UA59371C2 - Проміжні сполуки та спосіб одержання оланзапіну, фармацевтична композиція - Google Patents

Проміжні сполуки та спосіб одержання оланзапіну, фармацевтична композиція Download PDF

Info

Publication number
UA59371C2
UA59371C2 UA99031635A UA99031635A UA59371C2 UA 59371 C2 UA59371 C2 UA 59371C2 UA 99031635 A UA99031635 A UA 99031635A UA 99031635 A UA99031635 A UA 99031635A UA 59371 C2 UA59371 C2 UA 59371C2
Authority
UA
Ukraine
Prior art keywords
dihydrate
olanzapine
powder
ray pattern
pure
Prior art date
Application number
UA99031635A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Чарльз Артур Баннелл
Семюель Дін ЛАРСЕН
Джон Р. Ніколз
Сюзан Марія Рутцель
Грегорі А. Стефенсон
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA59371(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA59371C2 publication Critical patent/UA59371C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
UA99031635A 1996-09-23 1997-09-18 Проміжні сполуки та спосіб одержання оланзапіну, фармацевтична композиція UA59371C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23
PCT/US1997/016499 WO1998012199A1 (en) 1996-09-23 1997-09-18 Intermediates and process for preparing olanzapine

Publications (1)

Publication Number Publication Date
UA59371C2 true UA59371C2 (uk) 2003-09-15

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99031635A UA59371C2 (uk) 1996-09-23 1997-09-18 Проміжні сполуки та спосіб одержання оланзапіну, фармацевтична композиція

Country Status (35)

Country Link
US (1) US6020487A (OSRAM)
EP (1) EP0831098B1 (OSRAM)
JP (2) JP2001500877A (OSRAM)
KR (1) KR100560015B1 (OSRAM)
CN (1) CN1122036C (OSRAM)
AR (1) AR013838A1 (OSRAM)
AT (1) ATE209208T1 (OSRAM)
AU (1) AU719441B2 (OSRAM)
BR (1) BR9712100A (OSRAM)
CA (1) CA2265712C (OSRAM)
CO (1) CO4910140A1 (OSRAM)
CZ (1) CZ299248B6 (OSRAM)
DE (1) DE69708428T2 (OSRAM)
DK (1) DK0831098T3 (OSRAM)
EA (1) EA001642B1 (OSRAM)
EG (1) EG23861A (OSRAM)
ES (1) ES2166051T3 (OSRAM)
HU (1) HU226484B1 (OSRAM)
ID (1) ID27275A (OSRAM)
IL (1) IL128962A (OSRAM)
IN (1) IN187156B (OSRAM)
MY (1) MY125565A (OSRAM)
NO (1) NO323980B1 (OSRAM)
NZ (1) NZ334448A (OSRAM)
PE (1) PE110398A1 (OSRAM)
PL (3) PL196068B1 (OSRAM)
PT (1) PT831098E (OSRAM)
RS (1) RS49598B (OSRAM)
SI (1) SI0831098T1 (OSRAM)
SV (1) SV1997000081A (OSRAM)
TR (1) TR199900640T2 (OSRAM)
TW (1) TW470746B (OSRAM)
UA (1) UA59371C2 (OSRAM)
WO (1) WO1998012199A1 (OSRAM)
ZA (1) ZA978515B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507548A (ja) * 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
EP1440074A1 (en) * 2001-10-29 2004-07-28 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
WO2003055438A2 (en) 2001-12-24 2003-07-10 Sun Pharmaceutical Industries Limited Crystalline form i of 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
AU2003243153A1 (en) * 2002-04-23 2003-11-10 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
EP1513846B1 (en) 2002-05-31 2011-03-02 Sandoz Ag Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
AU2003300324A1 (en) * 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
AU2004291043A1 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
CA2551806A1 (en) * 2003-12-22 2005-07-14 Teva Pharmaceutical Industries, Ltd. Methods of preparing olanzapine
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
WO2005080401A1 (en) * 2004-02-19 2005-09-01 Neuland Laboratories Limited Process for the preparation of olanzapine form 1 useful as antipsychotic drug
US20080009481A1 (en) * 2004-07-14 2008-01-10 Shasun Chemicals And Drugs Limited Process For Making Form I Of Olanzapine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
ES2303462B1 (es) * 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
US7910577B2 (en) * 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンii型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
TW268005B (OSRAM) * 1992-05-29 1996-01-11 Lilly Industries Ltd
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
KR100516088B1 (ko) * 1996-09-23 2005-09-22 일라이 릴리 앤드 캄파니 올란자핀 이수화물 d

Also Published As

Publication number Publication date
SI0831098T1 (en) 2002-04-30
BR9712100A (pt) 1999-08-31
NO323980B1 (no) 2007-07-30
EP0831098A2 (en) 1998-03-25
PE110398A1 (es) 1999-01-14
KR20000048520A (ko) 2000-07-25
NZ334448A (en) 2000-08-25
WO1998012199A1 (en) 1998-03-26
ATE209208T1 (de) 2001-12-15
EA001642B1 (ru) 2001-06-25
CN1234802A (zh) 1999-11-10
AR013838A1 (es) 2001-01-31
IL128962A0 (en) 2000-02-17
RS49598B (sr) 2007-06-04
EP0831098B1 (en) 2001-11-21
HK1009807A1 (en) 1999-06-11
CO4910140A1 (es) 2000-04-24
CA2265712A1 (en) 1998-03-26
AU4484197A (en) 1998-04-14
CZ299248B6 (cs) 2008-05-28
NO991382D0 (no) 1999-03-22
US6020487A (en) 2000-02-01
DE69708428D1 (de) 2002-01-03
EA199900326A1 (ru) 1999-08-26
CN1122036C (zh) 2003-09-24
CA2265712C (en) 2006-10-31
PL332482A1 (en) 1999-09-13
SV1997000081A (es) 1999-01-14
ID27275A (id) 2001-03-22
PL196068B1 (pl) 2007-12-31
IL128962A (en) 2003-01-12
ES2166051T3 (es) 2002-04-01
PT831098E (pt) 2002-04-29
MY125565A (en) 2006-08-30
TR199900640T2 (xx) 1999-06-21
ZA978515B (en) 1999-03-23
CZ99099A3 (cs) 1999-11-17
HUP0000066A3 (en) 2000-11-28
DK0831098T3 (da) 2002-05-21
PL194565B1 (pl) 2007-06-29
YU15599A (sh) 2001-12-26
PL196069B1 (pl) 2007-12-31
HU226484B1 (en) 2009-03-02
TW470746B (en) 2002-01-01
EG23861A (en) 2007-11-18
IN187156B (OSRAM) 2002-02-16
JP2009242407A (ja) 2009-10-22
AU719441B2 (en) 2000-05-11
KR100560015B1 (ko) 2006-03-15
NO991382L (no) 1999-03-22
DE69708428T2 (de) 2002-07-04
JP2001500877A (ja) 2001-01-23
HUP0000066A2 (hu) 2000-06-28
EP0831098A3 (en) 1998-04-29

Similar Documents

Publication Publication Date Title
UA59371C2 (uk) Проміжні сполуки та спосіб одержання оланзапіну, фармацевтична композиція
EP3517535B1 (en) Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
EP0054951B1 (en) Dibenz(b,f)(1,4)oxazepine derivatives, process for preparing the same, and pharmaceutical compositions comprising the same
DK169409B1 (da) Vanduopløselige, farmaceutisk acceptable salte af substituerede derivater af rapamycin og farmaceutisk præparat indeholdende et sådant salt
EP0134946B1 (en) 3,6-Disubstituted-triazolo[3,4-a]phthalazine derivatives
UA46840C2 (uk) Дигідратна сіль мезилату 5-(2-4-(1,2-бензизотіазол-3-іл)-1-піперазиніл)етил)-6-хлор-1,3-дигідро-2h-індол-2-он, фармацевтична композиція для лікування психотичного розладу та спосіб лікування психотичного розладу у ссавців
LT3200B (en) Triazolopyridazine methodfor production thereof and use
JP2013505261A (ja) 4,5,6,7−テトラクロロ−3’,6’−ジヒドロキシ−2’,4’,5’,7’−テトラヨード−3h−スピロ[イソベンゾフラン−1,9’−キサンテン]−3−オン(ローズベンガル)及び関連するキサンテンを合成するプロセス
AU642829B2 (en) Benzopyran intermediates
ATE108440T1 (de) Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
SE8206229L (sv) Sett att framstella eburnamoninderivat
Da Re et al. . beta.-Adrenergic blocking agents of the chromone and xanthone groups. II. Propanolol type derivatives
EP0312773A3 (en) Substituted 3-aminosydnonimines, process for their preparation and their use
NO180297B (no) Ikke-ioniske joderte forbindelser og kontrastmidler inneholdende de samme
DE3365933D1 (en) Substituted thienobenzodiazepinones, process for their preparation and medicines containing these compounds
FI59595B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5 eller 6-trifluormetyl 3-(4-alkylpiperazin-1-yl)karbonyloxi-2-(1,8-naftyridin-2-yl)isoindolin-1-oner
RU2670763C1 (ru) Новые производные гелиомицина и фармацевтические композиции на их основе, ингибирующие опухолевый рост
KR20250130622A (ko) 피라졸로퀴나졸린계 화합물의 입체 이성질체와 중수소화 유도체 및 응용
FI115301B (fi) Menetelmä 1,3-dihydro-6-hydroksi-2H-indol-2-oni-johdannaisten valmistamiseksi
JPH02178282A (ja) ジアザビシクロアルカン誘導体
FR2470116A1 (fr) Derives benzylideniques, leur preparation et leur application en therapeutique
JPH0459790A (ja) ジエチレントリアミン三酢酸アルキルエステル化合物及びそれらの製造法
JPH0419998B2 (OSRAM)
FR2550532A1 (fr) Derives de l'indole, leur preparation et leur application en therapeutique
JPH06279446A (ja) 置換イミダゾピリダジン誘導体、その製造法、中間体および剤