NO20004281L - 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament - Google Patents

6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament

Info

Publication number
NO20004281L
NO20004281L NO20004281A NO20004281A NO20004281L NO 20004281 L NO20004281 L NO 20004281L NO 20004281 A NO20004281 A NO 20004281A NO 20004281 A NO20004281 A NO 20004281A NO 20004281 L NO20004281 L NO 20004281L
Authority
NO
Norway
Prior art keywords
present
provides
group
alkyl
formula
Prior art date
Application number
NO20004281A
Other languages
English (en)
Other versions
NO20004281D0 (no
Inventor
Jennifer Ann Dumont
Alan Joseph Bitonti
David Roger Borcherding
Harry Randall Munson
Patrick Wai-Kwok Shum
Norton Paul Peet
Original Assignee
Aventis Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Holdings Inc filed Critical Aventis Holdings Inc
Publication of NO20004281D0 publication Critical patent/NO20004281D0/no
Publication of NO20004281L publication Critical patent/NO20004281L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer nye forbindelser av formel (I). hvori R er valgt fra gruppen bestående av R, RNH-, eller HN-R- hvori Rer valgt fra gruppen bestående av C^-C,-alkyl og formel (II). hvori Z er valgt fra gruppen bestående av fenyl, heterosyklus og sykloalkyl, hver Rer uavhengig hydrogen eller C-C-alkyl, og n er et helt tall på 1-8;. hvori hver C-C-alkyl og Z eventuelt er substituert med 1 til 3 substituenter som kan være like eller forskjellige, valgt fra gruppen bestående av Hal, OH og Cj-C-alkyl; Rer q-C-alkylen; og R,, er valgt fra gruppen bestående av syklopentyl og isopropyl, og farmasøyt-isk akseptable salter, optiske isbmerer • og hydrater derav. I tillegg tilveiebringer foreliggende oppfinnelse en metode for inhibering av cellesyklus-progresjon. Mer spesifikt tilveiebringer foreliggende oppfinnelse en metode for inhibering av syklinav-hengige kinaser, i særdeleshet cdk-2. Foreliggende oppfinnelse tilveiebringer også en metode for forhindring av apoptose i neuronalceller og en metode for inhibering av utviklingen a-v neo-plasmer. I tillegg tilveiebringer foreliggende oppfinnelse et preparat, omfattende en målbar mengde av efor-. bindelse av formel (I) i blanding eller på annen måte i assosiasjon med en inert bærer. Foreliggende oppfinnelse tilveiebringer også et farmasøytisk preparat omfattende en effektiv inhi-berende mengde av en forbindelse av formel (I), i blanding eller på annen måte i assosiasjon med én eller flére farmasøytisk akseptable bærere eller eksipienser.
NO20004281A 1998-02-26 2000-08-25 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament NO20004281L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3238198A 1998-02-26 1998-02-26
PCT/US1999/003451 WO1999043676A2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (2)

Publication Number Publication Date
NO20004281D0 NO20004281D0 (no) 2000-08-25
NO20004281L true NO20004281L (no) 2000-10-18

Family

ID=21864658

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004281A NO20004281L (no) 1998-02-26 2000-08-25 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament

Country Status (31)

Country Link
EP (1) EP1056745B1 (no)
JP (1) JP2002504553A (no)
KR (1) KR100568658B1 (no)
CN (1) CN1128149C (no)
AP (1) AP1258A (no)
AR (1) AR019822A1 (no)
AT (1) ATE269332T1 (no)
AU (1) AU748178B2 (no)
BR (1) BR9908325A (no)
CA (1) CA2320448C (no)
CZ (1) CZ291604B6 (no)
DE (1) DE69918062T2 (no)
DK (1) DK1056745T3 (no)
EE (1) EE04315B1 (no)
ES (1) ES2219038T3 (no)
HK (1) HK1030948A1 (no)
HU (1) HUP0100931A3 (no)
IL (2) IL138044A0 (no)
NO (1) NO20004281L (no)
NZ (1) NZ506234A (no)
OA (1) OA11480A (no)
PL (1) PL344021A1 (no)
PT (1) PT1056745E (no)
RU (1) RU2191777C2 (no)
SI (1) SI1056745T1 (no)
SK (1) SK12912000A3 (no)
TR (1) TR200002482T2 (no)
TW (1) TW541308B (no)
UA (1) UA62996C2 (no)
WO (1) WO1999043676A2 (no)
ZA (1) ZA991548B (no)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
US6627633B2 (en) 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
BR0110302A (pt) 2000-04-18 2003-01-14 Agouron Pharma Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
JP2004505983A (ja) 2000-08-09 2004-02-26 アグーロン　ファーマシューティカルズ，インコーポレイテッド ピラゾール−チアゾール化合物、これらを含む医薬組成物、およびサイクリン依存性キナーゼの阻害のためのこれらの使用方法
ES2238463T3 (es) 2000-08-18 2005-09-01 Agouron Pharmaceuticals, Inc. Hidroxiimino-fluorenos heterociclicos y uso para inhibir proteina-quinasas.
DE60138140D1 (de) * 2000-10-31 2009-05-07 Aventis Pharma Inc Acyl- und sulfonylderivative 6,9-disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
GB2378180B8 (en) 2001-06-27 2009-10-21 Cyclacel Ltd New purine derivatives
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
EP1591112A4 (en) * 2003-02-04 2006-06-14 Yakult Honsha Kk INHIBITOR OF BREAST CANCER RESISTANT PROTEIN
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
JP5367563B2 (ja) * 2006-03-30 2013-12-11 ピーティーシー セラピューティクス，インコーポレーテッド ナンセンス突然変異を有するｄｎａからの機能的タンパク質の産生のための方法及びそれと関連した障害の治療
RU2681081C2 (ru) * 2007-10-05 2019-03-04 Верастэм, Инк. Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний
CN102241646B (zh) * 2010-05-14 2014-04-09 中国人民解放军军事医学科学院毒物药物研究所 己烯酮类化合物及其医药用途
WO2013130461A1 (en) 2012-02-29 2013-09-06 The Scripps Research Institute Wee1 degradation inhibitors
JPWO2015005491A1 (ja) * 2013-07-12 2017-03-02 国立大学法人京都大学 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
PL3244891T3 (pl) 2015-01-16 2022-12-27 The General Hospital Corporation Związki poprawiające splicing mRNA
CN107903274A (zh) * 2017-12-28 2018-04-13 窦玉玲 一种胺类化合物及其在抗肿瘤药物中的应用
EP3997089A4 (en) * 2019-07-21 2023-08-16 University Of Virginia Patent Foundation CYSTEINE BINDING COMPOSITIONS AND METHODS OF USE THEREOF
WO2024105159A1 (en) * 2022-11-16 2024-05-23 University Of Zurich Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
ES2196181T3 (es) * 1995-11-01 2003-12-16 Novartis Ag Derivados de purina y proceso para su preparacion.
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

Also Published As

Publication number Publication date
CA2320448A1 (en) 1999-09-02
ES2219038T3 (es) 2004-11-16
TW541308B (en) 2003-07-11
ATE269332T1 (de) 2004-07-15
SK12912000A3 (sk) 2001-08-06
AP2000001923A0 (en) 2000-09-30
AU3299099A (en) 1999-09-15
OA11480A (en) 2004-05-05
CA2320448C (en) 2005-02-01
TR200002482T2 (tr) 2002-10-21
EP1056745A2 (en) 2000-12-06
DE69918062D1 (de) 2004-07-22
DE69918062T2 (de) 2005-06-02
CZ20003106A3 (cs) 2000-12-13
SI1056745T1 (en) 2004-12-31
EP1056745B1 (en) 2004-06-16
KR20010041315A (ko) 2001-05-15
AR019822A1 (es) 2002-03-20
IL138044A0 (en) 2001-10-31
PT1056745E (pt) 2004-09-30
ZA991548B (en) 1999-08-26
BR9908325A (pt) 2000-11-07
EE200000501A (et) 2002-02-15
AU748178B2 (en) 2002-05-30
CN1291983A (zh) 2001-04-18
WO1999043676A3 (en) 1999-10-21
CN1128149C (zh) 2003-11-19
RU2191777C2 (ru) 2002-10-27
HUP0100931A2 (hu) 2002-04-29
IL138044A (en) 2006-04-10
HK1030948A1 (en) 2001-05-25
HUP0100931A3 (en) 2002-08-28
PL344021A1 (en) 2001-09-24
NZ506234A (en) 2003-05-30
EE04315B1 (et) 2004-06-15
CZ291604B6 (cs) 2003-04-16
WO1999043676A2 (en) 1999-09-02
NO20004281D0 (no) 2000-08-25
DK1056745T3 (da) 2004-10-25
UA62996C2 (en) 2004-01-15
KR100568658B1 (ko) 2006-04-07
JP2002504553A (ja) 2002-02-12
AP1258A (en) 2004-03-15

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