UA78562C2 - Pyrrolo-triazine aniline compounds useful as kinase inhibitors - Google Patents

Pyrrolo-triazine aniline compounds useful as kinase inhibitors Download PDF

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Publication number
UA78562C2
UA78562C2 UA20041109628A UA20041109628A UA78562C2 UA 78562 C2 UA78562 C2 UA 78562C2 UA 20041109628 A UA20041109628 A UA 20041109628A UA 20041109628 A UA20041109628 A UA 20041109628A UA 78562 C2 UA78562 C2 UA 78562C2
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UA
Ukraine
Prior art keywords
alkyl
optionally substituted
substituted
phenyl
heteroaryl
Prior art date
Application number
UA20041109628A
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English (en)
Ukrainian (uk)
Inventor
Stephen T Wrobleski
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of UA78562C2 publication Critical patent/UA78562C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

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  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
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  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
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UA20041109628A 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinase inhibitors UA78562C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37493802P 2002-04-23 2002-04-23
PCT/US2003/012426 WO2003090912A1 (en) 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
UA78562C2 true UA78562C2 (en) 2007-04-10

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ID=29270573

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20041109628A UA78562C2 (en) 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinase inhibitors

Country Status (30)

Country Link
US (5) US7160883B2 (zh)
EP (2) EP2289894A3 (zh)
JP (2) JP4669225B2 (zh)
KR (1) KR101025675B1 (zh)
CN (2) CN102093363B (zh)
AR (1) AR039649A1 (zh)
AU (1) AU2003231034B2 (zh)
BR (1) BR0309669A (zh)
CA (1) CA2483164C (zh)
DK (1) DK1497019T3 (zh)
ES (1) ES2543711T3 (zh)
GE (1) GEP20074148B (zh)
HR (1) HRP20040988A2 (zh)
HU (1) HUE025353T2 (zh)
IL (2) IL164573A (zh)
IS (1) IS7505A (zh)
MX (1) MXPA04010379A (zh)
MY (1) MY132094A (zh)
NO (1) NO329503B1 (zh)
NZ (1) NZ536014A (zh)
PE (1) PE20040590A1 (zh)
PL (1) PL219736B1 (zh)
PT (1) PT1497019E (zh)
RS (1) RS92004A (zh)
RU (1) RU2375363C2 (zh)
SI (1) SI1497019T1 (zh)
TW (1) TWI312782B (zh)
UA (1) UA78562C2 (zh)
WO (1) WO2003090912A1 (zh)
ZA (1) ZA200408541B (zh)

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DK1497019T3 (en) * 2002-04-23 2015-08-03 Bristol Myers Squibb Co PYRROLO-TRIAZINANILINE COMPOSITIONS USED AS KINase INHIBITORS
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US6951859B2 (en) * 2002-08-02 2005-10-04 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
CN1771234A (zh) 2003-02-05 2006-05-10 布里斯托尔-迈尔斯斯奎布公司 吡咯并三嗪激酶抑制剂的制备方法
JP2007506741A (ja) * 2003-09-23 2007-03-22 メルク　エンド　カムパニー　インコーポレーテッド 向代謝性グルタミン酸受容体のピラゾール系調節剤
US7419978B2 (en) * 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
US7309708B2 (en) * 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
AU2004299174A1 (en) * 2003-12-10 2005-06-30 Merck Patent Gmbh Diacylhydrazine derivatives
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
JP2007517052A (ja) * 2003-12-23 2007-06-28 ノバルティス アクチエンゲゼルシャフト 二環式ヘテロ環式ｐ−３８キナーゼ阻害剤
US7064203B2 (en) 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
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US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
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US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200600513A (en) 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
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US7504521B2 (en) 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
TW200618803A (en) * 2004-08-12 2006-06-16 Bristol Myers Squibb Co Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
US7151176B2 (en) 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
AU2005299730B2 (en) * 2004-10-26 2009-11-12 Novartis Ag Pyrrolo [1,2-d][1,2-4]triazine as inhibitors of c-Jun N terminal kinases (JNK) and p-38 kinases
US7534882B2 (en) 2005-04-06 2009-05-19 Bristol-Myers Squibb Company Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
US20060235020A1 (en) * 2005-04-18 2006-10-19 Soojin Kim Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
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