HK1030948A1 - 6,9-Disubstituted 2-Ätrans-(4-aminocyclohexyl) aminoÜ purines. - Google Patents

6,9-Disubstituted 2-Ätrans-(4-aminocyclohexyl) aminoÜ purines.

Info

Publication number
HK1030948A1
HK1030948A1 HK01101931A HK01101931A HK1030948A1 HK 1030948 A1 HK1030948 A1 HK 1030948A1 HK 01101931 A HK01101931 A HK 01101931A HK 01101931 A HK01101931 A HK 01101931A HK 1030948 A1 HK1030948 A1 HK 1030948A1
Authority
HK
Hong Kong
Prior art keywords
ätrans
aminoü
aminocyclohexyl
purines
disubstituted
Prior art date
Application number
HK01101931A
Other languages
English (en)
Inventor
Jennifer A Dumont
David R Borcherding
Randall H Munson
Alan J Bitonti
Norton P Peet
Patrick W K Shum
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of HK1030948A1 publication Critical patent/HK1030948A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK01101931A 1998-02-26 2001-03-16 6,9-Disubstituted 2-Ätrans-(4-aminocyclohexyl) aminoÜ purines. HK1030948A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3238198A 1998-02-26 1998-02-26
PCT/US1999/003451 WO1999043676A2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
HK1030948A1 true HK1030948A1 (en) 2001-05-25

Family

ID=21864658

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01101931A HK1030948A1 (en) 1998-02-26 2001-03-16 6,9-Disubstituted 2-Ätrans-(4-aminocyclohexyl) aminoÜ purines.

Country Status (31)

Country Link
EP (1) EP1056745B1 (xx)
JP (1) JP2002504553A (xx)
KR (1) KR100568658B1 (xx)
CN (1) CN1128149C (xx)
AP (1) AP1258A (xx)
AR (1) AR019822A1 (xx)
AT (1) ATE269332T1 (xx)
AU (1) AU748178B2 (xx)
BR (1) BR9908325A (xx)
CA (1) CA2320448C (xx)
CZ (1) CZ291604B6 (xx)
DE (1) DE69918062T2 (xx)
DK (1) DK1056745T3 (xx)
EE (1) EE04315B1 (xx)
ES (1) ES2219038T3 (xx)
HK (1) HK1030948A1 (xx)
HU (1) HUP0100931A3 (xx)
IL (2) IL138044A0 (xx)
NO (1) NO20004281L (xx)
NZ (1) NZ506234A (xx)
OA (1) OA11480A (xx)
PL (1) PL344021A1 (xx)
PT (1) PT1056745E (xx)
RU (1) RU2191777C2 (xx)
SI (1) SI1056745T1 (xx)
SK (1) SK12912000A3 (xx)
TR (1) TR200002482T2 (xx)
TW (1) TW541308B (xx)
UA (1) UA62996C2 (xx)
WO (1) WO1999043676A2 (xx)
ZA (1) ZA991548B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627633B2 (en) 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
CZ20022353A3 (cs) * 2000-01-07 2003-02-12 Universitaire Instelling Antwerpen Deriváty purinu, způsob jejich přípravy a jejich použití
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
MXPA02010222A (es) 2000-04-18 2003-05-23 Agouron Pharma Pirazoles para inhibir proteina cinasa.
JP2004505983A (ja) 2000-08-09 2004-02-26 アグーロン　ファーマシューティカルズ，インコーポレイテッド ピラゾール−チアゾール化合物、これらを含む医薬組成物、およびサイクリン依存性キナーゼの阻害のためのこれらの使用方法
WO2002016326A1 (en) 2000-08-18 2002-02-28 Agouron Pharmaceuticals, Inc. Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
AU2002239388B2 (en) * 2000-10-31 2006-05-25 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
JP4381804B2 (ja) 2001-06-27 2009-12-09 サイクラセル リミテッド ２，６，９−置換プリン誘導体及び増殖性疾患の治療におけるその使用
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
JPWO2004069233A1 (ja) * 2003-02-04 2006-05-25 株式会社ヤクルト本社 乳癌耐性蛋白阻害剤
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
EP2007365A2 (en) * 2006-03-30 2008-12-31 PTC Therapeutics, Inc. Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
EP2209786B1 (en) * 2007-10-05 2013-02-27 Verastem, Inc. Pyrimidine substituted purine derivatives
CN102241646B (zh) * 2010-05-14 2014-04-09 中国人民解放军军事医学科学院毒物药物研究所 己烯酮类化合物及其医药用途
WO2013130461A1 (en) 2012-02-29 2013-09-06 The Scripps Research Institute Wee1 degradation inhibitors
US9879014B2 (en) 2013-07-12 2018-01-30 Kyoto University Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease
CA3199430A1 (en) 2015-01-16 2016-07-21 The General Hospital Corporation Compounds for improving mrna splicing
CN107903274A (zh) * 2017-12-28 2018-04-13 窦玉玲 一种胺类化合物及其在抗肿瘤药物中的应用
WO2021016263A1 (en) * 2019-07-21 2021-01-28 University Of Virginia Patent Foundation Cysteine binding compositions and methods of use thereof
WO2024105159A1 (en) * 2022-11-16 2024-05-23 University Of Zurich Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
CA2234609C (en) * 1995-11-01 2006-11-28 Novartis Ag 2-amino-6-anilino-purine derivatives and processes for their preparation
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

Also Published As

Publication number Publication date
EE200000501A (et) 2002-02-15
NO20004281L (no) 2000-10-18
UA62996C2 (en) 2004-01-15
AU3299099A (en) 1999-09-15
AP1258A (en) 2004-03-15
ATE269332T1 (de) 2004-07-15
SK12912000A3 (sk) 2001-08-06
WO1999043676A2 (en) 1999-09-02
PL344021A1 (en) 2001-09-24
CZ291604B6 (cs) 2003-04-16
ZA991548B (en) 1999-08-26
AU748178B2 (en) 2002-05-30
KR100568658B1 (ko) 2006-04-07
SI1056745T1 (en) 2004-12-31
OA11480A (en) 2004-05-05
CA2320448A1 (en) 1999-09-02
JP2002504553A (ja) 2002-02-12
TW541308B (en) 2003-07-11
WO1999043676A3 (en) 1999-10-21
PT1056745E (pt) 2004-09-30
CA2320448C (en) 2005-02-01
CZ20003106A3 (cs) 2000-12-13
DE69918062D1 (de) 2004-07-22
KR20010041315A (ko) 2001-05-15
AP2000001923A0 (en) 2000-09-30
BR9908325A (pt) 2000-11-07
ES2219038T3 (es) 2004-11-16
CN1291983A (zh) 2001-04-18
HUP0100931A2 (hu) 2002-04-29
TR200002482T2 (tr) 2002-10-21
NZ506234A (en) 2003-05-30
CN1128149C (zh) 2003-11-19
AR019822A1 (es) 2002-03-20
IL138044A (en) 2006-04-10
HUP0100931A3 (en) 2002-08-28
DK1056745T3 (da) 2004-10-25
RU2191777C2 (ru) 2002-10-27
DE69918062T2 (de) 2005-06-02
NO20004281D0 (no) 2000-08-25
EP1056745A2 (en) 2000-12-06
EE04315B1 (et) 2004-06-15
EP1056745B1 (en) 2004-06-16
IL138044A0 (en) 2001-10-31

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100218