UA62996C2 - 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines - Google Patents

6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines Download PDF

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Publication number
UA62996C2
UA62996C2 UA2000095500A UA2000095500A UA62996C2 UA 62996 C2 UA62996 C2 UA 62996C2 UA 2000095500 A UA2000095500 A UA 2000095500A UA 2000095500 A UA2000095500 A UA 2000095500A UA 62996 C2 UA62996 C2 UA 62996C2
Authority
UA
Ukraine
Prior art keywords
amino
aminocyclohexyl
dihydrochloride
cyclopentylpurine
trans
Prior art date
Application number
UA2000095500A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Aventic Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventic Pharmaceuticals Inc filed Critical Aventic Pharmaceuticals Inc
Publication of UA62996C2 publication Critical patent/UA62996C2/uk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
UA2000095500A 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines UA62996C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3238198A 1998-02-26 1998-02-26
PCT/US1999/003451 WO1999043676A2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
UA62996C2 true UA62996C2 (en) 2004-01-15

Family

ID=21864658

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2000095500A UA62996C2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines

Country Status (31)

Country Link
EP (1) EP1056745B1 (de)
JP (1) JP2002504553A (de)
KR (1) KR100568658B1 (de)
CN (1) CN1128149C (de)
AP (1) AP1258A (de)
AR (1) AR019822A1 (de)
AT (1) ATE269332T1 (de)
AU (1) AU748178B2 (de)
BR (1) BR9908325A (de)
CA (1) CA2320448C (de)
CZ (1) CZ291604B6 (de)
DE (1) DE69918062T2 (de)
DK (1) DK1056745T3 (de)
EE (1) EE04315B1 (de)
ES (1) ES2219038T3 (de)
HK (1) HK1030948A1 (de)
HU (1) HUP0100931A3 (de)
IL (2) IL138044A0 (de)
NO (1) NO20004281L (de)
NZ (1) NZ506234A (de)
OA (1) OA11480A (de)
PL (1) PL344021A1 (de)
PT (1) PT1056745E (de)
RU (1) RU2191777C2 (de)
SI (1) SI1056745T1 (de)
SK (1) SK12912000A3 (de)
TR (1) TR200002482T2 (de)
TW (1) TW541308B (de)
UA (1) UA62996C2 (de)
WO (1) WO1999043676A2 (de)
ZA (1) ZA991548B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2681081C2 (ru) * 2007-10-05 2019-03-04 Верастэм, Инк. Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
US6627633B2 (en) 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
DE60118521T2 (de) * 2000-01-07 2006-10-12 Universitaire Instelling Antwerpen Purin derivate, ihre herstellung und verwendung
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
JP2004501083A (ja) 2000-04-18 2004-01-15 アゴーロン・ファーマシューティカルズ・インコーポレイテッド プロテインキナーゼを阻害するためのピラゾール
MXPA03001189A (es) 2000-08-09 2004-05-14 Agouron Pharma Compuestos de pirazol-tiazol, composiciones farmaceuticas que los contienen y su uso para inhibir las cinasas dependientes de ciclinas.
EP1309563B1 (de) 2000-08-18 2005-05-11 Agouron Pharmaceuticals, Inc. Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
MXPA03003774A (es) * 2000-10-31 2003-07-28 Aventis Pharm Prod Inc Derivados de acilo y sulfonilo de 2-(trans-1, 4-diaminociclohexil)-purinas 6,9-disubstituidas y sus uso como agentes antiproliferativos.
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
ATE301123T1 (de) 2001-06-27 2005-08-15 Cyclacel Ltd 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
CA2515135A1 (en) * 2003-02-04 2004-08-19 Kabushiki Kaisha Yakult Honsha Breast cancer-resistant protein inhibitor
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
MX2008012515A (es) * 2006-03-30 2008-11-19 Ptc Therapeutics Inc Metodos para la produccion de proteina funcional a partir de adn que tiene una mutacion sin sentido y el tratamiento de trastornos asociados con la misma.
CN102241646B (zh) * 2010-05-14 2014-04-09 中国人民解放军军事医学科学院毒物药物研究所 己烯酮类化合物及其医药用途
US9493464B2 (en) 2012-02-29 2016-11-15 The Scripps Research Institute Wee1 degradation inhibitors
WO2015005491A1 (ja) * 2013-07-12 2015-01-15 国立大学法人京都大学 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
EP4115882A1 (de) 2015-01-16 2023-01-11 The General Hospital Corporation Verbindungen zur verbesserung des spleissens von mrna
CN107903274A (zh) * 2017-12-28 2018-04-13 窦玉玲 一种胺类化合物及其在抗肿瘤药物中的应用
EP3997089A4 (de) * 2019-07-21 2023-08-16 University Of Virginia Patent Foundation Cysteinbindende zusammensetzungen und verfahren zu deren verwendung
WO2024105159A1 (en) * 2022-11-16 2024-05-23 University Of Zurich Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
CN1066147C (zh) * 1995-11-01 2001-05-23 诺瓦提斯公司 嘌呤衍生物及其制备方法
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2681081C2 (ru) * 2007-10-05 2019-03-04 Верастэм, Инк. Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний

Also Published As

Publication number Publication date
CZ291604B6 (cs) 2003-04-16
OA11480A (en) 2004-05-05
EP1056745A2 (de) 2000-12-06
PT1056745E (pt) 2004-09-30
CN1128149C (zh) 2003-11-19
KR20010041315A (ko) 2001-05-15
DK1056745T3 (da) 2004-10-25
NZ506234A (en) 2003-05-30
EE04315B1 (et) 2004-06-15
AR019822A1 (es) 2002-03-20
AU3299099A (en) 1999-09-15
DE69918062D1 (de) 2004-07-22
NO20004281L (no) 2000-10-18
ATE269332T1 (de) 2004-07-15
SI1056745T1 (en) 2004-12-31
HK1030948A1 (en) 2001-05-25
WO1999043676A2 (en) 1999-09-02
JP2002504553A (ja) 2002-02-12
CA2320448C (en) 2005-02-01
CZ20003106A3 (cs) 2000-12-13
EE200000501A (et) 2002-02-15
AU748178B2 (en) 2002-05-30
IL138044A (en) 2006-04-10
AP1258A (en) 2004-03-15
IL138044A0 (en) 2001-10-31
TW541308B (en) 2003-07-11
WO1999043676A3 (en) 1999-10-21
NO20004281D0 (no) 2000-08-25
HUP0100931A3 (en) 2002-08-28
EP1056745B1 (de) 2004-06-16
HUP0100931A2 (hu) 2002-04-29
CN1291983A (zh) 2001-04-18
ES2219038T3 (es) 2004-11-16
TR200002482T2 (tr) 2002-10-21
DE69918062T2 (de) 2005-06-02
BR9908325A (pt) 2000-11-07
AP2000001923A0 (en) 2000-09-30
PL344021A1 (en) 2001-09-24
SK12912000A3 (sk) 2001-08-06
ZA991548B (en) 1999-08-26
RU2191777C2 (ru) 2002-10-27
CA2320448A1 (en) 1999-09-02
KR100568658B1 (ko) 2006-04-07

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