UA76492C2 - Muscarinic agonists, a pharmaceutical composition on their basis - Google Patents
Muscarinic agonists, a pharmaceutical composition on their basis Download PDFInfo
- Publication number
- UA76492C2 UA76492C2 UA2004032068A UA2004032068A UA76492C2 UA 76492 C2 UA76492 C2 UA 76492C2 UA 2004032068 A UA2004032068 A UA 2004032068A UA 2004032068 A UA2004032068 A UA 2004032068A UA 76492 C2 UA76492 C2 UA 76492C2
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- UA
- Ukraine
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- alkyl
- fluorobenzyl
- carboxylic acid
- compound according
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
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- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US32414101P | 2001-09-21 | 2001-09-21 | |
PCT/US2002/025969 WO2003027061A2 (fr) | 2001-09-21 | 2002-09-09 | Agonistes muscariniques |
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UA76492C2 true UA76492C2 (en) | 2006-08-15 |
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UA2004032068A UA76492C2 (en) | 2001-09-21 | 2002-09-09 | Muscarinic agonists, a pharmaceutical composition on their basis |
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US (1) | US7326731B2 (fr) |
EP (1) | EP1436249B1 (fr) |
JP (1) | JP4409290B2 (fr) |
KR (1) | KR20040053130A (fr) |
CN (1) | CN1556788A (fr) |
AR (1) | AR036602A1 (fr) |
AU (1) | AU2002332541B2 (fr) |
BR (1) | BR0212353A (fr) |
CA (1) | CA2461218C (fr) |
CZ (1) | CZ2004397A3 (fr) |
EA (1) | EA006853B1 (fr) |
EC (1) | ECSP045027A (fr) |
EG (1) | EG25796A (fr) |
ES (1) | ES2439093T3 (fr) |
HR (1) | HRP20040230B1 (fr) |
HU (1) | HUP0401883A2 (fr) |
IL (2) | IL160751A0 (fr) |
MX (1) | MXPA04002633A (fr) |
MY (1) | MY142358A (fr) |
NO (1) | NO20041107L (fr) |
NZ (1) | NZ531135A (fr) |
PE (1) | PE20030707A1 (fr) |
PL (1) | PL205708B1 (fr) |
SV (1) | SV2004001250A (fr) |
TW (1) | TWI327997B (fr) |
UA (1) | UA76492C2 (fr) |
WO (1) | WO2003027061A2 (fr) |
ZA (1) | ZA200402191B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1534667B1 (fr) * | 2002-08-22 | 2010-12-15 | Eli Lilly And Company | Agonistes muscariniques |
EP1644320B1 (fr) | 2003-07-03 | 2008-01-16 | Eli Lilly And Company | Derives d'indane utilises comme agonistes du recepteur muscarinique |
RU2006106920A (ru) | 2003-08-06 | 2007-09-20 | Синомикс Инк. (Us) | Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения |
PT1670458E (pt) | 2003-10-08 | 2007-03-30 | Schering Ag | Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação |
US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
DE102004029325A1 (de) * | 2004-06-10 | 2006-01-05 | Universität Leipzig | Arzneitmittel zur Behandlung des fetalen Alkoholsyndroms |
DE102005017316A1 (de) * | 2005-04-14 | 2006-10-19 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20090012101A1 (en) * | 2005-12-27 | 2009-01-08 | University Of Toledo | Mucarinic Agonists and Methods of Use Thereof |
EP1834948A1 (fr) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Derives de tetrahydronaphtalene , procedes pour leur production et leur utilisation en tant qu'anti-inflammatoires |
DK3235811T3 (en) | 2006-04-21 | 2018-11-12 | Senomyx Inc | PROCEDURE FOR THE PREPARATION OF OXALAMIDS |
EP2296471A4 (fr) | 2008-05-15 | 2012-03-14 | Univ Toledo | Agonistes muscariniques servant de stimulateurs cognitifs |
MX2010014171A (es) * | 2008-06-19 | 2011-07-04 | Xcovery Holding Co Llc | Compuestos de piridazin-carboxamida sustituida como compuestos inhibidores de cinasa. |
JP2013523679A (ja) | 2010-03-29 | 2013-06-17 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌性イミノ誘導体 |
TWI402072B (zh) | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶s抑制劑化合物 |
US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US6429317B1 (en) * | 1996-01-22 | 2002-08-06 | Eli Lilly And Company | Indane derivatives for antipsychotic compositions |
JP2001510481A (ja) | 1997-01-22 | 2001-07-31 | イーライ・リリー・アンド・カンパニー | インダン様化合物の製造方法 |
WO1999004778A1 (fr) * | 1997-07-22 | 1999-02-04 | Eli Lilly And Company | Composes pharmaceutiques |
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