UY38926A - INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA - Google Patents
INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANAInfo
- Publication number
- UY38926A UY38926A UY0001038926A UY38926A UY38926A UY 38926 A UY38926 A UY 38926A UY 0001038926 A UY0001038926 A UY 0001038926A UY 38926 A UY38926 A UY 38926A UY 38926 A UY38926 A UY 38926A
- Authority
- UY
- Uruguay
- Prior art keywords
- alfa4beta7
- inhibition
- human integrin
- integrin
- human
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Abstract
Moléculas pequeñas antagonistas de la integrina humana alfa4beta7, y métodos para usarlas en el tratamiento de varias enfermedades y afecciones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962916062P | 2019-10-16 | 2019-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY38926A true UY38926A (es) | 2021-05-31 |
Family
ID=73198501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001038926A UY38926A (es) | 2019-10-16 | 2020-10-16 | INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA |
Country Status (22)
Country | Link |
---|---|
US (2) | US11104661B1 (es) |
EP (2) | EP4045039A4 (es) |
JP (6) | JP7437495B2 (es) |
KR (2) | KR20220102669A (es) |
CN (2) | CN115087444A (es) |
AR (1) | AR120244A1 (es) |
AU (2) | AU2020366435A1 (es) |
BR (1) | BR112022007284A2 (es) |
CA (1) | CA3154269A1 (es) |
CL (1) | CL2022000959A1 (es) |
CO (1) | CO2022005759A2 (es) |
CR (1) | CR20220205A (es) |
CU (1) | CU20220027A7 (es) |
DO (1) | DOP2022000081A (es) |
EC (1) | ECSP22038978A (es) |
IL (1) | IL292296A (es) |
MX (1) | MX2022004406A (es) |
PE (1) | PE20221829A1 (es) |
TW (4) | TWI775182B (es) |
UY (1) | UY38926A (es) |
WO (3) | WO2021076890A1 (es) |
ZA (1) | ZA202203872B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7365358B2 (ja) | 2018-04-12 | 2023-10-19 | モーフィック セラピューティック,インコーポレイテッド | ヒトインテグリンα4β7のアンタゴニスト |
AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
WO2021076890A1 (en) | 2019-10-16 | 2021-04-22 | Morphic Therapeutic, Inc. | INHIBITING HUMAN INTEGRIN α4β7 |
PE20221764A1 (es) | 2019-10-16 | 2022-11-11 | Chemocentryx Inc | Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1 |
WO2023125182A1 (zh) * | 2021-12-27 | 2023-07-06 | 海思科医药集团股份有限公司 | 一种丙酸衍生物及其在医药上的应用 |
WO2024051819A1 (zh) * | 2022-09-09 | 2024-03-14 | 西藏海思科制药有限公司 | 一种丙酸衍生物及其在医药上的应用 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721366A (en) | 1993-03-31 | 1998-02-24 | G. D. Searle & Co | Platelet aggregation inhibitors |
DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
WO1998016547A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
WO1998016524A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | HETEROCYCLIC DERIVATIVES AS FACTOR Xa INHIBITORS |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
EP1034164B1 (en) | 1997-11-24 | 2004-05-19 | Merck & Co., Inc. | Substituted beta-alanine derivatives as cell adhesion inhibitors |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
CA2333647A1 (en) | 1998-06-29 | 2000-01-06 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
JP2002521450A (ja) * | 1998-07-29 | 2002-07-16 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体アンタゴニスト |
GB9826174D0 (en) * | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
US6723711B2 (en) * | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
RO121640B1 (ro) * | 1999-05-07 | 2008-01-30 | Texas Biotechnology Corporation | Derivaţi de acid propionic ce inhibă legarea integrinelor de receptorii acestora, compoziţie farmaceutică ce îi conţine şi utilizare a acesteia |
US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
EP1214292B1 (en) | 1999-09-24 | 2007-06-13 | Genentech, Inc. | Tyrosine derivatives |
DE10041423A1 (de) | 2000-08-23 | 2002-03-07 | Merck Patent Gmbh | Biphenylderivate |
IL154496A0 (en) * | 2000-08-30 | 2003-09-17 | Pharmacia Corp | GEM-SUBSTITUTED alpha v beta3 INTEGRIN ANTAGONISTS |
DE10111876A1 (de) | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
DE10154280A1 (de) | 2001-11-05 | 2003-05-15 | Wilex Ag | Antagonisten für alpha¶4¶-Integrine |
BR0307975A (pt) | 2002-02-25 | 2005-01-11 | Elan Pharm Inc | Métodos para reduzir cronicamente a inflamação patológica em um paciente e para determinar a eficácia de um regime de administração crÈnica para tratar inflamação patológica em um indivìduo, composição e terapia combinada para tratamento crÈnico de inflamação patológica em um paciente e uso de um inibidor de alfa-4-integrina |
SI3530673T1 (sl) | 2004-09-03 | 2022-08-31 | Genentech, Inc. | Humanizirani antagonisti proti beta7 in njihove uporabe |
US7972775B2 (en) | 2005-03-03 | 2011-07-05 | Seedlings Life Science Ventures, Llc | Method of risk management for patients undergoing Natalizumab treatment |
WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | 6,7-不飽和-7-カルバモイル置換モルヒナン誘導体 |
NZ563739A (en) | 2005-06-09 | 2009-12-24 | Ucb Pharma Sa | 2,6 Quinolinyl derivatives, processes for preparing them and their use as medicament |
HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
WO2010091411A1 (en) | 2009-02-09 | 2010-08-12 | Glaxosmithkline Llc | Piperidinyl cyclic amido antiviral agents |
SG10201606950RA (en) | 2011-03-31 | 2016-10-28 | Genentech Inc | Methods of administering beta7 integrin antagonists |
KR101850591B1 (ko) | 2012-10-05 | 2018-04-19 | 제넨테크, 인크. | 염증성 장 질환의 진단 및 치료 방법 |
CN113604543A (zh) | 2014-03-27 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 用于诊断和治疗炎症性肠病的方法 |
WO2016011940A1 (zh) | 2014-07-25 | 2016-01-28 | 江苏恒瑞医药股份有限公司 | 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用 |
AR103782A1 (es) | 2015-02-26 | 2017-05-31 | Genentech Inc | ANTAGONISTAS DE INTEGRINA b7 Y MÉTODOS DE TRATAMIENTO DE LA ENFERMEDAD DE CROHN |
US20180244648A1 (en) * | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
US10246451B2 (en) | 2017-04-26 | 2019-04-02 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
US10875875B2 (en) * | 2017-04-26 | 2020-12-29 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
JP7365358B2 (ja) * | 2018-04-12 | 2023-10-19 | モーフィック セラピューティック,インコーポレイテッド | ヒトインテグリンα4β7のアンタゴニスト |
CR20210213A (es) | 2018-10-30 | 2021-06-24 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
AU2019373242B2 (en) * | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
US11179383B2 (en) * | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
WO2021076890A1 (en) | 2019-10-16 | 2021-04-22 | Morphic Therapeutic, Inc. | INHIBITING HUMAN INTEGRIN α4β7 |
-
2020
- 2020-10-16 WO PCT/US2020/055986 patent/WO2021076890A1/en active Application Filing
- 2020-10-16 EP EP20875989.4A patent/EP4045039A4/en active Pending
- 2020-10-16 WO PCT/US2020/056001 patent/WO2021076902A1/en active Application Filing
- 2020-10-16 BR BR112022007284A patent/BR112022007284A2/pt unknown
- 2020-10-16 MX MX2022004406A patent/MX2022004406A/es unknown
- 2020-10-16 TW TW109136036A patent/TWI775182B/zh active
- 2020-10-16 AR ARP200102870A patent/AR120244A1/es unknown
- 2020-10-16 TW TW111127993A patent/TWI802477B/zh active
- 2020-10-16 CU CU2022000027A patent/CU20220027A7/es unknown
- 2020-10-16 AU AU2020366435A patent/AU2020366435A1/en active Pending
- 2020-10-16 US US17/072,797 patent/US11104661B1/en active Active
- 2020-10-16 UY UY0001038926A patent/UY38926A/es unknown
- 2020-10-16 JP JP2022523102A patent/JP7437495B2/ja active Active
- 2020-10-16 TW TW112116098A patent/TW202332675A/zh unknown
- 2020-10-16 JP JP2022509595A patent/JP7437490B2/ja active Active
- 2020-10-16 CA CA3154269A patent/CA3154269A1/en active Pending
- 2020-10-16 CN CN202080088450.4A patent/CN115087444A/zh active Pending
- 2020-10-16 PE PE2022000633A patent/PE20221829A1/es unknown
- 2020-10-16 CR CR20220205A patent/CR20220205A/es unknown
- 2020-10-16 KR KR1020227015040A patent/KR20220102669A/ko active Search and Examination
-
2021
- 2021-07-16 US US17/378,282 patent/US11370773B1/en active Active
- 2021-10-15 KR KR1020237015039A patent/KR20230088376A/ko unknown
- 2021-10-15 WO PCT/US2021/055196 patent/WO2022081983A1/en active Application Filing
- 2021-10-15 EP EP21881178.4A patent/EP4228634A1/en active Pending
- 2021-10-15 CN CN202180083775.8A patent/CN116783161A/zh active Pending
- 2021-10-15 TW TW110138309A patent/TWI791304B/zh active
- 2021-10-15 AU AU2021361031A patent/AU2021361031A1/en active Pending
- 2021-10-15 JP JP2021576053A patent/JP7209116B2/ja active Active
-
2022
- 2022-04-05 ZA ZA2022/03872A patent/ZA202203872B/en unknown
- 2022-04-13 DO DO2022000081A patent/DOP2022000081A/es unknown
- 2022-04-14 CL CL2022000959A patent/CL2022000959A1/es unknown
- 2022-04-14 IL IL292296A patent/IL292296A/en unknown
- 2022-05-02 CO CONC2022/0005759A patent/CO2022005759A2/es unknown
- 2022-05-16 EC ECSENADI202238978A patent/ECSP22038978A/es unknown
-
2023
- 2023-01-06 JP JP2023000761A patent/JP2023036958A/ja active Pending
-
2024
- 2024-02-09 JP JP2024018765A patent/JP2024054293A/ja active Pending
- 2024-02-09 JP JP2024018866A patent/JP2024054296A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY38926A (es) | INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA | |
CO2019012353A2 (es) | Formulaciones de anticuerpos anti-lag3 y coformulaciones de anticuerpos anti-lag3 y anticuerpos anti-pd-1 | |
CO2017005784A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
CL2019001874A1 (es) | Inhibidores de tgfß1 isoforma-específicos contexto-permisivos y uso de los mismos. | |
SV2018005610A (es) | Derivados de oxopiridina sustituidos | |
CL2018002814A1 (es) | Composiciones y metodos para el tratamiento de heridas, trastornos, y enfermedades de la piel. | |
DOP2015000304A (es) | Inhibidores cristalinos de bromodominios | |
CL2018002359A1 (es) | Métodos para usar agonistas de fxr | |
CO2017007121A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
CL2016001895A1 (es) | Compuestos | |
UY38353A (es) | Inhibición de integrina alfavbeta6 | |
EA201791884A1 (ru) | Химерные антигенные рецепторы против dll3 и способы применения | |
DOP2016000109A (es) | Formas sólidas de ácido {[5-(3-clorofenil) -3-hidroxipiridin-2-carbonil] amino} acético, composiciones, y usos de las mismas. | |
BR112018003269A2 (pt) | conjugados de fármaco-anticorpo anti-dll3 e métodos de utilização | |
DOP2013000047A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
CR20130058A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
UY33707A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
UY33702A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
CR20130074A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
BR112016022855A2 (pt) | composições e métodos para modular a expressão de pkk | |
BR112019005139A2 (pt) | anticorpos anti-il-33 e usos dos mesmos | |
ECSP13012402A (es) | Inmunoglobulinas con dominio variable dual y su uso | |
BR112016022318A2 (pt) | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo | |
CL2015002835A1 (es) | Nuevos derivados de piridina | |
CO2017010621A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades |