TWI480064B - 人類抗－ＴＮＦα抗體之穩定高蛋白質濃度調配物 - Google Patents

人類抗－ＴＮＦα抗體之穩定高蛋白質濃度調配物 Download PDF

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TWI480064B
TWI480064B TW099114238A TW99114238A TWI480064B TW I480064 B TWI480064 B TW I480064B TW 099114238 A TW099114238 A TW 099114238A TW 99114238 A TW99114238 A TW 99114238A TW I480064 B TWI480064 B TW I480064B
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formulation
seq
acid sequence
amino acid
antibody
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TW099114238A
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TW201043263A (en
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Wolfgang Fraunhofer
Hans-Juergen Krause
Michael Neu
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Abbvie Biotechnology Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Urology & Nephrology (AREA)
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TW099114238A 2009-05-04 2010-05-04 人類抗－ＴＮＦα抗體之穩定高蛋白質濃度調配物 TWI480064B (zh)

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US17538009P 2009-05-04 2009-05-04

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TWI480064B true TWI480064B (zh) 2015-04-11

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TW104107818A TW201526923A (zh) 2009-05-04 2010-05-04 人類抗-ＴＮＦα抗體之穩定高蛋白質濃度調配物

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US (3) US20100278822A1 (enExample)
EP (1) EP2427211A4 (enExample)
JP (1) JP2012526121A (enExample)
KR (1) KR20120038406A (enExample)
CN (2) CN102458469B (enExample)
AR (1) AR076748A1 (enExample)
AU (1) AU2010246168A1 (enExample)
CA (1) CA2760185A1 (enExample)
IL (1) IL215643A0 (enExample)
MX (1) MX2011011772A (enExample)
NZ (2) NZ595694A (enExample)
RU (1) RU2560701C2 (enExample)
SG (2) SG10201401995UA (enExample)
TW (2) TWI480064B (enExample)
UY (1) UY32609A (enExample)
WO (1) WO2010129469A1 (enExample)

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