CY1109425T1 - Φαρμακευτικες συνθεσεις για τη χορηγηση με ελεγχομενη αποδεσμευση βιολογικα δραστικων ενωσεων - Google Patents

Φαρμακευτικες συνθεσεις για τη χορηγηση με ελεγχομενη αποδεσμευση βιολογικα δραστικων ενωσεων

Info

Publication number
CY1109425T1
CY1109425T1 CY20091100618T CY091100618T CY1109425T1 CY 1109425 T1 CY1109425 T1 CY 1109425T1 CY 20091100618 T CY20091100618 T CY 20091100618T CY 091100618 T CY091100618 T CY 091100618T CY 1109425 T1 CY1109425 T1 CY 1109425T1
Authority
CY
Cyprus
Prior art keywords
biologically active
active compounds
methods
provides
controlled
Prior art date
Application number
CY20091100618T
Other languages
English (en)
Inventor
Li Yuhua
Benjamin Chien
Original Assignee
Quest Pharmaceutical Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Pharmaceutical Services filed Critical Quest Pharmaceutical Services
Publication of CY1109425T1 publication Critical patent/CY1109425T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Η παρούσα εφεύρεση παρέχει συνθέσεις και μεθόδους για τη χορήγηση με ελεγχόμενη αποδέσμευση μιας ή περισσότερων βιολογικά δραστικών ενώσεων σε κάποιο ασθενή. Συγκεκριμένα, η εφεύρεση παρέχει μια φαρμακευτική σύνθεση για τη χορήγηση με ελεγχόμενη αποδέσμευση βιολογικά δραστικών ενώσεων σε κάποιο ασθενή, η οποία περιέχει: α) ένα σύμπλοκο μιας βιολογικά δραστικής ένωσης, η οποία έχει τουλάχιστον μία βασική λειτουργική ομάδα και ενός πολυανιόντος που προέρχεται από εξαϋδροξυκυκλοεξάνιο, το οποίο έχει τουλάχιστον δύο αρνητικά φορτισμένες λειτουργικές ομάδες, και β) ένα φαρμακευτικά αποδεκτό φορέα που περιέχει ένα βιοδιασπώμενο, αδιάλυτο στο νερό πολυμερές. Με τη συμπλοκοποίηση μιας βιολογικά δραστικής ένωσης με ένα πολυανιόν, το συμπαγές, σταθερό σύμπλοκο μπορεί να ενσωματωθεί σε ένα σύστημα δοσολογίας μακράς δράσης, το οποίο έχει μια περισσότερο επιθυμητή καμπύλη αποδέσμευσης φαρμάκου σε βάθος χρόνου σε σχέση με αυτή της στάθμης της τεχνικής. Η εφεύρεση παρέχει επίσης τις μεθόδους για την παραγωγή αυτών των συνθέσεων και τις μεθόδους χρήσης τους.
CY20091100618T 2004-08-12 2009-06-11 Φαρμακευτικες συνθεσεις για τη χορηγηση με ελεγχομενη αποδεσμευση βιολογικα δραστικων ενωσεων CY1109425T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60090704P 2004-08-12 2004-08-12
EP05807464A EP1786400B1 (en) 2004-08-12 2005-08-11 Pharmaceutical compositions for controlled release delivery of biologically active compounds

Publications (1)

Publication Number Publication Date
CY1109425T1 true CY1109425T1 (el) 2014-08-13

Family

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CY20091100618T CY1109425T1 (el) 2004-08-12 2009-06-11 Φαρμακευτικες συνθεσεις για τη χορηγηση με ελεγχομενη αποδεσμευση βιολογικα δραστικων ενωσεων

Country Status (21)

Country Link
US (1) US7964219B2 (el)
EP (1) EP1786400B1 (el)
JP (1) JP5053846B2 (el)
KR (1) KR101231856B1 (el)
CN (1) CN101035512B (el)
AT (1) ATE424848T1 (el)
AU (1) AU2005271242B9 (el)
BR (1) BRPI0514297A (el)
CA (1) CA2576689C (el)
CY (1) CY1109425T1 (el)
DE (1) DE602005013244D1 (el)
DK (1) DK1786400T3 (el)
ES (1) ES2323141T3 (el)
HK (1) HK1108638A1 (el)
MX (1) MX2007001760A (el)
NZ (1) NZ553149A (el)
PL (1) PL1786400T3 (el)
PT (1) PT1786400E (el)
RU (1) RU2390355C2 (el)
SI (1) SI1786400T1 (el)
WO (1) WO2006017852A2 (el)

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AU2005271242A1 (en) 2006-02-16
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AU2005271242B2 (en) 2011-09-15
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NZ553149A (en) 2010-01-29
PT1786400E (pt) 2009-06-19
BRPI0514297A (pt) 2008-06-10
CN101035512B (zh) 2012-01-18
WO2006017852A3 (en) 2006-08-31
CA2576689C (en) 2012-10-09
PL1786400T3 (pl) 2009-08-31
WO2006017852A2 (en) 2006-02-16
SI1786400T1 (sl) 2009-08-31
KR101231856B1 (ko) 2013-02-08
US20060034923A1 (en) 2006-02-16
MX2007001760A (es) 2007-07-24
US7964219B2 (en) 2011-06-21
ATE424848T1 (de) 2009-03-15
EP1786400A4 (en) 2008-07-09
JP2008511544A (ja) 2008-04-17
DE602005013244D1 (de) 2009-04-23
RU2390355C2 (ru) 2010-05-27
HK1108638A1 (en) 2008-05-16
EP1786400B1 (en) 2009-03-11
RU2007105872A (ru) 2008-09-20
JP5053846B2 (ja) 2012-10-24
CA2576689A1 (en) 2006-02-16
AU2005271242A2 (en) 2006-02-16
ES2323141T3 (es) 2009-07-07
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AU2005271242B9 (en) 2012-04-12
KR20070043881A (ko) 2007-04-25

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