AU2001277285A1 - Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases - Google Patents
Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinasesInfo
- Publication number
- AU2001277285A1 AU2001277285A1 AU2001277285A AU7728501A AU2001277285A1 AU 2001277285 A1 AU2001277285 A1 AU 2001277285A1 AU 2001277285 A AU2001277285 A AU 2001277285A AU 7728501 A AU7728501 A AU 7728501A AU 2001277285 A1 AU2001277285 A1 AU 2001277285A1
- Authority
- AU
- Australia
- Prior art keywords
- pyrazole
- methods
- pharmaceutical compositions
- compositions containing
- dependent kinases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22398900P | 2000-08-09 | 2000-08-09 | |
US60/223,989 | 2000-08-09 | ||
PCT/US2001/041466 WO2002012250A2 (en) | 2000-08-09 | 2001-07-31 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001277285A1 true AU2001277285A1 (en) | 2002-02-18 |
Family
ID=22838822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001277285A Abandoned AU2001277285A1 (en) | 2000-08-09 | 2001-07-31 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |
Country Status (15)
Country | Link |
---|---|
US (1) | US6566363B2 (en) |
EP (1) | EP1307462A2 (en) |
JP (1) | JP2004505983A (en) |
AR (1) | AR032763A1 (en) |
AU (1) | AU2001277285A1 (en) |
BR (1) | BR0113139A (en) |
CA (1) | CA2411928A1 (en) |
GT (1) | GT200100162A (en) |
HK (1) | HK1052354A1 (en) |
MX (1) | MXPA03001189A (en) |
MY (1) | MY117667A (en) |
PA (1) | PA8524801A1 (en) |
PE (1) | PE20020304A1 (en) |
UY (1) | UY26877A1 (en) |
WO (1) | WO2002012250A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
EP2221054A1 (en) * | 2002-04-30 | 2010-08-25 | Alcon, Inc. | CDK inhibitors for lowering intraocular pressure |
EP1616568A3 (en) * | 2002-04-30 | 2006-06-21 | Alcon, Inc | GSK-3 inhibitors and CDK inhibitors as anti-glaucoma agents |
US6818663B2 (en) * | 2002-05-17 | 2004-11-16 | Hoffmann-La Roches | Diaminothiazoles |
MXPA05008878A (en) * | 2003-02-21 | 2005-10-05 | Pfizer | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors. |
US7473783B2 (en) | 2003-12-17 | 2009-01-06 | Sgx Pharmaceuticals, Inc. | Bicyclic pyrazolo protein kinase modulators |
TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
AU2005228905A1 (en) * | 2004-03-31 | 2005-10-13 | Lexicon Pharmaceuticals, Inc. | Novel thiazolopyrazoles and methods of their use |
US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
FR2878442B1 (en) * | 2004-11-29 | 2008-10-24 | Aventis Pharma Sa | THIENO (2,3-c) SUBSTITUTED PYRAZOLES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
WO2007059341A2 (en) * | 2005-11-16 | 2007-05-24 | Sgx Pharmaceuticals, Inc. | Pyrazolothiazole protein kinase modulators |
CN101878219B (en) | 2007-09-27 | 2014-04-02 | 西班牙国家癌症研究中心 | Imidazolothiadiazoles for use as protein kinase inhibitors |
JP5490137B2 (en) * | 2008-12-19 | 2014-05-14 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Bicyclic pyrazoles as protein kinase inhibitors |
EP2414369B1 (en) * | 2009-04-02 | 2015-08-12 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Imidazo[2,1-b][1,3,4]thiadiazole derivatives |
DE102009058280A1 (en) * | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | thiazole |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2429195A1 (en) * | 1974-06-18 | 1976-02-05 | Basf Ag | 2-Amino-pyrazolo-(3,4-D)-thiazoles useful as dye inters - prepd. by ring-closing dehydrogenation of substd. pyrazolyl thioureas |
US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
US5631156A (en) | 1994-06-21 | 1997-05-20 | The University Of Michigan | DNA encoding and 18 KD CDK6 inhibiting protein |
ES2219670T3 (en) * | 1994-11-10 | 2004-12-01 | Millennium Pharmaceuticals, Inc. | USE OF PIRAZOLA COMPOUNDS FOR THE TREATMENT OF GLOMERULONEFRITIS, CANCER, ATEROSCLEROSIS OR RESTENOSIS. |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
US6495526B2 (en) | 1996-01-23 | 2002-12-17 | Gpc Biotech, Inc. | Inhibitors of cell-cycle progression and uses related thereto |
GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
US5849733A (en) | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
FR2752523B1 (en) * | 1996-08-26 | 1998-10-02 | Oreal | KERATINIC FIBER DYEING COMPOSITIONS CONTAINING PYRAZOLO- (3,4-D) -THIAZOLES THEIR USE FOR DYEING AS COUPLERS, DYEING METHOD |
GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
WO1998033798A2 (en) | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
AU744986B2 (en) | 1997-07-12 | 2002-03-07 | Cancer Research Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
JP2001518501A (en) * | 1997-10-06 | 2001-10-16 | ビーエーエスエフ アクチェンゲゼルシャフト | Indeno [1,2-c]-, naphtho [1,2-c]-and benzo [6,7] cyclohepta [1,2-c] pyrazole derivatives |
SK5212000A3 (en) * | 1997-10-27 | 2001-04-09 | Agouron Pharmaceuticals Inc Ag | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
SK12912000A3 (en) | 1998-02-26 | 2001-08-06 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino]purines |
BR9909597A (en) * | 1998-04-21 | 2001-10-02 | Du Pont Pharm Co | Compound, pharmaceutical composition and method of treating cancer and proliferative diseases |
UA60365C2 (en) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Isothiazole derivatives, a method for preparing thereof, a pharmaceutical composition and a method for treatment of hyperproliferative disease of mammal |
-
2001
- 2001-07-31 AU AU2001277285A patent/AU2001277285A1/en not_active Abandoned
- 2001-07-31 EP EP01955084A patent/EP1307462A2/en not_active Withdrawn
- 2001-07-31 MX MXPA03001189A patent/MXPA03001189A/en active IP Right Grant
- 2001-07-31 BR BR0113139-7A patent/BR0113139A/en not_active IP Right Cessation
- 2001-07-31 JP JP2002518225A patent/JP2004505983A/en not_active Withdrawn
- 2001-07-31 WO PCT/US2001/041466 patent/WO2002012250A2/en active Application Filing
- 2001-07-31 CA CA002411928A patent/CA2411928A1/en not_active Abandoned
- 2001-08-02 MY MYPI20013638A patent/MY117667A/en unknown
- 2001-08-03 PE PE2001000774A patent/PE20020304A1/en not_active Application Discontinuation
- 2001-08-08 GT GT200100162A patent/GT200100162A/en unknown
- 2001-08-08 US US09/923,432 patent/US6566363B2/en not_active Expired - Fee Related
- 2001-08-08 UY UY26877A patent/UY26877A1/en not_active Application Discontinuation
- 2001-08-09 PA PA20018524801A patent/PA8524801A1/en unknown
- 2001-08-09 AR ARP010103827A patent/AR032763A1/en unknown
-
2003
- 2003-07-02 HK HK03104680.4A patent/HK1052354A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
GT200100162A (en) | 2002-05-16 |
CA2411928A1 (en) | 2002-02-14 |
HK1052354A1 (en) | 2003-09-11 |
WO2002012250A3 (en) | 2002-09-06 |
WO2002012250A2 (en) | 2002-02-14 |
MXPA03001189A (en) | 2004-05-14 |
EP1307462A2 (en) | 2003-05-07 |
WO2002012250B1 (en) | 2002-11-21 |
MY117667A (en) | 2004-07-31 |
UY26877A1 (en) | 2002-03-22 |
PE20020304A1 (en) | 2002-05-29 |
US6566363B2 (en) | 2003-05-20 |
US20020049215A1 (en) | 2002-04-25 |
BR0113139A (en) | 2003-06-24 |
AR032763A1 (en) | 2003-11-26 |
JP2004505983A (en) | 2004-02-26 |
PA8524801A1 (en) | 2002-04-25 |
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AU2001277285A1 (en) | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |