TWI722400B - 間質幹細胞之胞外泌體及其用途 - Google Patents

間質幹細胞之胞外泌體及其用途 Download PDF

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TWI722400B
TWI722400B TW108109188A TW108109188A TWI722400B TW I722400 B TWI722400 B TW I722400B TW 108109188 A TW108109188 A TW 108109188A TW 108109188 A TW108109188 A TW 108109188A TW I722400 B TWI722400 B TW I722400B
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mesenchymal stem
stem cells
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TW108109188A
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TW202034932A (zh
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丁大清
吳坤佶
張宇勳
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佛教慈濟醫療財團法人
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Priority to JP2019054780A priority patent/JP7547032B2/ja
Priority to US16/821,481 priority patent/US12383580B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW108109188A 2019-03-18 2019-03-18 間質幹細胞之胞外泌體及其用途 TWI722400B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
TW108109188A TWI722400B (zh) 2019-03-18 2019-03-18 間質幹細胞之胞外泌體及其用途
JP2019054780A JP7547032B2 (ja) 2019-03-18 2019-03-22 間葉系幹細胞のエキソソームおよびその使用
US16/821,481 US12383580B2 (en) 2019-03-18 2020-03-17 Mesenchymal stem cell derived exosomes and method for preventing or treating a joint disorder by administering a composition comprising the same

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TW108109188A TWI722400B (zh) 2019-03-18 2019-03-18 間質幹細胞之胞外泌體及其用途

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TWI722400B true TWI722400B (zh) 2021-03-21

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112336750A (zh) * 2020-11-11 2021-02-09 中山大学附属第三医院 间充质干细胞源性小细胞外囊泡在制备治疗自身免疫性疾病药物中的应用
KR20220068148A (ko) * 2020-11-18 2022-05-25 주식회사 온코인사이트 역분화 줄기세포 유래 중간엽 줄기세포로부터 분리된 엑소좀의 제조방법 및 이의 용도
CN112410292B (zh) * 2020-11-19 2022-06-07 广东香雪干细胞再生医学科技有限公司 脐带间充质干细胞脂质囊泡体的制备方法及其在促进皮肤再生中的应用
KR102424333B1 (ko) * 2020-12-14 2022-07-22 조선대학교산학협력단 펩타이드를 이용하는 줄기세포 유래 고순도 세포외 소포체의 대량 생산 방법
US20240139376A1 (en) * 2021-02-12 2024-05-02 Rhode Island Hospital Reconstitution of extracellular matrixes for musculoskeletal joint tissue repair using biomimetic biologic and synthetic factors
CN113005093A (zh) * 2021-02-25 2021-06-22 翟骁 Cd73修饰的人脐带血来源的外泌体及其应用
CN113321709A (zh) * 2021-05-18 2021-08-31 南方医科大学 自组装多肽、缓释外泌体多肽水凝胶及其制备方法和应用
CN113197919B (zh) * 2021-05-27 2023-02-03 中国科学院动物研究所 鹿茸干细胞外泌体在制备改善或治疗骨关节炎和延缓细胞衰老的产品中的应用
CN113616675A (zh) * 2021-08-23 2021-11-09 上海太安堂生物医学有限公司 含间充质干细胞的组合物及其在治疗退行性关节炎的应用
JP2024530288A (ja) * 2021-08-24 2024-08-16 フォーエバー・ラボラトリーズ・インコーポレイテッド 細胞外小胞を単離するためのデバイス及び方法
CN114377034A (zh) * 2022-01-19 2022-04-22 四川大学华西医院 一种用于关节炎治疗的生物制剂及其制备方法和应用
CN114591901B (zh) * 2022-03-24 2023-11-24 和携科技有限公司 动物脐带间充质干细胞外泌体提取方法
CN114939128A (zh) * 2022-06-02 2022-08-26 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在修复关节软骨缺损中的应用
CN115068616A (zh) * 2022-06-16 2022-09-20 广州惠善医疗技术有限公司 间充质干细胞来源外泌体联合非甾体抗炎药在制备预防或治疗骨关节疾病药物中的应用
CN114891736A (zh) * 2022-07-01 2022-08-12 中晶生物技术股份有限公司 一种三维培养的间充质干细胞外泌体增强软骨细胞生长与特性维持的方法及其应用
CN115487208A (zh) * 2022-10-24 2022-12-20 格莱康美生物医学技术(北京)有限公司 一种用于治疗骨关节炎/软骨损伤的组合物及其制备方法
CN116115642A (zh) * 2023-01-18 2023-05-16 北京美欧赛奥金生物科技有限公司 改良富血小板血浆制备及制剂组合物应用
JPWO2024195878A1 (https=) * 2023-03-23 2024-09-26
US20240408237A1 (en) * 2023-06-08 2024-12-12 Far Eastern Memorial Hospital Method and pharmaceutical composition for treating a cartilage damage using sox9 gene
CN116445401B (zh) * 2023-06-14 2023-08-22 成都康景生物科技有限公司 间充质干细胞培养基、干细胞外泌体及制备方法
KR102739922B1 (ko) * 2024-02-22 2024-12-11 유한회사 스템메디케어 면역관용화된 태아 줄기세포 유래 세포외소포의 골관절염 치료용 약학조성물로서의 용도, 세포외소포 제조방법 및 이를 이용한 골관절염 치료용 조성물
CN118165927A (zh) * 2024-04-24 2024-06-11 广州汉密顿生物科技有限公司 一种人脐带间充质干细胞制剂、制备方法及其在治疗膝骨关节炎中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170296590A1 (en) * 2015-02-04 2017-10-19 Exostemtech Co., Ltd. Composition for inducing chondrocyte differentiation and regenerating cartilage tissue

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015038075A1 (en) * 2013-09-16 2015-03-19 Agency For Science, Technology And Research Method
JP6714932B2 (ja) 2015-12-01 2020-07-01 株式会社ＡｄｉｐｏＳｅｅｄｓ 脊椎動物の脂肪組織由来間葉系細胞株の製造方法
EP3254684B1 (en) 2016-06-08 2019-10-23 Lysatpharma GmbH Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine
US10946047B2 (en) * 2016-06-17 2021-03-16 United Therapeutics Corporation Extracellular vesicles with enhanced potency
CA3064064A1 (en) * 2017-05-16 2018-11-22 Exostem Biotec Ltd. Methods of inhibiting aging and treating aging-related disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170296590A1 (en) * 2015-02-04 2017-10-19 Exostemtech Co., Ltd. Composition for inducing chondrocyte differentiation and regenerating cartilage tissue

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cosenza S, et al. "Mesenchymal stem cells aderived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis" Scientific Reports 2017;7, Article number: 16214
Furuta T, et al. "Mesenchymal stem cell-derived exosokes promote fracture healing in a mouse model" Stem Cells Translational Medicine 2016;5(12):1620-1630
Li JJ, et al. "Stem cell-derived extracellular vesicles for treating joint injury and osteoarthritis" Nanomaterials 14 Feb 2019;9,261; doi:10.3390/nano9020261
Li JJ, et al. "Stem cell-derived extracellular vesicles for treating joint injury and osteoarthritis" Nanomaterials 14 Feb 2019;9,261; doi:10.3390/nano9020261 Toh WS, et al. "MSC exosome as a cell-free MSC therapy for artilage regeneration: Implications for osteoarthritis treatment" Seminars in Cell & Developmental Biology 2017;67:56-64 Cosenza S, et al. "Mesenchymal stem cells aderived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis" Scientific Reports 2017;7, Article number: 16214 Liu Y, et al. "MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via IncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis" Cell Cycle 2018;17(21-22):2411-2422 Furuta T, et al. "Mesenchymal stem cell-derived exosokes promote fracture healing in a mouse model" Stem Cells Translational Medicine 2016;5(12):1620-1630 *
Liu Y, et al. "MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via IncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis" Cell Cycle 2018;17(21-22):2411-2422
Toh WS, et al. "MSC exosome as a cell-free MSC therapy for artilage regeneration: Implications for osteoarthritis treatment" Seminars in Cell & Developmental Biology 2017;67:56-64

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US20200297761A1 (en) 2020-09-24
TW202034932A (zh) 2020-10-01
JP2020152698A (ja) 2020-09-24
JP7547032B2 (ja) 2024-09-09
US12383580B2 (en) 2025-08-12

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