ME00959B - Farmaceutska kompozicija sa sporim oslobađanjem koja je formirana od mikročestica - Google Patents
Farmaceutska kompozicija sa sporim oslobađanjem koja je formirana od mikročesticaInfo
- Publication number
- ME00959B ME00959B MEP-2009-341A MEP34109A ME00959B ME 00959 B ME00959 B ME 00959B ME P34109 A MEP34109 A ME P34109A ME 00959 B ME00959 B ME 00959B
- Authority
- ME
- Montenegro
- Prior art keywords
- microparticles
- pharmaceutical composition
- slow release
- micrometers
- composition made
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Farmaceutska kompozicija napravljena od mikročestica za sporo oslobađanje aktivne supstance najmanje tokom perioda koji pokriva šesti mesec posle injektiranja navedene kompozicije, pri čemu navedena kompozicija sadrži grupu mikročestica napravljenih od kopolimera PLGA tipa koji sadrži aktivnu supstancu u obliku peptidne soli koja je nerastvorljiva u vodi; pri čemu navedeni kopolimer pored toga sadrži najmanje 75% mlečne kiseline i ima viskoznost između 0.1 i 0.9 dl/g, kao što je mereno u hloroformu na 25°C i pri koncentraciji polimera od 0.5 g/dL; navedene mikročestice pored toga imaju raspodelu veličine defmisanu na sledeći način: -D (v, 0.1) je između 10 i 30 mikrometara, - D (v, 0.5) je između 30 i 70 mikrometara, - D (v, 0.9) je između 50 i 110 mikrometara.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109767 | 2007-06-06 | ||
IB2007054372 | 2007-10-27 | ||
PCT/IB2008/052241 WO2008149320A2 (en) | 2007-06-06 | 2008-06-06 | Slow release pharmaceutical composition made of microparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
ME00959B true ME00959B (me) | 2012-06-20 |
Family
ID=40032512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2009-341A ME00959B (me) | 2007-06-06 | 2008-06-06 | Farmaceutska kompozicija sa sporim oslobađanjem koja je formirana od mikročestica |
Country Status (32)
Country | Link |
---|---|
US (3) | US10166181B2 (me) |
EP (3) | EP3431077A1 (me) |
JP (1) | JP5419169B2 (me) |
KR (1) | KR101631475B1 (me) |
CN (1) | CN101677959B (me) |
AP (1) | AP3000A (me) |
AU (1) | AU2008259411B2 (me) |
BR (1) | BRPI0812250B8 (me) |
CA (1) | CA2688478C (me) |
CO (1) | CO6251234A2 (me) |
CY (2) | CY1118434T1 (me) |
DK (2) | DK2164467T3 (me) |
EA (1) | EA019284B1 (me) |
ES (2) | ES2694401T3 (me) |
HK (1) | HK1141737A1 (me) |
HR (2) | HRP20161785T1 (me) |
HU (2) | HUE040391T2 (me) |
IL (1) | IL202501A (me) |
LT (2) | LT2164467T (me) |
MA (1) | MA31422B1 (me) |
ME (1) | ME00959B (me) |
MX (1) | MX2009012856A (me) |
MY (1) | MY150450A (me) |
NZ (1) | NZ582423A (me) |
PL (2) | PL2164467T3 (me) |
PT (2) | PT2500014T (me) |
RS (2) | RS58248B1 (me) |
SI (2) | SI2500014T1 (me) |
TN (1) | TN2009000476A1 (me) |
UA (1) | UA99830C2 (me) |
WO (1) | WO2008149320A2 (me) |
ZA (1) | ZA200907940B (me) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS58248B1 (sr) | 2007-06-06 | 2019-03-29 | Debiopharm Res & Manufacturing Sa | Farmaceutska kompozicija sa sporim oslobađanjem pripremljena od mikročestica |
PT105270B (pt) | 2010-08-26 | 2012-05-31 | Domino Ind Ceramicas S A | Camada de sílica com libertação lenta de fragrância, telha cerâmica e respectivo processo de produção |
CN105267153B (zh) * | 2015-11-27 | 2018-05-11 | 上海苏豪逸明制药有限公司 | 一种曲普瑞林缓释微粒及其制备方法 |
CN105797134B (zh) * | 2016-03-29 | 2019-06-14 | 浙江圣兆药物科技股份有限公司 | 一种难溶亮丙瑞林缓释制剂 |
EP3535297B1 (en) | 2016-11-02 | 2022-08-10 | Debiopharm International, S.A. | Methods for improving anti-cd37 immunoconjugate therapy |
KR102402639B1 (ko) | 2017-11-24 | 2022-05-26 | 삼성전자주식회사 | 전자 장치 및 그의 통신 방법 |
CN111000798B (zh) * | 2019-12-26 | 2021-11-23 | 四川恒博生物科技有限公司 | 一种采用原位凝胶技术的犬用非手术去势注射液 |
IT202000017191A1 (it) | 2020-07-15 | 2022-01-15 | Xbrane Biopharma Ab | Procedimento senza acqua per preparare una composizione farmaceutica per un rilascio più prolungato e controllato di triptorelina o di un suo sale |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3678308D1 (de) | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
GB2209937B (en) | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
CH679207A5 (me) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
US5225205A (en) * | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
JP3277342B2 (ja) | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
CA2172507C (en) * | 1993-10-22 | 2008-12-02 | Jeffrey L. Cleland | Methods and compositions for microencapsulation of antigens for use as vaccines |
US5945128A (en) * | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
AR012448A1 (es) | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
AU1384199A (en) * | 1997-11-07 | 1999-05-31 | Chiron Corporation | Method for producing igf-1 sustained-release formulations |
TWI284048B (en) * | 2000-01-27 | 2007-07-21 | Zentaris Ag | Compressed microparticles for dry injection |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
EP1450766B1 (fr) | 2001-10-10 | 2015-04-22 | Pierre Fabre Medicament | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
WO2004096259A1 (en) | 2003-04-30 | 2004-11-11 | Debiopharm S.A. | Methods and compositions using gonadotropin hormone releasing hormone |
KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
FR2865938B1 (fr) * | 2004-02-05 | 2006-06-02 | Sod Conseils Rech Applic | Formulation retard solide comprenant de l'acetate de triptoreline |
WO2007071395A1 (en) | 2005-12-22 | 2007-06-28 | Novartis Ag | Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers |
RS58248B1 (sr) | 2007-06-06 | 2019-03-29 | Debiopharm Res & Manufacturing Sa | Farmaceutska kompozicija sa sporim oslobađanjem pripremljena od mikročestica |
-
2008
- 2008-06-06 RS RS20181349A patent/RS58248B1/sr unknown
- 2008-06-06 MX MX2009012856A patent/MX2009012856A/es active IP Right Grant
- 2008-06-06 SI SI200832014T patent/SI2500014T1/sl unknown
- 2008-06-06 UA UAA200913838A patent/UA99830C2/uk unknown
- 2008-06-06 WO PCT/IB2008/052241 patent/WO2008149320A2/en active Application Filing
- 2008-06-06 EP EP18186642.7A patent/EP3431077A1/en active Pending
- 2008-06-06 JP JP2010510946A patent/JP5419169B2/ja active Active
- 2008-06-06 ES ES12172232.6T patent/ES2694401T3/es active Active
- 2008-06-06 DK DK08763237.8T patent/DK2164467T3/en active
- 2008-06-06 CN CN200880018833.3A patent/CN101677959B/zh active Active
- 2008-06-06 DK DK12172232.6T patent/DK2500014T3/en active
- 2008-06-06 EP EP12172232.6A patent/EP2500014B1/en active Active
- 2008-06-06 LT LTEP08763237.8T patent/LT2164467T/lt unknown
- 2008-06-06 US US12/601,649 patent/US10166181B2/en active Active
- 2008-06-06 EA EA200971132A patent/EA019284B1/ru unknown
- 2008-06-06 ES ES08763237.8T patent/ES2611020T3/es active Active
- 2008-06-06 HU HUE12172232A patent/HUE040391T2/hu unknown
- 2008-06-06 CA CA2688478A patent/CA2688478C/en active Active
- 2008-06-06 EP EP08763237.8A patent/EP2164467B1/en not_active Revoked
- 2008-06-06 RS RS20170032A patent/RS55591B1/sr unknown
- 2008-06-06 PT PT12172232T patent/PT2500014T/pt unknown
- 2008-06-06 MY MYPI20094886 patent/MY150450A/en unknown
- 2008-06-06 PL PL08763237T patent/PL2164467T3/pl unknown
- 2008-06-06 NZ NZ582423A patent/NZ582423A/en unknown
- 2008-06-06 AP AP2009005088A patent/AP3000A/xx active
- 2008-06-06 LT LTEP12172232.6T patent/LT2500014T/lt unknown
- 2008-06-06 KR KR1020107000176A patent/KR101631475B1/ko active IP Right Grant
- 2008-06-06 PT PT87632378T patent/PT2164467T/pt unknown
- 2008-06-06 AU AU2008259411A patent/AU2008259411B2/en active Active
- 2008-06-06 BR BRPI0812250A patent/BRPI0812250B8/pt active IP Right Grant
- 2008-06-06 HU HUE08763237A patent/HUE031550T2/en unknown
- 2008-06-06 SI SI200831754A patent/SI2164467T1/sl unknown
- 2008-06-06 ME MEP-2009-341A patent/ME00959B/me unknown
- 2008-06-06 PL PL12172232T patent/PL2500014T3/pl unknown
-
2009
- 2009-11-09 TN TNP2009000476A patent/TN2009000476A1/fr unknown
- 2009-11-11 ZA ZA200907940A patent/ZA200907940B/xx unknown
- 2009-12-01 MA MA32391A patent/MA31422B1/fr unknown
- 2009-12-02 CO CO09137855A patent/CO6251234A2/es not_active Application Discontinuation
- 2009-12-03 IL IL202501A patent/IL202501A/en active IP Right Grant
-
2010
- 2010-09-02 HK HK10108338.2A patent/HK1141737A1/xx unknown
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2016
- 2016-12-27 HR HRP20161785TT patent/HRP20161785T1/hr unknown
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2017
- 2017-01-17 CY CY20171100060T patent/CY1118434T1/el unknown
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2018
- 2018-11-07 CY CY181101171T patent/CY1120891T1/el unknown
- 2018-11-07 HR HRP20181854TT patent/HRP20181854T1/hr unknown
- 2018-11-15 US US16/192,674 patent/US20190192423A1/en not_active Abandoned
-
2022
- 2022-09-15 US US17/932,621 patent/US20230082575A1/en active Pending
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