UA68372C2 - Solid pharmaceutical composition containing hexadecylphosphocholine (miltefosine) for oral administration in treatment of leishmaniasis - Google Patents
Solid pharmaceutical composition containing hexadecylphosphocholine (miltefosine) for oral administration in treatment of leishmaniasis Download PDFInfo
- Publication number
- UA68372C2 UA68372C2 UA2000084909A UA2000084909A UA68372C2 UA 68372 C2 UA68372 C2 UA 68372C2 UA 2000084909 A UA2000084909 A UA 2000084909A UA 2000084909 A UA2000084909 A UA 2000084909A UA 68372 C2 UA68372 C2 UA 68372C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pharmaceutical composition
- miltefosine
- leishmaniasis
- hexadecylphosphocholine
- oral administration
- Prior art date
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- PQLXHQMOHUQAKB-UHFFFAOYSA-N miltefosine Chemical compound CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C PQLXHQMOHUQAKB-UHFFFAOYSA-N 0.000 title claims abstract description 100
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
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- SXQFCVDSOLSHOQ-UHFFFAOYSA-N lactamide Chemical class CC(O)C(N)=O SXQFCVDSOLSHOQ-UHFFFAOYSA-N 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
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- 238000011068 loading method Methods 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
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- 235000014593 oils and fats Nutrition 0.000 description 1
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- 229940044551 receptor antagonist Drugs 0.000 description 1
- 235000019970 saccharin and its sodium salt Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
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- YQDGWZZYGYKDLR-UZVLBLASSA-K sodium stibogluconate Chemical compound O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].O1[C@H]([C@H](O)CO)[C@H](O2)[C@H](C([O-])=O)O[Sb]21([O-])O[Sb]1(O)(O[C@H]2C([O-])=O)O[C@H]([C@H](O)CO)[C@@H]2O1 YQDGWZZYGYKDLR-UZVLBLASSA-K 0.000 description 1
- 229960001567 sodium stibogluconate Drugs 0.000 description 1
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- 238000011301 standard therapy Methods 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 235000010447 xylitol Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1998/000345 WO1999037289A1 (en) | 1998-01-22 | 1998-01-22 | Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA68372C2 true UA68372C2 (en) | 2004-08-16 |
Family
ID=8166843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2000084909A UA68372C2 (en) | 1998-01-22 | 1998-01-22 | Solid pharmaceutical composition containing hexadecylphosphocholine (miltefosine) for oral administration in treatment of leishmaniasis |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6544551B1 (cs) |
| EP (1) | EP1051159B1 (cs) |
| JP (1) | JP2002501015A (cs) |
| KR (1) | KR100517399B1 (cs) |
| CN (1) | CN100413492C (cs) |
| AT (1) | ATE215817T1 (cs) |
| AU (1) | AU756805B2 (cs) |
| BR (1) | BR9814772A (cs) |
| CA (1) | CA2318260C (cs) |
| CZ (1) | CZ299229B6 (cs) |
| DE (1) | DE69804865T2 (cs) |
| DK (1) | DK1051159T3 (cs) |
| ES (1) | ES2175663T3 (cs) |
| HU (1) | HUP0004363A3 (cs) |
| IL (1) | IL136196A (cs) |
| NO (1) | NO20003674D0 (cs) |
| NZ (1) | NZ505648A (cs) |
| PL (1) | PL189654B1 (cs) |
| PT (1) | PT1051159E (cs) |
| SI (1) | SI1051159T1 (cs) |
| SK (1) | SK284839B6 (cs) |
| TR (1) | TR200001717T2 (cs) |
| UA (1) | UA68372C2 (cs) |
| WO (1) | WO1999037289A1 (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10203195A1 (de) * | 2002-01-25 | 2003-08-07 | Zentaris Ag | Verwendung von Alkylphosphocholinen in der Präventivbehandlung von Protozoenerkrankungen |
| US7887817B2 (en) * | 2002-01-25 | 2011-02-15 | Aeterna Zentaris Gmbh | Process for preventing protozoal diseases |
| BR0215680A (pt) * | 2002-04-26 | 2005-02-01 | Rudolf Perl | Composição farmacêutica oral estável |
| US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
| AU2003253350B2 (en) | 2002-07-30 | 2008-06-26 | Aeterna Zentaris Gmbh | Use of alkyl phosphocholines in combination with antitumor medicaments |
| BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
| DE14172398T1 (de) | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| US8703179B2 (en) * | 2006-05-11 | 2014-04-22 | Kimberly-Clark Worldwide, Inc. | Mucosal formulation |
| WO2010020276A1 (en) * | 2008-08-19 | 2010-02-25 | Orphanidis Pharma Research Gmbh | Treatment of coccidian parasites |
| CA2794513A1 (en) | 2010-03-31 | 2011-10-06 | Aeterna Zentaris Gmbh | Perifosine and capecitabine as a combined treatment for cancer |
| PT2642981T (pt) | 2010-11-22 | 2017-06-16 | Oblita Therapeutics Bvba | Resumo |
| RU2678561C9 (ru) | 2011-06-24 | 2019-03-05 | ДжиАрАй Био, Инк. | Предупреждение и лечение воспалительных состояний |
| EP2983709A1 (en) * | 2013-04-08 | 2016-02-17 | Academisch Medisch Centrum | Miltefosin or perifosin for use in the treatment of ibd |
| US20170252295A1 (en) | 2014-09-17 | 2017-09-07 | Steerlife India Private Limited | Effervescent composition and method of making it |
| CN104473941A (zh) * | 2014-12-20 | 2015-04-01 | 长沙佰顺生物科技有限公司 | 一种含有米替福新的药物制剂及其制备方法 |
| WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| CA3136525A1 (en) * | 2019-04-12 | 2020-10-15 | Oblita Therapeutics Bvba | Tablet dosage formulations of oleyl phosphocholine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE888444C (de) * | 1951-11-10 | 1953-08-31 | Benckiser Gmbh Joh A | Verfahren zum Tablettieren von hygroskopischen Praeparaten |
| IE59777B1 (en) * | 1985-12-04 | 1994-04-06 | Max Planck Gesellschaft | Medicaments |
| US4762658A (en) * | 1986-10-08 | 1988-08-09 | Central Soya Company, Inc. | Method of tableting of de-oiled phosphatides (lecithin) |
| US5290769A (en) * | 1989-09-27 | 1994-03-01 | Asta Pharma Aktiengesellschaft | Use of hexadecylphosphocholine for the treatment of psoriasis |
| EP0916343A1 (de) * | 1989-09-27 | 1999-05-19 | ASTA Medica Aktiengesellschaft | Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen |
| DE4132344A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis |
-
1998
- 1998-01-22 AU AU62121/98A patent/AU756805B2/en not_active Ceased
- 1998-01-22 SI SI9830205T patent/SI1051159T1/xx unknown
- 1998-01-22 PT PT98904121T patent/PT1051159E/pt unknown
- 1998-01-22 CA CA002318260A patent/CA2318260C/en not_active Expired - Fee Related
- 1998-01-22 BR BR9814772-2A patent/BR9814772A/pt not_active Application Discontinuation
- 1998-01-22 DK DK98904121T patent/DK1051159T3/da active
- 1998-01-22 SK SK986-2000A patent/SK284839B6/sk unknown
- 1998-01-22 UA UA2000084909A patent/UA68372C2/uk unknown
- 1998-01-22 HU HU0004363A patent/HUP0004363A3/hu unknown
- 1998-01-22 NZ NZ505648A patent/NZ505648A/xx unknown
- 1998-01-22 ES ES98904121T patent/ES2175663T3/es not_active Expired - Lifetime
- 1998-01-22 WO PCT/EP1998/000345 patent/WO1999037289A1/en active IP Right Grant
- 1998-01-22 TR TR2000/01717T patent/TR200001717T2/xx unknown
- 1998-01-22 JP JP2000528271A patent/JP2002501015A/ja active Pending
- 1998-01-22 CN CNB988125714A patent/CN100413492C/zh not_active Expired - Fee Related
- 1998-01-22 EP EP98904121A patent/EP1051159B1/en not_active Expired - Lifetime
- 1998-01-22 DE DE69804865T patent/DE69804865T2/de not_active Expired - Lifetime
- 1998-01-22 KR KR10-2000-7008029A patent/KR100517399B1/ko not_active IP Right Cessation
- 1998-01-22 IL IL13619698A patent/IL136196A/en not_active IP Right Cessation
- 1998-01-22 PL PL98342838A patent/PL189654B1/pl not_active IP Right Cessation
- 1998-01-22 AT AT98904121T patent/ATE215817T1/de not_active IP Right Cessation
- 1998-01-22 CZ CZ20002596A patent/CZ299229B6/cs not_active IP Right Cessation
-
2000
- 2000-07-18 NO NO20003674A patent/NO20003674D0/no not_active Application Discontinuation
- 2000-07-24 US US09/624,890 patent/US6544551B1/en not_active Expired - Lifetime
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