HUP0100931A2 - 2,6-Diszubsztituált 2-{transz-(4-amino-ciklohexil)-amino}-purinok és ezeket tartalmazó gyógyászati készítmények - Google Patents
2,6-Diszubsztituált 2-{transz-(4-amino-ciklohexil)-amino}-purinok és ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0100931A2 HUP0100931A2 HU0100931A HUP0100931A HUP0100931A2 HU P0100931 A2 HUP0100931 A2 HU P0100931A2 HU 0100931 A HU0100931 A HU 0100931A HU P0100931 A HUP0100931 A HU P0100931A HU P0100931 A2 HUP0100931 A2 HU P0100931A2
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- group
- alkyl
- carbon atoms
- compound
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 150000003212 purines Chemical class 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 102000000578 Cyclin-Dependent Kinase Inhibitor p21 Human genes 0.000 abstract 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 101150073031 cdk2 gene Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A tal lm ny t rgya az (I) ltal nos képletű új vegyületek - amelyképletben R jelentése egy R2, R2-NH- vagy H2N-R3- ltal nos képletűcsoport, amelyekben R2 jelentése 1-8 szénatomos alkil- vagyalkenilcsoport, vagy egy ltal nos képletű csoport, amelyben Zjelentése egy fenil-, egy heterociklusos vagy egy cikloalkil- vagycikloalkenilcsoport; mindkét R4 jelentése egym stól függetlenülhidrogénatom vagy 1-4 szénatomos alkil- vagy alkenilcsoport; és nértéke 1-8; ahol az 1-8 szénatomos alkil- vagy alkenilcsoport és a Zltal nos képletű csoport adott esetben 13 szubsztituenssel lehetszubsztitu lva, amelyek azonosak vagy kül"nb"zőek, és lehetnekhalogénatomok, hidroxilcsoportok vagy 1-4 szénatomos alkil- vagyalkenilcsoportok; R3 jelentése 1-8 szénatomos alkilén- vagyalkeniléncsoport; és R1 jelentése ciklopentil- vagy izopropilcsoportvalamint ezek gyógyszerészetileg elfogadható sói, optikai izomerei éshidr tjai. A tal lm ny t rgy t képezi egy elj r s a sejtciklus előrehalad s nak g tl s ra a cdk2 g tl s n keresztül. A tal lm ny t rgy hoztartozik még egy elj r s idegsejtek apoptózis nak megelőzésére vagyneopl zi k kifejlődésének megakad lyoz s ra. Az elj r s abból ll, hogyegy, a fenti megbetegedésben szenvedő betegnek egy (I) ltal nosképletű vegyületet adnak be. A fentiek mellett a tal lm ny t rgya egykészítmény, amely egy (I) ltal nos képletű vegyület meghat rozhatómennyiségét tartalmazza egy inert hordozóval "sszekeverve vagy m smódon t rsítva. A tal lm ny t rgy t képezi tov bb egygyógyszerkészítmény, amely egy (I) ltal nos képletű vegyület cdk2-inhibitorként hat sos mennyiségét tartalmazza egy vagy t"bbgyógyszerészetileg elfogadható vivő- vagy segédanyaggal "sszekevervevagy m s módon t rsítva. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3238198A | 1998-02-26 | 1998-02-26 | |
| PCT/US1999/003451 WO1999043676A2 (en) | 1998-02-26 | 1999-02-18 | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100931A2 true HUP0100931A2 (hu) | 2002-04-29 |
| HUP0100931A3 HUP0100931A3 (en) | 2002-08-28 |
Family
ID=21864658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100931A HUP0100931A3 (en) | 1998-02-26 | 1999-02-18 | 6,9-disubstituted 2-[trans-(-aminocyclohexyl)amino]purines and pharmaceutical compositions containing them |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1056745B1 (hu) |
| JP (1) | JP2002504553A (hu) |
| KR (1) | KR100568658B1 (hu) |
| CN (1) | CN1128149C (hu) |
| AP (1) | AP1258A (hu) |
| AR (1) | AR019822A1 (hu) |
| AT (1) | ATE269332T1 (hu) |
| AU (1) | AU748178B2 (hu) |
| BR (1) | BR9908325A (hu) |
| CA (1) | CA2320448C (hu) |
| CZ (1) | CZ291604B6 (hu) |
| DE (1) | DE69918062T2 (hu) |
| DK (1) | DK1056745T3 (hu) |
| EE (1) | EE04315B1 (hu) |
| ES (1) | ES2219038T3 (hu) |
| HK (1) | HK1030948A1 (hu) |
| HU (1) | HUP0100931A3 (hu) |
| IL (2) | IL138044A0 (hu) |
| NO (1) | NO20004281L (hu) |
| NZ (1) | NZ506234A (hu) |
| OA (1) | OA11480A (hu) |
| PL (1) | PL344021A1 (hu) |
| PT (1) | PT1056745E (hu) |
| RU (1) | RU2191777C2 (hu) |
| SI (1) | SI1056745T1 (hu) |
| SK (1) | SK12912000A3 (hu) |
| TR (1) | TR200002482T2 (hu) |
| TW (1) | TW541308B (hu) |
| UA (1) | UA62996C2 (hu) |
| WO (1) | WO1999043676A2 (hu) |
| ZA (1) | ZA991548B (hu) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969720B2 (en) | 1999-03-17 | 2005-11-29 | Amr Technology, Inc. | Biaryl substituted purine derivatives as potent antiproliferative agents |
| US6627633B2 (en) * | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
| CZ20022353A3 (cs) * | 2000-01-07 | 2003-02-12 | Universitaire Instelling Antwerpen | Deriváty purinu, způsob jejich přípravy a jejich použití |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
| EP1274706A1 (en) | 2000-04-18 | 2003-01-15 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinases |
| MXPA03001189A (es) | 2000-08-09 | 2004-05-14 | Agouron Pharma | Compuestos de pirazol-tiazol, composiciones farmaceuticas que los contienen y su uso para inhibir las cinasas dependientes de ciclinas. |
| DE60110802T2 (de) | 2000-08-18 | 2005-10-06 | Agouron Pharmaceuticals, Inc., San Diego | Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen |
| DE60138140D1 (de) * | 2000-10-31 | 2009-05-07 | Aventis Pharma Inc | Acyl- und sulfonylderivative 6,9-disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel |
| GB0117075D0 (en) * | 2000-10-31 | 2001-09-05 | Aventis Pharm Prod Inc | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| DE60205376T2 (de) | 2001-06-27 | 2006-04-06 | Cyclacel Ltd. | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
| US6812232B2 (en) | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
| US6667311B2 (en) | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
| GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| US20060135445A1 (en) * | 2003-02-04 | 2006-06-22 | Kabushiki Kaisha Yakult Honsha | Breast cancer-resistant protein inhibitor |
| US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| SG170819A1 (en) * | 2006-03-30 | 2011-05-30 | Ptc Therapeutics Inc | Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith |
| RU2681081C2 (ru) * | 2007-10-05 | 2019-03-04 | Верастэм, Инк. | Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний |
| CN102241646B (zh) * | 2010-05-14 | 2014-04-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 己烯酮类化合物及其医药用途 |
| WO2013130461A1 (en) | 2012-02-29 | 2013-09-06 | The Scripps Research Institute | Wee1 degradation inhibitors |
| JPWO2015005491A1 (ja) * | 2013-07-12 | 2017-03-02 | 国立大学法人京都大学 | 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法 |
| DK3244891T3 (da) | 2015-01-16 | 2022-10-24 | Massachusetts Gen Hospital | Forbindelser til forbedring af mrna-splejsning |
| CN107903274A (zh) * | 2017-12-28 | 2018-04-13 | 窦玉玲 | 一种胺类化合物及其在抗肿瘤药物中的应用 |
| EP3997089A4 (en) * | 2019-07-21 | 2023-08-16 | University Of Virginia Patent Foundation | CYSTEINE BINDING COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
| GB9414208D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
| US7091346B1 (en) * | 1995-11-01 | 2006-08-15 | Novartis Ag | Purine derivatives and processes for their preparation |
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
-
1999
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 EE EEP200000501A patent/EE04315B1/xx not_active IP Right Cessation
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 EP EP99936074A patent/EP1056745B1/en not_active Expired - Lifetime
- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active IP Right Cessation
- 1999-02-18 CZ CZ20003106A patent/CZ291604B6/cs not_active IP Right Cessation
- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en active IP Right Grant
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 HU HU0100931A patent/HUP0100931A3/hu unknown
- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
-
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown
-
2001
- 2001-03-16 HK HK01101931A patent/HK1030948A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |