UA99830C2 - Фармацевтическая композиция с пролонгированным высвобождением, изготовленная из микрочастиц - Google Patents
Фармацевтическая композиция с пролонгированным высвобождением, изготовленная из микрочастиц Download PDFInfo
- Publication number
- UA99830C2 UA99830C2 UAA200913838A UAA200913838A UA99830C2 UA 99830 C2 UA99830 C2 UA 99830C2 UA A200913838 A UAA200913838 A UA A200913838A UA A200913838 A UAA200913838 A UA A200913838A UA 99830 C2 UA99830 C2 UA 99830C2
- Authority
- UA
- Ukraine
- Prior art keywords
- composition
- micrometers
- microparticles
- triptorelin
- pharmaceutical composition
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 46
- 238000002347 injection Methods 0.000 abstract description 10
- 239000007924 injection Substances 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 150000003839 salts Chemical class 0.000 abstract description 5
- 239000013543 active substance Substances 0.000 abstract description 3
- 229920000642 polymer Polymers 0.000 abstract description 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 21
- 239000004005 microsphere Substances 0.000 description 13
- ZBVJFYPGLGEMIN-OYLNGHKZSA-N (2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-[[(2s)-1-[[(2s)-1-[(2s)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]amino]-3-( Chemical group C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1.C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 ZBVJFYPGLGEMIN-OYLNGHKZSA-N 0.000 description 11
- 229960000294 triptorelin pamoate Drugs 0.000 description 11
- 239000000556 agonist Substances 0.000 description 10
- 229960004824 triptorelin Drugs 0.000 description 10
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 10
- 239000012074 organic phase Substances 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 239000012736 aqueous medium Substances 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229960003604 testosterone Drugs 0.000 description 3
- 239000008215 water for injection Substances 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 2
- 229940011051 isopropyl acetate Drugs 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 241000282461 Canis lupus Species 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000008576 chronic process Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение касается фармацевтической композиции, изготовленной из микрочастиц, для пролонгированного высвобождения агониста LHRH по меньшей мере на протяжении периода, который охватывает шестой месяц после инъекции указанной композиции, которая содержит смесь первой композиции микрочастиц и второй композиции микрочастиц, где:a) указанная первая композиция микрочастиц изготовлена из сополимера типа PLGA, который включает указанный агонист LHRH в форме водонерастворимой пептидной соли; указанный сополимер включает по меньшей мере 85 % (в мольных %) молочной кислоты и имеет характерис�
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109767 | 2007-06-06 | ||
IB2007054372 | 2007-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA99830C2 true UA99830C2 (ru) | 2012-10-10 |
Family
ID=40032512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200913838A UA99830C2 (ru) | 2007-06-06 | 2008-06-06 | Фармацевтическая композиция с пролонгированным высвобождением, изготовленная из микрочастиц |
Country Status (32)
Country | Link |
---|---|
US (3) | US10166181B2 (ru) |
EP (3) | EP2164467B1 (ru) |
JP (1) | JP5419169B2 (ru) |
KR (1) | KR101631475B1 (ru) |
CN (1) | CN101677959B (ru) |
AP (1) | AP3000A (ru) |
AU (1) | AU2008259411B2 (ru) |
BR (1) | BRPI0812250B8 (ru) |
CA (1) | CA2688478C (ru) |
CO (1) | CO6251234A2 (ru) |
CY (2) | CY1118434T1 (ru) |
DK (2) | DK2164467T3 (ru) |
EA (1) | EA019284B1 (ru) |
ES (2) | ES2611020T3 (ru) |
HK (1) | HK1141737A1 (ru) |
HR (2) | HRP20161785T1 (ru) |
HU (2) | HUE031550T2 (ru) |
IL (1) | IL202501A (ru) |
LT (2) | LT2164467T (ru) |
MA (1) | MA31422B1 (ru) |
ME (1) | ME00959B (ru) |
MX (1) | MX2009012856A (ru) |
MY (1) | MY150450A (ru) |
NZ (1) | NZ582423A (ru) |
PL (2) | PL2164467T3 (ru) |
PT (2) | PT2500014T (ru) |
RS (2) | RS55591B1 (ru) |
SI (2) | SI2164467T1 (ru) |
TN (1) | TN2009000476A1 (ru) |
UA (1) | UA99830C2 (ru) |
WO (1) | WO2008149320A2 (ru) |
ZA (1) | ZA200907940B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2164467T3 (en) | 2007-06-06 | 2017-01-30 | Debiopharm Res & Mfg Sa | Slow release pharmaceutical composition consisting of microparticles |
PT105270B (pt) | 2010-08-26 | 2012-05-31 | Domino Ind Ceramicas S A | Camada de sílica com libertação lenta de fragrância, telha cerâmica e respectivo processo de produção |
CN105267153B (zh) * | 2015-11-27 | 2018-05-11 | 上海苏豪逸明制药有限公司 | 一种曲普瑞林缓释微粒及其制备方法 |
CN105797134B (zh) * | 2016-03-29 | 2019-06-14 | 浙江圣兆药物科技股份有限公司 | 一种难溶亮丙瑞林缓释制剂 |
US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
KR102402639B1 (ko) | 2017-11-24 | 2022-05-26 | 삼성전자주식회사 | 전자 장치 및 그의 통신 방법 |
CN111000798B (zh) * | 2019-12-26 | 2021-11-23 | 四川恒博生物科技有限公司 | 一种采用原位凝胶技术的犬用非手术去势注射液 |
IT202000017191A1 (it) | 2020-07-15 | 2022-01-15 | Xbrane Biopharma Ab | Procedimento senza acqua per preparare una composizione farmaceutica per un rilascio più prolungato e controllato di triptorelina o di un suo sale |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3678308D1 (de) | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
GB2209937B (en) | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
US5225205A (en) | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
CH679207A5 (ru) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
JP3277342B2 (ja) | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
CA2172507C (en) * | 1993-10-22 | 2008-12-02 | Jeffrey L. Cleland | Methods and compositions for microencapsulation of antigens for use as vaccines |
US5945128A (en) * | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
MY118835A (en) * | 1997-04-18 | 2005-01-31 | Ipsen Pharma Biotech | Sustained release compositions and the process for their preparation |
EP1028746B1 (en) * | 1997-11-07 | 2003-02-26 | Chiron Corporation | Method for producing igf-i sustained-release formulations |
TW200800298A (en) * | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
BRPI0213226B1 (pt) | 2001-10-10 | 2016-03-01 | Pf Medicament | processo de preparação de uma composição farmacêutica sob forma de microesferas com liberação prolongada de um princípio ativo hidrossolúvel, e, microesferas |
KR20060033859A (ko) | 2003-04-30 | 2006-04-20 | 데비오 팜 소시에떼 아노님 | 생식선 자극 호르몬 방출 호르몬을 이용한 방법 및 조성물 |
KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
FR2865938B1 (fr) * | 2004-02-05 | 2006-06-02 | Sod Conseils Rech Applic | Formulation retard solide comprenant de l'acetate de triptoreline |
IN2015DN03936A (ru) | 2005-12-22 | 2015-10-02 | Novartis Ag | |
DK2164467T3 (en) | 2007-06-06 | 2017-01-30 | Debiopharm Res & Mfg Sa | Slow release pharmaceutical composition consisting of microparticles |
-
2008
- 2008-06-06 DK DK08763237.8T patent/DK2164467T3/en active
- 2008-06-06 WO PCT/IB2008/052241 patent/WO2008149320A2/en active Application Filing
- 2008-06-06 PT PT12172232T patent/PT2500014T/pt unknown
- 2008-06-06 LT LTEP08763237.8T patent/LT2164467T/lt unknown
- 2008-06-06 ME MEP-2009-341A patent/ME00959B/me unknown
- 2008-06-06 UA UAA200913838A patent/UA99830C2/ru unknown
- 2008-06-06 KR KR1020107000176A patent/KR101631475B1/ko active IP Right Grant
- 2008-06-06 ES ES08763237.8T patent/ES2611020T3/es active Active
- 2008-06-06 EP EP08763237.8A patent/EP2164467B1/en not_active Revoked
- 2008-06-06 NZ NZ582423A patent/NZ582423A/en unknown
- 2008-06-06 AP AP2009005088A patent/AP3000A/xx active
- 2008-06-06 EP EP12172232.6A patent/EP2500014B1/en active Active
- 2008-06-06 AU AU2008259411A patent/AU2008259411B2/en active Active
- 2008-06-06 US US12/601,649 patent/US10166181B2/en active Active
- 2008-06-06 EP EP18186642.7A patent/EP3431077A1/en active Pending
- 2008-06-06 JP JP2010510946A patent/JP5419169B2/ja active Active
- 2008-06-06 BR BRPI0812250A patent/BRPI0812250B8/pt active IP Right Grant
- 2008-06-06 HU HUE08763237A patent/HUE031550T2/en unknown
- 2008-06-06 HU HUE12172232A patent/HUE040391T2/hu unknown
- 2008-06-06 PL PL08763237T patent/PL2164467T3/pl unknown
- 2008-06-06 EA EA200971132A patent/EA019284B1/ru unknown
- 2008-06-06 MY MYPI20094886 patent/MY150450A/en unknown
- 2008-06-06 LT LTEP12172232.6T patent/LT2500014T/lt unknown
- 2008-06-06 CN CN200880018833.3A patent/CN101677959B/zh active Active
- 2008-06-06 PL PL12172232T patent/PL2500014T3/pl unknown
- 2008-06-06 ES ES12172232.6T patent/ES2694401T3/es active Active
- 2008-06-06 PT PT87632378T patent/PT2164467T/pt unknown
- 2008-06-06 MX MX2009012856A patent/MX2009012856A/es active IP Right Grant
- 2008-06-06 RS RS20170032A patent/RS55591B1/sr unknown
- 2008-06-06 SI SI200831754A patent/SI2164467T1/sl unknown
- 2008-06-06 SI SI200832014T patent/SI2500014T1/sl unknown
- 2008-06-06 RS RS20181349A patent/RS58248B1/sr unknown
- 2008-06-06 DK DK12172232.6T patent/DK2500014T3/en active
- 2008-06-06 CA CA2688478A patent/CA2688478C/en active Active
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2009
- 2009-11-09 TN TNP2009000476A patent/TN2009000476A1/fr unknown
- 2009-11-11 ZA ZA200907940A patent/ZA200907940B/xx unknown
- 2009-12-01 MA MA32391A patent/MA31422B1/fr unknown
- 2009-12-02 CO CO09137855A patent/CO6251234A2/es not_active Application Discontinuation
- 2009-12-03 IL IL202501A patent/IL202501A/en active IP Right Grant
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2010
- 2010-09-02 HK HK10108338.2A patent/HK1141737A1/xx unknown
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2016
- 2016-12-27 HR HRP20161785TT patent/HRP20161785T1/hr unknown
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2017
- 2017-01-17 CY CY20171100060T patent/CY1118434T1/el unknown
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2018
- 2018-11-07 HR HRP20181854TT patent/HRP20181854T1/hr unknown
- 2018-11-07 CY CY181101171T patent/CY1120891T1/el unknown
- 2018-11-15 US US16/192,674 patent/US20190192423A1/en not_active Abandoned
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2022
- 2022-09-15 US US17/932,621 patent/US20230082575A1/en active Pending
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