PT1465861E - Derivados de α-(n-sulfonamido)-acetamida como inibidores β-amilóides - Google Patents

Derivados de α-(n-sulfonamido)-acetamida como inibidores β-amilóides Download PDF

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Publication number
PT1465861E
PT1465861E PT02805633T PT02805633T PT1465861E PT 1465861 E PT1465861 E PT 1465861E PT 02805633 T PT02805633 T PT 02805633T PT 02805633 T PT02805633 T PT 02805633T PT 1465861 E PT1465861 E PT 1465861E
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Portugal
Prior art keywords
beta
alpha
sulphonamido
acetamide derivatives
amyloid inhibitors
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PT02805633T
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English (en)
Inventor
Michael F Parker
Katharine E Mcelhone
Robert A Mate
Joanne J Bronson
Yonghua Gai
Carl P Bergstrom
Lawrence R Marcin
John E Macor
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Bristol Myers Squibb Co
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Publication of PT1465861E publication Critical patent/PT1465861E/pt

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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PT02805633T 2001-12-20 2002-12-20 Derivados de α-(n-sulfonamido)-acetamida como inibidores β-amilóides PT1465861E (pt)

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ATE430727T1 (de) 2009-05-15
US20080085894A1 (en) 2008-04-10
JP2005513123A (ja) 2005-05-12
DK1465861T3 (da) 2009-08-31
EP1465861A1 (en) 2004-10-13
IL162498A (en) 2010-06-16
CN1617852A (zh) 2005-05-18
NO328976B1 (no) 2010-07-05
NZ533603A (en) 2007-02-23
WO2003053912A1 (en) 2003-07-03
HUP0500173A3 (en) 2009-03-30
US8513253B2 (en) 2013-08-20
HUP0500173A2 (hu) 2005-05-30
BR0215182A (pt) 2004-10-19
RU2300518C2 (ru) 2007-06-10
AU2002357333B2 (en) 2008-02-28
DE60232276D1 (de) 2009-06-18
IL162498A0 (en) 2005-11-20
CA2471099A1 (en) 2003-07-03
GEP20063920B (en) 2006-09-11
US7786122B2 (en) 2010-08-31
CO5590894A2 (es) 2005-12-30
MXPA04005927A (es) 2004-11-01
EP1465861B1 (en) 2009-05-06
IS7325A (is) 2004-06-18
JP5030982B2 (ja) 2012-09-19
AU2002357333A1 (en) 2003-07-09
CY1109275T1 (el) 2014-07-02
ZA200404811B (en) 2006-02-22
NO20043098L (no) 2004-09-01
RU2004122481A (ru) 2006-01-20
KR100966705B1 (ko) 2010-06-29
PL204281B1 (pl) 2009-12-31
JP2009102435A (ja) 2009-05-14
EP1465861A4 (en) 2005-12-07
US7300936B2 (en) 2007-11-27
US20110105485A1 (en) 2011-05-05
ES2325205T3 (es) 2009-08-28
SI1465861T1 (sl) 2009-12-31
JP4287746B2 (ja) 2009-07-01
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