BR0002265A - Inibidores da metaloprotease, um processo para seu preparo e composições farmacêuticas contendo os mesmos - Google Patents
Inibidores da metaloprotease, um processo para seu preparo e composições farmacêuticas contendo os mesmosInfo
- Publication number
- BR0002265A BR0002265A BR0002265-9A BR0002265A BR0002265A BR 0002265 A BR0002265 A BR 0002265A BR 0002265 A BR0002265 A BR 0002265A BR 0002265 A BR0002265 A BR 0002265A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- preparation
- pharmaceutical compositions
- compositions containing
- same
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Patente de Invenção: <B>''INIBIDORES DA METALOPROTEASE, UM PROCESSO PARA SEU PREPARO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS''<D>. Compostos da fórmula (I): em que: R~ 1~ representa um átomo de hidrogênio ou halogênio ou um grupo alquila ou alcóxi, R~ 2~ representa um grupo hidróxi, alcóxi ou -NHOH, Ar~ 1~ representa um grupo fenileno ou bifenileno, X representa um átomo de oxigênio ou enxofre, um grupo NR, um grupo -C<154>C- ou uma ligação, R representa um átomo de hidrogênio ou um grupo alquila, n é um número inteiro de 0 a 6 inclusive, Ar~ 2~ representa qualquer um dos grupos definidos na descrição, seus isómeros e sais de adição dos mesmos com um ácido ou base farmaceuticamente aceitável.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9908448A FR2795730B1 (fr) | 1999-07-01 | 1999-07-01 | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0002265A true BR0002265A (pt) | 2001-03-13 |
Family
ID=9547562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0002265-9A BR0002265A (pt) | 1999-07-01 | 2000-07-03 | Inibidores da metaloprotease, um processo para seu preparo e composições farmacêuticas contendo os mesmos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6339092B1 (pt) |
| EP (1) | EP1065209B1 (pt) |
| JP (1) | JP3330583B2 (pt) |
| KR (1) | KR100472521B1 (pt) |
| CN (1) | CN1147492C (pt) |
| AT (1) | ATE239021T1 (pt) |
| AU (1) | AU770168B2 (pt) |
| BR (1) | BR0002265A (pt) |
| CA (1) | CA2313302C (pt) |
| DE (1) | DE60002395T2 (pt) |
| DK (1) | DK1065209T3 (pt) |
| EA (1) | EA002527B1 (pt) |
| ES (1) | ES2198262T3 (pt) |
| FR (1) | FR2795730B1 (pt) |
| HK (1) | HK1034968A1 (pt) |
| HU (1) | HUP0002554A3 (pt) |
| NO (1) | NO20003431L (pt) |
| NZ (1) | NZ505522A (pt) |
| PL (1) | PL341134A1 (pt) |
| PT (1) | PT1065209E (pt) |
| SI (1) | SI1065209T1 (pt) |
| ZA (1) | ZA200003310B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770647B2 (en) * | 2001-08-17 | 2004-08-03 | Bristol-Myers Squibb Pharma Company | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| DE102005002500A1 (de) * | 2005-01-19 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen |
| WO2009086138A1 (en) * | 2007-12-21 | 2009-07-09 | Wyeth | Benzimidazole compounds |
| KR100962022B1 (ko) | 2010-01-12 | 2010-06-08 | (주) 유니크코리아엔아이 | 정전용량형 압력센서 및 그 제조방법 |
| CN105189515B (zh) * | 2013-03-14 | 2018-07-03 | 葛兰素史克知识产权第二有限公司 | 作为溴结构域抑制剂的呋喃并吡啶类 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
| CA2297988A1 (en) * | 1997-08-04 | 1999-02-11 | Amgen Inc. | Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors |
-
1999
- 1999-07-01 FR FR9908448A patent/FR2795730B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-28 KR KR10-2000-0035946A patent/KR100472521B1/ko not_active IP Right Cessation
- 2000-06-29 JP JP2000195536A patent/JP3330583B2/ja not_active Expired - Fee Related
- 2000-06-30 PL PL00341134A patent/PL341134A1/xx not_active Application Discontinuation
- 2000-06-30 AU AU43784/00A patent/AU770168B2/en not_active Ceased
- 2000-06-30 ZA ZA200003310A patent/ZA200003310B/xx unknown
- 2000-06-30 CN CNB001199099A patent/CN1147492C/zh not_active Expired - Fee Related
- 2000-06-30 US US09/608,240 patent/US6339092B1/en not_active Expired - Fee Related
- 2000-06-30 PT PT00401864T patent/PT1065209E/pt unknown
- 2000-06-30 NO NO20003431A patent/NO20003431L/no not_active Application Discontinuation
- 2000-06-30 ES ES00401864T patent/ES2198262T3/es not_active Expired - Lifetime
- 2000-06-30 HU HU0002554A patent/HUP0002554A3/hu unknown
- 2000-06-30 CA CA002313302A patent/CA2313302C/fr not_active Expired - Fee Related
- 2000-06-30 DK DK00401864T patent/DK1065209T3/da active
- 2000-06-30 DE DE60002395T patent/DE60002395T2/de not_active Expired - Fee Related
- 2000-06-30 NZ NZ505522A patent/NZ505522A/en unknown
- 2000-06-30 AT AT00401864T patent/ATE239021T1/de not_active IP Right Cessation
- 2000-06-30 EA EA200000598A patent/EA002527B1/ru not_active IP Right Cessation
- 2000-06-30 SI SI200030088T patent/SI1065209T1/xx unknown
- 2000-06-30 EP EP00401864A patent/EP1065209B1/fr not_active Expired - Lifetime
- 2000-07-03 BR BR0002265-9A patent/BR0002265A/pt not_active IP Right Cessation
-
2001
- 2001-08-15 HK HK01105716A patent/HK1034968A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1065209T1 (en) | 2003-08-31 |
| US6339092B1 (en) | 2002-01-15 |
| CA2313302A1 (fr) | 2001-01-01 |
| CA2313302C (fr) | 2004-06-15 |
| EA200000598A1 (ru) | 2001-02-26 |
| AU770168B2 (en) | 2004-02-12 |
| NZ505522A (en) | 2001-12-21 |
| DK1065209T3 (da) | 2003-08-25 |
| EP1065209A1 (fr) | 2001-01-03 |
| NO20003431L (no) | 2001-01-02 |
| HK1034968A1 (en) | 2001-11-09 |
| PL341134A1 (en) | 2001-01-02 |
| CN1147492C (zh) | 2004-04-28 |
| DE60002395D1 (de) | 2003-06-05 |
| ES2198262T3 (es) | 2004-02-01 |
| JP2001039983A (ja) | 2001-02-13 |
| FR2795730A1 (fr) | 2001-01-05 |
| AU4378400A (en) | 2001-01-04 |
| DE60002395T2 (de) | 2004-04-08 |
| EP1065209B1 (fr) | 2003-05-02 |
| NO20003431D0 (no) | 2000-06-30 |
| PT1065209E (pt) | 2003-08-29 |
| FR2795730B1 (fr) | 2001-08-31 |
| ZA200003310B (en) | 2001-01-25 |
| JP3330583B2 (ja) | 2002-09-30 |
| CN1290703A (zh) | 2001-04-11 |
| HU0002554D0 (en) | 2000-08-28 |
| EA002527B1 (ru) | 2002-06-27 |
| HUP0002554A2 (hu) | 2002-04-29 |
| ATE239021T1 (de) | 2003-05-15 |
| KR20010039689A (ko) | 2001-05-15 |
| HUP0002554A3 (en) | 2002-12-28 |
| KR100472521B1 (ko) | 2005-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9913592A (pt) | Compostos, processo de preparação dos compostos, e, composições farmacêuticas | |
| BR0210297A (pt) | Derivados de n-arilfenilacetamida e composição farmacêutcia contendo os mesmos | |
| BR9911771A (pt) | Compostos cìclicos substituìdos, um processo para sua preparação e composições farmacêuticas que contêm os mesmos | |
| PT1058683E (pt) | Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao | |
| BRPI0016395B8 (pt) | derivados de adamantano | |
| BR0108893A (pt) | Composição farmacêutica, composto e processo de preparação de compostos | |
| BR0316386A (pt) | Benzoxazin-3-onas e seus derivados como inibidores de p13k | |
| BRPI0015203B8 (pt) | derivado de quinazolina, composição farmacêutica, e, uso de um composto | |
| BR9908325A (pt) | 6 9-dissubstituìdo 2-[trans-4(4-aminociclohexil)amino]purinas | |
| BR0208489A (pt) | Derivados de n-(arilsulfonil) beta-aminoácidos, comportando um grupo aminoetilado substituìdo, o respectivo processo de preparação e as composições farmacêuticas que os contêm | |
| BR9911274A (pt) | Derivados da artemisinina, seus processos de preparação e as composições farmacêuticas que os contêm | |
| BR9802804A (pt) | Compostos benzimidazol, benzoxazol e benzotiazol, processo para sua preparação e composições farmacéuticas contendo os mesmos. | |
| BR9813124A (pt) | Compostos indol 2,3-substituìdos como inibidores cox-2 | |
| BR0003848A (pt) | Compostos de piridina, processo para sua preparação e composições farmacêuticas que os contêm | |
| BR0104471A (pt) | Compostos de ciclobutenodiona, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os mesmos | |
| BR0100234A (pt) | Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos | |
| BR0308765A (pt) | Compostos (4,2-dissubstituìdo-tiazol-5-il)amina como inibidores de pde7 | |
| BR0011282A (pt) | Derivados da purina, seu processo de preparo e composiçoes farmacêuticas que as contêm | |
| BR0106248A (pt) | Inibidores de metaloprotease, processo para a sua preparação e composições farmacêuticas contendo os mesmos | |
| BR0002265A (pt) | Inibidores da metaloprotease, um processo para seu preparo e composições farmacêuticas contendo os mesmos | |
| HRP20060023A2 (en) | Use of bicyclo[2.2.1]heptane derivatives for the preparation of neuroprotective pharmaceutical compositions | |
| BR0004823A (pt) | Compostos policìclicos de azaindol, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos | |
| UY24697A1 (es) | Metodos para producir inhibidores de vih-proteasa y productos intermedios para producir inhibidores de vih-proteasa | |
| BR0308807A (pt) | Compostos tiazol-2-il-imina como inibidores de pde-7 | |
| BR9903867A (pt) | Compsto de indan-1-ol, processo para seu preparo e compostos farmacêuticos contento os mesmo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: LES LABORATOIRES SERVIER (FR) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009. |