NO20004281L - 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament - Google Patents
6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikamentInfo
- Publication number
- NO20004281L NO20004281L NO20004281A NO20004281A NO20004281L NO 20004281 L NO20004281 L NO 20004281L NO 20004281 A NO20004281 A NO 20004281A NO 20004281 A NO20004281 A NO 20004281A NO 20004281 L NO20004281 L NO 20004281L
- Authority
- NO
- Norway
- Prior art keywords
- present
- provides
- group
- alkyl
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 6,9-disubstituted 2- [trans- (4-aminocyclohexyl) amino] purines Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091007914 CDKs Proteins 0.000 abstract 1
- 101100439046 Caenorhabditis elegans cdk-2 gene Proteins 0.000 abstract 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000006369 cell cycle progression Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3238198A | 1998-02-26 | 1998-02-26 | |
| PCT/US1999/003451 WO1999043676A2 (en) | 1998-02-26 | 1999-02-18 | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004281D0 NO20004281D0 (no) | 2000-08-25 |
| NO20004281L true NO20004281L (no) | 2000-10-18 |
Family
ID=21864658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004281A NO20004281L (no) | 1998-02-26 | 2000-08-25 | 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1056745B1 (de) |
| JP (1) | JP2002504553A (de) |
| KR (1) | KR100568658B1 (de) |
| CN (1) | CN1128149C (de) |
| AP (1) | AP1258A (de) |
| AR (1) | AR019822A1 (de) |
| AT (1) | ATE269332T1 (de) |
| AU (1) | AU748178B2 (de) |
| BR (1) | BR9908325A (de) |
| CA (1) | CA2320448C (de) |
| CZ (1) | CZ291604B6 (de) |
| DE (1) | DE69918062T2 (de) |
| DK (1) | DK1056745T3 (de) |
| EE (1) | EE04315B1 (de) |
| ES (1) | ES2219038T3 (de) |
| HU (1) | HUP0100931A3 (de) |
| IL (2) | IL138044A0 (de) |
| NO (1) | NO20004281L (de) |
| NZ (1) | NZ506234A (de) |
| OA (1) | OA11480A (de) |
| PL (1) | PL344021A1 (de) |
| PT (1) | PT1056745E (de) |
| RU (1) | RU2191777C2 (de) |
| SI (1) | SI1056745T1 (de) |
| SK (1) | SK12912000A3 (de) |
| TR (1) | TR200002482T2 (de) |
| TW (1) | TW541308B (de) |
| UA (1) | UA62996C2 (de) |
| WO (1) | WO1999043676A2 (de) |
| ZA (1) | ZA991548B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6627633B2 (en) | 1999-03-17 | 2003-09-30 | Albany Molecular Research, Inc. | 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents |
| US6969720B2 (en) | 1999-03-17 | 2005-11-29 | Amr Technology, Inc. | Biaryl substituted purine derivatives as potent antiproliferative agents |
| DE60118521T2 (de) * | 2000-01-07 | 2006-10-12 | Universitaire Instelling Antwerpen | Purin derivate, ihre herstellung und verwendung |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
| WO2001079198A1 (en) | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
| BR0113139A (pt) | 2000-08-09 | 2003-06-24 | Agouron Pharma | Compostos, seus sais, formas multiméricas, pró-drogas ou metabólitos, composições farmacêuticas, método de tratamento de uma doença ou disfunção mediana através da inibição de cdk4 ou um complexo de cdk4/ciclina, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase e método de modulação ou inibição da atividade de um receptor de proteìna cinase |
| DE60110802T2 (de) | 2000-08-18 | 2005-10-06 | Agouron Pharmaceuticals, Inc., San Diego | Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen |
| DK1377579T3 (da) * | 2000-10-31 | 2009-08-31 | Aventis Pharma Inc | Acyl- og sulfonylderivater af 6,9-disubstitueret-2(trans-1,4-diaminocyklohexyl)puriner og deres anvendelse som antiproliferative midler |
| GB0117075D0 (en) * | 2000-10-31 | 2001-09-05 | Aventis Pharm Prod Inc | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| GB2378180B8 (en) | 2001-06-27 | 2009-10-21 | Cyclacel Ltd | New purine derivatives |
| US6812232B2 (en) | 2001-09-11 | 2004-11-02 | Amr Technology, Inc. | Heterocycle substituted purine derivatives as potent antiproliferative agents |
| US6667311B2 (en) | 2001-09-11 | 2003-12-23 | Albany Molecular Research, Inc. | Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents |
| GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| WO2004069233A1 (ja) * | 2003-02-04 | 2004-08-19 | Kabushiki Kaisha Yakult Honsha | 乳癌耐性蛋白阻害剤 |
| US7211576B2 (en) | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| JP5367563B2 (ja) * | 2006-03-30 | 2013-12-11 | ピーティーシー セラピューティクス，インコーポレーテッド | ナンセンス突然変異を有するｄｎａからの機能的タンパク質の産生のための方法及びそれと関連した障害の治療 |
| RU2681081C2 (ru) * | 2007-10-05 | 2019-03-04 | Верастэм, Инк. | Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний |
| CN102241646B (zh) * | 2010-05-14 | 2014-04-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 己烯酮类化合物及其医药用途 |
| WO2013130461A1 (en) | 2012-02-29 | 2013-09-06 | The Scripps Research Institute | Wee1 degradation inhibitors |
| WO2015005491A1 (ja) * | 2013-07-12 | 2015-01-15 | 国立大学法人京都大学 | 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法 |
| PT3244891T (pt) | 2015-01-16 | 2022-10-20 | Massachusetts Gen Hospital | Compostos para melhorar o splicing do arnm |
| CN107903274A (zh) * | 2017-12-28 | 2018-04-13 | 窦玉玲 | 一种胺类化合物及其在抗肿瘤药物中的应用 |
| WO2021016263A1 (en) * | 2019-07-21 | 2021-01-28 | University Of Virginia Patent Foundation | Cysteine binding compositions and methods of use thereof |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
| GB9414208D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
| BR9611157A (pt) * | 1995-11-01 | 1999-03-30 | Novartis Ag | Derivados de purina e processos para sua preparação |
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
-
1999
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en not_active Ceased
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 EE EEP200000501A patent/EE04315B1/xx not_active IP Right Cessation
- 1999-02-18 EP EP99936074A patent/EP1056745B1/de not_active Expired - Lifetime
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
- 1999-02-18 CZ CZ20003106A patent/CZ291604B6/cs not_active IP Right Cessation
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active Expired - Fee Related
- 1999-02-18 HU HU0100931A patent/HUP0100931A3/hu unknown
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
-
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20004281L (no) | 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament | |
| CA2320474A1 (en) | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines | |
| DK1406876T3 (da) | 2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser | |
| NO20061660L (no) | 2-pyridonderivate som neutrofil elasaeinhibitor og deres anvendelse | |
| NO20045099L (no) | Peptid-derivater omfattende tiazepingruppen for behandling av hyperlipidemiske tilstander | |
| NO20061700L (no) | 2-pyridonderivater som neutrofil elastase inhibitorer og deres anvendelse | |
| NO20063931L (no) | Nye sammensetninger inneholdende kinolinforbindelser | |
| NO20044599L (no) | 3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem | |
| NO20043851L (no) | Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet | |
| NO20062692L (no) | Heterosykliske MEK inhibitorer og fremgangsmater for anvendelse derav | |
| NO992524L (no) | Konsenserte bicykliske pyrimidin-derivater | |
| NO20063231L (no) | Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer | |
| NO983493L (no) | Nye benzimidazol-, benzoksazol- og benzotiazolforbindelser, fremgangsmÕte ved fremstilling derav og farmas°ytiske sammensetninger inneholdende slike | |
| NO20053133L (no) | Kjemiske forbindelser. | |
| NO994900L (no) | Forbindelser | |
| NO160297C (no) | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oksoazetidinderivater | |
| NO20023001L (no) | Substituerte piperazinderivater som MTP inhibitorer | |
| NO982072D0 (no) | Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase | |
| NO20026081L (no) | Nye forbindelser | |
| NO20045132L (no) | Benzo(c)kinolizinderivater, deres fremstilling og anvendelse som 5alfa- reduktaseinhibitorer | |
| NO992731L (no) | Nye substituerte tetrahydropyridinforbindelser, fremgangsmÕte ved fremstilling av dem og farmas°ytiske sammensetninger derav | |
| SE0202461D0 (sv) | Novel compounds | |
| TR199902720T2 (xx) | Nitrik oksit sentaz�n�n inhibit�rleri olarak amidin t�revleri. | |
| NO20041761L (no) | Nye hydroksyalkylindolokarbazolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem | |
| NO973341L (no) | Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for vasodilatorisk behandling eller profylakse |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |