JP7547032B2 - 間葉系幹細胞のエキソソームおよびその使用 - Google Patents

間葉系幹細胞のエキソソームおよびその使用 Download PDF

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JP7547032B2
JP7547032B2 JP2019054780A JP2019054780A JP7547032B2 JP 7547032 B2 JP7547032 B2 JP 7547032B2 JP 2019054780 A JP2019054780 A JP 2019054780A JP 2019054780 A JP2019054780 A JP 2019054780A JP 7547032 B2 JP7547032 B2 JP 7547032B2
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mesenchymal stem
stem cells
exosomes
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JP2020152698A (ja
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大清 丁
坤佶 呉
宇勳 張
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Buddhist Tzu Chi Medical Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019054780A 2019-03-18 2019-03-22 間葉系幹細胞のエキソソームおよびその使用 Active JP7547032B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW108109188 2019-03-18
TW108109188A TWI722400B (zh) 2019-03-18 2019-03-18 間質幹細胞之胞外泌體及其用途

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CN112336750A (zh) * 2020-11-11 2021-02-09 中山大学附属第三医院 间充质干细胞源性小细胞外囊泡在制备治疗自身免疫性疾病药物中的应用
KR20220068148A (ko) * 2020-11-18 2022-05-25 주식회사 온코인사이트 역분화 줄기세포 유래 중간엽 줄기세포로부터 분리된 엑소좀의 제조방법 및 이의 용도
CN112410292B (zh) * 2020-11-19 2022-06-07 广东香雪干细胞再生医学科技有限公司 脐带间充质干细胞脂质囊泡体的制备方法及其在促进皮肤再生中的应用
KR102424333B1 (ko) * 2020-12-14 2022-07-22 조선대학교산학협력단 펩타이드를 이용하는 줄기세포 유래 고순도 세포외 소포체의 대량 생산 방법
US20240139376A1 (en) * 2021-02-12 2024-05-02 Rhode Island Hospital Reconstitution of extracellular matrixes for musculoskeletal joint tissue repair using biomimetic biologic and synthetic factors
CN113005093A (zh) * 2021-02-25 2021-06-22 翟骁 Cd73修饰的人脐带血来源的外泌体及其应用
CN113321709A (zh) * 2021-05-18 2021-08-31 南方医科大学 自组装多肽、缓释外泌体多肽水凝胶及其制备方法和应用
CN113197919B (zh) * 2021-05-27 2023-02-03 中国科学院动物研究所 鹿茸干细胞外泌体在制备改善或治疗骨关节炎和延缓细胞衰老的产品中的应用
CN113616675A (zh) * 2021-08-23 2021-11-09 上海太安堂生物医学有限公司 含间充质干细胞的组合物及其在治疗退行性关节炎的应用
JP2024530288A (ja) * 2021-08-24 2024-08-16 フォーエバー・ラボラトリーズ・インコーポレイテッド 細胞外小胞を単離するためのデバイス及び方法
CN114377034A (zh) * 2022-01-19 2022-04-22 四川大学华西医院 一种用于关节炎治疗的生物制剂及其制备方法和应用
CN114591901B (zh) * 2022-03-24 2023-11-24 和携科技有限公司 动物脐带间充质干细胞外泌体提取方法
CN114939128A (zh) * 2022-06-02 2022-08-26 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在修复关节软骨缺损中的应用
CN115068616A (zh) * 2022-06-16 2022-09-20 广州惠善医疗技术有限公司 间充质干细胞来源外泌体联合非甾体抗炎药在制备预防或治疗骨关节疾病药物中的应用
CN114891736A (zh) * 2022-07-01 2022-08-12 中晶生物技术股份有限公司 一种三维培养的间充质干细胞外泌体增强软骨细胞生长与特性维持的方法及其应用
CN115487208A (zh) * 2022-10-24 2022-12-20 格莱康美生物医学技术(北京)有限公司 一种用于治疗骨关节炎/软骨损伤的组合物及其制备方法
CN116115642A (zh) * 2023-01-18 2023-05-16 北京美欧赛奥金生物科技有限公司 改良富血小板血浆制备及制剂组合物应用
JPWO2024195878A1 (https=) * 2023-03-23 2024-09-26
US20240408237A1 (en) * 2023-06-08 2024-12-12 Far Eastern Memorial Hospital Method and pharmaceutical composition for treating a cartilage damage using sox9 gene
CN116445401B (zh) * 2023-06-14 2023-08-22 成都康景生物科技有限公司 间充质干细胞培养基、干细胞外泌体及制备方法
KR102739922B1 (ko) * 2024-02-22 2024-12-11 유한회사 스템메디케어 면역관용화된 태아 줄기세포 유래 세포외소포의 골관절염 치료용 약학조성물로서의 용도, 세포외소포 제조방법 및 이를 이용한 골관절염 치료용 조성물
CN118165927A (zh) * 2024-04-24 2024-06-11 广州汉密顿生物科技有限公司 一种人脐带间充质干细胞制剂、制备方法及其在治疗膝骨关节炎中的应用

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US10946047B2 (en) * 2016-06-17 2021-03-16 United Therapeutics Corporation Extracellular vesicles with enhanced potency
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WO2017211906A1 (en) 2016-06-08 2017-12-14 De Miroschedji Kyra Natalia Matahari Human platelet lysate derived extracellular vesicles for use in medicine

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TW202034932A (zh) 2020-10-01
JP2020152698A (ja) 2020-09-24
TWI722400B (zh) 2021-03-21
US12383580B2 (en) 2025-08-12

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