UA130059C2 - ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ - Google Patents

ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ

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Publication number
UA130059C2
UA130059C2 UAA202201185A UAA202201185A UA130059C2 UA 130059 C2 UA130059 C2 UA 130059C2 UA A202201185 A UAA202201185 A UA A202201185A UA A202201185 A UAA202201185 A UA A202201185A UA 130059 C2 UA130059 C2 UA 130059C2
Authority
UA
Ukraine
Prior art keywords
compound
substituted
certain embodiments
unsubstituted
alkyl
Prior art date
Application number
UAA202201185A
Other languages
English (en)
Ukrainian (uk)
Inventor
Меттью Г. Бурсавіч
Мэттью Г. Бурсавич
Дан Цуй
Джеймс Е. Доулінг
Джеймс Е. Доулинг
Крістофер Н. Хан
Кристофер Н. Хан
Брайс А. Харрісон
Брайс А. Харрисон
Фу-Ян Лінь
Фу-Ян Линь
Блейз С. Ліппа
Блейз С. ЛИППА
Брюс Н. Роджерс
Дон М. Троуст
Чен Чжун
Кайл Д. Конзе
Алексєй І. Герасюто
Алексей И. ГЕРАСЮТО
Бунгчан Кім
Бунгчан Ким
Сальма Рафі
Сальма Рафи
Тайлер Дей
Тайлер Дэй
Євген Хіккі
Евген Хикки
Евелін Хуан
Эвелин Хуан
Роберт Залер
Original Assignee
Морфік Терапьютік, Інк.
Морфик Терапьютик, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Морфік Терапьютік, Інк., Морфик Терапьютик, Инк. filed Critical Морфік Терапьютік, Інк.
Publication of UA130059C2 publication Critical patent/UA130059C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)
UAA202201185A 2019-10-16 2020-10-16 ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ UA130059C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16
PCT/US2020/055986 WO2021076890A1 (en) 2019-10-16 2020-10-16 INHIBITING HUMAN INTEGRIN α4β7

Publications (1)

Publication Number Publication Date
UA130059C2 true UA130059C2 (uk) 2025-10-29

Family

ID=73198501

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA202201185A UA130059C2 (uk) 2019-10-16 2020-10-16 ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ

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TW (7) TWI802477B (enExample)
UA (1) UA130059C2 (enExample)
UY (1) UY38926A (enExample)
WO (3) WO2021076890A1 (enExample)
ZA (2) ZA202203872B (enExample)

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Also Published As

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MA57399B1 (fr) 2025-06-30
ZA202303992B (en) 2024-06-26
PY2065718A (es) 2023-01-17
DOP2022000081A (es) 2022-07-31
CU20220027A7 (es) 2022-12-12
SI4045039T1 (sl) 2025-07-31
PE20221829A1 (es) 2022-11-29
CN115087444B (zh) 2024-09-17
TWI888065B (zh) 2025-06-21
JP2022548809A (ja) 2022-11-22
AU2020366435A1 (en) 2022-04-21
CA3154269A1 (en) 2021-04-22
ECSP22038978A (es) 2022-06-30
TW202332675A (zh) 2023-08-16
CO2022005759A2 (es) 2022-05-20
FI4045039T3 (fi) 2025-06-20
JP2024054293A (ja) 2024-04-16
JP2023500437A (ja) 2023-01-06
DK4045039T3 (da) 2025-06-30
TW202126624A (zh) 2021-07-16
EP4045039A1 (en) 2022-08-24
US11104661B1 (en) 2021-08-31
KR20230088376A (ko) 2023-06-19
MD4045039T2 (ro) 2025-11-30
JP2024054296A (ja) 2024-04-16
JP2022542184A (ja) 2022-09-29
IL292296A (en) 2022-06-01
AU2021361031A1 (en) 2023-06-08
JP7437490B2 (ja) 2024-02-22
EP4559525A2 (en) 2025-05-28
TWI791304B (zh) 2023-02-01
HRP20250749T1 (hr) 2025-08-15
IL292296B1 (en) 2025-03-01
US20240174632A1 (en) 2024-05-30
MX2022004406A (es) 2022-08-25
IL319053A (en) 2025-04-01
KR20220102669A (ko) 2022-07-20
EP4559525A3 (en) 2025-08-20
TW202500559A (zh) 2025-01-01
TWI900200B (zh) 2025-10-01
WO2021076890A4 (en) 2021-06-10
TWI775182B (zh) 2022-08-21
ZA202203872B (en) 2024-01-31
US11370773B1 (en) 2022-06-28
TW202315868A (zh) 2023-04-16
TW202222793A (zh) 2022-06-16
TWI857592B (zh) 2024-10-01
AR120244A1 (es) 2022-02-09
JP7702004B2 (ja) 2025-07-02
ES3035561T3 (en) 2025-09-04
CR20220205A (es) 2022-07-22
WO2021076890A1 (en) 2021-04-22
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