ATE430727T1 - Alpha-(n-sulfonamid)acetamidderivate als beta- amyloidinhibitoren - Google Patents

Alpha-(n-sulfonamid)acetamidderivate als beta- amyloidinhibitoren

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Publication number
ATE430727T1
ATE430727T1 AT02805633T AT02805633T ATE430727T1 AT E430727 T1 ATE430727 T1 AT E430727T1 AT 02805633 T AT02805633 T AT 02805633T AT 02805633 T AT02805633 T AT 02805633T AT E430727 T1 ATE430727 T1 AT E430727T1
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Austria
Prior art keywords
beta
alpha
sulfonamide
acetamide derivatives
amyloid inhibitors
Prior art date
Application number
AT02805633T
Other languages
English (en)
Inventor
Michael Parker
Katharine E Mcelhone
Robert Mate
Joanne Bronson
Yonghua Gai
Carl Bergstrom
Lawrence MARCIN
John Macor
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Bristol Myers Squibb Co
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Publication of ATE430727T1 publication Critical patent/ATE430727T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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AT02805633T 2001-12-20 2002-12-20 Alpha-(n-sulfonamid)acetamidderivate als beta- amyloidinhibitoren ATE430727T1 (de)

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EP1465861B1 (de) 2009-05-06
US20080085894A1 (en) 2008-04-10
HUP0500173A2 (hu) 2005-05-30
EP1465861A1 (de) 2004-10-13
RS53704A (en) 2006-12-15
MXPA04005927A (es) 2004-11-01
EP1465861A4 (de) 2005-12-07
HUP0500173A3 (en) 2009-03-30
NO328976B1 (no) 2010-07-05
CA2471099A1 (en) 2003-07-03
RU2300518C2 (ru) 2007-06-10
IS2879B (is) 2014-04-15
AU2002357333B2 (en) 2008-02-28
DE60232276D1 (de) 2009-06-18
US8513253B2 (en) 2013-08-20
NO20043098L (no) 2004-09-01
IS7325A (is) 2004-06-18
PT1465861E (pt) 2009-07-08
AU2002357333A1 (en) 2003-07-09
JP4287746B2 (ja) 2009-07-01
BR0215182A (pt) 2004-10-19
CY1109275T1 (el) 2014-07-02
IL162498A0 (en) 2005-11-20
JP2005513123A (ja) 2005-05-12
SI1465861T1 (sl) 2009-12-31
RS51155B (sr) 2010-10-31
NZ533603A (en) 2007-02-23
HRP20040566A2 (en) 2004-10-31
KR20040068957A (ko) 2004-08-02
CA2471099C (en) 2011-04-12
US7786122B2 (en) 2010-08-31
US20110105485A1 (en) 2011-05-05
HK1067963A1 (en) 2005-04-22
KR100966705B1 (ko) 2010-06-29
CN1617852A (zh) 2005-05-18
WO2003053912A1 (en) 2003-07-03
PL371046A1 (en) 2005-06-13
CN1289469C (zh) 2006-12-13
JP5030982B2 (ja) 2012-09-19
CO5590894A2 (es) 2005-12-30
GEP20063920B (en) 2006-09-11
ZA200404811B (en) 2006-02-22
ES2325205T3 (es) 2009-08-28
US7300936B2 (en) 2007-11-27
JP2009102435A (ja) 2009-05-14
DK1465861T3 (da) 2009-08-31
US20040127494A1 (en) 2004-07-01
UA78537C2 (en) 2007-04-10
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PL204281B1 (pl) 2009-12-31
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