TWI638829B - 分枝桿菌抗原疫苗 - Google Patents

分枝桿菌抗原疫苗 Download PDF

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Publication number
TWI638829B
TWI638829B TW102124693A TW102124693A TWI638829B TW I638829 B TWI638829 B TW I638829B TW 102124693 A TW102124693 A TW 102124693A TW 102124693 A TW102124693 A TW 102124693A TW I638829 B TWI638829 B TW I638829B
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Taiwan
Prior art keywords
fusion
antigens
antigen
fusion polypeptide
mycobacterial
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TW102124693A
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English (en)
Chinese (zh)
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TW201408691A (zh
Inventor
艾曼鈕 土賓
羅曼 米可
查爾斯A 寇佩特
吉納維芙 英賈柏斯
瑪琍 果安維克
納薩里 錫維斯翠
珍 派普堤斯特 瑪章德
塞斯里 班尼
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法商傳斯堅公司
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Publication of TW201408691A publication Critical patent/TW201408691A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1289Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW102124693A 2012-07-10 2013-07-10 分枝桿菌抗原疫苗 TWI638829B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
??12305825.7 2012-07-10
EP12305825 2012-07-10
??12306539.3 2012-12-07
EP12306539 2012-12-07
EP13305737 2013-06-03
??13305737.2 2013-06-03

Publications (2)

Publication Number Publication Date
TW201408691A TW201408691A (zh) 2014-03-01
TWI638829B true TWI638829B (zh) 2018-10-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW102124693A TWI638829B (zh) 2012-07-10 2013-07-10 分枝桿菌抗原疫苗

Country Status (16)

Country Link
US (1) US10357555B2 (enExample)
EP (1) EP2872172B1 (enExample)
JP (1) JP6333814B2 (enExample)
KR (1) KR20150058152A (enExample)
CN (1) CN104640564B (enExample)
BR (1) BR112015000530A2 (enExample)
CA (1) CA2878800A1 (enExample)
EA (1) EA029492B1 (enExample)
IL (1) IL236650B (enExample)
MX (1) MX366206B (enExample)
MY (1) MY173004A (enExample)
SG (1) SG11201500171YA (enExample)
TW (1) TWI638829B (enExample)
UA (1) UA119228C2 (enExample)
WO (1) WO2014009438A2 (enExample)
ZA (1) ZA201500784B (enExample)

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KR101631054B1 (ko) * 2015-12-31 2016-06-16 중앙대학교 산학협력단 마이코박테리아 유래 CFP-10 또는 Ag85B에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편
CN105567660B (zh) * 2016-01-08 2018-11-20 中国人民解放军第四军医大学 一种大肠杆菌重组表达结核分枝杆菌Rv2837c活性蛋白的方法及其应用
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CN110291037A (zh) * 2017-02-17 2019-09-27 卫理公会医院 用于确定对象中的感染水平的组合物和方法
CN107236023B (zh) * 2017-05-12 2021-05-07 苏州创澜生物科技有限公司 一种用于检测结核感染的抗原组合物及其应用
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KR102135328B1 (ko) * 2018-12-19 2020-07-17 대한민국 결핵 2가 항원을 발현하는 약독화된 재조합 백시니아 바이러스 및 이를 포함하는 결핵 예방용 조성물
KR102157770B1 (ko) * 2019-01-11 2020-09-18 주식회사 파이지노믹스 가축의 결핵 진단을 위한 항원 펩타이드 조성물 및 이의 용도
CN109970183B (zh) * 2019-03-31 2021-01-15 浙江大学 一种复苏促进因子在印染废水处理中的应用及处理方法
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CN116162141B (zh) * 2022-11-30 2024-04-12 中国疾病预防控制中心传染病预防控制所 一种结核分枝杆菌抗原epcra013及其应用
CN116041543B (zh) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌多抗原融合蛋白及其编码基因和应用
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BR112015000530A2 (pt) 2018-08-28
HK1207962A1 (en) 2016-02-19
EP2872172A2 (en) 2015-05-20
US10357555B2 (en) 2019-07-23
WO2014009438A3 (en) 2014-04-10
JP6333814B2 (ja) 2018-05-30
US20150165014A1 (en) 2015-06-18
IL236650A0 (en) 2015-02-26
TW201408691A (zh) 2014-03-01
SG11201500171YA (en) 2015-02-27
CA2878800A1 (en) 2014-01-16
MX2015000449A (es) 2015-07-14
IL236650B (en) 2019-09-26
KR20150058152A (ko) 2015-05-28
ZA201500784B (en) 2020-07-29
MY173004A (en) 2019-12-18
CN104640564A (zh) 2015-05-20
UA119228C2 (uk) 2019-05-27
JP2015524794A (ja) 2015-08-27
EP2872172B1 (en) 2018-11-14
WO2014009438A2 (en) 2014-01-16
CN104640564B (zh) 2020-08-04
MX366206B (es) 2019-07-02
EA201590184A1 (ru) 2015-06-30
EA029492B1 (ru) 2018-04-30

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