KR100687165B1 - 결정성 2,5-디온-3-(1-메틸-1ｈ-인돌-3-일)-4-[1-[1-(피리딘-2-일메틸)피페리딘-4-일]-1ｈ-인돌-3-일]-1ｈ-피롤 모노-하이드로클로라이드 - Google Patents

결정성 2,5-디온-3-(1-메틸-1ｈ-인돌-3-일)-4-[1-[1-(피리딘-2-일메틸)피페리딘-4-일]-1ｈ-인돌-3-일]-1ｈ-피롤 모노-하이드로클로라이드 Download PDF

Info

Publication number
KR100687165B1
KR100687165B1 KR1020057000501A KR20057000501A KR100687165B1 KR 100687165 B1 KR100687165 B1 KR 100687165B1 KR 1020057000501 A KR1020057000501 A KR 1020057000501A KR 20057000501 A KR20057000501 A KR 20057000501A KR 100687165 B1 KR100687165 B1 KR 100687165B1
Authority
KR
South Korea
Prior art keywords
indol
crystalline
hydrochloride
methyl
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057000501A
Other languages
English (en)
Korean (ko)
Other versions
KR20050021453A (ko
Inventor
줄리 케이 부시
마가렛 메리 폴
수잔 마리 루트젤-에덴스
Original Assignee
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100687165(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 일라이 릴리 앤드 캄파니 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR20050021453A publication Critical patent/KR20050021453A/ko
Application granted granted Critical
Publication of KR100687165B1 publication Critical patent/KR100687165B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020057000501A 2002-07-12 2003-07-08 결정성 2,5-디온-3-(1-메틸-1ｈ-인돌-3-일)-4-[1-[1-(피리딘-2-일메틸)피페리딘-4-일]-1ｈ-인돌-3-일]-1ｈ-피롤 모노-하이드로클로라이드 Expired - Fee Related KR100687165B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12
US60/395,976 2002-07-12

Publications (2)

Publication Number Publication Date
KR20050021453A KR20050021453A (ko) 2005-03-07
KR100687165B1 true KR100687165B1 (ko) 2007-02-27

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057000501A Expired - Fee Related KR100687165B1 (ko) 2002-07-12 2003-07-08 결정성 2,5-디온-3-(1-메틸-1ｈ-인돌-3-일)-4-[1-[1-(피리딘-2-일메틸)피페리딘-4-일]-1ｈ-인돌-3-일]-1ｈ-피롤 모노-하이드로클로라이드

Country Status (21)

Country Link
US (2) US8114901B2 (https=)
EP (1) EP1523313B1 (https=)
JP (2) JP4771356B2 (https=)
KR (1) KR100687165B1 (https=)
CN (1) CN100430058C (https=)
AU (1) AU2003280958B9 (https=)
CA (1) CA2393720C (https=)
DE (1) DE60317675T2 (https=)
EA (1) EA007463B1 (https=)
EC (1) ECSP055537A (https=)
ES (1) ES2295605T3 (https=)
HR (1) HRP20050035B1 (https=)
IL (1) IL165747A (https=)
NO (1) NO330254B1 (https=)
NZ (1) NZ537137A (https=)
PE (1) PE20040652A1 (https=)
PL (1) PL373046A1 (https=)
TW (1) TWI315667B (https=)
UA (1) UA78801C2 (https=)
WO (1) WO2004006928A1 (https=)
ZA (1) ZA200500065B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2010101626A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
MX339926B (es) * 2010-09-30 2016-06-16 Wisconsin Alumni Res Found * (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina.
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP6121400B2 (ja) 2011-04-29 2017-04-26 セブンス センス バイオシステムズ，インコーポレーテッド 流体の送達および／または受け取り
CN109952341A (zh) 2016-06-17 2019-06-28 洛斯安第斯大学 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين
CN116199590B (zh) * 2022-12-26 2024-12-24 湖北美林药业有限公司 一种盐酸多巴酚丁胺及其注射剂

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625738A1 (de) * 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4923986A (en) * 1987-03-09 1990-05-08 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance K-252
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5489608A (en) * 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
GB9123396D0 (en) 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
DE4243321A1 (de) 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
SE501711C2 (sv) * 1993-09-08 1995-05-02 Jimek Int Ab Sprayrör för en duktvättanordning vid en tryckpress
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
GB9620390D0 (en) * 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
WO2001030331A2 (en) * 1999-10-22 2001-05-03 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
WO2002002116A2 (en) * 2000-06-29 2002-01-10 Eli Lilly And Company Therapeutic treatment of cancer with a protein kinase c inhibitor
AU2001271257A1 (en) * 2000-06-29 2002-01-14 Eli Lilly And Company Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy
EP1513830A1 (en) * 2002-06-05 2005-03-16 Janssen Pharmaceutica N.V. Bisindolyl-maleimid derivatives as kinase inhibitors

Also Published As

Publication number Publication date
PL373046A1 (en) 2005-08-08
JP2011144182A (ja) 2011-07-28
AU2003280958B2 (en) 2008-12-18
US20050288332A1 (en) 2005-12-29
NO20050676L (no) 2005-02-09
HK1075839A1 (en) 2005-12-30
ECSP055537A (es) 2005-03-10
JP4771356B2 (ja) 2011-09-14
JP5242718B2 (ja) 2013-07-24
CN1668304A (zh) 2005-09-14
ES2295605T3 (es) 2008-04-16
HRP20050035B1 (hr) 2013-07-31
NO330254B1 (no) 2011-03-14
CA2393720C (en) 2010-09-14
ZA200500065B (en) 2006-03-29
US20070270465A1 (en) 2007-11-22
KR20050021453A (ko) 2005-03-07
TWI315667B (en) 2009-10-11
DE60317675D1 (de) 2008-01-03
AU2003280958B9 (en) 2009-07-02
EP1523313B1 (en) 2007-11-21
HRP20050035A2 (en) 2005-04-30
EA200500191A1 (ru) 2005-06-30
NZ537137A (en) 2007-11-30
CA2393720A1 (en) 2004-01-16
WO2004006928A1 (en) 2004-01-22
IL165747A (en) 2010-05-17
DE60317675T2 (de) 2008-10-30
AU2003280958B8 (en) 2009-02-19
AU2003280958A1 (en) 2004-02-02
EP1523313A1 (en) 2005-04-20
UA78801C2 (en) 2007-04-25
TW200408392A (en) 2004-06-01
IL165747A0 (en) 2006-01-15
EA007463B1 (ru) 2006-10-27
PE20040652A1 (es) 2004-10-05
US8114901B2 (en) 2012-02-14
JP2006502115A (ja) 2006-01-19
CN100430058C (zh) 2008-11-05

Similar Documents

Publication Publication Date Title
JP5242718B2 (ja) ２，５−ジオン−３−（１−メチル−１ｈ−インドール−３−イル）−４−［１−（ピリジン−２−イルメチル）ピペリジン−４−イル］−１ｈ−インドール−３−イル］−１ｈ−ピロール一塩酸塩の結晶
KR102142797B1 (ko) 피리디닐아미노피리미딘 유도체의 메실레이트 염의 결정질 형태, 그의 제조 방법, 및 그의 용도
US20250115616A1 (en) Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
CN116390728B (zh) 喹唑啉衍生物及其制备方法和用途
US12116374B2 (en) Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
EP1966192B1 (en) Pyrimidine derivatives for the treatment of abnormal cell growth
CN118574825A (zh) 作为fak抑制剂的化合物及其用途
TW202321223A (zh) ＥｒｂＢ和ＢＴＫ抑制劑之新穎的藥學鹽和多晶型形式
EP4169915A1 (en) Crystalline form of compound
MXPA02007150A (es) Monoclorohidrato crsitalino de 2, 5-diona-3-(1-metil -1h-indol-3-il) -4-[1-(piridin-2-ilmetil) piperidin-4-il) -1h-indol-3-il) -1h-pirrol.
HK1075839B (en) Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
WO2026021545A1 (zh) Atr激酶抑制剂的盐、其固体形式及其制备方法和用途
HK40109564A (zh) Erbb和btk抑制剂的新型药用盐和多晶型形式

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20130130

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20140129

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20150221

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20150221