TWI694073B - 作為組蛋白去乙醯酶６抑制劑之二唑胺衍生物及含彼之醫藥組合物 - Google Patents
作為組蛋白去乙醯酶６抑制劑之二唑胺衍生物及含彼之醫藥組合物 Download PDFInfo
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- TWI694073B TWI694073B TW105132939A TW105132939A TWI694073B TW I694073 B TWI694073 B TW I694073B TW 105132939 A TW105132939 A TW 105132939A TW 105132939 A TW105132939 A TW 105132939A TW I694073 B TWI694073 B TW I694073B
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- Taiwan
- Prior art keywords
- amine
- diazol
- cyclobutyl
- pyrimidine
- difluoromethyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 108010023925 Histone Deacetylase 6 Proteins 0.000 title abstract description 34
- 102000011427 Histone Deacetylase 6 Human genes 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 20
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 17
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 14
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 12
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 12
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
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Classifications
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- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| KR101839137B1 (ko) | 2018-03-26 |
| WO2017065473A1 (en) | 2017-04-20 |
| DK3362445T3 (da) | 2023-02-27 |
| BR112018007289A2 (pt) | 2018-10-23 |
| ES2940413T3 (es) | 2023-05-08 |
| JP2018530571A (ja) | 2018-10-18 |
| US10494355B2 (en) | 2019-12-03 |
| CA3001666C (en) | 2021-03-30 |
| AU2016338118B2 (en) | 2019-03-14 |
| CN108699048B (zh) | 2021-12-28 |
| PH12018500773B1 (en) | 2018-10-29 |
| HRP20230201T1 (hr) | 2023-03-31 |
| MX2018004447A (es) | 2018-08-01 |
| EP3362445A1 (en) | 2018-08-22 |
| EP3362445B1 (en) | 2023-01-25 |
| CA3001666A1 (en) | 2017-04-20 |
| PL3362445T3 (pl) | 2023-08-07 |
| FI3362445T3 (fi) | 2023-03-21 |
| KR20170043091A (ko) | 2017-04-20 |
| PT3362445T (pt) | 2023-03-20 |
| TW201716397A (zh) | 2017-05-16 |
| CN108699048A (zh) | 2018-10-23 |
| MX384527B (es) | 2025-03-14 |
| MY196174A (en) | 2023-03-20 |
| HUE061967T2 (hu) | 2023-09-28 |
| JP6697074B2 (ja) | 2020-05-20 |
| EP3362445A4 (en) | 2019-05-22 |
| PH12018500773A1 (en) | 2018-10-29 |
| RU2695133C1 (ru) | 2019-07-22 |
| NZ740809A (en) | 2019-04-26 |
| US20180273495A1 (en) | 2018-09-27 |
| AU2016338118A1 (en) | 2018-04-12 |
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