TWI771313B - 皮膚貼附材料及皮膚貼附材料捲繞體 - Google Patents
皮膚貼附材料及皮膚貼附材料捲繞體 Download PDFInfo
- Publication number
- TWI771313B TWI771313B TW106126875A TW106126875A TWI771313B TW I771313 B TWI771313 B TW I771313B TW 106126875 A TW106126875 A TW 106126875A TW 106126875 A TW106126875 A TW 106126875A TW I771313 B TWI771313 B TW I771313B
- Authority
- TW
- Taiwan
- Prior art keywords
- skin
- adhesive
- adhesive layer
- mass
- acrylic copolymer
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims abstract description 83
- 238000004804 winding Methods 0.000 title 1
- 239000000853 adhesive Substances 0.000 claims abstract description 50
- 239000012790 adhesive layer Substances 0.000 claims abstract description 39
- 229920006243 acrylic copolymer Polymers 0.000 claims abstract description 29
- 229920003225 polyurethane elastomer Polymers 0.000 claims abstract description 21
- 230000001070 adhesive effect Effects 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000000178 monomer Substances 0.000 claims description 38
- 239000007933 dermal patch Substances 0.000 claims description 26
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 125000005456 glyceride group Chemical group 0.000 claims description 7
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- 150000007942 carboxylates Chemical class 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 3
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims description 3
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 claims description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 230000007803 itching Effects 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 22
- -1 alkoxyalkyl acrylates Chemical class 0.000 description 17
- 208000002193 Pain Diseases 0.000 description 16
- 230000035699 permeability Effects 0.000 description 14
- 239000003431 cross linking reagent Substances 0.000 description 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
- 238000004132 cross linking Methods 0.000 description 7
- 206010040880 Skin irritation Diseases 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 230000036556 skin irritation Effects 0.000 description 6
- 231100000475 skin irritation Toxicity 0.000 description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 239000012948 isocyanate Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000123 paper Substances 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 235000003441 saturated fatty acids Nutrition 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CUXGDKOCSSIRKK-UHFFFAOYSA-N 7-methyloctyl prop-2-enoate Chemical compound CC(C)CCCCCCOC(=O)C=C CUXGDKOCSSIRKK-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010016059 Facial pain Diseases 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- OBNIRVVPHSLTEP-UHFFFAOYSA-N 1-ethoxy-2-(2-hydroxyethoxy)ethanol;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(O)COCCO OBNIRVVPHSLTEP-UHFFFAOYSA-N 0.000 description 1
- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 description 1
- PHTZMGCAFZLFOL-UHFFFAOYSA-N 14-methylpentadecyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCCCCCCCCCCCCCC(C)C PHTZMGCAFZLFOL-UHFFFAOYSA-N 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- OATHWIHWTWDNLJ-UHFFFAOYSA-N 2-(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCCCCCCCC(C)C OATHWIHWTWDNLJ-UHFFFAOYSA-N 0.000 description 1
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- PTJDGKYFJYEAOK-UHFFFAOYSA-N 2-butoxyethyl prop-2-enoate Chemical compound CCCCOCCOC(=O)C=C PTJDGKYFJYEAOK-UHFFFAOYSA-N 0.000 description 1
- FWWXYLGCHHIKNY-UHFFFAOYSA-N 2-ethoxyethyl prop-2-enoate Chemical compound CCOCCOC(=O)C=C FWWXYLGCHHIKNY-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 1
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 1
- ONKUXPIBXRRIDU-UHFFFAOYSA-N Diethyl decanedioate Chemical compound CCOC(=O)CCCCCCCCC(=O)OCC ONKUXPIBXRRIDU-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical group CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000005233 alkylalcohol group Chemical group 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 210000003092 coiled body Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- JBSLOWBPDRZSMB-FPLPWBNLSA-N dibutyl (z)-but-2-enedioate Chemical compound CCCCOC(=O)\C=C/C(=O)OCCCC JBSLOWBPDRZSMB-FPLPWBNLSA-N 0.000 description 1
- 229940100539 dibutyl adipate Drugs 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- KWABLUYIOFEZOY-UHFFFAOYSA-N dioctyl butanedioate Chemical compound CCCCCCCCOC(=O)CCC(=O)OCCCCCCCC KWABLUYIOFEZOY-UHFFFAOYSA-N 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- WUKXMJCZWYUIRZ-UHFFFAOYSA-N hexadecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(C)O WUKXMJCZWYUIRZ-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 229940093629 isopropyl isostearate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 239000005001 laminate film Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- PIUVNPNBPWVVKZ-UHFFFAOYSA-N octadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC PIUVNPNBPWVVKZ-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00072—Packaging of dressings
- A61F13/00076—Packaging of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J7/00—Adhesives in the form of films or foils
- C09J7/20—Adhesives in the form of films or foils characterised by their carriers
- C09J7/22—Plastics; Metallised plastics
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J7/00—Adhesives in the form of films or foils
- C09J7/20—Adhesives in the form of films or foils characterised by their carriers
- C09J7/22—Plastics; Metallised plastics
- C09J7/25—Plastics; Metallised plastics based on macromolecular compounds obtained otherwise than by reactions involving only carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J7/00—Adhesives in the form of films or foils
- C09J7/30—Adhesives in the form of films or foils characterised by the adhesive composition
- C09J7/38—Pressure-sensitive adhesives [PSA]
- C09J7/381—Pressure-sensitive adhesives [PSA] based on macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- C09J7/385—Acrylic polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1809—C9-(meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/10—Esters; Ether-esters
- C08K5/101—Esters; Ether-esters of monocarboxylic acids
- C08K5/103—Esters; Ether-esters of monocarboxylic acids with polyalcohols
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J2301/00—Additional features of adhesives in the form of films or foils
- C09J2301/40—Additional features of adhesives in the form of films or foils characterized by the presence of essential components
- C09J2301/408—Additional features of adhesives in the form of films or foils characterized by the presence of essential components additives as essential feature of the adhesive layer
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J2433/00—Presence of (meth)acrylic polymer
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J2475/00—Presence of polyurethane
- C09J2475/006—Presence of polyurethane in the substrate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Anesthesiology (AREA)
Abstract
本發明提供一種具有對皮膚面之良好之貼附性、服貼感，且可減少貼附時之悶熱、瘙癢感之皮膚貼附材料及皮膚貼附材料捲繞體。 本發明之皮膚貼附材料係於聚胺基甲酸酯彈性體膜之一面設置黏著劑層，並且具有覆蓋上述黏著劑層之黏著面且以可剝離之方式積層的剝離襯墊者，且以如下方式構成皮膚貼附材料：上述聚胺基甲酸酯彈性體膜之厚度為1～9 μm，上述黏著劑層包含丙烯酸系共聚物、及於室溫下為液狀或糊狀之成分。
Description
本發明係關於一種貼附於皮膚而使用之皮膚貼附材料及皮膚貼附材料捲繞體。
於基材膜之單面設置黏著劑層而成之皮膚貼附材料係經由黏著劑層貼合於皮膚面而使用。若將此種皮膚貼附材料貼合於皮膚面，則亦有於皮膚面產生悶熱或瘙癢，有時引起炎症之情況。因此，業界對皮膚貼附材料要求較高之透濕性。 進而，由於皮膚面具有不規則且複雜之表面形狀，故而構成皮膚貼附材料之黏著劑層難以與皮膚面完全密接，但若對皮膚面牢固地接著固定，則有可能於剝離時產生皮膚刺激，而謀求如下皮膚貼附材料：其具有貼附時之良好之貼附性，並且具有感覺不到貼附般之良好之服貼感、與減少剝離時之皮膚刺激的絕妙特性之平衡。 [先前技術文獻] [專利文獻] [專利文獻1]日本專利特開平10-33655號公報
[發明所欲解決之問題] 鑒於上述現狀，本發明之目的在於提供一種具有對皮膚面之良好之貼附性、服貼感，可減少貼附時之悶熱、瘙癢感，進而可減少剝離時之物理性皮膚刺激之皮膚貼附材料及皮膚貼附材料捲繞體。 [解決問題之技術手段] 本發明者等人為了達成上述目的而反覆進行努力研究，結果發現，藉由在皮膚貼附材料中將作為基材膜之聚胺基甲酸酯彈性體膜之厚度控制於特定之範圍內，且使黏著劑層中含有於室溫下為液狀或糊狀之成分，可解決上述課題，從而完成了本發明。 即，本發明係關於一種皮膚貼附材料，其特徵在於： 其係於聚胺基甲酸酯彈性體膜之一面設置黏著劑層，並且具有覆蓋上述黏著劑層之黏著面且以可剝離之方式積層的剝離襯墊者，且 上述聚胺基甲酸酯彈性體膜之厚度為1～9 μm， 上述黏著劑層包含含有丙烯酸系共聚物、及於室溫下為液狀或糊狀之成分的黏著劑。 [發明之效果] 本發明之皮膚貼附材料具有對皮膚面之良好之貼附性、及於貼附時感覺不到貼附般之良好之服貼感，並且可抑制貼附時之悶熱、瘙癢感，進而減少剝離時之物理性皮膚刺激。
於本發明中，作為支持以下將說明之黏著劑層的基材膜而發揮功能之聚胺基甲酸酯彈性體膜之厚度必須為1～9 μm，較佳為3～9 μm。若聚胺基甲酸酯彈性體膜之厚度未達1 μm，則於使用皮膚貼附材料時，或於使用後自皮膚面剝離時，有皮膚貼附材料斷裂之虞。另一方面，若聚胺基甲酸酯彈性體膜之厚度超過9 μm，則於將皮膚貼附材料貼附於皮膚面時，存在對於皮膚面之柔軟動作而產生緊繃感般之不適感之情形。 又，於本發明中，使用聚胺基甲酸酯彈性體膜作為基材膜之原因在於：該膜之伸縮性及透濕性優異，故而該膜可追隨於身體之彎曲部之動作，並且可抑制皮膚悶熱而起斑疹。 (黏著劑層) 黏著劑層就容易調整皮膚接著力，於與皮膚接觸時皮膚刺激性較少等方面而言，係包含丙烯酸系共聚物者。 作為丙烯酸系共聚物，並無特別限定，例如較佳為使用由包含(甲基)丙烯酸烷基酯單體、及含烷氧基之乙烯性不飽和單體的單體混合物所獲得之丙烯酸系共聚物。 (甲基)丙烯酸烷基酯單體成為對黏著劑層賦予良好之皮膚貼附性之主成分，尤其若使用烷基之碳數為6以上、進而為6～18之長鏈烷基則較有效。再者，(甲基)丙烯酸烷基酯單體具有對皮膚之刺激性相對較少，且即便長時間使用亦不易因此而產生黏著力之降低之優點。 作為此種(甲基)丙烯酸烷基酯單體之具體例，可使用丙烯酸或甲基丙烯酸之丁酯、丙酯、辛酯、壬酯、癸酯、十二烷基酯、月桂酯等之一種，或者併用兩種以上而使用。再者，該等烷基酯鏈當然可為直鏈亦可為分支鏈。 含烷氧基之乙烯性不飽和單體係對丙烯酸系共聚物賦予水蒸氣透過性、所謂透濕性之成分。此種含烷氧基之乙烯性不飽和單體並無特別限定，例如較佳為使用甲氧基聚乙二醇丙烯酸酯、乙氧基二乙二醇丙烯酸酯、丁氧基二乙二醇丙烯酸酯、丙烯酸甲氧基乙酯、丙烯酸乙氧基乙酯、丙烯酸丁氧基乙酯等具有碳數為1～4之烷氧基之丙烯酸烷氧基烷基酯。 又，本發明中之丙烯酸系共聚物較佳為使用由進而含有含羧基之乙烯性不飽和單體的單體混合物所獲得之丙烯酸系共聚物。藉由含有含羧基之乙烯性不飽和單體，所獲得之共聚物之凝集力提高，故而於調整黏著劑層之特性之方面成為重要之單體。作為此種單體之代表例，可列舉丙烯酸、伊康酸、丁烯酸、反丁烯二酸、順丁烯二酸(酐)等。該等之中，就共聚合性或處理性等方面而言，作為較佳之單體，可列舉丙烯酸。 構成上述黏著劑之丙烯酸系共聚物較佳為藉由上述(甲基)丙烯酸烷基酯單體與含烷氧基之乙烯性不飽和單體進行共聚合而獲得，更佳為藉由(甲基)丙烯酸烷基酯單體、含烷氧基之乙烯性不飽和單體及含羧基之乙烯性不飽和單體進行共聚合而獲得。 本發明之丙烯酸系共聚物視需要除上述各單體以外，作為用以進行親水性之賦予等各種改質之改質用單體，還可將苯乙烯或乙酸乙烯酯、N-乙烯基-2-吡咯啶酮等單體適當共聚合。 丙烯酸系共聚物中之(甲基)丙烯酸烷基酯單體之含量較佳為設為40質量%～80質量%，更佳為設為50質量%～75質量%之範圍。若(甲基)丙烯酸烷基酯單體之含量為上述範圍內，則顯示出良好之皮膚貼合性，且於自皮膚剝離時，不會對該皮膚產生糊劑殘留現象而具有優異之剝離性。 又，丙烯酸系共聚物中之含烷氧基之乙烯性不飽和單體之含量較佳為設為10質量%～60質量%，更佳為設為20質量%～60質量%，進而較佳為設為25質量%～50質量%之範圍。若含烷氧基之乙烯性不飽和單體之含量為上述範圍內，則可對黏著劑層賦予優異之透濕性。 再者，於含有含羧基之乙烯性不飽和單體之情形時，上述含烷氧基之乙烯性不飽和單體之含量較佳為設為10質量%～50質量%，更佳為設為20質量%～45質量%之範圍。 上述含羧基之乙烯性不飽和單體之含量較佳為1質量%～10質量%，更佳為3質量%～8質量%。若含羧基之乙烯性不飽和單體之含量為上述範圍內，則可對黏著劑層賦予優異之凝集力，可抑制糊劑殘留現象等，並且亦可抑制皮膚刺激性。 丙烯酸系共聚物對分子量測定溶劑之可溶成分之重量平均分子量較理想為調整為50萬～250萬、較佳為60萬～200萬左右者。 再者，此處重量平均分子量及分子量分佈係使用凝膠滲透層析法(GPC)測定之值，係利用四氫呋喃溶解測定樣本，對通過0.45 μmf之薄膜過濾器之可溶成分進行測定，並藉由聚苯乙烯換算而算出。 於本發明之黏著劑層中包含於室溫(25℃)下為液狀或糊狀之成分。於室溫下為液狀或糊狀之成分係用以對黏著劑層賦予柔軟性，而於該黏著劑與皮膚接觸之情形時，減少皮膚刺激性。 作為此種於室溫下為液狀或糊狀之成分，只要與丙烯酸系共聚物相溶，則並無特別限制。例如可使用：鄰苯二甲酸、順丁烯二酸、己二酸、硬脂酸或各種脂肪酸與烷基醇之酯類，與乙二醇、甘油等多元醇之酯類等。更具體而言，作為一元醇之酯，可列舉：鄰苯二甲酸二丁酯、鄰苯二甲酸二-2-乙基己酯、己二酸二丁酯、癸二酸二-2-乙基己酯、馬來酸二丁酯、肉豆蔻酸乙酯、肉豆蔻酸異丙酯、棕櫚酸異丙酯、硬脂酸丁酯、異硬脂酸異丙酯、月桂酸己酯、乳酸鯨蠟酯、乳酸肉豆蔻酯、鄰苯二甲酸二乙酯、肉豆蔻酸辛基十二烷基酯、油酸辛基十二烷基酯、二甲基辛酸己基癸酯、2-乙基己酸鯨蠟酯、2-乙基己酸異鯨蠟酯、2-乙基己酸硬脂酯、琥珀酸二辛酯等。又，作為2元以上之醇之酯，可使用二辛酸丙二醇酯、二癸酸丙二醇酯、二異硬脂酸丙二醇酯、單辛酸甘油酯、三辛酸甘油酯、三-2-乙基己酸甘油酯、三癸酸甘油酯、三月桂酸甘油酯、三異硬脂酸甘油酯、三油酸甘油酯、三-2-乙基己酸三羥甲基丙烷等之一種，或者併用兩種以上而使用。此種於室溫下為液狀或糊狀之成分可根據皮膚貼附材料之其他因素等而適當決定，就與丙烯酸系共聚物之相容性之觀點而言，可適宜地使用羧酸酯、進而較佳為甘油脂肪酸酯、更佳為飽和脂肪酸之甘油酯。 又，作為上述脂肪酸，可列舉辛酸、癸酸、2-乙基己酸等飽和脂肪酸，該等可單獨使用或者使用兩種以上。該等飽和脂肪酸由於不具有不飽和雙鍵，故而可防止黏著劑、即黏著劑層之氧化劣化。 於使用如上所述之辛酸等作為飽和脂肪酸之情形時，作為各種飽和脂肪酸與醇之酯類，可獲得三辛酸甘油酯或三癸酸甘油酯、三-2-乙基己酸甘油酯。該等羧酸酯之中，就與丙烯酸系共聚物之相容性等方面而言，尤佳為使用三辛酸甘油酯。 再者，關於丙烯酸系共聚物與上述羧酸酯等在室溫下為液狀或糊狀之成分之含有比率，例如較佳為相對於丙烯酸系共聚物之100質量份而為20質量份～100質量份。藉由該成分之含有比率處於上述範圍內，可對黏著劑層賦予充分之柔軟性，故而具有良好之皮膚貼附性，並且可抑制自皮膚剝離貼附材料時之物理性皮膚刺激，實現良好之剝離性。 為了對構成本發明之皮膚貼附材料之黏著劑層賦予適度之凝集力，較佳為實施交聯處理。作為交聯處理，存在利用電子束或γ射線、X射線等電離輻射線之照射進行之物理交聯與利用交聯劑進行之化學交聯，就操作性或再現性良好地實施交聯之觀點而言，較佳為實施利用交聯劑進行之化學交聯處理。例如，藉由向調配有構成黏著劑層之材料之黏著劑組合物中添加交聯劑，並進行加熱處理，而實施交聯處理。作為此種交聯劑，可使用異氰酸酯系交聯劑、過氧化物系交聯劑、金屬螯合物系交聯劑等在進行交聯處理時所使用之交聯劑。 以上述方法實施了交聯處理之黏著劑層係藉由交聯程度而保持適度之皮膚貼附性與凝集性之平衡，丙烯酸系共聚物之分子量或分子量分佈亦會對該等之調整造成影響。 黏著劑層之厚度並無特別限定，可根據本發明之皮膚貼附材料之用途、或所貼附之皮膚之應用部位等而適當設定。作為一例，較佳為可設為10～100 μm左右，更佳為可設為16～50 μm，進而較佳為可設為20～35 μm左右。藉此，可對皮膚面賦予適度之黏著力。 本發明中之皮膚貼合材料為了防止黏著劑層之表面之污染，而於使用前預先利用剝離襯墊被覆黏著劑層表面。該剝離襯墊通常可使用用於皮膚或貼附於皮膚之膠帶者。具體而言可使用：於優質紙、玻璃紙、羊皮紙等之表面塗佈有聚矽氧樹脂或氟樹脂等具有剝離性能之剝離劑者，或於優質紙上增黏塗佈有樹脂者，或於經聚乙烯層壓者等之表面塗佈有聚矽氧樹脂或氟樹脂等具有剝離性能之剝離劑者。 再者，雖然未特別圖示，但本發明之皮膚貼附材料可於上述基材膜之與形成有黏著劑層之面為相反側之面，以可剝離之方式積層擔載膜。 作為擔載膜之素材，可列舉塑膠膜(例如聚乙烯、聚丙烯、聚酯、及該等之積層複合體等)、紙(例如優質紙、牛皮紙等)等作為較佳者。該等之中，具有透明性之塑膠膜由於可一面介隔皮膚貼附材料觀察貼附部位一面進行貼附，故而於固定導液管等醫療器具時，其有用性變得尤其顯著。於將擔載膜以可剝離之方式貼合於基材膜之背面時，可使用吹脹成型、擠出層壓成型、積層成型、流延等公知之方法。 擔載膜之厚度亦根據素材而有所不同，通常較佳為15～200 μm左右，更佳為20～100 μm左右。 又，雖然未特別圖示，但本發明之皮膚貼附材料亦可於如上所述般積層於擔載膜之狀態下捲繞，製成捲繞體。 其次，將本發明之皮膚貼合材料之製造方法之一例示於以下，但並不受該等之任何限定。 首先，例如使包含(甲基)丙烯酸烷基酯單體、含烷氧基之乙烯性不飽和單體、及視需要之含羧基之乙烯性不飽和單體的單體混合物於有機溶劑中藉由通常之自由基聚合進行共聚合反應，製備丙烯酸系共聚物溶液。其次，相對於該丙烯酸系共聚物溶液之固形物成分(丙烯酸系共聚物)100質量份，調配20～100質量份之羧酸酯等在室溫下為液狀或糊狀之成分、進而視需要之交聯劑等，製備黏著劑組合物之溶液。 繼而，將所獲得之黏著劑溶液塗佈於剝離襯墊之剝離處理面之整個面，或局部地塗佈。於局部地塗佈之情形時，例如較佳為塗佈為點狀或條狀。於條狀之情形時，例如可列舉直線狀塗佈或波狀塗佈等，只要確保作為氣體之通氣管路而發揮功能之空間、即帶狀空間，則可為任意形狀。波狀塗佈由於貼附於皮膚之過程中的帶狀空間之截面積之經時變化較少，故而較佳。於使塗佈於剝離襯墊之黏著劑溶液乾燥後，貼合積層有擔載膜之聚胺基甲酸酯彈性體膜，而獲得皮膚貼附材料。 [實施例] 以下列舉實施例更具體地說明本發明，但該等實施例並未限定本發明。再者，以下所謂「份」及「%」分別係指「質量份」及「質量%」。 (實施例1) 於使包含丙烯酸異壬酯65份、丙烯酸2-甲氧基乙酯30份、丙烯酸5份之單體混合物進行共聚合反應而獲得之丙烯酸系共聚物之溶液中，相對於丙烯酸系共聚物100份，調配三辛酸甘油酯60份、作為交聯劑之三官能性異氰酸酯化合物0.04份而製作均勻之黏著劑溶液。 其次，以乾燥後之厚度成為26 μm之方式將該溶液塗佈於單面經聚矽氧剝離處理的剝離襯墊之剝離處理面，進行乾燥而形成黏著劑層。將該黏著劑層貼合於在厚度8 μm之聚胺基甲酸酯彈性體膜上以可剝離之方式積層有厚度40 μm之聚丙烯膜(擔載膜)的積層膜之聚胺基甲酸酯彈性體膜面，而獲得實施例1之皮膚貼附材料。 (比較例1) 將厚度8 μm之聚胺基甲酸酯彈性體膜變更為厚度30 μm之聚胺基甲酸酯彈性體膜，並且將乾燥後之黏著劑層之厚度變更為30 μm，除此以外，以與實施例1相同之方式獲得比較例1之皮膚貼附材料。 (透濕度) 針對實施例1及比較例1之各皮膚貼附材料，向口徑38 mm之玻璃容器中添加純化水10 mL，利用剝離了剝離襯墊及擔載膜之皮膚貼附材料將玻璃容器之口覆蓋，並於玻璃容器之口部分外周纏繞膠帶而進行密封。測定該玻璃容器之重量後，將其於溫度40℃、濕度30%RH之條件下保存24小時。保存24小時後，測定玻璃容器之重量，根據保存前後之重量差求出透過水蒸氣之量。根據該值算出試片之每1 m2
之透濕量(透濕度)(n＝3之平均值)。 (貼附時之官能評價) 針對實施例1及比較例1之各皮膚貼附材料，於志願者5人之前臂部，於對經裁切為寬度50 mm×長度50 mm之矩形狀的皮膚貼附材料將剝離襯墊剝離後，貼合黏著劑層面。繼而，將擔載膜剝離，於該狀態下於室溫下經過3小時，以3等級對此時之貼附部位之緊繃感、皮膚貼附材料之端部之隆起狀態、悶熱程度進行評價。進而，以3等級對剝離皮膚貼附材料時之疼痛程度進行評價。 [表1] 
[表2] 
(緊繃感) 3：無緊繃感，2：略有緊繃感，1：有緊繃感 (隆起之狀態) 3：無隆起，2：端部略有隆起，1：一半以上有隆起 (疼痛程度) 3：並無疼痛，2：略有疼痛，1：有疼痛 (悶熱程度) 3：於貼附部位不會積汗，2：於貼附部位略微積汗，1：於貼附部位積汗 將結果示於表1、2。 實施例1之皮膚貼附材料於貼附之期間中亦不會產生悶熱，且未見端部之隆起而顯示出良好之皮膚貼附性。又，實施例1之皮膚貼附材料對於皮膚之動作顯示出良好之追隨性，幾乎無緊繃感，且係感覺不到貼附般之良好之服貼感。進而，實施例1之皮膚貼附材料儘管顯示出良好之皮膚貼附性，但亦無剝離時之糊劑殘留，且幾乎不存在剝離時之物理性皮膚刺激(疼痛)。 另一方面，比較例1之皮膚貼附材料係於貼附過程中可見緊繃感，且感覺到貼附。又，比較例1之皮膚貼附材料存在於貼附部位積汗之情形。 (實施例2) 於使包含丙烯酸異壬酯65份、丙烯酸2-甲氧基乙酯30份、丙烯酸5份之單體混合物進行共聚合反應而獲得之丙烯酸系共聚物之溶液中，相對於丙烯酸系共聚物100份，調配三辛酸甘油酯60份、作為交聯劑之三官能性異氰酸酯化合物0.13份，製作均勻之黏著劑溶液。 其次，以乾燥後之厚度成為23 μm之方式將該溶液塗佈於單面經聚矽氧剝離處理的剝離襯墊之剝離處理面，進行乾燥而形成黏著劑層。將該黏著劑層貼合於在厚度8 μm之聚胺基甲酸酯彈性體膜(基材膜)上以可剝離之方式積層有厚度40 μm之聚丙烯膜(擔載膜)的積層膜之聚胺基甲酸酯彈性體膜面，獲得實施例2之皮膚貼附材料。 (實施例3～5、比較例2～3) 如表3中所記載般變更聚胺基甲酸酯彈性體膜之厚度及乾燥後之黏著劑層之厚度，除此以外，以與實施例2相同之方式獲得實施例3～5及比較例2～3之皮膚貼附材料。 (比較例4) 不調配三辛酸甘油酯及作為交聯劑之三官能性異氰酸酯化合物而製作均勻之黏著劑溶液，除此以外，以與實施例2相同之方式獲得比較例4之皮膚貼附材料。 (比較例5) 將厚度8 μm之聚胺基甲酸酯彈性體膜換成厚度6 μm之聚對苯二甲酸乙二酯膜，除此以外，以與實施例2相同之方式獲得比較例5之皮膚貼附材料。 關於實施例2～5及比較例2～5之皮膚貼附材料，彙總示於表3。 [表3] 
PU：聚胺基甲酸酯彈性體膜，PET：聚對苯二甲酸乙二酯膜 (模數) 針對實施例2～5及比較例2～5之皮膚貼附材料，將皮膚貼附材料裁切為寬度10 mm×長度100 mm之矩形狀，於將剝離襯墊剝離後，以拉伸試驗機之夾頭間成為40 mm之方式進行安裝。其次，於剝離擔載膜後，以速度300 mm/min拉伸，並讀取伸長率為10%、30%、100%時之荷重(N/10 mm)(n＝3之平均值)。 (透濕度) 針對實施例2～5及比較例2～5之皮膚貼附材料，以與實施例1及比較例1之皮膚貼附材料相同之方式測定透濕度。 (發黏) 針對實施例2～5及比較例2～5之皮膚貼附材料，將皮膚貼附材料裁切為寬度19 mm×長度約70 mm之矩形狀，於將剝離襯墊剝離後，自被試驗者之手指之第一關節捲至第二關節後，將擔載膜剝離。以手掌將皮膚貼附材料按壓30秒鐘，其後於纏繞有皮膚貼附材料之狀態下經過5分鐘後，將皮膚貼附材料剝離，以5等級對此時之發黏狀態進行評價(n＝5之平均值)。 5分：與貼附前無變化，未發黏 4分：略微感覺到油狀成分 3分：略微發黏，感覺到黏著成分 2分：目測存在少許糊劑殘留 1分：目測存在明顯之糊劑殘留 (剝離時之疼痛) 針對實施例2～5及比較例2～5之皮膚貼附材料，將皮膚貼附材料裁切為寬度19 mm×長度約70 mm之矩形狀，於將剝離襯墊剝離後，自被試驗者之手指之第一關節捲至第二關節後，將擔載膜剝離。以手掌將皮膚貼附材料按壓30秒鐘，其後於纏繞有皮膚貼附材料之狀態下經過5分鐘後，將皮膚貼附材料剝離，依據圖1之Face Pain Scale以5等級對此時之疼痛進行評價(n＝5之平均值)。 ＜評分＞ 5分：感覺不到疼痛 4分：略微感覺到疼痛 3分：感覺到能夠忍耐之程度之疼痛 2分：明顯地感覺到疼痛 1分：感覺到難以忍耐之疼痛 [表4] 
將結果示於表4。 實施例2～5之皮膚貼附材料由於顯示出較低之模數，故而具有忘記貼附般之良好之服貼感，並且顯示出較高之透濕度，故而不易產生貼附時之悶熱。又，實施例2～5之皮膚貼附材料係貼附後之發黏或剝離時之疼痛顯示出良好之結果，且不易產生貼附時之瘙癢感，抑制剝離時之物理刺激，具有對皮膚溫和之特性。 另一方面，比較例2、3之皮膚貼附材料與實施例2～5之皮膚貼附材料相比，具有較高之模數，顯示出貼附時之服貼感較差之傾向，又，透濕度略低，顯示出容易發黏之傾向。比較例5之皮膚貼附材料明顯具有較高之模數，貼附時之服貼感較差，又，透濕度亦較低，容易發黏。 可認為實施例2之皮膚貼附材料與比較例4之皮膚貼附材料係由有無液狀或糊狀之成分所導致之不同，實施例2之皮膚貼附材料藉由含有液狀或糊狀之成分，不僅確認到減輕剝離時之疼痛之效果，亦確認到透濕度提高之未預期之效果，發黏之評分顯示出較高之值。 以上，根據上述具體例詳細地說明了本發明，但本發明並不限定於上述具體例，只要不脫離本發明之範疇，則可進行任何變化或變更。
圖1係表示與實施例2～5及比較例2～5之皮膚貼附材料相關的自皮膚剝離時之疼痛之評價中所使用之面部表情疼痛等級(Face Pain Scale)之圖。
Claims (8)
- 一種皮膚貼附材料，其特徵在於：其係於聚胺基甲酸酯彈性體膜之一面設置黏著劑層，並且具有覆蓋上述黏著劑層之黏著面且以可剝離之方式積層的剝離襯墊者，且上述聚胺基甲酸酯彈性體膜之厚度為1~9μm，上述黏著劑層包含丙烯酸系共聚物、及於室溫下為液狀或糊狀之成分，上述丙烯酸系共聚物含有由包含40質量%~80質量%之(甲基)丙烯酸烷基酯單體、及10質量%~60質量%之含烷氧基之乙烯性不飽和單體之單體混合物所獲得之丙烯酸系共聚物。
- 如請求項1之皮膚貼附材料，其中上述於室溫下為液狀或糊狀之成分為羧酸酯。
- 如請求項2之皮膚貼附材料，其中上述羧酸酯為飽和脂肪酸之甘油酯。
- 如請求項3之皮膚貼附材料，其中上述飽和脂肪酸係選自由辛酸、癸酸、及2-乙基己酸所組成之群中之至少一種。
- 如請求項2之皮膚貼附材料，其中上述羧酸酯係選自由三辛酸甘油酯、三癸酸甘油酯、及三-2-乙基己酸甘油酯所組成之群中之至少一種。
- 如請求項1之皮膚貼附材料，其中上述黏著劑層相對於上述丙烯酸系共聚物100質量份，包含20~100質量份之於室溫下為液狀或糊狀之成分。
- 如請求項1至6中任一項之皮膚貼附材料，其具有覆蓋上述聚胺基甲酸酯彈性體膜之另一面且以可剝離之方式積層的擔載膜。
- 一種皮膚貼附材料捲繞體，其特徵在於將如請求項7之皮膚貼附材料捲繞而成。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016156971 | 2016-08-09 | ||
| JP??2016-156971 | 2016-08-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201806629A TW201806629A (zh) | 2018-03-01 |
| TWI771313B true TWI771313B (zh) | 2022-07-21 |
Family
ID=59655890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW106126875A TWI771313B (zh) | 2016-08-09 | 2017-08-09 | 皮膚貼附材料及皮膚貼附材料捲繞體 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180043144A1 (zh) |
| EP (1) | EP3281996B1 (zh) |
| JP (1) | JP2018023784A (zh) |
| KR (1) | KR102337039B1 (zh) |
| CN (1) | CN107693839A (zh) |
| TW (1) | TWI771313B (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7369552B2 (ja) * | 2018-06-29 | 2023-10-26 | ニチバン株式会社 | 医療用貼付材 |
| WO2020059861A1 (ja) * | 2018-09-20 | 2020-03-26 | 凸版印刷株式会社 | 検査用シール |
| JP2020103490A (ja) * | 2018-12-27 | 2020-07-09 | 桐灰化学株式会社 | 発熱具 |
| US20220151836A1 (en) * | 2019-01-28 | 2022-05-19 | Nitto Denko Corporation | Adhesive skin patch material |
| CN112451162A (zh) * | 2019-12-13 | 2021-03-09 | 周文杰 | 一种防皮肤病扩散的肉牛自动按摩装置及方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1033655A (ja) | 1996-07-30 | 1998-02-10 | Nitto Denko Corp | 皮膚炎処置用貼付材 |
| US6998432B2 (en) * | 2000-09-01 | 2006-02-14 | Nitto Denko Corporation | Adhesive composition for skin and adhesive tape or sheet for skin comprising the composition |
| JP3808771B2 (ja) * | 2001-12-28 | 2006-08-16 | 日東電工株式会社 | 皮膚貼付用粘着シートおよびその製造方法 |
| JP2005304756A (ja) * | 2004-04-21 | 2005-11-04 | Nitto Denko Corp | 皮膚貼付用粘着シート |
| US7925332B2 (en) * | 2005-05-13 | 2011-04-12 | Infrared Imaging Systems, Inc. | Disposable light source patch for enhanced visualization of subcutaneous structures |
| US20100217171A1 (en) * | 2007-09-28 | 2010-08-26 | Nichiban Co., Ltd. | Patch Material |
| JP2009273581A (ja) * | 2008-05-13 | 2009-11-26 | Nitto Denko Corp | 粘着フィルムおよびシート |
| JP2010082102A (ja) * | 2008-09-30 | 2010-04-15 | Nitto Denko Corp | 皮膚貼付用粘着テープもしくはシートおよびその製造方法 |
| JP2012061171A (ja) * | 2010-09-16 | 2012-03-29 | New Tac Kasei Co Ltd | ドレッシング材 |
| CA2783917A1 (en) * | 2011-08-01 | 2013-02-01 | Nitto Denko Corporation | Roll body of band-like patch |
| JP6129487B2 (ja) * | 2012-07-09 | 2017-05-17 | 日東電工株式会社 | 貼付材巻回体の包装構造 |
| JP2014054889A (ja) * | 2012-09-12 | 2014-03-27 | Ichikoh Ind Ltd | 側方照射灯システム |
| JP2015173948A (ja) * | 2014-03-18 | 2015-10-05 | 日東電工株式会社 | 皮膚貼着テープもしくはシート |
-
2017
- 2017-08-09 US US15/672,433 patent/US20180043144A1/en not_active Abandoned
- 2017-08-09 KR KR1020170101012A patent/KR102337039B1/ko active IP Right Grant
- 2017-08-09 EP EP17185482.1A patent/EP3281996B1/en active Active
- 2017-08-09 JP JP2017154298A patent/JP2018023784A/ja active Pending
- 2017-08-09 CN CN201710675583.1A patent/CN107693839A/zh active Pending
- 2017-08-09 TW TW106126875A patent/TWI771313B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107693839A (zh) | 2018-02-16 |
| EP3281996A1 (en) | 2018-02-14 |
| JP2018023784A (ja) | 2018-02-15 |
| KR20180018395A (ko) | 2018-02-21 |
| EP3281996B1 (en) | 2021-06-16 |
| TW201806629A (zh) | 2018-03-01 |
| US20180043144A1 (en) | 2018-02-15 |
| KR102337039B1 (ko) | 2021-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI771313B (zh) | 皮膚貼附材料及皮膚貼附材料捲繞體 | |
| JP2015173948A (ja) | 皮膚貼着テープもしくはシート | |
| TW200538478A (en) | Film base material for adhesive skin patch and adhesive skin patch | |
| JP4153070B2 (ja) | 貼付材用基材およびそれを用いてなる医療用貼付材、ならびに救急絆創膏 | |
| TW201834544A (zh) | 皮膚貼附材料及皮膚貼附材料捲繞體 | |
| JP2011126865A (ja) | 貼付剤および貼付製剤 | |
| JP5177726B2 (ja) | 皮膚貼付用粘着剤組成物、および皮膚貼付用粘着テープもしくはシート | |
| JPWO2011136330A1 (ja) | 貼付剤とその使用 | |
| JP2005218496A (ja) | 皮膚貼付材用フィルム基材及び皮膚貼付材 | |
| JP7384824B2 (ja) | 皮膚貼着用テープもしくはシート | |
| CN113316437A (zh) | 皮肤粘贴材料 | |
| JP2000230157A (ja) | 伸縮性粘着テープもしくはシート | |
| JP7473485B2 (ja) | 皮膚貼付材 | |
| JP2005304756A (ja) | 皮膚貼付用粘着シート | |
| TWI835980B (zh) | 皮膚貼附材料 | |
| JP3407895B2 (ja) | 貼付材および貼付製剤の皮膚刺激性を評価する方法 | |
| JP2004313710A (ja) | 皮膚保護用粘着剤、皮膚保護用粘着剤組成物及び皮膚保護用粘着 シート | |
| TW202320724A (zh) | 皮膚貼附材料 | |
| JP6318356B2 (ja) | ビソプロロール含有貼付製剤およびその包装体 | |
| JP2012219045A (ja) | 貼付剤および貼付製剤 | |
| JP2002315775A (ja) | 皮膚貼付用粘着シート | |
| JP2005218494A (ja) | 皮膚貼付材用フィルム基材及び皮膚貼付材 | |
| JP2011254909A (ja) | 医療用粘着テープまたはシート |