UA79296C2 - Substituted heterocyclic derivatives and method for treatment with use thereof - Google Patents

Info

Publication number

UA79296C2

UA79296C2 UAA200501187A UA2005001187A UA79296C2 UA 79296 C2 UA79296 C2 UA 79296C2 UA A200501187 A UAA200501187 A UA A200501187A UA 2005001187 A UA2005001187 A UA 2005001187A UA 79296 C2 UA79296 C2 UA 79296C2

Authority

UA

Ukraine

Prior art keywords

compound

room temperature

vacuo

inhibitor

mixture

Prior art date

2002-07-09

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 title claims description 57
• 125000000623 heterocyclic group Chemical group 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 369
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 45
• 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 22
• 150000002367 halogens Chemical class 0.000 claims abstract description 20
• 125000003545 alkoxy group Chemical group 0.000 claims abstract description 19
• 229910052736 halogen Inorganic materials 0.000 claims abstract description 18
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 18
• 239000003472 antidiabetic agent Substances 0.000 claims abstract description 13
• 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 11
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• 239000000883 anti-obesity agent Substances 0.000 claims abstract description 7
• 229940125708 antidiabetic agent Drugs 0.000 claims abstract description 7
• 229940125710 antiobesity agent Drugs 0.000 claims abstract description 7
• 235000020824 obesity Nutrition 0.000 claims abstract description 7
• -1 amino, substituted amino Chemical group 0.000 claims description 112
• 239000003112 inhibitor Substances 0.000 claims description 67
• 125000003118 aryl group Chemical group 0.000 claims description 33
• 150000002148 esters Chemical class 0.000 claims description 26
• 239000003795 chemical substances by application Substances 0.000 claims description 24
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• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 18
• 239000000556 agonist Substances 0.000 claims description 16
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 16
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 15
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• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
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• 101001090074 Homo sapiens Small nuclear protein PRAC1 Proteins 0.000 claims description 6
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• HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 6
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 6
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• ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 4
• ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 claims description 4
• SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims description 4
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• AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 4
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• UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 4
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 4
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• 150000001420 substituted heterocyclic compounds Chemical class 0.000 claims description 4
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