BR9908325A - 6 9-dissubstituìdo 2-[trans-4(4-aminociclohexil)amino]purinas - Google Patents
6 9-dissubstituìdo 2-[trans-4(4-aminociclohexil)amino]purinasInfo
- Publication number
- BR9908325A BR9908325A BR9908325-6A BR9908325A BR9908325A BR 9908325 A BR9908325 A BR 9908325A BR 9908325 A BR9908325 A BR 9908325A BR 9908325 A BR9908325 A BR 9908325A
- Authority
- BR
- Brazil
- Prior art keywords
- present
- provides
- group
- alkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3238198A | 1998-02-26 | 1998-02-26 | |
PCT/US1999/003451 WO1999043676A2 (en) | 1998-02-26 | 1999-02-18 | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9908325A true BR9908325A (pt) | 2000-11-07 |
Family
ID=21864658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9908325-6A BR9908325A (pt) | 1998-02-26 | 1999-02-18 | 6 9-dissubstituìdo 2-[trans-4(4-aminociclohexil)amino]purinas |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1056745B1 (pt) |
JP (1) | JP2002504553A (pt) |
KR (1) | KR100568658B1 (pt) |
CN (1) | CN1128149C (pt) |
AP (1) | AP1258A (pt) |
AR (1) | AR019822A1 (pt) |
AT (1) | ATE269332T1 (pt) |
AU (1) | AU748178B2 (pt) |
BR (1) | BR9908325A (pt) |
CA (1) | CA2320448C (pt) |
CZ (1) | CZ291604B6 (pt) |
DE (1) | DE69918062T2 (pt) |
DK (1) | DK1056745T3 (pt) |
EE (1) | EE04315B1 (pt) |
ES (1) | ES2219038T3 (pt) |
HK (1) | HK1030948A1 (pt) |
HU (1) | HUP0100931A3 (pt) |
IL (2) | IL138044A0 (pt) |
NO (1) | NO20004281L (pt) |
NZ (1) | NZ506234A (pt) |
OA (1) | OA11480A (pt) |
PL (1) | PL344021A1 (pt) |
PT (1) | PT1056745E (pt) |
RU (1) | RU2191777C2 (pt) |
SI (1) | SI1056745T1 (pt) |
SK (1) | SK12912000A3 (pt) |
TR (1) | TR200002482T2 (pt) |
TW (1) | TW541308B (pt) |
UA (1) | UA62996C2 (pt) |
WO (1) | WO1999043676A2 (pt) |
ZA (1) | ZA991548B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6969720B2 (en) | 1999-03-17 | 2005-11-29 | Amr Technology, Inc. | Biaryl substituted purine derivatives as potent antiproliferative agents |
US6627633B2 (en) | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
US20030187261A1 (en) * | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
WO2001079198A1 (en) | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
AU2001277285A1 (en) | 2000-08-09 | 2002-02-18 | Agouron Pharmaceuticals, Inc. | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |
EP1309563B1 (en) | 2000-08-18 | 2005-05-11 | Agouron Pharmaceuticals, Inc. | Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases |
GB0117075D0 (en) * | 2000-10-31 | 2001-09-05 | Aventis Pharm Prod Inc | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
WO2002042303A2 (en) * | 2000-10-31 | 2002-05-30 | Aventis Pharmaceuticals Inc. | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
WO2003002565A1 (en) * | 2001-06-27 | 2003-01-09 | Cyclacel Limited | 2,6,9-substituted purine derivatives and their use n the treatment of proliferative disorders |
US6812232B2 (en) | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
US6667311B2 (en) | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
WO2004069233A1 (ja) * | 2003-02-04 | 2004-08-19 | Kabushiki Kaisha Yakult Honsha | 乳癌耐性蛋白阻害剤 |
US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
RU2462246C2 (ru) * | 2006-03-30 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней |
MX2010003668A (es) * | 2007-10-05 | 2010-07-02 | S Bio Pte Ltd | Derivados de purina sustituidas con primidina. |
CN102241646B (zh) * | 2010-05-14 | 2014-04-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 己烯酮类化合物及其医药用途 |
US9493464B2 (en) | 2012-02-29 | 2016-11-15 | The Scripps Research Institute | Wee1 degradation inhibitors |
EP3020829B1 (en) | 2013-07-12 | 2021-11-17 | Kyoto University | Pharmaceutical composition capable of inhibiting abnormal splicing causative of onset or progress of a genetic disease |
AU2016206589B2 (en) | 2015-01-16 | 2020-09-10 | The General Hospital Corporation | Compounds for improving mRNA splicing |
CN107903274A (zh) * | 2017-12-28 | 2018-04-13 | 窦玉玲 | 一种胺类化合物及其在抗肿瘤药物中的应用 |
WO2021016263A1 (en) * | 2019-07-21 | 2021-01-28 | University Of Virginia Patent Foundation | Cysteine binding compositions and methods of use thereof |
WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
GB9414208D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
CN1066147C (zh) * | 1995-11-01 | 2001-05-23 | 诺瓦提斯公司 | 嘌呤衍生物及其制备方法 |
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
-
1999
- 1999-02-18 HU HU0100931A patent/HUP0100931A3/hu unknown
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 CZ CZ20003106A patent/CZ291604B6/cs not_active IP Right Cessation
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
- 1999-02-18 EP EP99936074A patent/EP1056745B1/en not_active Expired - Lifetime
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active IP Right Cessation
- 1999-02-18 EE EEP200000501A patent/EE04315B1/xx not_active IP Right Cessation
- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en active IP Right Grant
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
-
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
-
2001
- 2001-03-16 HK HK01101931A patent/HK1030948A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT. CL.: CO7D 473/16; A61K 31/52; A61P 35/00; A61P 25/28. Ipc: C07D 473/16 (2008.04), A61K 31/52 (2008.04) |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O, 13, 24 E 25 DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |
|
B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
B25A | Requested transfer of rights approved |
Owner name: HMR PHARMA, INC. (US) Free format text: TRANSFERIDO DE: AVENTIS PHARMACEUTICALS, INC. |
|
B25A | Requested transfer of rights approved |
Owner name: AVENTIS HOLDINGS INC. (US) Free format text: TRANSFERIDO DE: HMR PHARMA, INC. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 12A E 13A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |