TWI315667B - Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl )piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono -hydrochloride - Google Patents

Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl )piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono -hydrochloride

Info

Publication number
TWI315667B
TWI315667B TW092118725A TW92118725A TWI315667B TW I315667 B TWI315667 B TW I315667B TW 092118725 A TW092118725 A TW 092118725A TW 92118725 A TW92118725 A TW 92118725A TW I315667 B TWI315667 B TW I315667B
Authority
TW
Taiwan
Prior art keywords
indol
piperidin
ylmethyl
dione
pyridin
Prior art date
Application number
TW092118725A
Other languages
English (en)
Chinese (zh)
Other versions
TW200408392A (en
Inventor
Kay Bush Julie
Mary Faul Margaret
Marie Reutzel-Edens Susan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI315667(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TW200408392A publication Critical patent/TW200408392A/zh
Application granted granted Critical
Publication of TWI315667B publication Critical patent/TWI315667B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW092118725A 2002-07-12 2003-07-09 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl )piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono -hydrochloride TWI315667B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12

Publications (2)

Publication Number Publication Date
TW200408392A TW200408392A (en) 2004-06-01
TWI315667B true TWI315667B (en) 2009-10-11

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092118725A TWI315667B (en) 2002-07-12 2003-07-09 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl )piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono -hydrochloride

Country Status (21)

Country Link
US (2) US8114901B2 (https=)
EP (1) EP1523313B1 (https=)
JP (2) JP4771356B2 (https=)
KR (1) KR100687165B1 (https=)
CN (1) CN100430058C (https=)
AU (1) AU2003280958B9 (https=)
CA (1) CA2393720C (https=)
DE (1) DE60317675T2 (https=)
EA (1) EA007463B1 (https=)
EC (1) ECSP055537A (https=)
ES (1) ES2295605T3 (https=)
HR (1) HRP20050035B1 (https=)
IL (1) IL165747A (https=)
NO (1) NO330254B1 (https=)
NZ (1) NZ537137A (https=)
PE (1) PE20040652A1 (https=)
PL (1) PL373046A1 (https=)
TW (1) TWI315667B (https=)
UA (1) UA78801C2 (https=)
WO (1) WO2004006928A1 (https=)
ZA (1) ZA200500065B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2010101626A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
MX339926B (es) * 2010-09-30 2016-06-16 Wisconsin Alumni Res Found * (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina.
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP6121400B2 (ja) 2011-04-29 2017-04-26 セブンス センス バイオシステムズ，インコーポレーテッド 流体の送達および／または受け取り
CN109952341A (zh) 2016-06-17 2019-06-28 洛斯安第斯大学 衍生自天然来源的冷适应海洋物种的明胶聚合物及其用途
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين
CN116199590B (zh) * 2022-12-26 2024-12-24 湖北美林药业有限公司 一种盐酸多巴酚丁胺及其注射剂

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625738A1 (de) * 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4923986A (en) * 1987-03-09 1990-05-08 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance K-252
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5489608A (en) * 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
GB9123396D0 (en) 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
DE4243321A1 (de) 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
SE501711C2 (sv) * 1993-09-08 1995-05-02 Jimek Int Ab Sprayrör för en duktvättanordning vid en tryckpress
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
GB9620390D0 (en) * 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
WO2001030331A2 (en) * 1999-10-22 2001-05-03 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
WO2002002116A2 (en) * 2000-06-29 2002-01-10 Eli Lilly And Company Therapeutic treatment of cancer with a protein kinase c inhibitor
AU2001271257A1 (en) * 2000-06-29 2002-01-14 Eli Lilly And Company Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy
EP1513830A1 (en) * 2002-06-05 2005-03-16 Janssen Pharmaceutica N.V. Bisindolyl-maleimid derivatives as kinase inhibitors

Also Published As

Publication number Publication date
PL373046A1 (en) 2005-08-08
KR100687165B1 (ko) 2007-02-27
JP2011144182A (ja) 2011-07-28
AU2003280958B2 (en) 2008-12-18
US20050288332A1 (en) 2005-12-29
NO20050676L (no) 2005-02-09
HK1075839A1 (en) 2005-12-30
ECSP055537A (es) 2005-03-10
JP4771356B2 (ja) 2011-09-14
JP5242718B2 (ja) 2013-07-24
CN1668304A (zh) 2005-09-14
ES2295605T3 (es) 2008-04-16
HRP20050035B1 (hr) 2013-07-31
NO330254B1 (no) 2011-03-14
CA2393720C (en) 2010-09-14
ZA200500065B (en) 2006-03-29
US20070270465A1 (en) 2007-11-22
KR20050021453A (ko) 2005-03-07
DE60317675D1 (de) 2008-01-03
AU2003280958B9 (en) 2009-07-02
EP1523313B1 (en) 2007-11-21
HRP20050035A2 (en) 2005-04-30
EA200500191A1 (ru) 2005-06-30
NZ537137A (en) 2007-11-30
CA2393720A1 (en) 2004-01-16
WO2004006928A1 (en) 2004-01-22
IL165747A (en) 2010-05-17
DE60317675T2 (de) 2008-10-30
AU2003280958B8 (en) 2009-02-19
AU2003280958A1 (en) 2004-02-02
EP1523313A1 (en) 2005-04-20
UA78801C2 (en) 2007-04-25
TW200408392A (en) 2004-06-01
IL165747A0 (en) 2006-01-15
EA007463B1 (ru) 2006-10-27
PE20040652A1 (es) 2004-10-05
US8114901B2 (en) 2012-02-14
JP2006502115A (ja) 2006-01-19
CN100430058C (zh) 2008-11-05

Similar Documents

Publication Publication Date Title
TWI315667B (en) Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl )piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono -hydrochloride
ZA200407985B (en) 1-(4-Piperidinyl) benzimidazolones as histamine H3antagonists.
DE60038481D1 (de) Kristalline form des (r)-2-äää3-methyl-4-(2,2,2-trifluorethoxy)-2-pyridinylümethylüsulfinylü-1h-benzimidazols
IL238911A0 (en) Polymorphic form of 3-(4-amino-1-oxo-3,1 dihydro-isoindol-2-yl)-piperidine-6,2-dione
AP2003002836A0 (en) 3-(4-Amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors.
PL356265A1 (en) 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor antagonists
PL375220A1 (en) Piperidine derivatives
ATE208392T1 (de) 1-(1,2-disubstituierte piperidinyl)-4- (kondensierte imidazole)-piperidin derivate
IL174926A0 (en) Crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(-2-chlorophenyl)-methanone
MXPA03004540A (es) Derivados de 4-(bifenilcarbonilamino) piperidina, composiciones que los comprenden y uso de los mismos.
PL376716A1 (pl) Podstawiona 4-amino-1-(pirydylometylo) piperydyna i związki pokrewne
PT1549637E (pt) Derivados de 1-[(indol-3-il)carbonil]piperazina
AU2002361876A8 (en) Stacked borehole packer modules
AU1048602A (en) Substituted 4-phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
EP1847535A4 (en) 1- (piperidin-4-yl) -1H-indole derivatives
EP1556394A4 (en) ASYMMETRIC GROUP 8 (VIII) METALOCO COMPOUNDS
ATE355285T1 (de) In 3-position heterocyclisch substituierte piperidin-2,6-dione
WO2005075456A8 (en) 2-(piperidin-4-yl) -4, 5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
TW549593U (en) Central-pad memories stack package
AU2003236207A8 (en) The hydrochloride of (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
AU2003235895A1 (en) Process for producing 1-(4-pyridyl)-4-piperidone
SI1315700T1 (sl) Substituirani 4-fenil-1-(1-fenil-cikloheksil)-1,2,3,6-tetrahidropiridini
AU2003243930A1 (en) Pharmaceutical composition comprising (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
ZA9610894B (en) 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives.
TWI320414B (en) Asymmetric group 8 (viii) metallocene compounds

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees