ATE426603T1 - Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel - Google Patents
Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittelInfo
- Publication number
- ATE426603T1 ATE426603T1 AT01987144T AT01987144T ATE426603T1 AT E426603 T1 ATE426603 T1 AT E426603T1 AT 01987144 T AT01987144 T AT 01987144T AT 01987144 T AT01987144 T AT 01987144T AT E426603 T1 ATE426603 T1 AT E426603T1
- Authority
- AT
- Austria
- Prior art keywords
- diaminocyclohexyl
- purines
- disubstituted
- acyl
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24456700P | 2000-10-31 | 2000-10-31 | |
| GBGB0117075.2A GB0117075D0 (en) | 2000-10-31 | 2001-07-13 | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE426603T1 true ATE426603T1 (de) | 2009-04-15 |
Family
ID=26246308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01987144T ATE426603T1 (de) | 2000-10-31 | 2001-10-31 | Acyl- und sulfonylderivative 6,9- disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1377579B1 (de) |
| JP (1) | JP4348081B2 (de) |
| AT (1) | ATE426603T1 (de) |
| AU (2) | AU2002239388B2 (de) |
| BR (1) | BR0115080A (de) |
| CA (1) | CA2427338C (de) |
| DE (1) | DE60138140D1 (de) |
| DK (1) | DK1377579T3 (de) |
| ES (1) | ES2324763T3 (de) |
| IL (1) | IL155590A0 (de) |
| MX (1) | MXPA03003774A (de) |
| NO (1) | NO20031939L (de) |
| NZ (1) | NZ525264A (de) |
| WO (1) | WO2002042303A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| FR2851248B1 (fr) * | 2003-02-18 | 2005-04-08 | Aventis Pharma Sa | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| KR20060021881A (ko) * | 2003-06-12 | 2006-03-08 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파제의 억제제로서의 사용을 위한 치환된피페리딘 카르바메이트 |
| US8389533B2 (en) * | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| EP2937345B1 (de) | 2009-12-29 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Typ-ii-raf-kinase-hemmer |
| EP3569598A1 (de) | 2011-11-17 | 2019-11-20 | Dana Farber Cancer Institute, Inc. | Inhibitoren der c-jun-n-terminal-kinase (jnk) |
| CN105849099B (zh) | 2013-10-18 | 2020-01-17 | 达纳-法伯癌症研究所股份有限公司 | 周期蛋白依赖性激酶7(cdk7)的多环抑制剂 |
| EP3236959A4 (de) | 2014-12-23 | 2018-04-25 | Dana Farber Cancer Institute, Inc. | Hemmer der cyclinabhängigen kinase 7 (cdk7) |
| WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| EP4019515A1 (de) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| AR119765A1 (es) | 2019-08-14 | 2022-01-12 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
| WO2021072232A1 (en) * | 2019-10-11 | 2021-04-15 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0100931A3 (en) * | 1998-02-26 | 2002-08-28 | Aventis Pharma Inc | 6,9-disubstituted 2-[trans-(-aminocyclohexyl)amino]purines and pharmaceutical compositions containing them |
| US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| FR2793794B1 (fr) * | 1999-05-21 | 2001-07-27 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| CA2394646A1 (en) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Novel purines |
| IL150594A0 (en) * | 2000-01-07 | 2003-02-12 | Ustav Ex Botan Adademie Ved Ce | Purine derivatives, process for their preparation and use |
-
2001
- 2001-10-31 DK DK01987144T patent/DK1377579T3/da active
- 2001-10-31 WO PCT/US2001/044835 patent/WO2002042303A2/en active Application Filing
- 2001-10-31 BR BR0115080-4A patent/BR0115080A/pt not_active Application Discontinuation
- 2001-10-31 CA CA002427338A patent/CA2427338C/en not_active Expired - Lifetime
- 2001-10-31 AU AU2002239388A patent/AU2002239388B2/en not_active Expired
- 2001-10-31 EP EP01987144A patent/EP1377579B1/de not_active Expired - Lifetime
- 2001-10-31 AU AU3938802A patent/AU3938802A/xx active Pending
- 2001-10-31 JP JP2002544437A patent/JP4348081B2/ja not_active Expired - Lifetime
- 2001-10-31 NZ NZ525264A patent/NZ525264A/en not_active IP Right Cessation
- 2001-10-31 MX MXPA03003774A patent/MXPA03003774A/es active IP Right Grant
- 2001-10-31 AT AT01987144T patent/ATE426603T1/de active
- 2001-10-31 ES ES01987144T patent/ES2324763T3/es not_active Expired - Lifetime
- 2001-10-31 DE DE60138140T patent/DE60138140D1/de not_active Expired - Lifetime
- 2001-10-31 IL IL15559001A patent/IL155590A0/xx unknown
-
2003
- 2003-04-29 NO NO20031939A patent/NO20031939L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2427338A1 (en) | 2002-05-30 |
| EP1377579B1 (de) | 2009-03-25 |
| WO2002042303A3 (en) | 2003-10-30 |
| AU2002239388B2 (en) | 2006-05-25 |
| CA2427338C (en) | 2008-06-10 |
| NZ525264A (en) | 2005-12-23 |
| JP4348081B2 (ja) | 2009-10-21 |
| NO20031939D0 (no) | 2003-04-29 |
| IL155590A0 (en) | 2003-11-23 |
| NO20031939L (no) | 2003-06-19 |
| MXPA03003774A (es) | 2003-07-28 |
| EP1377579A2 (de) | 2004-01-07 |
| DE60138140D1 (de) | 2009-05-07 |
| WO2002042303A2 (en) | 2002-05-30 |
| ES2324763T3 (es) | 2009-08-14 |
| AU3938802A (en) | 2002-06-03 |
| DK1377579T3 (da) | 2009-08-31 |
| BR0115080A (pt) | 2003-09-23 |
| JP2004517075A (ja) | 2004-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60138140D1 (de) | Acyl- und sulfonylderivative 6,9-disubstitutierter 2-(trans-1,4-diaminocyclohexyl)-purine und ihre verwendung als antiproliferative mittel | |
| DE69910831D1 (de) | Epothilonderivate und ihre verwendung als antitumormittel | |
| ATE297386T1 (de) | Biphenylderivate und ihre verwendung als aktivatoren des ppar-gamma-rezeptors | |
| CY1109484T1 (el) | Παραγωγα πυριμιδιν-5-ονης ως αναστολεις της ldl-pla2 | |
| BR0111981A (pt) | herbicidas de piridina substituìda | |
| DE59913617D1 (de) | Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4. | |
| NO20032181L (no) | Anvendelse av CCI-779 som et antineoplastisk middel | |
| ECSP045081A (es) | Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y trastornos relacionados | |
| CY1105836T1 (el) | 12, 13-τροποποιημενα παραγωγα εποθιλονης | |
| DE60136736D1 (de) | Pyrimidinonderivate und deren verwendung bei der behandlung von atherosklerose | |
| DE60133897D1 (de) | Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren | |
| ATE448238T1 (de) | 3-beta-d-ribofuranosylthiazolo(4,5- delta)pyridimin-nucleoside und ihre verwendung | |
| DK1254899T3 (da) | Piperazinderivater og deres anvendelse som anti-inflammatoriske midler | |
| ATE348805T1 (de) | 2-acyl-indolderivate und deren verwendung als antitumormittel | |
| DE60118155D1 (de) | 3-phenoxy-1-phenyl acetylenderivate und ihre verwendung als herbizide | |
| DE60100620D1 (de) | Gezielte elektrochemische reduktion von halogenierten 4-amino-picolinsäuren | |
| ATE259813T1 (de) | Triazolopyrimidinderivate | |
| AR028068A1 (es) | Nuevos derivados de 1,1-dioxotiocromano y su uso como inhibidores de trombina | |
| ATE343582T1 (de) | Derivate von (6, 7-dihydro -5h-imidazo(1,2 - a)imidazol -3 -sulfonylamino)-propionamid und deren verwendung als inhibitoren der interaktion von cams und leukointreginen | |
| ATE483714T1 (de) | Podophyllotoxine als antiproliferative mittel | |
| ATE260258T1 (de) | Substituierte isochinoline derivate und ihre verwendung als anticonvulsiva | |
| DE50313185D1 (de) | 2-pyrrolidin-2-yl-ä1,3,4ü -oxadiazol-derivate und ihre verwendung als antidepressiva | |
| TR199902807A2 (xx) | 2-(tio ikameli)tiazolo-$4,5-b]piridin bile�iklerinin pestisit ve parasitisel kullan�m�. | |
| DE29717551U1 (de) | Beutelgebinde, Beutelgebindesortiment und Produktpalette von Beuteln | |
| BR0316544A (pt) | Compostos calcilìticos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1377579 Country of ref document: EP |