1 (en) 2005-11-04 2022-07-22 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272

Family Applications After (5)

Application Number Title Priority Date Filing Date
US12/539,914 Abandoned US20090297519A1 (en) 2005-11-04 2009-08-12 ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272
US13/454,768 Abandoned US20120308560A1 (en) 2005-11-04 2012-04-24 Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272
US13/874,147 Active 2027-02-14 US10729672B2 (en) 2005-11-04 2013-04-30 Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272
US17/548,340 Pending US20220354820A1 (en) 2005-11-04 2021-12-10 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272
US17/871,397 Pending US20230201155A1 (en) 2005-11-04 2022-07-22 Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272

Country Status (17)

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US (6) US20070104721A1 (fr)
EP (2) EP3488866A1 (fr)
JP (7) JP2009514870A (fr)
KR (1) KR101354828B1 (fr)
CN (1) CN103110948A (fr)
AR (1) AR057854A1 (fr)
AU (1) AU2006311877A1 (fr)
BR (1) BRPI0618042A2 (fr)
CA (1) CA2626326C (fr)
CR (1) CR9901A (fr)
EC (1) ECSP088423A (fr)
IL (1) IL190805A (fr)
NO (1) NO20081837L (fr)
PE (1) PE20070763A1 (fr)
RU (2) RU2451524C2 (fr)
TW (1) TW200803892A (fr)
WO (1) WO2007056118A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054001A1 (fr) * 2007-10-22 2009-04-30 Biocon Limited Composition pharmaceutique et procédé correspondant
US20090312360A1 (en) * 2008-06-17 2009-12-17 Wyeth Antineoplastic Combinations Containing HKI-272 and Vinorelbine
US20100081681A1 (en) * 2006-08-16 2010-04-01 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
US20100087482A1 (en) * 2005-02-03 2010-04-08 Haber Daniel A Method for Treating Gefitinib Resistant Cancer
US20100113474A1 (en) * 2008-08-04 2010-05-06 Wyeth Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine
US20100260733A1 (en) * 2009-04-10 2010-10-14 Haiyan Qi Novel anti aging agents and methods to identify them
WO2010117633A1 (fr) 2009-04-06 2010-10-14 Wyeth Llc Régime de traitement à l'aide de nératinib pour un cancer du sein
US20110111059A1 (en) * 2008-05-21 2011-05-12 Jianhui Guo Compositions Comprising Quinazoline Derivatives, Preparation Methods and Uses Thereof
WO2011070499A1 (fr) 2009-12-11 2011-06-16 Wyeth Llc Biomarqueurs de la voie de la phosphatidylinotisol-3-kinase
US20110165257A1 (en) * 2009-11-09 2011-07-07 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
WO2011087926A1 (fr) 2010-01-13 2011-07-21 Wyeth Llc Point de découpage dans l'expression de la protéine pten qui identifie avec précision les tumeurs et qui permet de prédire la réponse médicamenteuse à un inhibiteur de pan-erbb
US9139558B2 (en) 2007-10-17 2015-09-22 Wyeth Llc Maleate salts of (E)-N-{4-[3-Chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
WO2018133838A1 (fr) * 2017-01-22 2018-07-26 江苏恒瑞医药股份有限公司 Utilisations d'un inhibiteur de egfr/her2 combiné à un médicament anti-métabolique de type pyrimidine
US10729672B2 (en) 2005-11-04 2020-08-04 Wyeth Llc Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272

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* Cited by examiner, † Cited by third party
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DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
CA2645633A1 (fr) 2006-04-05 2007-11-01 Novartis Ag Combinaisons d'agents therapeutiques pour traiter un cancer
WO2008121467A2 (fr) * 2007-02-28 2008-10-09 Dana-Farber Cancer Institute, Inc. Polythérapie pour le traitement du cancer
NZ578824A (en) 2007-03-02 2012-03-30 Genentech Inc Predicting response to a her dimerisation inhibitor based on low her3 expression
MX2010012501A (es) * 2008-05-16 2010-12-20 Pharma Mar Sa Terapia de combinacion con un alcaloide antitumoral.
WO2010070117A1 (fr) * 2008-12-18 2010-06-24 Universite Libre De Bruxelles Procédé de traitement par administration de composés actifs ciblés anti-her2 à des patients atteints d'un cancer du sein précoce et d'une tumeur primaire her2 négative
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JP2014504902A (ja) 2010-11-22 2014-02-27 プロテウス デジタル ヘルス， インコーポレイテッド 医薬品を有する摂取可能なデバイス
WO2015112603A1 (fr) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Produit ingérable pouvant être mâché et système de communication associé
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
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JP5941240B2 (ja) 2013-03-15 2016-06-29 プロテウス デジタル ヘルス， インコーポレイテッド 金属検出器装置、システム、および方法
TWI482782B (zh) 2013-05-31 2015-05-01 Univ Nat Chiao Tung 架接抗體之雙乳化核殼奈米結構
CA3172586A1 (fr) 2013-07-31 2015-02-05 Avalyn Pharma Inc. Composes d'imatinib en aerosol et utilisations connexes
US20180057603A1 (en) * 2013-08-09 2018-03-01 The Trustees Of The University Of Pennsylvania Combination of IFN-gamma with Anti-ERBB Antibody for the Treatment of Cancers
US11446516B2 (en) 2013-08-09 2022-09-20 The Trustees Of The University Of Pennsylvania Methods of increasing response to cancer radiation therapy
DK3033086T3 (da) * 2013-08-14 2022-01-03 Novartis Ag Kombinationsterapi til behandling af cancer
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
SG11201900511VA (en) 2016-07-22 2019-02-27 Proteus Digital Health Inc Electromagnetic sensing and detection of ingestible event markers
CA3041041A1 (fr) 2016-10-26 2018-05-03 Proteus Digital Health, Inc. Procedes de preparation de capsules avec des marqueurs d'evenement ingerables
RU2648642C1 (ru) * 2017-06-06 2018-03-26 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ неоадъювантного лечения больных местно-распространенным раком шейки матки
JP7317343B2 (ja) * 2019-03-20 2023-07-31 公立大学法人大阪 乳がんの予防又は治療剤及び乳がん細胞の増殖抑制剤
WO2022076917A1 (fr) * 2020-10-08 2022-04-14 Kumquat Biosciences Inc. Modulateurs de la proliferation cellulaire et leurs utilisations
GB202111193D0 (en) 2021-08-03 2021-09-15 Phoremost Ltd Pharmaceutical compounds

Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5705151A (en) * 1995-05-18 1998-01-06 National Jewish Center For Immunology & Respiratory Medicine Gene therapy for T cell regulation
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
US6387371B1 (en) * 1988-01-12 2002-05-14 Genentech, Inc. Monoclonal antibodies directed to the HER2 receptor
US20020183240A1 (en) * 2001-04-06 2002-12-05 Wyeth Antineoplastic combinations
US20020198137A1 (en) * 2001-06-01 2002-12-26 Wyeth Antineoplastic combinations
US6511986B2 (en) * 2000-08-11 2003-01-28 Wyeth Method of treating estrogen receptor positive carcinoma
US20030153593A1 (en) * 2000-11-15 2003-08-14 Wyeth Use of CCI-779 as an antineoplastic agent
US6617333B2 (en) * 2001-08-07 2003-09-09 Wyeth Antineoplastic combinations comprising
US20040039010A1 (en) * 2002-05-30 2004-02-26 Grupp Stephan A. Methods for treatment of acute lymphocytic leukemia
US20040176339A1 (en) * 2003-03-05 2004-09-09 Wyeth Antineoplastic combinations
US6821515B1 (en) * 1995-07-27 2004-11-23 Genentech, Inc. Protein formulation
US20040258662A1 (en) * 2003-04-22 2004-12-23 Wyeth Antineoplastic agents
US20050032825A1 (en) * 2002-02-01 2005-02-10 Metcalf Chester A. Phosphorus-containing compounds and uses thereof
US20050059678A1 (en) * 2003-09-15 2005-03-17 Wyeth Protein tyrosine kinase enzyme inhibitors
US20050272758A1 (en) * 2004-03-11 2005-12-08 Wyeth Antineoplastic combinations of CCI-779 and rituximab
US20060035904A1 (en) * 2001-04-06 2006-02-16 Wyeth Antineoplastic combinations
US20060094674A1 (en) * 2002-07-05 2006-05-04 Neel Benjamin G Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US7306801B2 (en) * 2000-05-15 2007-12-11 Health Research, Inc. Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316885A (en) 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4650803A (en) 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
CA1327358C (fr) 1987-11-17 1994-03-01 Morio Fujiu Derives fluorocytidine
US5023264A (en) 1990-07-16 1991-06-11 American Home Products Corporation Rapamycin oximes
US5221670A (en) 1990-09-19 1993-06-22 American Home Products Corporation Rapamycin esters
US5233036A (en) 1990-10-16 1993-08-03 American Home Products Corporation Rapamycin alkoxyesters
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
US5162333A (en) 1991-09-11 1992-11-10 American Home Products Corporation Aminodiesters of rapamycin
US5177203A (en) 1992-03-05 1993-01-05 American Home Products Corporation Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5302584A (en) 1992-10-13 1994-04-12 American Home Products Corporation Carbamates of rapamycin
US5489680A (en) 1992-10-13 1996-02-06 American Home Products Corporation Carbamates of rapamycin
US5411967A (en) 1992-10-13 1995-05-02 American Home Products Corporation Carbamates of rapamycin
US5480988A (en) 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5480989A (en) 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5434260A (en) 1992-10-13 1995-07-18 American Home Products Corporation Carbamates of rapamycin
US5262423A (en) 1992-10-29 1993-11-16 American Home Products Corporation Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5260300A (en) 1992-11-19 1993-11-09 American Home Products Corporation Rapamycin carbonate esters as immuno-suppressant agents
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (fr) 1992-12-18 1995-08-21 Hoffmann La Roche
US5504091A (en) 1993-04-23 1996-04-02 American Home Products Corporation Biotin esters of rapamycin
US5373014A (en) 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
US5378836A (en) 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
US5391730A (en) 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385910A (en) 1993-11-22 1995-01-31 American Home Products Corporation Gem-distributed esters of rapamycin
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5389639A (en) 1993-12-29 1995-02-14 American Home Products Company Amino alkanoic esters of rapamycin
US5463048A (en) 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
UA41909C2 (uk) 1994-07-22 2001-10-15 Елі Ліллі Енд Компані Використання комбінації сполук для інгібірування остеопорозу, фармацевтичний препарат
US5476932A (en) 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
US5491231A (en) 1994-11-28 1996-02-13 American Home Products Corporation Hindered N-oxide esters of rapamycin
US5563145A (en) 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JP3437685B2 (ja) 1995-09-12 2003-08-18 株式会社東芝 交直変換装置の制御保護システム
DE69622183D1 (de) 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US5780462A (en) 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
WO1998002441A2 (fr) 1996-07-12 1998-01-22 Ariad Pharmaceuticals, Inc. Elements et procedes pour traiter ou prevenir les mycoses pathogènes
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6426383B1 (en) 1997-05-28 2002-07-30 Nalco Chemical Company Preparation of water soluble polymer dispersions from vinylamide monomers
US6251912B1 (en) 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
TW557297B (en) 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
DK1117659T3 (da) 1998-09-29 2004-03-22 Wyeth Corp Substituerede 3-cyanoquinoliner som hæmmere af proteintyrosinkinaser
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
AU783158B2 (en) 1999-08-24 2005-09-29 Ariad Pharmaceuticals, Inc. 28-epirapalogs
TWI256395B (en) 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
NZ519984A (en) 2000-01-07 2004-03-26 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
US6384051B1 (en) 2000-03-13 2002-05-07 American Cyanamid Company Method of treating or inhibiting colonic polyps
TWI310684B (en) 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
GB0008368D0 (en) 2000-04-06 2000-05-24 Astrazeneca Ab Combination product
DE60228699D1 (de) 2001-04-06 2008-10-16 Wyeth Corp Antineoplastische kombinationspräparate enthaltend cci-779 (rapamycin derivat) zusammen mit gemcitabin oder fluoro-uracil
JP4477303B2 (ja) * 2001-05-16 2010-06-09 ノバルティス アーゲー Ｎ−｛５−［４−（４−メチル−ピペラジノ−メチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤
BR0210101A (pt) * 2001-06-01 2004-06-08 Wyeth Corp Combinações antineoplásticas
EP1466174B1 (fr) 2001-06-14 2009-05-13 The Regents of the University of California Mutations dans la tyrosine kinase bcr-abl associees a la resistance a sti-571
AR037438A1 (es) 2001-11-27 2004-11-10 Wyeth Corp 3-cianoquinolinas como inhibidores de egf-r y her2 quinasas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
EP1837025A3 (fr) 2002-06-05 2007-12-19 Cedars-Sinai Medical Center Procédé de traitement du cancer utilisant des inhibiteurs de kinase
BR0313024A (pt) 2002-07-30 2005-07-12 Wyeth Corp Formulações parenterais contendo um hidroxiéster de rapamicina
CN100415233C (zh) 2002-09-17 2008-09-03 惠氏公司 口服制剂
US20040209930A1 (en) 2002-10-02 2004-10-21 Carboni Joan M. Synergistic methods and compositions for treating cancer
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
CN1437942A (zh) 2003-02-08 2003-08-27 杭州华卫制药技术开发有限公司 注射用长春瑞滨粉针剂及制备方法
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
CL2004001834A1 (es) 2003-07-23 2005-06-03 Bayer Pharmaceuticals Corp Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol
US20050025825A1 (en) 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
AU2004266572A1 (en) 2003-08-01 2005-03-03 Wyeth Holdings Corporation Use of combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer
DK1658295T3 (da) 2003-08-07 2007-09-24 Wyeth Corp Regioselektiv syntese af CCI-779
RU2345069C2 (ru) 2003-08-19 2009-01-27 Уайт Холдингз Корпорейшн Способ получения 4-амино-3-хинолинкарбонитрилов
CA2537978C (fr) 2003-09-15 2011-08-02 Wyeth Utilisation de quinolines substituees comme inhibiteurs de la tyrosine kinase
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20050142192A1 (en) 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
WO2005049021A1 (fr) 2003-11-03 2005-06-02 Oy Helsinki Transplantation R & D Ltd Substances et procedes pour inhiber l'hyperplasie neointime
EP1756137A4 (fr) 2003-11-05 2007-10-31 Univ Texas Methodes diagnostiques et therapeutiques et compositions impliquant des pten et le cancer du sein
AR046639A1 (es) * 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
WO2005055943A2 (fr) 2003-12-04 2005-06-23 Amr Technology, Inc. Derives de la vinorelbine
US9016221B2 (en) 2004-02-17 2015-04-28 University Of Florida Research Foundation, Inc. Surface topographies for non-toxic bioadhesion control
KR101289774B1 (ko) 2004-03-31 2013-08-07 다나-파버 캔서 인스티튜트 인크. 표피성장인자 수용체를 표적으로 하는 치료에 대한 암의반응성을 결정하는 방법
AU2005250484B2 (en) 2004-06-04 2011-08-11 Genentech, Inc. EGFR mutations
BRPI0513589A (pt) 2004-07-23 2008-05-13 Astrazeneca Ab método para selecionar um mamìfero tendo ou suspeito de ter um tumor para tratamento com uma droga de receptor de erbb
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
TW200616612A (en) 2004-10-08 2006-06-01 Wyeth Corp Method for the teatment of polycystic kidney disease field of invention
AR051388A1 (es) 2004-10-13 2007-01-10 Wyeth Corp Analogos de 17-hidroxiwortmanina como inhibidores de pi3k
WO2006044748A2 (fr) 2004-10-15 2006-04-27 Monogram Biosciences, Inc. Predicteurs de reponse pour medicaments specifiques de la voie erbb
US20060084666A1 (en) 2004-10-18 2006-04-20 Harari Paul M Combined treatment with radiation and an epidermal growth factor receptor kinase inhibitor
WO2006085168A2 (fr) 2005-01-07 2006-08-17 Ranbaxy Laboratories Limited Formes de dosage orales solides de ziprasidone
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
PL1848414T3 (pl) 2005-02-03 2011-10-31 Wyeth Llc Sposób leczenia nowotworu opornego na gefitinib
WO2006081985A1 (fr) 2005-02-04 2006-08-10 F. Hoffmann-La Roche Ag Traitement combine par un derive de n4-(oxycarbonyl substitue)-5'-desoxy-5-fluorocytidine et un inhibiteur de l'activite kinase du recepteur du facteur de croissance epidermique
EP1859793B1 (fr) 2005-02-28 2011-04-20 Eisai R&D Management Co., Ltd. Nouvelle utilisation combinee d'un compose de sulfonamide dans le traitment du cancer
EP1854463A4 (fr) 2005-03-03 2011-03-23 Takeda Pharmaceutical Composition a liberation controlee
CA2599445C (fr) 2005-03-09 2022-05-03 Abbott Laboratories Procede diagnostique d'identification des patients candidats a un traitement au trastuzumab
GB0504994D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
US20060235006A1 (en) 2005-04-13 2006-10-19 Lee Francis Y Combinations, methods and compositions for treating cancer
MX2007012662A (es) * 2005-04-14 2008-04-04 Wyeth Corp Uso de un inhibidor de la cinasa del receptor del factor de crecimiento epidermico (egfr) en pacientes resistentes al gefitinib.
US20110045459A1 (en) 2005-04-21 2011-02-24 Mischel Paul S Molecular determinants of EGFR kinase inhibitor response in glioblastoma
AU2006241113B2 (en) 2005-04-28 2011-08-18 Wyeth Micronized tanaproget, compositions, and methods of preparing the same
BRPI0609957A2 (pt) 2005-05-12 2010-05-11 Pfizer uso de malato de sunitinib na preparação de um medicamento para o tratamento de cáncer
RU2007143161A (ru) 2005-05-25 2009-07-10 Вайет (Us) Способы синтеза замещенных 3-цианохинов и их продуктов
EP1883621A2 (fr) 2005-05-25 2008-02-06 Wyeth Procedes de preparation de 3-cyano-quinoleines et intermediaires conçus au moyen de ceux-ci
DE102005053679A1 (de) 2005-06-24 2006-12-28 Bayer Healthcare Ag Therapeutischer Einsatz von Moxifloxacin zur Rekonstruktion von Funktionsstörungen des Immunsystems
RU2007148195A (ru) 2005-07-15 2009-08-20 Вайет (Us) Пероральные дозированные формы о-десметилвенлафаксин сукцината повышенной биодоступности с отсроченным высвобождением
WO2007015569A1 (fr) 2005-08-01 2007-02-08 Eisai R & D Management Co., Ltd. Procédé de prédiction de l’efficacité d’un inhibiteur de vascularisation
EP1925676A4 (fr) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd Procédé d'analyse de l' effet d 'un inhibiteur de vascularisation
ZA200802854B (en) 2005-10-05 2009-06-24 Astrazeneca Ltd Method to predict or monitor the response of a patient to an ErbB receptor drug
US20110052570A1 (en) 2005-10-26 2011-03-03 Children's Medical Center Corporation Method to prognose response to anti-egfr therapeutics
PE20070763A1 (es) 2005-11-04 2007-08-08 Wyeth Corp COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
AR058505A1 (es) 2005-11-04 2008-02-06 Wyeth Corp Combinaciones antineoplasicas de temsirolimus y malato de sunitinib
EP1948180B1 (fr) 2005-11-11 2013-03-13 Boehringer Ingelheim International GmbH Traitement combine du cancer comprenant des inhibiteurs de egfr/her2
PL1951274T3 (pl) 2005-11-24 2010-05-31 Aicuris Gmbh & Co Kg Parapoksywirusy w kombinacji z klasycznymi cytotoksycznymi środkami chemioterapeutycznymi jako biochemioterapia do leczenia raka
JP2007145745A (ja) 2005-11-25 2007-06-14 Osaka Univ 変異型ＥＧＦＲ下流シグナルを抑制するＳｒｃファミリーチロシンキナーゼ阻害剤を含む肺癌治療剤およびその利用
AU2006331688A1 (en) 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
WO2007095038A2 (fr) 2006-02-09 2007-08-23 Novartis Ag Mutations et polymorphismes du gène erbb2
AU2007235976A1 (en) 2006-04-07 2007-10-18 Novartis Ag Use of c-Src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia
TW200806282A (en) 2006-05-05 2008-02-01 Wyeth Corp Solid dosage formulations
RU2008146868A (ru) 2006-05-18 2010-06-27 Кэрис МПИ, Инк.445 Норт Фифс Стрит, 3-ий Флор, Феникс, Аризона 85004, США (US) Система и способ определения персонализированого медицинского вмешательства при болезненном состоянии
US20100113299A1 (en) 2008-10-14 2010-05-06 Von Hoff Daniel D Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
TW200808728A (en) 2006-05-23 2008-02-16 Wyeth Corp Method of preparing 4-halogenated quinoline intermediates
ES2427924T3 (es) 2006-06-30 2013-11-04 Merck Sharp & Dohme Corp. Biomarcador IGFBP2
AU2007299080B2 (en) 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
BRPI0719509A2 (pt) 2006-09-28 2013-12-31 Follica Inc Métodos, kits e composições para geração de novos folículos pilosos e crescimento de cabelos
WO2008043576A1 (fr) 2006-10-13 2008-04-17 Medigene Ag Utilisation de virus oncolytiques et d'agents anti-angiogéniques dans le traitement du cancer
AU2007334456A1 (en) 2006-12-13 2008-06-26 Merck Sharp & Dohme Corp. Methods of cancer treatment with IGF1R inhibitors
EP2121018A2 (fr) 2006-12-13 2009-11-25 Schering Corporation Procédés et compositions pour traiter le cancer
PL2101759T3 (pl) 2006-12-14 2019-05-31 Exelixis Inc Sposoby stosowania inhibitorów MEK
WO2008076143A1 (fr) 2006-12-18 2008-06-26 Osi Pharmaceuticals, Inc. Combinaison d'un inhibiteur de l'igfr et d'un agent anticancéreux
MX2009006700A (es) 2006-12-21 2009-06-30 Vertex Pharma Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.
MX2009007254A (es) 2007-01-12 2009-08-12 Wyeth Corp Composiciones de tableta en tableta.
ES2609094T3 (es) 2007-01-25 2017-04-18 Dana-Farber Cancer Institute, Inc. Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante
WO2008093878A1 (fr) 2007-02-01 2008-08-07 Takeda Pharmaceutical Company Limited Préparation de comprimé ne provoquant pas de problème de pastillage
WO2008121467A2 (fr) 2007-02-28 2008-10-09 Dana-Farber Cancer Institute, Inc. Polythérapie pour le traitement du cancer
GB0706633D0 (en) 2007-04-04 2007-05-16 Cyclacel Ltd Combination
EP1978106A1 (fr) 2007-04-07 2008-10-08 Universitätsklinikum Hamburg-Eppendorf Amplificateur ayant une protection de sortie, en particulier un amplificateur opérationnel pour une application audio
ES2529790T3 (es) 2007-04-13 2015-02-25 Dana-Farber Cancer Institute, Inc. Métodos de tratamiento de cáncer resistente a agentes terapéuticos de ERBB
JP2010525326A (ja) 2007-04-19 2010-07-22 ウェルスタット バイオロジックス コーポレイション 分離されていない循環癌細胞由来のＨｅｒ−２／ｎｅｕタンパク質の上昇したレベルの検出および治療
WO2008136838A1 (fr) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Nouveaux dérivés d'amide de cddo et leurs procédés d'utilisation
US20110014117A1 (en) 2007-06-28 2011-01-20 Schering Corporation Anti-igf1r
ES2569215T3 (es) 2007-09-10 2016-05-09 Boston Biomedical, Inc. Un nuevo grupo de inhibidores de la ruta de Stat3 e inhibidores de la ruta de las células madre del cáncer
CA2700665A1 (fr) 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Polytherapie pour le traitement de cancer au moyen d'inhibiteurs de la cox-2 et d'inhibiteurs doubles de l'egfr [erbb1] et de l'her-2 [erbb2]
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
JP2011500086A (ja) 2007-10-22 2011-01-06 シェーリング コーポレイション 完全ヒト抗ｖｅｇｆ抗体および使用方法
JP2011502571A (ja) 2007-11-05 2011-01-27 ピュアテック ベンチャーズ 医薬化合物を投与するための方法、キット、および組成物
CN101185633A (zh) 2007-12-14 2008-05-28 山东蓝金生物工程有限公司 一种治疗实体肿瘤的尼拉替尼缓释植入剂
MX2010006854A (es) 2007-12-18 2010-09-09 Schering Corp Biomarcadores para sensibilidad a terapia anti-receptor-1 del factor de crecimiento tipo insulina.
US20100297118A1 (en) 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
WO2009100176A2 (fr) 2008-02-07 2009-08-13 Abbott Laboratories Forme pharmaceutique pour administration orale d’un inhibiteur de tyrosine kinase
WO2009105234A2 (fr) 2008-02-19 2009-08-27 Combinatorx, Incorporated Procédés et compositions pour le traitement de troubles associés à des défauts du gène ou de la protéine du régulateur de la conductance transmembranaire d'une fibrose kystique
CN103399144B (zh) 2008-02-25 2015-10-28 雀巢产品技术援助有限公司 用抗体阵列选择乳腺癌治疗药物
US20100081632A1 (en) 2008-03-06 2010-04-01 Odyssey Thera, Inc. High-content and high throughput assays for identification of lipid-regulating pathways, and novel therapeutic agents for lipid disorders
MX2010010480A (es) 2008-03-25 2010-10-15 Schering Corp Metodos de tratamiento o prevencion del cancer colorrectal.
EP2279267A4 (fr) 2008-03-27 2012-01-18 Vascular Biosciences Inc Procédé d'identification de nouveaux candidats thérapeutiques via l'analyse d'expression génique dans les maladies d'origine vasculaire
US20090246198A1 (en) 2008-03-31 2009-10-01 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors and methods of use thereof
US20110182888A1 (en) 2008-04-08 2011-07-28 Peter Ordentlich Administration of an Inhibitor of HDAC, an Inhibitor of HER-2, and a Selective Estrogen Receptor Modulator
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
TWI442925B (zh) 2008-04-18 2014-07-01 Reata Pharmaceuticals Inc 抗氧化性發炎調節劑：ｃ－環飽和之齊墩果酸衍生物
ES2703274T3 (es) 2008-04-18 2019-03-07 Reata Pharmaceuticals Inc Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
CA2721665C (fr) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Composes comprenant un pharmacore anti-inflammatoire et procedes d'utilisation
KR101782020B1 (ko) 2008-04-18 2017-09-26 리타 파마슈티컬스 잉크. 산화방지성 염증 조절제 ｃ-17 일치된 올레아놀산 유도체
EP2282739A2 (fr) 2008-05-05 2011-02-16 Schering Corporation Administration séquentielle d agents de chimiothérapie pour le traitement du cancer
WO2009151910A2 (fr) 2008-05-25 2009-12-17 Wyeth Produit de combinaison d'un inhibiteur de tyrosine kinase de récepteur et d'un inhibiteur d'acide gras synthase pour le traitement du cancer
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
AU2009274037B2 (en) 2008-07-22 2015-07-09 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
CN102202667A (zh) 2008-08-04 2011-09-28 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
WO2010030835A2 (fr) 2008-09-11 2010-03-18 Wyeth Llc Compositions pharmaceutiques à base d'un inhibiteur de la src kinase et d'un inhibiteur de l'aromatase
WO2010048477A2 (fr) 2008-10-24 2010-04-29 Wyeth Llc Procede ameliore de preparation de produits couples a partir de 4-amino-3-cyanoquinoleines utilisant des intermediaires stabilises
AU2009313510A1 (en) 2008-11-07 2010-05-14 Enzon Pharmaceuticals, Inc. ERBB-3 (HER3)-selective combination therapy
WO2010085845A1 (fr) 2009-01-28 2010-08-05 The University Of Queensland Diagnostic du cancer et/ou thérapie contre celui-ci
TW201032796A (en) 2009-02-04 2010-09-16 Bipar Sciences Inc Treatment of lung cancer with a PARP inhibitor in combination with a growth factor inhibitor
WO2010098627A2 (fr) 2009-02-27 2010-09-02 한올바이오파마주식회사 Préparation pharmaceutique
CN105541836A (zh) 2009-03-11 2016-05-04 奥克兰联合服务有限公司 激酶抑制剂的前药形式及其在治疗中的用途
MX356593B (es) 2009-04-06 2018-06-05 Wyeth Llc Régimen de tratamiento que utiliza neratinib para cáncer de mama.
AR076053A1 (es) 2009-04-14 2011-05-18 Schering Corp Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor
WO2010124009A2 (fr) 2009-04-21 2010-10-28 Schering Corporation Anticorps anti-vegf entièrement humains et méthodes d'utilisation de ceux-ci
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
EP2448563A2 (fr) 2009-07-02 2012-05-09 Wyeth LLC Formulations de comprimé de 3- cyanoquinoline et leurs utilisations
KR20110007984A (ko) 2009-07-17 2011-01-25 한올바이오파마주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
KR20110007985A (ko) 2009-07-17 2011-01-25 한올바이오파마주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 부틸산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
WO2011025267A2 (fr) 2009-08-25 2011-03-03 한올바이오파마주식회사 Méthanesulfonate de metformine, procédé de préparation correspondant, composition pharmaceutique le comprenant et formulation combinée le comprenant
WO2011025271A2 (fr) 2009-08-25 2011-03-03 한올바이오파마주식회사 Ascorbate de metformine, procédé de préparation correspondant, composition pharmaceutique le comprenant et formulation combiné le comprenant
KR101190953B1 (ko) 2009-08-25 2012-10-12 한올바이오파마주식회사 메트포르민 타우린염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
US20110055838A1 (en) 2009-08-28 2011-03-03 Moyes William A Optimized thread scheduling via hardware performance monitoring
WO2011038467A1 (fr) 2009-10-01 2011-04-07 Csl Limited Procédé de traitement de la leucémie à chromosome philadelphie positive
WO2011056741A2 (fr) 2009-11-09 2011-05-12 Wyeth Llc Sphéroïdes de médicament enrobés et utilisations de ceux-ci pour éliminer ou réduire des affections telles que le vomissement et la diarrhée
RS59599B2 (sr) 2009-11-09 2023-03-31 Wyeth Llc Formulacije tableta neratinib maleata
CN105999263B (zh) 2009-11-13 2021-06-29 第一三共欧洲有限公司 用于治疗或预防人表皮生长因子受体-3(her-3)相关疾病的材料和方法
EP2509592A1 (fr) 2009-12-07 2012-10-17 Boehringer Ingelheim International GmbH Bibw 2992 pour utilisation dans le traitement du cancer du sein triple négatif
EP2510121A1 (fr) 2009-12-11 2012-10-17 Wyeth LLC Biomarqueurs de la voie de la phosphatidylinotisol-3-kinase
EP2524231B1 (fr) 2010-01-13 2017-06-28 Wyeth LLC Point de découpage dans l'expression de la protéine pten qui identifie avec précision les tumeurs et qui permet de prédire la réponse médicamenteuse à un inhibiteur de pan-erbb

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387371B1 (en) * 1988-01-12 2002-05-14 Genentech, Inc. Monoclonal antibodies directed to the HER2 receptor
US6399063B1 (en) * 1988-01-12 2002-06-04 Genentech, Inc. Monoclonal antibodies directed to the HER2 receptor
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5705151A (en) * 1995-05-18 1998-01-06 National Jewish Center For Immunology & Respiratory Medicine Gene therapy for T cell regulation
US6821515B1 (en) * 1995-07-27 2004-11-23 Genentech, Inc. Protein formulation
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
US7306801B2 (en) * 2000-05-15 2007-12-11 Health Research, Inc. Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
US6511986B2 (en) * 2000-08-11 2003-01-28 Wyeth Method of treating estrogen receptor positive carcinoma
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
US20030153593A1 (en) * 2000-11-15 2003-08-14 Wyeth Use of CCI-779 as an antineoplastic agent
US20020183240A1 (en) * 2001-04-06 2002-12-05 Wyeth Antineoplastic combinations
US20050187184A1 (en) * 2001-04-06 2005-08-25 Wyeth Antineoplastic combinations
US20060035904A1 (en) * 2001-04-06 2006-02-16 Wyeth Antineoplastic combinations
US20020198137A1 (en) * 2001-06-01 2002-12-26 Wyeth Antineoplastic combinations
US20060030547A1 (en) * 2001-06-01 2006-02-09 Wyeth Antineoplastic combinations
US6617333B2 (en) * 2001-08-07 2003-09-09 Wyeth Antineoplastic combinations comprising
US20050032825A1 (en) * 2002-02-01 2005-02-10 Metcalf Chester A. Phosphorus-containing compounds and uses thereof
US20040039010A1 (en) * 2002-05-30 2004-02-26 Grupp Stephan A. Methods for treatment of acute lymphocytic leukemia
US20060094674A1 (en) * 2002-07-05 2006-05-04 Neel Benjamin G Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US20040176339A1 (en) * 2003-03-05 2004-09-09 Wyeth Antineoplastic combinations
US20040258662A1 (en) * 2003-04-22 2004-12-23 Wyeth Antineoplastic agents
US20050059678A1 (en) * 2003-09-15 2005-03-17 Wyeth Protein tyrosine kinase enzyme inhibitors
US20050272758A1 (en) * 2004-03-11 2005-12-08 Wyeth Antineoplastic combinations of CCI-779 and rituximab

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100087482A1 (en) * 2005-02-03 2010-04-08 Haber Daniel A Method for Treating Gefitinib Resistant Cancer
US10603314B2 (en) 2005-02-03 2020-03-31 The General Hospital Corporation Method for treating gefitinib resistant cancer
US10596162B2 (en) 2005-02-03 2020-03-24 Wyeth Llc Method for treating gefitinib resistant cancer
US10729672B2 (en) 2005-11-04 2020-08-04 Wyeth Llc Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272
US20100081681A1 (en) * 2006-08-16 2010-04-01 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
US9630946B2 (en) 2007-10-17 2017-04-25 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
US9139558B2 (en) 2007-10-17 2015-09-22 Wyeth Llc Maleate salts of (E)-N-{4-[3-Chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
US10035788B2 (en) 2007-10-17 2018-07-31 Wyeth Llc Maleate salts of (E)-N-{4[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
WO2009054001A1 (fr) * 2007-10-22 2009-04-30 Biocon Limited Composition pharmaceutique et procédé correspondant
US8507010B2 (en) * 2008-05-21 2013-08-13 Shanghai Allist Pharmaceuticals, Inc. Compositions comprising quinazoline derivatives
US20110111059A1 (en) * 2008-05-21 2011-05-12 Jianhui Guo Compositions Comprising Quinazoline Derivatives, Preparation Methods and Uses Thereof
EP3443961A1 (fr) 2008-06-17 2019-02-20 Wyeth LLC Combinaisons antinéoplasiques contenant du hki-272 et de la vinorelbine
US10111868B2 (en) 2008-06-17 2018-10-30 Wyeth Llc Antineoplastic combinations containing HKI-272 and vinorelbine
KR101922096B1 (ko) 2008-06-17 2018-11-27 와이어쓰 엘엘씨 Ｈｋｉ-272 및 비노렐빈을 함유하는 항신생물성 조합물
US9511063B2 (en) 2008-06-17 2016-12-06 Wyeth Llc Antineoplastic combinations containing HKI-272 and vinorelbine
EP2915532A1 (fr) 2008-06-17 2015-09-09 Wyeth LLC Combinaisons antinéoplasiques contenant du HKI-272 et de la vinorelbine
EP3730139A1 (fr) 2008-06-17 2020-10-28 Wyeth LLC Combinaisons antinéoplasiques contenant du hki-272 et de la vinorelbine
US20090312360A1 (en) * 2008-06-17 2009-12-17 Wyeth Antineoplastic Combinations Containing HKI-272 and Vinorelbine
EP3135285A1 (fr) 2008-06-17 2017-03-01 Wyeth LLC Combinaisons antinéoplasiques contenant du hki-272 et de la vinorelbine
EP3175853A1 (fr) 2008-08-04 2017-06-07 Wyeth LLC Combinaisons antinéoplasiques contenant du neratinib et de la capécitabine
US8669273B2 (en) 2008-08-04 2014-03-11 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
US20100113474A1 (en) * 2008-08-04 2010-05-06 Wyeth Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine
US9265784B2 (en) 2008-08-04 2016-02-23 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
US9211291B2 (en) 2009-04-06 2015-12-15 Wyeth Llc Treatment regimen utilizing neratinib for breast cancer
EP4218760A2 (fr) 2009-04-06 2023-08-02 Wyeth LLC Régime de traitement utilisant du nératinib pour le cancer du sein
CN105999264A (zh) * 2009-04-06 2016-10-12 惠氏有限责任公司 用于乳腺癌的利用奈拉替尼的治疗方案
EP3000467A1 (fr) 2009-04-06 2016-03-30 Wyeth LLC Régime de traitement à l'aide de nératinib pour le cancer du sein
WO2010117633A1 (fr) 2009-04-06 2010-10-14 Wyeth Llc Régime de traitement à l'aide de nératinib pour un cancer du sein
US9360471B2 (en) 2009-04-10 2016-06-07 Haiyan Qi Anti-aging agents and methods to identify them
EP2965763A1 (fr) 2009-04-10 2016-01-13 Haiyan Qi Agents anti-vieillissement
US20100260733A1 (en) * 2009-04-10 2010-10-14 Haiyan Qi Novel anti aging agents and methods to identify them
US8492110B2 (en) 2009-04-10 2013-07-23 Haiyan Qi Anti aging agents and methods to identify them
US8524281B2 (en) * 2009-11-09 2013-09-03 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
US20110165257A1 (en) * 2009-11-09 2011-07-07 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
US20140004203A1 (en) * 2009-11-09 2014-01-02 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
US9211264B2 (en) * 2009-11-09 2015-12-15 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
EP3575413A1 (fr) 2009-12-11 2019-12-04 Wyeth LLC Biomarqueurs de la voie phosphatidylinositol-3-kinase
WO2011070499A1 (fr) 2009-12-11 2011-06-16 Wyeth Llc Biomarqueurs de la voie de la phosphatidylinotisol-3-kinase
US20160222467A1 (en) * 2009-12-11 2016-08-04 Wyeth Llc Phosphatidylinositol-3-kinase pathway biomarkers
US8338456B2 (en) 2010-01-13 2012-12-25 Wyeth Llc Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor
WO2011087926A1 (fr) 2010-01-13 2011-07-21 Wyeth Llc Point de découpage dans l'expression de la protéine pten qui identifie avec précision les tumeurs et qui permet de prédire la réponse médicamenteuse à un inhibiteur de pan-erbb
WO2018133838A1 (fr) * 2017-01-22 2018-07-26 江苏恒瑞医药股份有限公司 Utilisations d'un inhibiteur de egfr/her2 combiné à un médicament anti-métabolique de type pyrimidine
CN108778275A (zh) * 2017-01-22 2018-11-09 江苏恒瑞医药股份有限公司 Egfr/her2抑制剂联合嘧啶类抗代谢药物的用途

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