CU20220027A7 - COMPUESTOS QUÍMICOS DERIVADOS SUSTITUIDOS DEL ÁCIDO PROPANOICO ÚTILES EN LA INHIBICIÓN DE INTEGRINA A4ß7 HUMANA Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN - Google Patents

COMPUESTOS QUÍMICOS DERIVADOS SUSTITUIDOS DEL ÁCIDO PROPANOICO ÚTILES EN LA INHIBICIÓN DE INTEGRINA A4ß7 HUMANA Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN

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Publication number
CU20220027A7
CU20220027A7 CU2022000027A CU20220027A CU20220027A7 CU 20220027 A7 CU20220027 A7 CU 20220027A7 CU 2022000027 A CU2022000027 A CU 2022000027A CU 20220027 A CU20220027 A CU 20220027A CU 20220027 A7 CU20220027 A7 CU 20220027A7
Authority
CU
Cuba
Prior art keywords
inhibition
pharmaceutical compositions
propanoic acid
chemical compounds
compositions containing
Prior art date
Application number
CU2022000027A
Other languages
English (en)
Inventor
Matthew G Bursavich
Dan Cui
Tyler Day
James E Dowling
Aleksey I Gerasyuto
Kristopher N Hahn
Bryce A Harrison
Eugene Hickey
Evelyne Houang
Byungchan Kim
Kyle D Konze
fu-yang Lin
Blaise S Lippa
Salma Rafi
Bruce N Rogers
Dawn M Troast
Robert Zahler
Cheng Zhong
Original Assignee
Morphic Therapeutic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphic Therapeutic Inc filed Critical Morphic Therapeutic Inc
Publication of CU20220027A7 publication Critical patent/CU20220027A7/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)

Abstract

<p>Se describen compuestos químicos derivados sustituidos del ácido propanoico de fórmula I</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>útiles en la inhibición de la integrina humana α4ß7 humana y, composiciones farmacéuticas que los contienen. </p>
CU2022000027A 2019-10-16 2020-10-16 COMPUESTOS QUÍMICOS DERIVADOS SUSTITUIDOS DEL ÁCIDO PROPANOICO ÚTILES EN LA INHIBICIÓN DE INTEGRINA A4ß7 HUMANA Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN CU20220027A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16
PCT/US2020/055986 WO2021076890A1 (en) 2019-10-16 2020-10-16 INHIBITING HUMAN INTEGRIN α4β7

Publications (1)

Publication Number Publication Date
CU20220027A7 true CU20220027A7 (es) 2022-12-12

Family

ID=73198501

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2022000027A CU20220027A7 (es) 2019-10-16 2020-10-16 COMPUESTOS QUÍMICOS DERIVADOS SUSTITUIDOS DEL ÁCIDO PROPANOICO ÚTILES EN LA INHIBICIÓN DE INTEGRINA A4ß7 HUMANA Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN

Country Status (22)

Country Link
US (3) US11104661B1 (es)
EP (2) EP4045039A4 (es)
JP (7) JP7437495B2 (es)
KR (2) KR20220102669A (es)
CN (2) CN115087444B (es)
AR (1) AR120244A1 (es)
AU (2) AU2020366435A1 (es)
BR (1) BR112022007284A2 (es)
CA (1) CA3154269A1 (es)
CL (1) CL2022000959A1 (es)
CO (1) CO2022005759A2 (es)
CR (1) CR20220205A (es)
CU (1) CU20220027A7 (es)
DO (1) DOP2022000081A (es)
EC (1) ECSP22038978A (es)
IL (1) IL292296A (es)
MX (1) MX2022004406A (es)
PE (1) PE20221829A1 (es)
TW (4) TWI802477B (es)
UY (1) UY38926A (es)
WO (3) WO2021076902A1 (es)
ZA (2) ZA202203872B (es)

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MX2022004450A (es) 2019-10-16 2022-05-03 Chemocentryx Inc Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1.
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WO2024051819A1 (zh) * 2022-09-09 2024-03-14 西藏海思科制药有限公司 一种丙酸衍生物及其在医药上的应用
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WO2024175907A1 (en) * 2023-02-21 2024-08-29 C4X Discovery Limited Macrocyclic alpha4beta7 integrin inhibitors

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US20240174632A1 (en) 2024-05-30
TW202126624A (zh) 2021-07-16
JP2022542184A (ja) 2022-09-29
TW202332675A (zh) 2023-08-16
WO2021076890A1 (en) 2021-04-22
JP7437490B2 (ja) 2024-02-22
WO2021076902A1 (en) 2021-04-22
UY38926A (es) 2021-05-31
TWI840047B (zh) 2024-04-21
JP2024054293A (ja) 2024-04-16
CN116783161A (zh) 2023-09-19
DOP2022000081A (es) 2022-07-31
WO2022081983A1 (en) 2022-04-21
EP4228634A1 (en) 2023-08-23
WO2021076890A4 (en) 2021-06-10
CA3154269A1 (en) 2021-04-22
TWI775182B (zh) 2022-08-21
ZA202303992B (en) 2024-06-26
KR20220102669A (ko) 2022-07-20
JP2024116230A (ja) 2024-08-27
JP2022548809A (ja) 2022-11-22
MX2022004406A (es) 2022-08-25
CL2022000959A1 (es) 2023-04-28
ZA202203872B (en) 2024-01-31
CR20220205A (es) 2022-07-22
US11370773B1 (en) 2022-06-28
AU2020366435A1 (en) 2022-04-21
TW202244040A (zh) 2022-11-16
JP2023036958A (ja) 2023-03-14
ECSP22038978A (es) 2022-06-30
TWI791304B (zh) 2023-02-01
CN115087444A (zh) 2022-09-20
KR20230088376A (ko) 2023-06-19
JP2023500437A (ja) 2023-01-06
EP4045039A1 (en) 2022-08-24
JP2024054296A (ja) 2024-04-16
TW202315868A (zh) 2023-04-16
US11104661B1 (en) 2021-08-31
AR120244A1 (es) 2022-02-09
CO2022005759A2 (es) 2022-05-20
BR112022007284A2 (pt) 2022-07-05
JP7437495B2 (ja) 2024-02-22
TWI802477B (zh) 2023-05-11
IL292296A (en) 2022-06-01
TW202222793A (zh) 2022-06-16
PE20221829A1 (es) 2022-11-29
AU2021361031A1 (en) 2023-06-08
EP4045039A4 (en) 2023-12-13
CN115087444B (zh) 2024-09-17
JP7500785B2 (ja) 2024-06-17
JP7209116B2 (ja) 2023-01-19

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