UA78801C2 - Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4- 1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride - Google Patents

Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4- 1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride Download PDF

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Publication number
UA78801C2
UA78801C2 UA20041210897A UA20041210897A UA78801C2 UA 78801 C2 UA78801 C2 UA 78801C2 UA 20041210897 A UA20041210897 A UA 20041210897A UA 20041210897 A UA20041210897 A UA 20041210897A UA 78801 C2 UA78801 C2 UA 78801C2
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UA
Ukraine
Prior art keywords
temperature
indol
crystalline
treatment
salt
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UA20041210897A
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English (en)
Ukrainian (uk)
Inventor
Julie Kay Bush
Margaret Mary Faul
Susan Marie Reutzel-Edens
Original Assignee
Lilly Co Eli
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Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of UA78801C2 publication Critical patent/UA78801C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
UA20041210897A 2002-07-12 2003-08-07 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4- 1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride UA78801C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12
PCT/US2003/019548 WO2004006928A1 (en) 2002-07-12 2003-07-08 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride

Publications (1)

Publication Number Publication Date
UA78801C2 true UA78801C2 (en) 2007-04-25

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20041210897A UA78801C2 (en) 2002-07-12 2003-08-07 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4- 1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride

Country Status (21)

Country Link
US (2) US8114901B2 (https=)
EP (1) EP1523313B1 (https=)
JP (2) JP4771356B2 (https=)
KR (1) KR100687165B1 (https=)
CN (1) CN100430058C (https=)
AU (1) AU2003280958B9 (https=)
CA (1) CA2393720C (https=)
DE (1) DE60317675T2 (https=)
EA (1) EA007463B1 (https=)
EC (1) ECSP055537A (https=)
ES (1) ES2295605T3 (https=)
HR (1) HRP20050035B1 (https=)
IL (1) IL165747A (https=)
NO (1) NO330254B1 (https=)
NZ (1) NZ537137A (https=)
PE (1) PE20040652A1 (https=)
PL (1) PL373046A1 (https=)
TW (1) TWI315667B (https=)
UA (1) UA78801C2 (https=)
WO (1) WO2004006928A1 (https=)
ZA (1) ZA200500065B (https=)

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JP5475234B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
CN102405018B (zh) 2009-03-02 2014-11-19 第七感生物系统有限公司 与血液取样相关联的技术和装置
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2012009613A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
NZ606180A (en) * 2010-09-30 2014-10-31 Wisconsin Alumni Res Found (20r,25s)-2-methylene-19,26-dinor-1α, 25-dihydroxyvitamin d3 in crystalline form
EP2992827B1 (en) 2010-11-09 2017-04-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
JP2019525990A (ja) 2016-06-17 2019-09-12 ウニベルシダッド デ ロス アンデス 低温適応海洋種の天然資源に由来するゼラチンポリマー及びその使用
TWI777658B (zh) 2016-08-10 2022-09-11 瑞士商赫孚孟拉羅股份公司 包含Akt蛋白質激酶抑制劑之醫藥組合物
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين
CN116199590B (zh) * 2022-12-26 2024-12-24 湖北美林药业有限公司 一种盐酸多巴酚丁胺及其注射剂

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US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
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CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
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DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
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US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
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US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
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AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
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Also Published As

Publication number Publication date
AU2003280958A1 (en) 2004-02-02
US8114901B2 (en) 2012-02-14
IL165747A (en) 2010-05-17
TW200408392A (en) 2004-06-01
ECSP055537A (es) 2005-03-10
ZA200500065B (en) 2006-03-29
JP2006502115A (ja) 2006-01-19
AU2003280958B2 (en) 2008-12-18
EA200500191A1 (ru) 2005-06-30
JP5242718B2 (ja) 2013-07-24
CN100430058C (zh) 2008-11-05
NO20050676L (no) 2005-02-09
NO330254B1 (no) 2011-03-14
DE60317675D1 (de) 2008-01-03
DE60317675T2 (de) 2008-10-30
HK1075839A1 (en) 2005-12-30
JP4771356B2 (ja) 2011-09-14
KR20050021453A (ko) 2005-03-07
NZ537137A (en) 2007-11-30
KR100687165B1 (ko) 2007-02-27
HRP20050035A2 (en) 2005-04-30
CA2393720A1 (en) 2004-01-16
PE20040652A1 (es) 2004-10-05
IL165747A0 (en) 2006-01-15
EA007463B1 (ru) 2006-10-27
EP1523313A1 (en) 2005-04-20
JP2011144182A (ja) 2011-07-28
US20070270465A1 (en) 2007-11-22
CA2393720C (en) 2010-09-14
ES2295605T3 (es) 2008-04-16
HRP20050035B1 (hr) 2013-07-31
US20050288332A1 (en) 2005-12-29
AU2003280958B8 (en) 2009-02-19
PL373046A1 (en) 2005-08-08
TWI315667B (en) 2009-10-11
AU2003280958B9 (en) 2009-07-02
EP1523313B1 (en) 2007-11-21
CN1668304A (zh) 2005-09-14
WO2004006928A1 (en) 2004-01-22

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