RU2729011C2 - Производные fgf21 и их применения - Google Patents
Производные fgf21 и их применения Download PDFInfo
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- RU2729011C2 RU2729011C2 RU2017125050A RU2017125050A RU2729011C2 RU 2729011 C2 RU2729011 C2 RU 2729011C2 RU 2017125050 A RU2017125050 A RU 2017125050A RU 2017125050 A RU2017125050 A RU 2017125050A RU 2729011 C2 RU2729011 C2 RU 2729011C2
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- RU
- Russia
- Prior art keywords
- ethoxy
- amino
- fgf21
- oxo
- ethylamino
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- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title claims abstract description 389
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title claims abstract description 388
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 claims abstract description 93
- 102000056713 human FGF21 Human genes 0.000 claims abstract description 93
- 230000000694 effects Effects 0.000 claims abstract description 74
- 239000003814 drug Substances 0.000 claims abstract description 8
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 400
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 319
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 187
- -1 11-carboxyundecanoyl- amino Chemical group 0.000 claims description 130
- 150000001875 compounds Chemical class 0.000 claims description 113
- 238000000034 method Methods 0.000 claims description 104
- 125000005647 linker group Chemical group 0.000 claims description 77
- 108090000623 proteins and genes Proteins 0.000 claims description 74
- 102000004169 proteins and genes Human genes 0.000 claims description 73
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 70
- 150000001413 amino acids Chemical group 0.000 claims description 35
- 238000006467 substitution reaction Methods 0.000 claims description 25
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 22
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 21
- 206010012601 diabetes mellitus Diseases 0.000 claims description 21
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 20
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 20
- 230000002265 prevention Effects 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 17
- 125000004434 sulfur atom Chemical group 0.000 claims description 14
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| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| US20240279297A1 (en) | 2021-05-11 | 2024-08-22 | Cytoki Pharma Aps | Therapeutic derivatives of interleukin-22 |
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