SI1056745T1 - 6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines - Google Patents

6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines

Info

Publication number
SI1056745T1
SI1056745T1 SI9930621T SI9930621T SI1056745T1 SI 1056745 T1 SI1056745 T1 SI 1056745T1 SI 9930621 T SI9930621 T SI 9930621T SI 9930621 T SI9930621 T SI 9930621T SI 1056745 T1 SI1056745 T1 SI 1056745T1
Authority
SI
Slovenia
Prior art keywords
aminocyclohexyl
purines
disubstituted
trans
amino
Prior art date
Application number
SI9930621T
Other languages
English (en)
Slovenian (sl)
Inventor
Jennifer A. Dumont
Alan J. Bitonti
David R. Borcherding
Norton P. Peet
H. Randall Munson
Patrick W. K. Shum
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SI1056745T1 publication Critical patent/SI1056745T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9930621T 1998-02-26 1999-02-18 6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines SI1056745T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3238198A 1998-02-26 1998-02-26
EP99936074A EP1056745B1 (de) 1998-02-26 1999-02-18 6,9-disubstituierte 2-(trans-(4-aminocyclohexyl)amino)purine
PCT/US1999/003451 WO1999043676A2 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number Publication Date
SI1056745T1 true SI1056745T1 (en) 2004-12-31

Family

ID=21864658

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930621T SI1056745T1 (en) 1998-02-26 1999-02-18 6,9-disubstituted 2- trans-(4- aminocyclohexyl) amino)purines

Country Status (31)

Country Link
EP (1) EP1056745B1 (de)
JP (1) JP2002504553A (de)
KR (1) KR100568658B1 (de)
CN (1) CN1128149C (de)
AP (1) AP1258A (de)
AR (1) AR019822A1 (de)
AT (1) ATE269332T1 (de)
AU (1) AU748178B2 (de)
BR (1) BR9908325A (de)
CA (1) CA2320448C (de)
CZ (1) CZ291604B6 (de)
DE (1) DE69918062T2 (de)
DK (1) DK1056745T3 (de)
EE (1) EE04315B1 (de)
ES (1) ES2219038T3 (de)
HK (1) HK1030948A1 (de)
HU (1) HUP0100931A3 (de)
IL (2) IL138044A0 (de)
NO (1) NO20004281L (de)
NZ (1) NZ506234A (de)
OA (1) OA11480A (de)
PL (1) PL344021A1 (de)
PT (1) PT1056745E (de)
RU (1) RU2191777C2 (de)
SI (1) SI1056745T1 (de)
SK (1) SK12912000A3 (de)
TR (1) TR200002482T2 (de)
TW (1) TW541308B (de)
UA (1) UA62996C2 (de)
WO (1) WO1999043676A2 (de)
ZA (1) ZA991548B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
US6627633B2 (en) 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
CZ20022353A3 (cs) * 2000-01-07 2003-02-12 Universitaire Instelling Antwerpen Deriváty purinu, způsob jejich přípravy a jejich použití
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
WO2002012250A2 (en) 2000-08-09 2002-02-14 Agouron Pharmaceuticals, Inc. Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases
AU2001279090A1 (en) 2000-08-18 2002-03-04 Agouron Pharmaceuticals, Inc. Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
CA2427338C (en) * 2000-10-31 2008-06-10 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
ATE301123T1 (de) 2001-06-27 2005-08-15 Cyclacel Ltd 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0219052D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New puring derivatives
GB0219054D0 (en) 2002-08-15 2002-09-25 Cyclacel Ltd New purine derivatives
EP1591112A4 (de) * 2003-02-04 2006-06-14 Yakult Honsha Kk Brustkrebsresistenter proteinhemmer
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
EP2007365A2 (de) * 2006-03-30 2008-12-31 PTC Therapeutics, Inc. Verfahren zur produktion von funktionellem protein aus dna mit nonsense-mutation und behandlung von damit assoziierten erkrankungen
KR101701109B1 (ko) * 2007-10-05 2017-02-13 베라스템, 인코포레이티드 피리미딘 치환된 퓨린 유도체
CN102241646B (zh) * 2010-05-14 2014-04-09 中国人民解放军军事医学科学院毒物药物研究所 己烯酮类化合物及其医药用途
US9493464B2 (en) 2012-02-29 2016-11-15 The Scripps Research Institute Wee1 degradation inhibitors
EP3020829B1 (de) * 2013-07-12 2021-11-17 Kyoto University Pharmazeutische zusammensetzung zur hemmung von abnormalem spleissen als ursache des ausbruchs oder der progression einer genetischen erkrankung
PT3244891T (pt) 2015-01-16 2022-10-20 Massachusetts Gen Hospital Compostos para melhorar o splicing do arnm
CN107903274A (zh) * 2017-12-28 2018-04-13 窦玉玲 一种胺类化合物及其在抗肿瘤药物中的应用
EP3997089A4 (de) * 2019-07-21 2023-08-16 University Of Virginia Patent Foundation Cysteinbindende zusammensetzungen und verfahren zu deren verwendung
WO2024105159A1 (en) * 2022-11-16 2024-05-23 University Of Zurich Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
EP0874846B1 (de) * 1995-11-01 2003-04-02 Novartis AG Purinderivate und verfahren zu ihrer herstellung
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

Also Published As

Publication number Publication date
AP2000001923A0 (en) 2000-09-30
NZ506234A (en) 2003-05-30
KR20010041315A (ko) 2001-05-15
WO1999043676A3 (en) 1999-10-21
ZA991548B (en) 1999-08-26
TR200002482T2 (tr) 2002-10-21
EP1056745B1 (de) 2004-06-16
DE69918062T2 (de) 2005-06-02
WO1999043676A2 (en) 1999-09-02
NO20004281D0 (no) 2000-08-25
EE04315B1 (et) 2004-06-15
PL344021A1 (en) 2001-09-24
AU3299099A (en) 1999-09-15
PT1056745E (pt) 2004-09-30
NO20004281L (no) 2000-10-18
AU748178B2 (en) 2002-05-30
BR9908325A (pt) 2000-11-07
ES2219038T3 (es) 2004-11-16
DK1056745T3 (da) 2004-10-25
SK12912000A3 (sk) 2001-08-06
CZ291604B6 (cs) 2003-04-16
CA2320448A1 (en) 1999-09-02
CN1291983A (zh) 2001-04-18
CZ20003106A3 (cs) 2000-12-13
UA62996C2 (en) 2004-01-15
AR019822A1 (es) 2002-03-20
IL138044A (en) 2006-04-10
KR100568658B1 (ko) 2006-04-07
CA2320448C (en) 2005-02-01
TW541308B (en) 2003-07-11
CN1128149C (zh) 2003-11-19
RU2191777C2 (ru) 2002-10-27
IL138044A0 (en) 2001-10-31
EE200000501A (et) 2002-02-15
ATE269332T1 (de) 2004-07-15
HUP0100931A3 (en) 2002-08-28
EP1056745A2 (de) 2000-12-06
JP2002504553A (ja) 2002-02-12
HK1030948A1 (en) 2001-05-25
HUP0100931A2 (hu) 2002-04-29
AP1258A (en) 2004-03-15
DE69918062D1 (de) 2004-07-22
OA11480A (en) 2004-05-05

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