SG175188A1 - Stable high protein concentration formulations of human anti-tnf-alpha-antibodies - Google Patents
Stable high protein concentration formulations of human anti-tnf-alpha-antibodies Download PDFInfo
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- SG175188A1 SG175188A1 SG2011074341A SG2011074341A SG175188A1 SG 175188 A1 SG175188 A1 SG 175188A1 SG 2011074341 A SG2011074341 A SG 2011074341A SG 2011074341 A SG2011074341 A SG 2011074341A SG 175188 A1 SG175188 A1 SG 175188A1
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Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| WO1997029131A1 (en) | 1996-02-09 | 1997-08-14 | Basf Aktiengesellschaft | HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a) |
| CA2385745C (en) | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040136991A1 (en) * | 2002-07-19 | 2004-07-15 | Abbott Biotechnology Ltd. | Treatment of anemia using TNFalpha inhibitors |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| EP1885397A4 (en) | 2005-05-16 | 2010-01-20 | Abbott Biotech Ltd | USE OF A TNF HEMMER FOR THE TREATMENT OF EROSIVE POLYARTHRITIS |
| DK1948235T3 (da) | 2005-11-01 | 2013-11-25 | Abbvie Biotechnology Ltd | Fremgangsmåder til bestemmelse af effektiviteten af adalimumab hos patienter med Bechterews sygdom med CTX-II og MMP3 som biomarkører |
| EP2738178A1 (en) | 2006-04-05 | 2014-06-04 | AbbVie Biotechnology Ltd | Antibody purification |
| US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| WO2008063213A2 (en) | 2006-04-10 | 2008-05-29 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| TWI527603B (zh) | 2006-06-30 | 2016-04-01 | 艾伯維生物技術有限責任公司 | 自動注射裝置 |
| NZ613356A (en) | 2006-10-27 | 2015-02-27 | Abbvie Biotechnology Ltd | Crystalline anti-htnfalpha antibodies |
| CA2681752A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
| US8999337B2 (en) | 2007-06-11 | 2015-04-07 | Abbvie Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis by inhibition of TNFα |
| WO2009011782A2 (en) * | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | METHODS AND COMPOSITIONS FOR PULMONARY ADMINISTRATION OF A TNFa INHIBITOR |
| WO2009020654A1 (en) | 2007-08-08 | 2009-02-12 | Abbott Laboratories | Compositions and methods for crystallizing antibodies |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| TW200938221A (en) * | 2007-11-30 | 2009-09-16 | Abbott Lab | Protein formulations and methods of making same |
| EP2238446A4 (en) * | 2008-01-03 | 2011-07-20 | Abbott Biotech Ltd | PREDICTING THE LONG-TERM EFFECT OF A CONNECTION IN THE TREATMENT OF PSORIASIS |
| NZ601913A (en) | 2008-01-15 | 2014-02-28 | Abbott Gmbh & Co Kg | Powdered protein compositions and methods of making same |
| BRPI1012162A2 (pt) | 2009-04-29 | 2016-01-12 | Abbott Biotech Ltd | dispositivo de injeção automática |
| WO2011075524A1 (en) | 2009-12-15 | 2011-06-23 | Abbott Biotechnology Ltd | Improved firing button for automatic injection device |
| US20120014956A1 (en) | 2010-02-02 | 2012-01-19 | Hartmut Kupper | Methods and compositions for predicting responsiveness to treatment with tnf-alpha inhibitor |
| CN103079594B (zh) | 2010-06-03 | 2016-04-13 | 艾伯维生物技术有限公司 | 用于治疗化脓性汗腺炎(hs)的用途和组合物 |
| TWI606840B (zh) * | 2010-11-11 | 2017-12-01 | 艾伯維生物技術有限責任公司 | 具有增進高濃度之抗-ＴＮＦα抗體之液體調配物 |
| CA2825316C (en) | 2011-01-24 | 2020-05-05 | Abbvie Biotechnology Ltd. | Automatic injection devices having overmolded gripping surfaces |
| WO2012111762A1 (ja) * | 2011-02-17 | 2012-08-23 | 協和発酵キリン株式会社 | 抗ｃｄ４０抗体の高濃度製剤 |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2704751B1 (en) * | 2011-05-02 | 2019-04-17 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| GB201112429D0 (en) * | 2011-07-19 | 2011-08-31 | Glaxo Group Ltd | Antigen-binding proteins with increased FcRn binding |
| WO2013096835A1 (en) * | 2011-12-23 | 2013-06-27 | Abbvie Inc. | Stable protein formulations |
| WO2013164837A1 (en) | 2012-03-07 | 2013-11-07 | Cadila Healthcare Limited | Pharmaceutical formulations of tnf-alpha antibodies |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| EP2863951A1 (en) * | 2012-06-12 | 2015-04-29 | Boehringer Ingelheim International GmbH | Pharmaceutical formulation for a therapeutic antibody |
| US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| CN104768576A (zh) | 2012-09-07 | 2015-07-08 | 科荣生生物科学公司 | 稳定的阿达木单抗水性制剂 |
| EP2919801B1 (en) * | 2012-10-26 | 2020-04-29 | Lupin Atlantis Holdings, SA | Stable pharmaceutical composition of the tnfr:fc fusion protein etanercept |
| US9649383B2 (en) * | 2012-11-19 | 2017-05-16 | Merck Sharp & Dohme Corp. | Liquid formulations for TNFR:Fc fusion proteins |
| WO2014099636A1 (en) * | 2012-12-18 | 2014-06-26 | Merck Sharp & Dohme Corp. | Liquid formulations for an anti-tnf alpha antibody |
| CN102988984B (zh) * | 2012-12-21 | 2015-05-20 | 嘉和生物药业有限公司 | 增强稳定性的抗TNF-α人单克隆抗体的含水药物制剂 |
| BR112015017619A2 (pt) * | 2013-01-24 | 2017-11-21 | Glaxosmithkline Ip Dev Ltd | formulação líquida, uso de uma formulação, e, kit |
| CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US20160002342A1 (en) * | 2013-03-15 | 2016-01-07 | Xinghang Ma | Anti-prolactin receptor antibody formulations |
| CN103446583B (zh) * | 2013-03-21 | 2015-11-18 | 百奥泰生物科技(广州)有限公司 | 一种治疗TNF-α相关疾病的人抗体制剂 |
| JP2014202667A (ja) * | 2013-04-08 | 2014-10-27 | 株式会社島津製作所 | 抗体医薬用粒子径分布測定装置及び抗体医薬の粒子径分布測定方法 |
| EP3003369A4 (en) * | 2013-05-28 | 2017-04-26 | Momenta Pharmaceuticals, Inc. | Pharmaceutical compositions comprising pyrophosphate |
| WO2015007912A1 (en) * | 2013-07-19 | 2015-01-22 | Hexal Ag | Methods and formulations which allow the modulation of immune responses related to the administration of a biopharmaceutical drug |
| IL312865B2 (en) * | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| MX374124B (es) | 2013-10-16 | 2025-03-05 | Outlook Therapeutics Inc | Formulaciones de tampón para la estabilidad de anticuerpo mejorada. |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| WO2015061584A1 (en) * | 2013-10-24 | 2015-04-30 | Medimmune, Llc | Stable, aqueous antibody formulations |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN104666242B (zh) * | 2013-11-26 | 2018-01-02 | 信达生物制药(苏州)有限公司 | 一种稳定的抗TNF‑α抗体制剂及其用途 |
| EP3073992A4 (en) * | 2013-11-29 | 2017-09-13 | Ares Trading S.A. | A liquid formulation of a fusion protein comprising tnfr and fc region |
| CN104707146B (zh) * | 2013-12-16 | 2019-04-16 | 浙江海正药业股份有限公司 | 一种含有阿达木单抗的药物组合物 |
| WO2015150968A2 (en) * | 2014-03-29 | 2015-10-08 | Intas Pharmaceuticals Ltd. | Lyophilized pharmaceutical composition of fc-peptide fusion protein |
| ES2607489T3 (es) * | 2014-05-23 | 2017-03-31 | Ares Trading S.A. | Composición farmacéutica líquida |
| EP2946765B1 (en) * | 2014-05-23 | 2016-08-31 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP2946766B1 (en) | 2014-05-23 | 2016-03-02 | Ares Trading S.A. | Liquid pharmaceutical composition |
| FI3149045T3 (fi) * | 2014-05-27 | 2023-03-20 | Academia Sinica | Koostumuksia ja menetelmiä, jotka liittyvät yleisglykoformeihin vasta-aineiden parannettua tehokkuutta varten |
| US20170189528A1 (en) * | 2014-06-10 | 2017-07-06 | Meiji Seika Pharma Co., Ltd. | Stable aqueous adalimumab formulation |
| TW201628649A (zh) * | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| WO2016120413A1 (en) * | 2015-01-28 | 2016-08-04 | Mabxience S.A. | Pharmaceutical formulations for anti-tnf-alpha antibodies |
| EP3053572A1 (en) * | 2015-02-06 | 2016-08-10 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3078675A1 (en) | 2015-04-10 | 2016-10-12 | Ares Trading S.A. | Induction dosing regimen for the treatment of tnf alpha mediated disorders |
| US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
| SG10202109655VA (en) | 2015-12-04 | 2021-10-28 | Novartis Ag | Compositions and methods for immunooncology |
| WO2017136433A1 (en) * | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2017184880A1 (en) | 2016-04-20 | 2017-10-26 | Coherus Biosciences, Inc. | A method of filling a container with no headspace |
| PT3479819T (pt) * | 2016-06-30 | 2024-04-15 | Celltrion Inc | Preparação farmacêutica líquida estável |
| WO2018034885A1 (en) | 2016-08-16 | 2018-02-22 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| MX2019004316A (es) | 2016-10-25 | 2019-08-05 | Regeneron Pharma | Metodos y sistemas para analisis de datos cromatograficos. |
| RU2764521C2 (ru) * | 2017-12-29 | 2022-01-18 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция рекомбинантного моноклонального антитела к ФНОа |
| RU2665966C2 (ru) * | 2016-12-30 | 2018-09-05 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция рекомбинантного моноклонального антитела к ФНОα |
| US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
| EP3372241A1 (en) * | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3372242A1 (en) * | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| SG11201907434RA (en) | 2017-03-22 | 2019-10-30 | Novartis Ag | Compositions and methods for immunooncology |
| WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN107485713B (zh) * | 2017-07-31 | 2018-08-28 | 百奥泰生物科技(广州)有限公司 | 针对TNF-α的抗体组合物及其应用 |
| KR20190024572A (ko) * | 2017-08-30 | 2019-03-08 | (주)셀트리온 | TNFα 관련 질환을 치료하기 위한 피하 투여 요법 |
| CN111201042B (zh) | 2017-09-19 | 2024-05-10 | 里珍纳龙药品有限公司 | 减少粒子形成的方法以及由其形成的组合物 |
| CN111491664A (zh) | 2017-09-20 | 2020-08-04 | 阿尔沃科技Hf公司 | 阿达木单抗的药物制剂 |
| KR102545825B1 (ko) | 2017-09-30 | 2023-06-22 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 흥분성 신경 독성 관련 손상 치료를 위한 펩타이드 조성물 |
| TW202003036A (zh) * | 2018-03-23 | 2020-01-16 | 德商艾伯維德國有限及兩合公司 | 穩定水性抗-tau抗體調配物 |
| TW202448568A (zh) | 2018-07-02 | 2024-12-16 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| MX2021005394A (es) | 2018-11-07 | 2021-07-06 | Merck Sharp & Dohme Llc | Co-formulaciones de anticuerpos anti-gen de activacion de linfocitos 3 (anti-lag3) y anticuerpos anti-muerte programada-1 (anti-pd-1). |
| US20230203147A1 (en) * | 2019-03-18 | 2023-06-29 | Alvotech Hf | Aqueous formulations of tnf-alpha antibodies in high concentrations |
| WO2021234584A1 (en) * | 2020-05-21 | 2021-11-25 | Shilpa Biologicals Private Limited | Pharmaceutical compositions comprising adalimumab |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5237054A (en) * | 1987-02-20 | 1993-08-17 | Akzo Pharma | Stabilized aqueous composition containing antibodies |
| US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| GB9122820D0 (en) * | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| ZA955642B (en) * | 1994-07-07 | 1997-05-06 | Ortho Pharma Corp | Lyophilized imaging agent formulation |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| WO1997029131A1 (en) * | 1996-02-09 | 1997-08-14 | Basf Aktiengesellschaft | HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a) |
| GB9610992D0 (en) * | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| SE9803710L (sv) * | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
| EP1174148A4 (en) * | 1999-04-28 | 2005-05-04 | Yamanouchi Pharma Co Ltd | PARENTAL MEDICAL COMPOSITIONS CONTAINING FRAGMENTS OF HUMANIZED MONOCLONAL ANTIBODIES AND METHOD FOR STABILIZING THE SAME |
| DE10022092A1 (de) * | 2000-05-08 | 2001-11-15 | Aventis Behring Gmbh | Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung |
| EP1336410A4 (en) * | 2000-08-04 | 2005-10-12 | Chugai Pharmaceutical Co Ltd | PROTEIN INJECTION PREPARATIONS |
| UA81743C2 (uk) * | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| SE0003045D0 (sv) * | 2000-08-29 | 2000-08-29 | Probi Ab | New method |
| EP1324776B2 (en) * | 2000-10-12 | 2018-03-21 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| BR0206160A (pt) * | 2001-05-25 | 2004-10-26 | Abbott Gmbh & Co Kg | Uso de anticorpos anti-tnf como medicamentos no tratamento de distúrbios sépticos de pacientes anêmicos |
| US20040156835A1 (en) * | 2001-05-30 | 2004-08-12 | Taiji Imoto | Protein preparation |
| DK1397155T3 (en) * | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
| ES2338218T3 (es) * | 2001-07-25 | 2010-05-05 | Facet Biotech Corporation | Formulacion farmacologica liofilizada estable de anticuerpos igg daclizumab. |
| US20030138417A1 (en) * | 2001-11-08 | 2003-07-24 | Kaisheva Elizabet A. | Stable liquid pharmaceutical formulation of IgG antibodies |
| EP1585477A4 (en) * | 2001-11-30 | 2007-06-27 | Centocor Inc | ANTI-TNF ANTIBODIES, COMPOSITIONS, METHODS AND USES |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| EP3192528A1 (en) * | 2002-02-14 | 2017-07-19 | Chugai Seiyaku Kabushiki Kaisha | Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer |
| US20030161828A1 (en) * | 2002-02-19 | 2003-08-28 | Abbott Gmbh & Co. Kg | Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| AU2003251592A1 (en) * | 2002-06-21 | 2004-01-06 | Biogen Idec Inc. | Buffered formulations for concentrating antibodies and methods of use thereof |
| US20040136991A1 (en) * | 2002-07-19 | 2004-07-15 | Abbott Biotechnology Ltd. | Treatment of anemia using TNFalpha inhibitors |
| US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| HUE051878T2 (hu) * | 2003-02-10 | 2021-03-29 | Biogen Ma Inc | Immunglobulin készítmény és annak elõállítási módszere |
| AU2004216298B2 (en) * | 2003-02-28 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
| ATE394123T1 (de) * | 2003-02-28 | 2008-05-15 | Ares Trading Sa | Flüssige formulierungen des tumornekrosefraktor- bindungsproteins tbp-1 |
| JP4869064B2 (ja) * | 2003-04-04 | 2012-02-01 | ジェネンテック， インコーポレイテッド | 高濃度抗体及びタンパク質製剤 |
| FR2853551B1 (fr) * | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee |
| WO2005033143A1 (ja) * | 2003-10-01 | 2005-04-14 | Kyowa Hakko Kogyo Co., Ltd. | 抗体の安定化方法及び安定化された溶液状抗体製剤 |
| DE10355251A1 (de) * | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
| JPWO2005063291A1 (ja) * | 2003-12-25 | 2007-07-19 | 麒麟麦酒株式会社 | 抗体を含有する安定な水性医薬製剤 |
| EP1722819B1 (en) * | 2004-03-12 | 2007-12-26 | Intercell AG | Method for solubilising peptide mixtures |
| US7279448B2 (en) * | 2004-07-08 | 2007-10-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Poly(hydroxy thioether) vegetable oil derivatives useful as lubricant additives |
| TW200621282A (en) * | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations |
| US7119876B2 (en) * | 2004-10-18 | 2006-10-10 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| TWI398272B (zh) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
| CA2604840A1 (en) * | 2005-04-18 | 2006-10-26 | Xtl Biopharmaceuticals Ltd. | Stabilized anti-hepatitis b (hbv) antibody formulations |
| EP1885397A4 (en) * | 2005-05-16 | 2010-01-20 | Abbott Biotech Ltd | USE OF A TNF HEMMER FOR THE TREATMENT OF EROSIVE POLYARTHRITIS |
| DK1899462T3 (da) * | 2005-07-02 | 2011-06-06 | Arecor Ltd | Stabile vandige systemer omfattende proteiner |
| AU2006275475A1 (en) * | 2005-07-29 | 2007-02-08 | Amgen Inc. | Formulations that inhibit protein aggregation |
| NZ564843A (en) * | 2005-08-03 | 2012-05-25 | Immunogen Inc | Immunoconjugate formulations comprising an immunoconjugate and an excipient in a buffered aqueous solution |
| CA2915270C (en) * | 2005-08-05 | 2017-07-11 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
| US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| DK1948235T3 (da) * | 2005-11-01 | 2013-11-25 | Abbvie Biotechnology Ltd | Fremgangsmåder til bestemmelse af effektiviteten af adalimumab hos patienter med Bechterews sygdom med CTX-II og MMP3 som biomarkører |
| EP1962907A2 (en) * | 2005-12-21 | 2008-09-03 | Wyeth a Corporation of the State of Delaware | Protein formulations with reduced viscosity and uses thereof |
| WO2007092772A2 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Inc. | Protein formulations |
| JP5364382B2 (ja) * | 2006-02-07 | 2013-12-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 遊離チオール部分を有するタンパク質の安定化された組成物 |
| EP2738178A1 (en) * | 2006-04-05 | 2014-06-04 | AbbVie Biotechnology Ltd | Antibody purification |
| WO2007120626A2 (en) * | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US9399061B2 (en) * | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| MX2008013535A (es) * | 2006-04-21 | 2008-10-29 | Amgen Inc | Agentes amortiguadores para formulaciones biofarmaceuticas. |
| US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| TWI527603B (zh) * | 2006-06-30 | 2016-04-01 | 艾伯維生物技術有限責任公司 | 自動注射裝置 |
| WO2008039761A2 (en) * | 2006-09-25 | 2008-04-03 | Medimmune, Llc. | Stabilized antibody formulations and uses thereof |
| CL2007002880A1 (es) * | 2006-10-06 | 2008-05-09 | Amgen Inc | Formulacion estable que comprende un tampon de acido acetico, un tampon de acido glutamico o un tampon de acido succinico con un ph de 4,5 a 7, por lo menos un excipiente que comprende un azucar o un poliol, y un anticuerpo anti-receptor del factor d |
| TW200833357A (en) * | 2006-10-20 | 2008-08-16 | Amgen Inc | Stable polypeptide formulations |
| NZ613356A (en) * | 2006-10-27 | 2015-02-27 | Abbvie Biotechnology Ltd | Crystalline anti-htnfalpha antibodies |
| BRPI0720125A2 (pt) * | 2006-12-06 | 2014-01-28 | Wyeth Corp | Método para armazenar uma formulação líquida; método para a preparação de uma formulação líquida; composição; e método para inibir a agregação induzida por manitol de uma proteína em uma formulação líquida. |
| GB0700523D0 (en) * | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
| BRPI0810500A2 (pt) * | 2007-04-26 | 2014-10-14 | Bayer Healthcare Llc | Estabilização de soluções líquidas de proteína recombinante para armazenagem no estado de congelamento |
| US8092998B2 (en) * | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
| MX2009012964A (es) * | 2007-06-01 | 2010-01-14 | Acologix Inc | Formulacion de peptido estable a alta temperatura. |
| EP2152318A4 (en) * | 2007-06-01 | 2011-12-07 | Abbott Biotech Ltd | COMPOSITIONS AND USES FOR THE TREATMENT OF PSORIASIS AND CROHN'S DISEASE |
| WO2009006301A2 (en) * | 2007-06-29 | 2009-01-08 | Battelle Memorial Institute | Protein stabilization |
| WO2009011782A2 (en) * | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | METHODS AND COMPOSITIONS FOR PULMONARY ADMINISTRATION OF A TNFa INHIBITOR |
| US20090029794A1 (en) * | 2007-07-23 | 2009-01-29 | Yung-Hsiung Chen | Golf Club Head that Reduces a Contact Resistance with the Ground |
| WO2009020654A1 (en) * | 2007-08-08 | 2009-02-12 | Abbott Laboratories | Compositions and methods for crystallizing antibodies |
| CN102282173A (zh) * | 2008-03-24 | 2011-12-14 | 艾博特生物技术有限公司 | 用于治疗骨丢失的方法和组合物 |
| BRPI1012162A2 (pt) * | 2009-04-29 | 2016-01-12 | Abbott Biotech Ltd | dispositivo de injeção automática |
| US20120014956A1 (en) * | 2010-02-02 | 2012-01-19 | Hartmut Kupper | Methods and compositions for predicting responsiveness to treatment with tnf-alpha inhibitor |
-
2010
- 2010-05-03 CN CN201410669393.5A patent/CN104490767A/zh active Pending
- 2010-05-03 WO PCT/US2010/033387 patent/WO2010129469A1/en not_active Ceased
- 2010-05-03 US US12/772,595 patent/US20100278822A1/en not_active Abandoned
- 2010-05-03 CA CA2760185A patent/CA2760185A1/en not_active Abandoned
- 2010-05-03 AU AU2010246168A patent/AU2010246168A1/en not_active Abandoned
- 2010-05-03 NZ NZ613809A patent/NZ613809A/en not_active IP Right Cessation
- 2010-05-03 JP JP2012509873A patent/JP2012526121A/ja active Pending
- 2010-05-03 RU RU2011149327/15A patent/RU2560701C2/ru not_active IP Right Cessation
- 2010-05-03 MX MX2011011772A patent/MX2011011772A/es not_active Application Discontinuation
- 2010-05-03 SG SG2011074341A patent/SG175188A1/en unknown
- 2010-05-03 CN CN201080030083.9A patent/CN102458469B/zh not_active Expired - Fee Related
- 2010-05-03 EP EP10772644.0A patent/EP2427211A4/en not_active Withdrawn
- 2010-05-03 KR KR1020117029006A patent/KR20120038406A/ko not_active Withdrawn
- 2010-05-03 NZ NZ595694A patent/NZ595694A/xx not_active IP Right Cessation
- 2010-05-03 SG SG10201401995UA patent/SG10201401995UA/en unknown
- 2010-05-04 TW TW104107818A patent/TW201526923A/zh unknown
- 2010-05-04 UY UY0001032609A patent/UY32609A/es not_active Application Discontinuation
- 2010-05-04 TW TW099114238A patent/TWI480064B/zh not_active IP Right Cessation
- 2010-05-04 AR ARP100101510A patent/AR076748A1/es unknown
-
2011
- 2011-10-09 IL IL215643A patent/IL215643A0/en unknown
-
2014
- 2014-01-31 US US14/170,061 patent/US20140141008A1/en not_active Abandoned
- 2014-01-31 US US14/170,026 patent/US20140141007A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW201043263A (en) | 2010-12-16 |
| TWI480064B (zh) | 2015-04-11 |
| KR20120038406A (ko) | 2012-04-23 |
| RU2560701C2 (ru) | 2015-08-20 |
| CN102458469B (zh) | 2014-12-24 |
| NZ613809A (en) | 2015-02-27 |
| US20140141007A1 (en) | 2014-05-22 |
| CA2760185A1 (en) | 2010-11-11 |
| IL215643A0 (en) | 2012-01-31 |
| RU2011149327A (ru) | 2013-06-10 |
| AR076748A1 (es) | 2011-07-06 |
| CN104490767A (zh) | 2015-04-08 |
| NZ595694A (en) | 2013-09-27 |
| EP2427211A1 (en) | 2012-03-14 |
| CN102458469A (zh) | 2012-05-16 |
| US20140141008A1 (en) | 2014-05-22 |
| US20100278822A1 (en) | 2010-11-04 |
| MX2011011772A (es) | 2012-02-08 |
| SG10201401995UA (en) | 2014-08-28 |
| AU2010246168A1 (en) | 2011-11-10 |
| EP2427211A4 (en) | 2013-05-01 |
| WO2010129469A8 (en) | 2012-02-23 |
| WO2010129469A1 (en) | 2010-11-11 |
| UY32609A (es) | 2010-12-31 |
| TW201526923A (zh) | 2015-07-16 |
| JP2012526121A (ja) | 2012-10-25 |
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