EA200971132A1 - Фармацевтическая композиция с пролонгированным высвобождением, приготовленная из микрочастиц - Google Patents

Фармацевтическая композиция с пролонгированным высвобождением, приготовленная из микрочастиц

Info

Publication number
EA200971132A1
EA200971132A1 EA200971132A EA200971132A EA200971132A1 EA 200971132 A1 EA200971132 A1 EA 200971132A1 EA 200971132 A EA200971132 A EA 200971132A EA 200971132 A EA200971132 A EA 200971132A EA 200971132 A1 EA200971132 A1 EA 200971132A1
Authority
EA
Eurasian Patent Office
Prior art keywords
microparticles
pharmaceutical composition
prolonged delivery
microns
moreover
Prior art date
Application number
EA200971132A
Other languages
English (en)
Other versions
EA019284B1 (ru
Inventor
Бертран Дюкре
Патрик Гарруст
Катрин Курди
Мари-Анна Барде
Эрве Порше
Эйя Лундстром
Фредерик Хаймгартнер
Original Assignee
Дебио Решерш Фармасетик С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40032512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200971132(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дебио Решерш Фармасетик С.А. filed Critical Дебио Решерш Фармасетик С.А.
Publication of EA200971132A1 publication Critical patent/EA200971132A1/ru
Publication of EA019284B1 publication Critical patent/EA019284B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Фармацевтическая композиция, приготовленная из микрочастиц, для пролонгированного высвобождения действующего вещества, по меньшей мере, в течение периода, охватывающего шестой месяц после инъекции указанной композиции, причем указанная композиция содержит группу микрочастиц, изготовленных из сополимера типа PLGA, который включает действующее вещество в форме водонерастворимой соли пептида; кроме того, указанный сополимер включает по меньшей мере 75% молочной кислоты и имеет характеристическую вязкость между 0,1 и 0,9 дл/г согласно измерению в хлороформе при 25°С и при концентрации полимера 0,5 г/дл; помимо этого указанные микрочастицы имеют распределение по размеру, определенное следующим образом: D (v,0.1) - между 10 и 30 мкм, D (v,0.5) - между 30 и 70 мкм, D (v,0.9) - между 50 и 110 мкм.
EA200971132A 2007-06-06 2008-06-06 Фармацевтическая композиция с пролонгированным высвобождением, приготовленная из микрочастиц EA019284B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07109767 2007-06-06
IB2007054372 2007-10-27
PCT/IB2008/052241 WO2008149320A2 (en) 2007-06-06 2008-06-06 Slow release pharmaceutical composition made of microparticles

Publications (2)

Publication Number Publication Date
EA200971132A1 true EA200971132A1 (ru) 2010-04-30
EA019284B1 EA019284B1 (ru) 2014-02-28

Family

ID=40032512

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200971132A EA019284B1 (ru) 2007-06-06 2008-06-06 Фармацевтическая композиция с пролонгированным высвобождением, приготовленная из микрочастиц

Country Status (32)

Country Link
US (3) US10166181B2 (ru)
EP (3) EP2500014B1 (ru)
JP (1) JP5419169B2 (ru)
KR (1) KR101631475B1 (ru)
CN (1) CN101677959B (ru)
AP (1) AP3000A (ru)
AU (1) AU2008259411B2 (ru)
BR (1) BRPI0812250B8 (ru)
CA (1) CA2688478C (ru)
CO (1) CO6251234A2 (ru)
CY (2) CY1118434T1 (ru)
DK (2) DK2164467T3 (ru)
EA (1) EA019284B1 (ru)
ES (2) ES2694401T3 (ru)
HK (1) HK1141737A1 (ru)
HR (2) HRP20161785T1 (ru)
HU (2) HUE040391T2 (ru)
IL (1) IL202501A (ru)
LT (2) LT2164467T (ru)
MA (1) MA31422B1 (ru)
ME (1) ME00959B (ru)
MX (1) MX2009012856A (ru)
MY (1) MY150450A (ru)
NZ (1) NZ582423A (ru)
PL (2) PL2164467T3 (ru)
PT (2) PT2500014T (ru)
RS (2) RS55591B1 (ru)
SI (2) SI2164467T1 (ru)
TN (1) TN2009000476A1 (ru)
UA (1) UA99830C2 (ru)
WO (1) WO2008149320A2 (ru)
ZA (1) ZA200907940B (ru)

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UA99830C2 (ru) 2007-06-06 2012-10-10 Дебио Ресшерчи Фармасютикю С.А. Фармацевтическая композиция с пролонгированным высвобождением, изготовленная из микрочастиц
PT105270B (pt) 2010-08-26 2012-05-31 Domino Ind Ceramicas S A Camada de sílica com libertação lenta de fragrância, telha cerâmica e respectivo processo de produção
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN105797134B (zh) * 2016-03-29 2019-06-14 浙江圣兆药物科技股份有限公司 一种难溶亮丙瑞林缓释制剂
EP3535297B1 (en) 2016-11-02 2022-08-10 Debiopharm International, S.A. Methods for improving anti-cd37 immunoconjugate therapy
KR102402639B1 (ko) 2017-11-24 2022-05-26 삼성전자주식회사 전자 장치 및 그의 통신 방법
CN111000798B (zh) * 2019-12-26 2021-11-23 四川恒博生物科技有限公司 一种采用原位凝胶技术的犬用非手术去势注射液
IT202000017191A1 (it) 2020-07-15 2022-01-15 Xbrane Biopharma Ab Procedimento senza acqua per preparare una composizione farmaceutica per un rilascio più prolungato e controllato di triptorelina o di un suo sale

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WO1999024061A1 (en) * 1997-11-07 1999-05-20 Chiron Corporation Method for producing igf-1 sustained-release formulations
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MXPA04003433A (es) * 2001-10-10 2004-08-11 Pf Medicament Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas.
EP1617859A1 (en) * 2003-04-30 2006-01-25 Debiopharm S.A. Methods and compositions using gonadotropin hormone releasing hormone
KR100466637B1 (ko) * 2003-06-26 2005-01-13 주식회사 펩트론 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
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UA99830C2 (ru) 2007-06-06 2012-10-10 Дебио Ресшерчи Фармасютикю С.А. Фармацевтическая композиция с пролонгированным высвобождением, изготовленная из микрочастиц

Also Published As

Publication number Publication date
UA99830C2 (ru) 2012-10-10
EP2500014A2 (en) 2012-09-19
AP3000A (en) 2014-10-31
EP2500014A3 (en) 2012-11-07
HRP20161785T1 (hr) 2017-03-10
PL2500014T3 (pl) 2019-04-30
HUE031550T2 (en) 2017-07-28
AU2008259411A1 (en) 2008-12-11
AU2008259411B2 (en) 2013-10-17
RS55591B1 (sr) 2017-06-30
HUE040391T2 (hu) 2019-03-28
CA2688478C (en) 2015-10-27
US20190192423A1 (en) 2019-06-27
MY150450A (en) 2014-01-30
IL202501A (en) 2015-11-30
CA2688478A1 (en) 2008-12-11
HK1141737A1 (en) 2010-11-19
CN101677959B (zh) 2014-02-26
PT2500014T (pt) 2018-11-21
DK2500014T3 (en) 2018-12-03
PT2164467T (pt) 2017-01-13
ES2694401T3 (es) 2018-12-20
CN101677959A (zh) 2010-03-24
US20230082575A1 (en) 2023-03-16
RS58248B1 (sr) 2019-03-29
TN2009000476A1 (en) 2011-03-31
CY1120891T1 (el) 2019-12-11
MX2009012856A (es) 2009-12-15
LT2500014T (lt) 2019-01-25
EP3431077A1 (en) 2019-01-23
KR101631475B1 (ko) 2016-06-20
EP2164467B1 (en) 2016-12-14
US20110052717A1 (en) 2011-03-03
ES2611020T3 (es) 2017-05-04
ME00959B (me) 2012-06-20
EA019284B1 (ru) 2014-02-28
BRPI0812250B1 (pt) 2020-03-03
SI2164467T1 (sl) 2017-05-31
HRP20181854T1 (hr) 2019-02-08
NZ582423A (en) 2011-10-28
MA31422B1 (fr) 2010-06-01
BRPI0812250B8 (pt) 2021-05-25
DK2164467T3 (en) 2017-01-30
KR20100023950A (ko) 2010-03-04
EP2164467A2 (en) 2010-03-24
AP2009005088A0 (en) 2009-12-31
EP2500014B1 (en) 2018-08-08
PL2164467T3 (pl) 2017-07-31
SI2500014T1 (sl) 2019-02-28
CY1118434T1 (el) 2017-06-28
CO6251234A2 (es) 2011-02-21
BRPI0812250A2 (pt) 2014-12-23
LT2164467T (lt) 2017-01-25
JP5419169B2 (ja) 2014-02-19
WO2008149320A2 (en) 2008-12-11
WO2008149320A3 (en) 2009-02-05
IL202501A0 (en) 2010-06-30
JP2010529106A (ja) 2010-08-26
ZA200907940B (en) 2010-08-25
US10166181B2 (en) 2019-01-01

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