UA62930C2 - Быстрорастворимые таблетки, содержащие галантаминовую соль бромистоводородной кислоты, и способ их изготовления - Google Patents
Быстрорастворимые таблетки, содержащие галантаминовую соль бромистоводородной кислоты, и способ их изготовления Download PDFInfo
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- UA62930C2 UA62930C2 UA98126372A UA98126372A UA62930C2 UA 62930 C2 UA62930 C2 UA 62930C2 UA 98126372 A UA98126372 A UA 98126372A UA 98126372 A UA98126372 A UA 98126372A UA 62930 C2 UA62930 C2 UA 62930C2
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- 238000004519 manufacturing process Methods 0.000 title claims description 18
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract description 28
- 229960003980 galantamine Drugs 0.000 title abstract description 15
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- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims abstract description 12
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- QORVDGQLPPAFRS-XPSHAMGMSA-N galantamine hydrobromide Chemical compound Br.O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 QORVDGQLPPAFRS-XPSHAMGMSA-N 0.000 claims description 25
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- 229920002472 Starch Polymers 0.000 description 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
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- Addiction (AREA)
- Psychiatry (AREA)
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- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретение относится к быстрорастворимым таблеткам для внутреннего применения, содержащим терапевтически эффективное количество гидробромида галантамина (1:1) в качестве действующего ингредиента и фармацевтически приемлемую основу. Характерная особенность основы заключается в том, что в ее состав входит высушенная распылением смесь моногидрата лактозы и микрокристаллической целлюлозы (75:25) в качестве растворителя та дезинтегрирующего агента. Кроме того, в изобретении представлены способы изготовления быстрорастворимых таблеток методом прямого прессования.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201676 | 1996-06-14 | ||
| PCT/EP1997/002986 WO1997047304A1 (en) | 1996-06-14 | 1997-06-06 | Fast-dissolving galanthamine hydrobromide tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA62930C2 true UA62930C2 (ru) | 2004-01-15 |
Family
ID=8224084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98126372A UA62930C2 (ru) | 1996-06-14 | 1997-06-06 | Быстрорастворимые таблетки, содержащие галантаминовую соль бромистоводородной кислоты, и способ их изготовления |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US6099863A (ru) |
| EP (1) | EP0915701B1 (ru) |
| JP (1) | JP4172820B2 (ru) |
| KR (1) | KR100358676B1 (ru) |
| CN (1) | CN1102390C (ru) |
| AR (2) | AR008237A1 (ru) |
| AT (1) | ATE285777T1 (ru) |
| AU (1) | AU726212B2 (ru) |
| BG (1) | BG64168B1 (ru) |
| BR (1) | BR9709729A (ru) |
| CA (1) | CA2257431C (ru) |
| CZ (1) | CZ295226B6 (ru) |
| DE (1) | DE69732113T2 (ru) |
| DK (1) | DK0915701T3 (ru) |
| EA (1) | EA001193B1 (ru) |
| EE (1) | EE03337B1 (ru) |
| ES (1) | ES2235234T3 (ru) |
| HK (1) | HK1019703A1 (ru) |
| HR (1) | HRP970321B1 (ru) |
| ID (1) | ID17088A (ru) |
| IL (1) | IL127519A (ru) |
| MY (1) | MY121669A (ru) |
| NO (1) | NO322892B1 (ru) |
| NZ (1) | NZ333280A (ru) |
| PL (1) | PL189329B1 (ru) |
| PT (1) | PT915701E (ru) |
| SI (1) | SI0915701T1 (ru) |
| SK (1) | SK284620B6 (ru) |
| TR (1) | TR199802592T2 (ru) |
| TW (1) | TW506836B (ru) |
| UA (1) | UA62930C2 (ru) |
| WO (1) | WO1997047304A1 (ru) |
| ZA (1) | ZA975281B (ru) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| TW506836B (en) * | 1996-06-14 | 2002-10-21 | Janssen Pharmaceutica Nv | Fast-dissolving galanthamine hydrobromide tablet |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| WO2000038686A1 (en) * | 1998-12-24 | 2000-07-06 | Janssen Pharmaceutica N.V. | Controlled release galantamine composition |
| US20050063998A1 (en) * | 1999-10-26 | 2005-03-24 | Francois Marc Karel Jozef | Oral solution containing galantamine and a sweetening agent |
| US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
| AU5702201A (en) * | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US6500454B1 (en) * | 2001-10-04 | 2002-12-31 | Eurand Pharmaceuticals Ltd. | Timed, sustained release systems for propranolol |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| DE10235556A1 (de) * | 2002-08-03 | 2004-02-19 | Hf Arzneimittelforschung Gmbh | Medikament und Verfahren zur Verringerung des Alkohol- und/oder Tabakkonsums |
| US20040097484A1 (en) * | 2002-11-14 | 2004-05-20 | Marc Cantillion | Once a day galantamine pharmaceutical compositions and methods of use |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
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| DE3506276C1 (de) * | 1985-02-22 | 1986-04-24 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Direkttablettiermittel |
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1997
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