NO20051870L - 1H-1,2,4-triazol-3-karboksamidderivater som cannabinoid-CB1-reseptorligander - Google Patents

1H-1,2,4-triazol-3-karboksamidderivater som cannabinoid-CB1-reseptorligander

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Publication number
NO20051870L
NO20051870L NO20051870A NO20051870A NO20051870L NO 20051870 L NO20051870 L NO 20051870L NO 20051870 A NO20051870 A NO 20051870A NO 20051870 A NO20051870 A NO 20051870A NO 20051870 L NO20051870 L NO 20051870L
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Norway
Prior art keywords
triazole
carboxamide derivatives
compounds
cannabinoid
receptor ligands
Prior art date
Application number
NO20051870A
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English (en)
Inventor
Herman Heinrich Va Stuivenberg
Cornelis Gerrit Kruse
Josephus H M Lange
Andrew C Mccreary
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Solvay Pharm Bv
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Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20051870L publication Critical patent/NO20051870L/no

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
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  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
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  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører en gruppe av 1H-1, 2, 4-triazol-3-karboksamidderivater, fremgangsmåter for fremstilling av disse forbindelsene, og farmasøytiske sammensetninger som inneholder minst én av disse forbindelsene som en aktiv ingrediens. Disse 1H-1, 2, 4-triazol-3-karboksarnidderivatene er kraftige, binoid-CB1 reseptoragonister, delagonister, inverse agonister eller antagonister, som er nyttige ved behandling av forstyrrelser som omfatter cannobinoidnevrotransmisjon. Forbindelsene har den generelle formelen (I), der R og R1-R3 har betydningene som er angitt i beskrivelsen.
NO20051870A 2002-09-19 2005-04-18 1H-1,2,4-triazol-3-karboksamidderivater som cannabinoid-CB1-reseptorligander NO20051870L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02078966 2002-09-19
PCT/EP2003/050628 WO2004026301A1 (en) 2002-09-19 2003-09-17 1h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands

Publications (1)

Publication Number Publication Date
NO20051870L true NO20051870L (no) 2005-06-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051870A NO20051870L (no) 2002-09-19 2005-04-18 1H-1,2,4-triazol-3-karboksamidderivater som cannabinoid-CB1-reseptorligander

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Country Link
US (1) US7319110B2 (no)
EP (1) EP1542678B1 (no)
JP (1) JP2006501275A (no)
KR (1) KR100996828B1 (no)
CN (1) CN1319529C (no)
AR (1) AR041268A1 (no)
AT (1) ATE458479T1 (no)
AU (1) AU2003299024B2 (no)
BR (1) BR0312020A (no)
CA (1) CA2491394C (no)
DE (1) DE60331444D1 (no)
DK (1) DK1542678T3 (no)
ES (1) ES2341540T3 (no)
HK (1) HK1078796A1 (no)
HR (1) HRP20050053A2 (no)
IL (1) IL165611A (no)
MX (1) MXPA05002862A (no)
NO (1) NO20051870L (no)
PL (1) PL375020A1 (no)
PT (1) PT1542678E (no)
RU (1) RU2325382C2 (no)
SI (1) SI1542678T1 (no)
UA (1) UA80298C2 (no)
WO (1) WO2004026301A1 (no)
ZA (1) ZA200500133B (no)

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