UA73177C2 - Condensed azepins derivatives and use thereof as antidiuretic agents - Google Patents
Condensed azepins derivatives and use thereof as antidiuretic agents Download PDFInfo
- Publication number
- UA73177C2 UA73177C2 UA20021210560A UA20021210560A UA73177C2 UA 73177 C2 UA73177 C2 UA 73177C2 UA 20021210560 A UA20021210560 A UA 20021210560A UA 20021210560 A UA20021210560 A UA 20021210560A UA 73177 C2 UA73177 C2 UA 73177C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tetrahydro
- pharmaceutically acceptable
- acceptable salt
- tautomer
- compound according
- Prior art date
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- 229940124538 antidiuretic agent Drugs 0.000 title abstract description 4
- 239000003160 antidiuretic agent Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 116
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 150000001538 azepines Chemical class 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 95
- 239000000203 mixture Substances 0.000 claims description 80
- 150000003839 salts Chemical class 0.000 claims description 54
- -1 2,6-difluorophenyl Chemical group 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 10
- 125000004076 pyridyl group Chemical group 0.000 claims description 10
- 201000010064 diabetes insipidus Diseases 0.000 claims description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
- 208000003450 Neurogenic Diabetes Insipidus Diseases 0.000 claims description 7
- 201000005119 neurohypophyseal diabetes insipidus Diseases 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 7
- 208000008967 Enuresis Diseases 0.000 claims description 6
- 206010046543 Urinary incontinence Diseases 0.000 claims description 6
- 206010029446 nocturia Diseases 0.000 claims description 6
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- 239000013543 active substance Substances 0.000 claims description 2
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- SEPCNFYUTXGKHU-UHFFFAOYSA-N methyl 4-[[2-chloro-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]methylamino]-4-oxobutanoate Chemical compound C1=C(Cl)C(CNC(=O)CCC(=O)OC)=CC=C1C(=O)N1C2=CC=CC=C2CCCC1 SEPCNFYUTXGKHU-UHFFFAOYSA-N 0.000 claims description 2
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- 239000007864 aqueous solution Substances 0.000 description 19
- YXHDLKWTPVMIOH-UHFFFAOYSA-N 1,3-difluoro-2-isocyanatobenzene Chemical compound FC1=CC=CC(F)=C1N=C=O YXHDLKWTPVMIOH-UHFFFAOYSA-N 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 17
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0015601.8A GB0015601D0 (en) | 2000-06-26 | 2000-06-26 | Novel antidiuretic agents |
| PCT/GB2001/002737 WO2002000626A1 (en) | 2000-06-26 | 2001-06-21 | Fused azepine derivatives and their use as antidiuretic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73177C2 true UA73177C2 (en) | 2005-06-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20021210560A UA73177C2 (en) | 2000-06-26 | 2001-06-21 | Condensed azepins derivatives and use thereof as antidiuretic agents |
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|---|---|
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| EP (1) | EP1294698B1 (ru) |
| JP (2) | JP3935071B2 (ru) |
| KR (1) | KR100805808B1 (ru) |
| CN (1) | CN1308313C (ru) |
| AT (1) | ATE368650T1 (ru) |
| AU (2) | AU7429001A (ru) |
| CA (1) | CA2412555A1 (ru) |
| CZ (1) | CZ304037B6 (ru) |
| DE (1) | DE60129697T2 (ru) |
| GB (1) | GB0015601D0 (ru) |
| HK (1) | HK1059780A1 (ru) |
| HU (1) | HU229315B1 (ru) |
| IL (1) | IL153358A0 (ru) |
| MX (1) | MXPA02012779A (ru) |
| NO (1) | NO324217B1 (ru) |
| NZ (1) | NZ523066A (ru) |
| PL (1) | PL359187A1 (ru) |
| RU (1) | RU2269517C2 (ru) |
| UA (1) | UA73177C2 (ru) |
| WO (1) | WO2002000626A1 (ru) |
| ZA (1) | ZA200300403B (ru) |
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| US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
| GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| EP2426122A1 (en) * | 2002-10-24 | 2012-03-07 | Merck Patent GmbH | Methylene urea derivative as RAF kinasse inhibitors |
| WO2004064730A2 (en) | 2003-01-14 | 2004-08-05 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| WO2004089896A1 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| AU2004237778B2 (en) * | 2003-05-02 | 2008-08-14 | Worcester Polytechnic Institute | Composite gas separation modules having high tamman temperature intermediate layers |
| EP1512687A1 (en) * | 2003-09-05 | 2005-03-09 | Ferring B.V. | Piperazines as oxytocin agonists |
| PT1530967E (pt) * | 2003-11-13 | 2006-09-29 | Ferring Bv | Embalagem blister e uma forma de dosagem solida que compreende desmopressina. |
| MXPA06014495A (es) * | 2004-06-17 | 2007-03-01 | Cytokinetics Inc | Compuestos, composiciones y metodos. |
| US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
| EP1627876A1 (en) * | 2004-08-20 | 2006-02-22 | Ferring B.V. | Heterocyclic condensed compounds useful as antidiuretic agents |
| EP1632494A1 (en) * | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
| JP4943858B2 (ja) * | 2004-11-17 | 2012-05-30 | キッセイ薬品工業株式会社 | 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途 |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
| EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| JP5178526B2 (ja) | 2005-12-19 | 2013-04-10 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| SE528446C2 (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
| WO2008141081A1 (en) * | 2007-05-10 | 2008-11-20 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| EP2197532A1 (en) | 2007-08-06 | 2010-06-23 | Serenity Pharmaceuticals Corporation | Methods and devices for desmopressin drug delivery |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| WO2009143356A1 (en) * | 2008-05-21 | 2009-11-26 | Ferring International Center S.A. | Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia |
| GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| EP2681196B1 (en) * | 2011-03-04 | 2015-09-09 | Life Technologies Corporation | Compounds and methods for conjugation of biomolecules |
| GB201105537D0 (en) | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
| CN103159641A (zh) * | 2011-12-14 | 2013-06-19 | 天津泰普药品科技发展有限公司 | 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法 |
| RU2480468C1 (ru) * | 2012-02-16 | 2013-04-27 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | КРИСТАЛЛИЧЕСКАЯ МОДИФИКАЦИЯ ПАРА-МЕТОКСИАНИЛИДА 6-ГИДРОКСИ-4-ОКСО-2,4-ДИГИДРО-1Н-ПИРРОЛО[3,2,1-ij]ХИНОЛИН-5-КАРБОНОВОЙ КИСЛОТЫ |
| CN103373960B (zh) * | 2012-04-24 | 2017-03-01 | 江苏康缘药业股份有限公司 | 一种托伐普坦中间体及其制备方法 |
| WO2020154581A1 (en) * | 2019-01-24 | 2020-07-30 | Assia Chemical Industries Ltd | Solid state forms of fedovapagon-salicyclic acid co-crystal |
Family Cites Families (6)
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| US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| CN100384825C (zh) * | 1994-06-15 | 2008-04-30 | 大塚制药株式会社 | 苯并杂环衍生物 |
| AU8592598A (en) * | 1997-07-30 | 1999-02-22 | Wyeth | Tricyclic vasopressin agonists |
| PT1000062E (pt) * | 1997-07-30 | 2004-12-31 | Wyeth Corp | Agonistas triciclicos de vasopressina |
| GB2355454A (en) | 1999-10-20 | 2001-04-25 | Ferring Bv | Antidiuretic agents |
| GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
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2000
- 2000-06-26 GB GBGB0015601.8A patent/GB0015601D0/en not_active Ceased
-
2001
- 2001-06-21 AT AT01940792T patent/ATE368650T1/de not_active IP Right Cessation
- 2001-06-21 NZ NZ523066A patent/NZ523066A/en not_active IP Right Cessation
- 2001-06-21 CN CNB018118135A patent/CN1308313C/zh not_active Expired - Fee Related
- 2001-06-21 CA CA002412555A patent/CA2412555A1/en not_active Abandoned
- 2001-06-21 CZ CZ20024157A patent/CZ304037B6/cs not_active IP Right Cessation
- 2001-06-21 PL PL01359187A patent/PL359187A1/xx not_active IP Right Cessation
- 2001-06-21 AU AU7429001A patent/AU7429001A/xx active Pending
- 2001-06-21 HU HU0301339A patent/HU229315B1/hu not_active IP Right Cessation
- 2001-06-21 JP JP2002505374A patent/JP3935071B2/ja not_active Expired - Fee Related
- 2001-06-21 WO PCT/GB2001/002737 patent/WO2002000626A1/en active IP Right Grant
- 2001-06-21 EP EP01940792A patent/EP1294698B1/en not_active Expired - Lifetime
- 2001-06-21 MX MXPA02012779A patent/MXPA02012779A/es active IP Right Grant
- 2001-06-21 US US10/311,301 patent/US7176195B2/en not_active Expired - Fee Related
- 2001-06-21 DE DE60129697T patent/DE60129697T2/de not_active Expired - Lifetime
- 2001-06-21 IL IL15335801A patent/IL153358A0/xx unknown
- 2001-06-21 UA UA20021210560A patent/UA73177C2/uk unknown
- 2001-06-21 RU RU2003101970/04A patent/RU2269517C2/ru not_active IP Right Cessation
- 2001-06-21 AU AU2001274290A patent/AU2001274290B9/en not_active Ceased
- 2001-06-21 KR KR1020027017214A patent/KR100805808B1/ko not_active IP Right Cessation
-
2002
- 2002-12-18 NO NO20026094A patent/NO324217B1/no not_active IP Right Cessation
-
2003
- 2003-01-15 ZA ZA200300403A patent/ZA200300403B/xx unknown
-
2004
- 2004-04-15 HK HK04102625A patent/HK1059780A1/xx unknown
-
2005
- 2005-01-19 JP JP2005011930A patent/JP2005104990A/ja not_active Withdrawn
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