TWI708781B - Fgf21衍生物及其用途 - Google Patents
Fgf21衍生物及其用途 Download PDFInfo
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- TWI708781B TWI708781B TW108144310A TW108144310A TWI708781B TW I708781 B TWI708781 B TW I708781B TW 108144310 A TW108144310 A TW 108144310A TW 108144310 A TW108144310 A TW 108144310A TW I708781 B TWI708781 B TW I708781B
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- ethoxy
- amino
- fgf21
- carboxy
- ethylamino
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- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title claims abstract description 392
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title claims abstract description 392
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 claims abstract description 80
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 331
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- 125000005825 oxyethoxy group Chemical group [H]C([H])(O[*:1])C([H])([H])O[*:2] 0.000 claims description 108
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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| KR102433503B1 (ko) | 2016-05-24 | 2022-08-18 | 노보 노르디스크 에이/에스 | Mic-1 화합물 및 이것의 사용 |
| CN106421753A (zh) * | 2016-10-19 | 2017-02-22 | 哈尔滨医科大学 | 重组人成纤维细胞生长因子‑21在制备预防和治疗缺血性心律失常药物中的应用 |
| TWI710377B (zh) * | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Ｍｉｃ－１化合物及其用途 |
| WO2019043457A2 (en) | 2017-09-04 | 2019-03-07 | 89Bio Ltd. | CONJUGATES OF MUTANT PEPTIDE FGF-21 AND USES THEREOF |
| KR20210027426A (ko) | 2018-07-03 | 2021-03-10 | 브리스톨-마이어스 스큅 컴퍼니 | Fgf21 제제 |
| US11427623B1 (en) | 2019-05-28 | 2022-08-30 | 89Bio Ltd. | Methods of treatment using mutant FGF-21 peptide conjugates |
| CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| EP4089108A1 (en) | 2021-05-11 | 2022-11-16 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| US20240279297A1 (en) | 2021-05-11 | 2024-08-22 | Cytoki Pharma Aps | Therapeutic derivatives of interleukin-22 |
| KR102631925B1 (ko) * | 2021-06-10 | 2024-02-01 | 토드제약 주식회사 | 신규 fgf21 변이체 개발 및 이의 생산기법과 용도 |
| WO2023284822A1 (en) * | 2021-07-14 | 2023-01-19 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion polypeptides for metabolic disorders |
| JP2024531980A (ja) * | 2021-09-08 | 2024-09-03 | リートー ラボラトリーズ カンパニー リミテッド | Ｆｇｆ２１変異タンパク質及びその応用 |
| MA71385A (fr) | 2022-07-08 | 2025-04-30 | Novo Nordisk A/S | Composés isvd hautement puissants capables de remplacer fviii(a) |
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| CN121194798A (zh) * | 2023-05-12 | 2025-12-23 | 诺和诺德股份有限公司 | 长效生长激素受体拮抗剂及其用途 |
| KR20250039299A (ko) | 2023-09-11 | 2025-03-20 | 노보 노르디스크 에이/에스 | 항-il-6 도메인 항체 |
| CN118307684B (zh) * | 2024-06-11 | 2024-10-18 | 北京志道生物科技有限公司 | 一种经脂肪酸链修饰的glp-1-fgf21融合蛋白及其制备方法和应用 |
| WO2026012311A1 (zh) * | 2024-07-08 | 2026-01-15 | 浙江道尔生物科技有限公司 | Fgf21衍生物及其用途 |
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| WO2012010553A1 (en) * | 2010-07-20 | 2012-01-26 | Novo Nordisk A/S | N-terminal modified fgf21 compounds |
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| DE122009000079I2 (de) | 1996-08-30 | 2011-06-16 | Novo Nordisk As Novo Alle | Glp-1 derivate |
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| EP1329227A1 (en) | 2002-01-22 | 2003-07-23 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Diagnostic conjugate useful for intercellular imaging and for differentiating between tumor- and non-tumor cells |
| ES2371072T3 (es) | 2003-06-12 | 2011-12-27 | Eli Lilly And Company | Proteínas de fusión análogas de glp-1. |
| EP1670515A2 (en) | 2003-09-19 | 2006-06-21 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
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| PL1751184T3 (pl) | 2004-05-13 | 2010-02-26 | Lilly Co Eli | Białka fuzyjne FGF-21 |
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| BRPI0514790A (pt) | 2004-09-02 | 2008-06-24 | Lilly Co Eli | muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano |
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| WO2011154349A2 (en) * | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Fgf21 analogues and derivatives |
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