UA70315C2 - Pharmaceutical composition comprising metformin anpharmaceutical composition comprising metformin and fibrate useful for formulations intended for lowd fibrate useful for formulations intended for lowering hyperglycemia ering hyperglycemia - Google Patents

Pharmaceutical composition comprising metformin anpharmaceutical composition comprising metformin and fibrate useful for formulations intended for lowd fibrate useful for formulations intended for lowering hyperglycemia ering hyperglycemia Download PDF

Info

Publication number
UA70315C2
UA70315C2 UA2000095172A UA2000095172A UA70315C2 UA 70315 C2 UA70315 C2 UA 70315C2 UA 2000095172 A UA2000095172 A UA 2000095172A UA 2000095172 A UA2000095172 A UA 2000095172A UA 70315 C2 UA70315 C2 UA 70315C2
Authority
UA
Ukraine
Prior art keywords
metformin
fibrate
hyperglycemia
useful
pharmaceutical composition
Prior art date
Application number
UA2000095172A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Merck Patent Gmbh Merck Patent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh Merck Patent filed Critical Merck Patent Gmbh Merck Patent
Publication of UA70315C2 publication Critical patent/UA70315C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2000095172A 1998-02-12 1999-01-30 Pharmaceutical composition comprising metformin anpharmaceutical composition comprising metformin and fibrate useful for formulations intended for lowd fibrate useful for formulations intended for lowering hyperglycemia ering hyperglycemia UA70315C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801709A FR2774591B1 (fr) 1998-02-12 1998-02-12 Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
PCT/EP1999/000614 WO1999040904A2 (en) 1998-02-12 1999-01-30 Pharmaceutical composition comprising a combination of metformin and fibrate, and its use for the treatment of hyperglycemia

Publications (1)

Publication Number Publication Date
UA70315C2 true UA70315C2 (en) 2004-10-15

Family

ID=9522912

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000095172A UA70315C2 (en) 1998-02-12 1999-01-30 Pharmaceutical composition comprising metformin anpharmaceutical composition comprising metformin and fibrate useful for formulations intended for lowd fibrate useful for formulations intended for lowering hyperglycemia ering hyperglycemia

Country Status (28)

Country Link
US (1) US6372790B1 (ja)
EP (1) EP1054665B1 (ja)
JP (1) JP4767411B2 (ja)
KR (1) KR100567608B1 (ja)
CN (1) CN1151785C (ja)
AR (1) AR018286A1 (ja)
AT (1) ATE204754T1 (ja)
AU (1) AU746821B2 (ja)
BR (1) BRPI9907866B8 (ja)
CA (1) CA2320039C (ja)
CZ (1) CZ290101B6 (ja)
DE (1) DE69900249T2 (ja)
DK (1) DK1054665T3 (ja)
ES (1) ES2162517T3 (ja)
FR (1) FR2774591B1 (ja)
HK (1) HK1034913A1 (ja)
HU (1) HU224619B1 (ja)
ID (1) ID26254A (ja)
MY (1) MY118164A (ja)
NO (1) NO328314B1 (ja)
PL (1) PL196874B1 (ja)
PT (1) PT1054665E (ja)
RU (1) RU2207850C2 (ja)
SK (1) SK283212B6 (ja)
TW (1) TW518222B (ja)
UA (1) UA70315C2 (ja)
WO (1) WO1999040904A2 (ja)
ZA (1) ZA991077B (ja)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2216335T3 (es) * 1997-12-08 2004-10-16 Bristol-Myers Squibb Company Nuevas sales de metformina y procedimiento.
US6982281B1 (en) 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
FR2796551B1 (fr) * 1999-07-23 2003-07-25 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
EP1246792B1 (en) * 2000-01-13 2014-08-13 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6531158B1 (en) * 2000-08-09 2003-03-11 Impax Laboratories, Inc. Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
JP4829411B2 (ja) * 2001-02-23 2011-12-07 キッセイ薬品工業株式会社 C型慢性肝炎治療剤
GB0119480D0 (en) 2001-08-09 2001-10-03 Jagotec Ag Novel compositions
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
EP1424070A1 (en) * 2002-11-28 2004-06-02 Fournier Laboratories Ireland Limited Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides
CN1310648C (zh) 2002-12-13 2007-04-18 佳高泰克有限公司 局部纳米颗粒螺甾内酯制剂
FR2851734B1 (fr) * 2003-02-28 2006-06-09 Galenix Innovations Procede pour la fabrication d'une composition pharmaceutique sous la forme de comprimes contenant un fibrate et comprimes obtenus selon le procede
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
US8062664B2 (en) * 2003-11-12 2011-11-22 Abbott Laboratories Process for preparing formulations of lipid-regulating drugs
TWI350751B (en) 2003-12-19 2011-10-21 Omega Bio Pharma Ip3 Ltd Pharmaceutical compositions for treating diabetes
EP1559419A1 (en) * 2004-01-23 2005-08-03 Fournier Laboratories Ireland Limited Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention
JP4901218B2 (ja) * 2004-02-09 2012-03-21 あすか製薬株式会社 併用医薬
EP1591114A1 (en) * 2004-03-12 2005-11-02 Fournier Laboratories Ireland Limited Use of metformin and orlistat for the treatment or prevention of obesity
US20060286182A1 (en) * 2005-06-21 2006-12-21 Abeille Pharmaceuticals, Inc. Synergistic cinnamon combinations and methods for enhancing insulin activity
GB0602639D0 (en) * 2006-02-09 2006-03-22 Novartis Ag Organic compounds
US20090318496A1 (en) 2006-08-04 2009-12-24 Aska Pharmaceutical Co., Ltd. Preparation containing fibrate agent and process for producing the same
CN101342164B (zh) * 2007-08-21 2011-04-20 阜新市仙鹤制药有限责任公司 苯扎贝特控释制剂及其制备方法
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
ES2344183B1 (es) * 2009-02-18 2011-06-10 Italfarmaco, S.A. Uso de agentes sensibilizantes a insulina por via vaginal.
US9339458B2 (en) * 2009-02-18 2016-05-17 Itf Research Pharma, S.L.U. Use of vaginal insulin sensitizing agents
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JP2012171911A (ja) 2011-02-22 2012-09-10 Kao Corp Ppar活性化剤
CN104684889A (zh) * 2012-07-10 2015-06-03 西蒂斯制药有限责任公司 二甲双胍的三盐形式
US9382187B2 (en) * 2012-07-10 2016-07-05 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US8765811B2 (en) * 2012-07-10 2014-07-01 Thetis Pharmaceuticals Llc Tri-salt form of metformin
EP3140316A1 (en) 2014-05-05 2017-03-15 Thetis Pharmaceuticals LLC Compositions and methods relating to ionic salts of peptides
WO2015183794A1 (en) 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
US9242008B2 (en) 2014-06-18 2016-01-26 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of fatty acids
WO2015195491A1 (en) 2014-06-18 2015-12-23 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of active agents
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
FR3050112B1 (fr) * 2016-04-15 2020-09-04 Soc Civ Immobiliere Gecinq Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
EP3454907B1 (en) 2016-06-03 2020-07-22 Thetis Pharmaceuticals LLC Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation
US10344002B2 (en) 2016-09-26 2019-07-09 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
FR3056908B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
GB2599950A (en) * 2020-10-16 2022-04-20 Zentiva Ks Pharmaceutical compositions with low amounts of nitrosamine impurities and methods for producing the same
WO2023119100A1 (en) * 2021-12-22 2023-06-29 Mankind Pharma Ltd. Stable pharmaceutical compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2264525B1 (ja) * 1974-03-22 1977-11-04 Expl Marques Brevets Et
US4080472A (en) 1974-03-22 1978-03-21 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformin 2-(p-chlorophenoxy)-2-methylpropionate
DE3729209A1 (de) 1987-09-01 1989-03-09 Boehringer Mannheim Gmbh Verwendung von bezafibrat zur behandlung von diabetes
JP3852621B2 (ja) * 1992-01-21 2006-12-06 あすか製薬株式会社 血管内皮細胞機能改善剤
WO1998005331A2 (en) * 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators

Also Published As

Publication number Publication date
AU2923399A (en) 1999-08-30
WO1999040904A3 (en) 1999-09-30
FR2774591B1 (fr) 2000-05-05
FR2774591A1 (fr) 1999-08-13
HUP0100801A2 (hu) 2001-08-28
CZ20002828A3 (cs) 2000-11-15
AR018286A1 (es) 2001-11-14
NO20004056D0 (no) 2000-08-11
JP4767411B2 (ja) 2011-09-07
NO20004056L (no) 2000-08-11
HU224619B1 (hu) 2005-11-28
MY118164A (en) 2004-09-30
CN1290160A (zh) 2001-04-04
SK283212B6 (sk) 2003-03-04
EP1054665A2 (en) 2000-11-29
BR9907866A (pt) 2000-10-31
EP1054665B1 (en) 2001-08-29
JP2002502869A (ja) 2002-01-29
NO328314B1 (no) 2010-01-25
ZA991077B (en) 1999-08-11
CZ290101B6 (cs) 2002-05-15
DE69900249T2 (de) 2002-06-13
ATE204754T1 (de) 2001-09-15
WO1999040904A2 (en) 1999-08-19
BRPI9907866B1 (pt) 2017-08-15
SK11562000A3 (sk) 2000-12-11
PL342665A1 (en) 2001-07-02
CN1151785C (zh) 2004-06-02
DE69900249D1 (de) 2001-10-04
AU746821B2 (en) 2002-05-02
TW518222B (en) 2003-01-21
PL196874B1 (pl) 2008-02-29
CA2320039C (en) 2008-07-22
ES2162517T3 (es) 2001-12-16
KR20010040925A (ko) 2001-05-15
DK1054665T3 (da) 2001-12-27
ID26254A (id) 2000-12-07
CA2320039A1 (en) 1999-08-19
HK1034913A1 (en) 2001-11-09
BRPI9907866B8 (pt) 2021-05-25
US6372790B1 (en) 2002-04-16
HUP0100801A3 (en) 2001-12-28
PT1054665E (pt) 2002-02-28
RU2207850C2 (ru) 2003-07-10
KR100567608B1 (ko) 2006-04-04

Similar Documents

Publication Publication Date Title
UA70315C2 (en) Pharmaceutical composition comprising metformin anpharmaceutical composition comprising metformin and fibrate useful for formulations intended for lowd fibrate useful for formulations intended for lowering hyperglycemia ering hyperglycemia
US5614560A (en) Method of preventing NMDA receptor-mediated neuronal damage
US5334618A (en) Method of preventing NMDA receptor-mediated neuronal damage
KR100573333B1 (ko) 지질 수준 저하를 위한 시부트라민 동족체의 용도
KR101125462B1 (ko) 모다피닐의 제약 제제
WO1994005275A9 (en) Method of preventing nmda receptor-mediated neuronal damage
US20080161604A1 (en) Acetyl L-Carnitine For Preventing Painful Peripheral Diabetic Neuropathy
NZ501966A (en) Use of alkanoyl carnitine derivatives for the treatment of attention-deficit/hyperactive disorders
CA2570268C (en) Use of acetyl l-carnitine for the preparation of a medicine for the treatment of neuropathic pain in diabetic patients
US8569366B2 (en) Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes
JPH0251885B2 (ja)
ES2425045T3 (es) Acetil-L-carnitina para la prevención de la neuropatía diabética periférica dolorosa
JP2019514978A (ja) イブジラストを使用したアルコール依存症並びにうつ病及び/又は不快な気分の治療
JP5685362B2 (ja) 有痛性末梢糖尿病性神経障害の予防のためのアセチルl−カルニチン
AU705888B2 (en) Method of preventing NMDA receptor-mediated neuronal damage
MXPA00007739A (en) Pharmaceutical composition comprising a combination of metformin and fibrate, and its use for the preparation of medicines intended to reduce hyperglycaemia
MXPA96002793A (en) Use of sertraline to treat patients after an infection of miocar
WO2003092726A1 (en) Combination of insulin and a thiazolidinedione derivative, and use thereof for treating diabetes