UA75053C2

UA75053C2 - Substituted pyridines and pyridazines able to inhibit angiogenesis

Substituted pyridines and pyridazines able to inhibit angiogenesis Download PDF

Info

Publication number: UA75053C2
Authority: UA; Ukraine
Prior art keywords: amino; alkyl; methyl; substituted; optionally substituted
Prior art date: 1999-09-28

Application number

UA2002043504A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Bayer Corp

Priority date

1999-09-28

Filing date

2000-09-26

Publication date

2006-03-15

2000-09-26 Application filed by Bayer Corp filed Critical Bayer Corp

2006-03-15 Publication of UA75053C2 publication Critical patent/UA75053C2/uk

Links

230000033115 angiogenesis Effects 0.000 title claims abstract description 25
150000003222 pyridines Chemical class 0.000 title abstract description 7
150000004892 pyridazines Chemical class 0.000 title abstract description 5
238000000034 method Methods 0.000 claims abstract description 131
125000001424 substituent group Chemical group 0.000 claims abstract description 72
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 27
125000003118 aryl group Chemical group 0.000 claims abstract description 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 22
241000124008 Mammalia Species 0.000 claims abstract description 9
230000002159 abnormal effect Effects 0.000 claims abstract description 8
230000008569 process Effects 0.000 claims abstract description 8
125000004076 pyridyl group Chemical group 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
125000000217 alkyl group Chemical group 0.000 claims description 192
150000001875 compounds Chemical class 0.000 claims description 136
125000003277 amino group Chemical group 0.000 claims description 103
239000012634 fragment Substances 0.000 claims description 103
125000004429 atom Chemical group 0.000 claims description 87
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 77
-1 amino- Chemical class 0.000 claims description 68
125000004446 heteroarylalkyl group Chemical group 0.000 claims description 63
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 53
125000004432 carbon atom Chemical group C* 0.000 claims description 52
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 49
125000000623 heterocyclic group Chemical group 0.000 claims description 48
125000001072 heteroaryl group Chemical group 0.000 claims description 40
125000001589 carboacyl group Chemical group 0.000 claims description 33
229910052736 halogen Inorganic materials 0.000 claims description 33
150000002367 halogens Chemical class 0.000 claims description 31
125000003107 substituted aryl group Chemical group 0.000 claims description 28
229910052799 carbon Inorganic materials 0.000 claims description 27
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ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 23
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 19
150000001409 amidines Chemical class 0.000 claims description 18
150000001412 amines Chemical class 0.000 claims description 18
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 17
125000003342 alkenyl group Chemical group 0.000 claims description 16
125000003282 alkyl amino group Chemical class 0.000 claims description 15
125000000392 cycloalkenyl group Chemical group 0.000 claims description 15
125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 14
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CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 11
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 11
125000005842 heteroatom Chemical group 0.000 claims description 11
125000003545 alkoxy group Chemical group 0.000 claims description 10
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208000017442 Retinal disease Diseases 0.000 claims description 4
206010038923 Retinopathy Diseases 0.000 claims description 4
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125000006413 ring segment Chemical group 0.000 claims description 2
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229910002651 NO3 Inorganic materials 0.000 claims 1
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