UA80298C2 - 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands - Google Patents
1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands Download PDFInfo
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- UA80298C2 UA80298C2 UAA200503704A UA2005003704A UA80298C2 UA 80298 C2 UA80298 C2 UA 80298C2 UA A200503704 A UAA200503704 A UA A200503704A UA 2005003704 A UA2005003704 A UA 2005003704A UA 80298 C2 UA80298 C2 UA 80298C2
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- heterocyclic group
- triazole
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078966 | 2002-09-19 | ||
| PCT/EP2003/050628 WO2004026301A1 (en) | 2002-09-19 | 2003-09-17 | 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA80298C2 true UA80298C2 (en) | 2007-09-10 |
Family
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Family Applications (1)
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| UAA200503704A UA80298C2 (en) | 2002-09-19 | 2003-09-17 | 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands |
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| EP (1) | EP1542678B1 (es) |
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| PL (1) | PL375020A1 (es) |
| PT (1) | PT1542678E (es) |
| RU (1) | RU2325382C2 (es) |
| SI (1) | SI1542678T1 (es) |
| UA (1) | UA80298C2 (es) |
| WO (1) | WO2004026301A1 (es) |
| ZA (1) | ZA200500133B (es) |
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| US6897240B2 (en) * | 2002-05-08 | 2005-05-24 | The Regents Of The University Of California | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use |
| EP1621537A4 (en) * | 2003-04-21 | 2008-12-31 | Daiichi Seiyaku Co | FIVE-GLASS HETEROCYCLIC DERIVATIVE |
| US7223780B2 (en) * | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
| AU2004283056A1 (en) * | 2003-10-24 | 2005-05-06 | Solvay Pharmaceuticals Gmbh | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| KR20060109926A (ko) * | 2003-11-19 | 2006-10-23 | 메타베이시스 테라퓨틱스, 인크. | 새로운 인-함유 갑상선 호르몬 모방약들 |
| US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
| FR2874012B1 (fr) * | 2004-08-09 | 2008-08-22 | Sanofi Synthelabo | Derives de pyrrole, leur preparation et leur utlisation en therapeutique |
| ES2255834B1 (es) * | 2004-09-14 | 2008-01-16 | Laboratorios Del Dr. Esteve, S.A. | Nuevos derivados 1,2,4-triazol-3-carboxamida. |
| AU2005291540B2 (en) * | 2004-10-01 | 2008-06-19 | F. Hoffmann-La Roche Ag | Hexafluoroisopropanol substituted ether derivatives |
| CA2585175A1 (en) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
| US7494985B2 (en) * | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| ES2329614T3 (es) * | 2005-04-29 | 2009-11-27 | Janssen Pharmaceutica Nv | Derivados de benzotriazol como antagonistas de los receptores cannabinoides. |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| EP1902034B1 (en) | 2005-06-02 | 2011-03-30 | Glenmark Pharmaceuticals S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| TW200726765A (en) * | 2005-06-17 | 2007-07-16 | Bristol Myers Squibb Co | Triazolopyridine cannabinoid receptor 1 antagonists |
| EP1910328A1 (en) * | 2005-06-29 | 2008-04-16 | AstraZeneca AB | Thiophene-2-carboxamide derivatives as alpha 7 nicotinic receptor modulators |
| EP2308840A1 (en) | 2005-06-30 | 2011-04-13 | Prosidion Limited | GPCR agonists |
| FR2894579B1 (fr) * | 2005-12-12 | 2008-01-18 | Sanofi Aventis Sa | Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique. |
| CA2657247A1 (en) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| WO2008033572A1 (en) * | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| PE20081849A1 (es) | 2007-01-04 | 2009-01-26 | Prosidion Ltd | Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr |
| ATE523507T1 (de) | 2007-01-04 | 2011-09-15 | Prosidion Ltd | Piperidin-gpcr-agonisten |
| AR064735A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| BRPI0806312A2 (pt) | 2007-01-04 | 2011-09-06 | Prosidion Ltd | agonistas cgpr piperidina |
| CN101302200B (zh) * | 2007-05-09 | 2011-04-20 | 上海医药工业研究院 | 制备n-哌啶子基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-甲酰胺的方法 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| EP2217565B1 (en) | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| US8957063B2 (en) | 2008-02-21 | 2015-02-17 | Boehringer Ingelheim International Gmbh | Amine and ether compounds which modulate the CB2 receptor |
| CA2730037A1 (en) | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
| US8048899B2 (en) | 2008-09-25 | 2011-11-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP5583694B2 (ja) | 2009-01-05 | 2014-09-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するピロリジン化合物 |
| WO2010079241A1 (es) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas |
| US8889670B2 (en) | 2009-02-18 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the CB2 receptor |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| EP2443107B1 (en) | 2009-06-16 | 2018-08-08 | Boehringer Ingelheim International GmbH | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
| EP2480544A1 (en) | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Compounds which selectively modulate the cb2 receptor |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| EP2542539B1 (en) | 2010-03-05 | 2014-02-26 | Boehringer Ingelheim International GmbH | Tetrazole compounds which selectively modulate the cb2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| CN102558157B (zh) * | 2010-12-20 | 2014-04-30 | 中国科学院上海药物研究所 | 羟乙基三唑类化合物或氨乙基三唑类化合物及其制备方法和用途 |
| CN102731418B (zh) * | 2012-07-15 | 2015-03-11 | 浙江大学 | 1-取代-1h-1,2,4-三氮唑-甲酰胺衍生物及其制备和用途 |
| JP6027244B2 (ja) * | 2012-09-17 | 2016-11-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾールカルボキサミド誘導体 |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| MX2016014890A (es) | 2014-06-06 | 2017-05-01 | Res Triangle Inst | Agonistas del receptor de apelina (apj) y usos de los mismos. |
| WO2016123533A1 (en) | 2015-01-30 | 2016-08-04 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| KR20180090852A (ko) | 2015-12-09 | 2018-08-13 | 리써치 트라이앵글 인스티튜트 | 개선된 아펠린 수용체(apj) 효능제 및 이의 용도 |
| MX2019004214A (es) * | 2016-10-12 | 2019-06-10 | Res Triangle Inst | Agonistas heterociclicos del receptor de apelina (apj) y usos de los mismos. |
| CN113166068B (zh) * | 2018-11-20 | 2024-08-16 | 上海科技大学 | MmpL3抑制剂、组合物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58194866A (ja) * | 1982-05-07 | 1983-11-12 | Kureha Chem Ind Co Ltd | トリアゾ−ル誘導体及び該誘導体を含有する除草剤 |
| DE3316300A1 (de) * | 1982-05-07 | 1983-11-24 | Kureha Kagaku Kogyo K.K., Tokyo | Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff |
| DE3817192A1 (de) * | 1988-05-20 | 1989-11-30 | Hoechst Ag | 1,2,4-triazolderivate enthaltende pflanzenschuetzende mittel sowie neue derivate des 1,2,4-triazols |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4225778A1 (de) * | 1992-08-04 | 1994-02-17 | Hoechst Ag | 1,2,4-Triazolyl-3-carbonsäure-4-aminopiperidide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel, insbesondere Fungizide |
| FR2741621B1 (fr) * | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| AU780572B2 (en) | 1999-10-18 | 2005-04-07 | University Of Connecticut, The | Pyrazole derivatives as cannabinoid receptor antagonists |
| WO2001058869A2 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
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- 2003-09-17 UA UAA200503704A patent/UA80298C2/uk unknown
- 2003-09-17 PL PL03375020A patent/PL375020A1/xx not_active Application Discontinuation
- 2003-09-17 JP JP2004537155A patent/JP2006501275A/ja active Pending
- 2003-09-17 RU RU2005103244/04A patent/RU2325382C2/ru not_active IP Right Cessation
- 2003-09-17 KR KR1020057004584A patent/KR100996828B1/ko not_active IP Right Cessation
- 2003-09-17 BR BR0312020-1A patent/BR0312020A/pt not_active IP Right Cessation
- 2003-09-17 PT PT03797318T patent/PT1542678E/pt unknown
- 2003-09-17 SI SI200331803T patent/SI1542678T1/sl unknown
- 2003-09-17 ES ES03797318T patent/ES2341540T3/es not_active Expired - Lifetime
- 2003-09-17 MX MXPA05002862A patent/MXPA05002862A/es active IP Right Grant
-
2004
- 2004-12-07 IL IL165611A patent/IL165611A/en not_active IP Right Cessation
-
2005
- 2005-01-06 ZA ZA200500133A patent/ZA200500133B/en unknown
- 2005-01-19 HR HR20050053A patent/HRP20050053A2/xx not_active Application Discontinuation
- 2005-04-18 NO NO20051870A patent/NO20051870L/no not_active Application Discontinuation
- 2005-12-01 HK HK05110963A patent/HK1078796A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1542678E (pt) | 2010-05-25 |
| DE60331444D1 (de) | 2010-04-08 |
| IL165611A (en) | 2010-04-15 |
| RU2005103244A (ru) | 2005-06-27 |
| US20040106614A1 (en) | 2004-06-03 |
| HRP20050053A2 (en) | 2005-04-30 |
| DK1542678T3 (da) | 2010-06-07 |
| CA2491394A1 (en) | 2004-04-01 |
| AU2003299024A1 (en) | 2004-04-08 |
| MXPA05002862A (es) | 2005-05-27 |
| PL375020A1 (en) | 2005-11-14 |
| SI1542678T1 (sl) | 2010-07-30 |
| NO20051870L (no) | 2005-06-03 |
| CN1319529C (zh) | 2007-06-06 |
| KR100996828B1 (ko) | 2010-11-29 |
| US7319110B2 (en) | 2008-01-15 |
| CA2491394C (en) | 2010-06-15 |
| BR0312020A (pt) | 2005-03-22 |
| EP1542678B1 (en) | 2010-02-24 |
| JP2006501275A (ja) | 2006-01-12 |
| IL165611A0 (en) | 2006-01-15 |
| CN1671377A (zh) | 2005-09-21 |
| EP1542678A1 (en) | 2005-06-22 |
| ES2341540T3 (es) | 2010-06-22 |
| KR20050057399A (ko) | 2005-06-16 |
| AU2003299024B2 (en) | 2008-03-06 |
| AR041268A1 (es) | 2005-05-11 |
| ATE458479T1 (de) | 2010-03-15 |
| WO2004026301A1 (en) | 2004-04-01 |
| HK1078796A1 (en) | 2006-03-24 |
| ZA200500133B (en) | 2005-11-01 |
| RU2325382C2 (ru) | 2008-05-27 |
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