TWI606064B - 細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途 - Google Patents
細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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| EP3560954B1 (en) | 2014-04-03 | 2021-08-04 | IGM Biosciences, Inc. | Modified j-chain |
| CN107207601A (zh) | 2015-01-20 | 2017-09-26 | Igm生物科学股份有限公司 | 肿瘤坏死因子(tnf)超家族受体结合分子及其应用 |
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| CA2980751A1 (en) | 2015-03-25 | 2016-09-29 | Stephen F. Carroll | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| US10570191B2 (en) | 2015-04-17 | 2020-02-25 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| FI3355913T3 (fi) | 2015-09-30 | 2024-12-02 | Igm Biosciences Inc | Muokatun j-ketjun sisältäviä sitoutuvia molekyylejä |
| JP7058213B2 (ja) | 2015-09-30 | 2022-04-21 | アイジーエム バイオサイエンシズ インコーポレイテッド | 改変ｊ鎖を有する結合分子 |
| JP6979971B2 (ja) | 2016-05-09 | 2021-12-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
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| JP2020506971A (ja) | 2017-02-08 | 2020-03-05 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞の活性化のための多重特異性結合タンパク質およびがんを処置するためのその治療的使用 |
| EP3579866A4 (en) * | 2017-02-08 | 2020-12-09 | Dragonfly Therapeutics, Inc. | HEAVY CHAIN VARIABLE ANTIBODY DOMAINS WITH NKG2D RECEPTOR AIMING |
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| CN110536900B (zh) | 2017-04-07 | 2024-06-11 | Igm生物科学股份有限公司 | 调节补体依赖性细胞溶解效应子功能的修饰的人igm恒定区 |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| FI3749346T3 (fi) | 2018-02-08 | 2024-09-04 | Dragonfly Therapeutics Inc | Nkg2d-reseptoriin kohdistuvat vasta-aineen vaihtelevan domeenin yhdistelmät |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| BR112020017296A2 (pt) | 2018-03-01 | 2020-12-29 | Igm Biosciences, Inc. | Mutações de igm fc e de cadeia j que afetam a meia-vida sérica de igm |
| JP7482363B2 (ja) | 2018-08-08 | 2024-05-14 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及び腫瘍関連抗原に結合するタンパク質 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202100883SA (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| MX2021005751A (es) * | 2018-11-16 | 2021-10-01 | Memorial Sloan Kettering Cancer Center | Anticuerpos contra mucina 16 y métodos de uso de los mismos. |
| US20230203119A1 (en) | 2019-08-15 | 2023-06-29 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
| CA3177024A1 (en) | 2020-05-06 | 2021-11-11 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and clec12a |
| AU2021401052A1 (en) | 2020-12-18 | 2023-06-22 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
| CN114181318B (zh) * | 2021-11-08 | 2023-08-01 | 四川大学 | 一种组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用 |
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| US20100322849A1 (en) * | 2003-11-05 | 2010-12-23 | Bhat Neelima M | Enhanced b cell cytotoxicity of cdim binding antibody |
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|---|---|
| US9409976B2 (en) | 2016-08-09 |
| CA2863714C (en) | 2022-07-05 |
| DK2812356T3 (da) | 2019-07-08 |
| WO2013120012A2 (en) | 2013-08-15 |
| MX2014009628A (es) | 2015-03-19 |
| ES2735289T3 (es) | 2019-12-17 |
| BR112014019459A8 (pt) | 2023-01-10 |
| CA2863714A1 (en) | 2013-08-15 |
| TW201345921A (zh) | 2013-11-16 |
| MX363819B (es) | 2019-04-03 |
| CN104254544B (zh) | 2017-04-26 |
| AU2013200903A1 (en) | 2013-08-22 |
| HK1205136A1 (en) | 2015-12-11 |
| IN2014MN01781A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-07-03 |
| KR20150001728A (ko) | 2015-01-06 |
| BR112014019459A2 (pt) | 2017-06-27 |
| AU2013200903B2 (en) | 2015-05-14 |
| JP6335796B2 (ja) | 2018-06-06 |
| EP2812356B1 (en) | 2019-03-27 |
| US20140044739A1 (en) | 2014-02-13 |
| KR102102111B1 (ko) | 2020-04-20 |
| WO2013120012A3 (en) | 2013-11-07 |
| BR112014019459B1 (pt) | 2023-04-18 |
| JP2015511817A (ja) | 2015-04-23 |
| EP2812356A2 (en) | 2014-12-17 |
| CN104254544A (zh) | 2014-12-31 |
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